当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Humoral control of water and electrolyte excretion during water restriction.

Humoral control of water and electrolyte excretion during water restriction.

Abstract：

:The goals of the present study were twofold: first, to assess the renal excretory and hormonal responses to chronic water restriction in dogs whose sodium retaining mechanisms had been stimulated through dietary sodium (Na+) deprivation; second, to determine the mediator(s) of the natriuresis which was observed with water restriction in these sodium deprived dogs. Three groups of dogs maintained on a low Na+ diet (5 mEq/day) for two weeks underwent a three day period of water restriction. In normal, intact dogs Group 1 (N = 5), water restriction resulted in a significant increase in Na+ excretion with a net cumulative loss of 26.3 +/- 2.6 mEq over three days. The natriuresis was associated with a significant increase in plasma vasopressin (PAVP) (1.7 to 10.2 pg/mliter) and a significant fall in plasma aldosterone (PALDO) from the levels observed with Na+ restriction alone (24.9 to 12.4 ng/dliter). The natriuresis could not be explained by decreases in food intake as determined by control studies in four dogs. Group 2 (N = 6) dogs had a decrease in PALDO with water restriction that was prevented by means of continuous i.v. aldosterone infusion (6.0 micrograms/kg/day). Dogs in this group failed to demonstrate a natriuresis during three days of water restriction, despite the fact that PAVP rose from 3.3 +/- 0.8 to a peak level of 14.95 +/- 1.9 pg/mliter. Group 3 (N = 6) dogs underwent selective neurohypophysectomy, thus preventing the rise in PAVP during three days of water restriction. In this group, PALDO also remained unchanged from the Na+ deprived level during water restriction, and no natriuresis was observed. We conclude: 1) that the natriuresis which occurs with water restriction is a potent physiological response that occurs even in the Na+ restricted state; and 2) this natriuresis can be explained by a fall in PALDO and not the rise in PAVP.

journal_name

Kidney Int

journal_title

Kidney international

authors

Merrill DC,Skelton MM,Cowley AW Jr

doi

10.1038/ki.1986.121

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

1152-61

issue

6

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)33704-2

journal_volume

29

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • DNAzyme for TGF-beta suppressed extracellular matrix accumulation in experimental glomerulonephritis.

    abstract：BACKGROUND:We developed an electroporation-mediated gene transfer method targeting glomerular mesangial cells. Injecting DNA solution via renal artery followed by electric pulses using tweezers-type electrodes could result in efficient transfection in mesangial cells. Therefore, this gene transfer system opened a feasi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00777.x

    authors： Isaka Y,Nakamura H,Mizui M,Takabatake Y,Horio M,Kawachi H,Shimizu F,Imai E,Hori M

    更新日期：2004-08-01 00:00:00

  • Longitudinal evaluation of peritoneal macrophage function and activation during CAPD: maturity, cytokine synthesis and arachidonic acid metabolism.

    abstract：:The release of cytokines and prostaglandins (PG) by peritoneal macrophages (PM luminal diameter of) may influence the cytokine network controlling peritoneal inflammation and in the long-term the function of the peritoneum as a dialysis membrane. In the present study, an evaluation of the long-term effects of peritone...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.75

    authors： McGregor SJ,Topley N,Jörres A,Speekenbrink AB,Gordon A,Gahl GM,Junor BJ,Briggs JD,Brock JH

    更新日期：1996-02-01 00:00:00

  • Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study.

    abstract：:The purpose of this study was to explore risk factors affecting the incidence of chronic kidney disease (CKD) in general population. We conducted a 10-year follow-up study with 123 764 (male: 41 012, female: 82 752) adults aged 40 years and over who received community-based annual examinations. The primary outcome for...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002017

    authors： Yamagata K,Ishida K,Sairenchi T,Takahashi H,Ohba S,Shiigai T,Narita M,Koyama A

    更新日期：2007-01-01 00:00:00

  • Role of vascular endothelial growth factor in the regulation of angiogenesis.

    abstract：:Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation d...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.1999.00610.x

    authors： Ferrara N

    更新日期：1999-09-01 00:00:00

  • Cell surface heparan sulfate proteoglycans control the response of renal interstitial fibroblasts to fibroblast growth factor-2.

    abstract：BACKGROUND:While the progression of renal disease to end stage is strongly correlated with tubulointerstitial changes, the control of the fibrotic process within the interstitium is poorly understood. Basic fibroblast growth factor (FGF-2) has been implicated as a major growth factor involved in fibroblast activation a...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00723.x

    authors： Clayton A,Thomas J,Thomas GJ,Davies M,Steadman R

    更新日期：2001-06-01 00:00:00

  • Limited urinary concentration and damaged tubules in rats with a syngeneic kidney graft.

    abstract：BACKGROUND:The underlying mechanisms of renal transplant dysfunction are poorly understood. There is little information on tubular function in kidney grafts. The cDNAs encoding kidney-specific cell surface proteins required for renal reabsorption of sodium (sodium cotransporter in thick ascending limb of Henle, rBSC1) ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.060002672.x

    authors： Michimata M,Wang W,Fujita S,Mizutani H,Fujimori K,Satomi S,Ohta M,Ito S,Kimura T,Araki T,Imai Y,Matsubara M

    更新日期：2001-08-01 00:00:00

  • The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy.

    abstract：BACKGROUND:Inhibition of angiotensin action, pharmacologically or genetically, during the neonatal period leads to renal anomalies involving hypoplastic papilla and dilated calyx. Recently, we documented that angiotensinogen (Agt -/-) or angiotensin type 1 receptor nullizygotes (Agtr1 -/-) do not develop renal pelvis n...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00420.x

    authors： Miyazaki Y,Tsuchida S,Fogo A,Ichikawa I

    更新日期：1999-05-01 00:00:00

  • Recombinant human growth hormone exacerbates chronic puromycin aminonucleoside nephropathy in rats.

    abstract：:Growth failure is a cardinal feature of chronic renal failure in children. Administration of recombinant human growth hormone (rhGH) ameliorates this problem but may adversely affect the kidney and hasten the progression to end-stage renal disease. We conducted experiments to examine the impact of rhGH on the severity...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.380

    authors： Trachtman H,Futterweit S,Schwob N,Maesaka J,Valderrama E

    更新日期：1993-12-01 00:00:00

  • Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease.

    abstract：:As an alternative to classical immunosuppressants in experimental lupus nephritis, we looked at bindarit, 2-methyl-2-[[1-phenylmethyl)-1H-indazol-3-y1]methoxy]propanoic acid, a novel molecule devoid of immunosuppressive effects, which selectively reduces chronic inflammation in rat adjuvant arthritis. Two groups of NZ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00804.x

    authors： Zoja C,Corna D,Benedetti G,Morigi M,Donadelli R,Guglielmotti A,Pinza M,Bertani T,Remuzzi G

    更新日期：1998-03-01 00:00:00

  • Vitamin D: a new hope for chronic kidney disease?

    abstract：:Vitamin D analogs may slow the progression of chronic kidney disease. Tan et al. report that paricalcitol has additive effects with an angiotensin-converting enzyme inhibitor (ACEI) in suppressing extracellular matrix expression, interstitial inflammation, and myofibroblast activation in obstructive nephropathy. Paric...

    journal_title：Kidney international

    pub_type： 评论,杂志文章,评审

    doi：10.1038/ki.2009.390

    authors： Li M,Batuman V

    更新日期：2009-12-01 00:00:00

  • Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO).

    abstract：:Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and are an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteod...

    journal_title：Kidney international

    pub_type： 共识发展会议,杂志文章

    doi：10.1038/sj.ki.5000414

    authors： Moe S,Drüeke T,Cunningham J,Goodman W,Martin K,Olgaard K,Ott S,Sprague S,Lameire N,Eknoyan G,Kidney Disease: Improving Global Outcomes (KDIGO).

    更新日期：2006-06-01 00:00:00

  • Presence of lipids in urine, crystals and stones: implications for the formation of kidney stones.

    abstract：BACKGROUND:Cell membranes and their lipids play critical roles in calcification. Specific membrane phospholipids promote the formation of calcium phosphate and become a part of the organic matrix of growing calcification. We propose that membrane lipids also promote the formation of calcium oxalate (CaOx) and calcium p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00676.x

    authors： Khan SR,Glenton PA,Backov R,Talham DR

    更新日期：2002-12-01 00:00:00

  • Activation of innate immune defense mechanisms contributes to polyomavirus BK-associated nephropathy.

    abstract：:Polyomavirus-associated nephropathy (PVAN) is a significant complication after kidney transplantation, often leading to premature graft loss. In order to identify antiviral responses of the renal tubular epithelium, we studied activation of the viral DNA and the double-stranded RNA (dsRNA) sensors Toll-like receptor 3...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.311

    authors： Ribeiro A,Wörnle M,Motamedi N,Anders HJ,Gröne EF,Nitschko H,Kurktschiev P,Debiec H,Kretzler M,Cohen CD,Gröne HJ,Schlöndorff D,Schmid H

    更新日期：2012-01-01 00:00:00

  • Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity.

    abstract：BACKGROUND:In cultured renal epithelial cells, exposure to oxalate, a constituent of many kidney stones, elicits a cascade of responses that often leads to cell death. Oxalate toxicity is mediated via generation of reactive oxygen species (ROS) in a process that depends at least in part upon lipid signaling molecules t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00963.x

    authors： Cao LC,Honeyman TW,Cooney R,Kennington L,Scheid CR,Jonassen JA

    更新日期：2004-11-01 00:00:00

  • The characterization of a specific Thy-1 molecular epitope expressed on rat mesangial cells.

    abstract：BACKGROUND:An Experimental model of proliferative glomerulonephritis induced by an antibody against Thy-1 antigen has been established. However, the pathophysiologic role and the critical epitope of Thy-1 molecule for induction of mesangial cell dysfunction remain unknown. We have reported that monoclonal antibody 1-22...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.66011.x

    authors： Morioka T,Yao J,Suzuki Y,Oite T

    更新日期：2004-12-01 00:00:00

  • Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication.

    abstract：BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00604.x

    authors： Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

    更新日期：1999-08-01 00:00:00

  • Effect of HDL and atherogenic lipoproteins on formation of O2- and renin release in juxtaglomerular cells.

    abstract：:Atherogenic lipoproteins and reactive oxygen species stimulate renin release from isolated juxtaglomerular (JG) cells. Here we assessed whether stimulation of renin release is mediated by formation of superoxide anion (O2-), and whether the effects of oxidized lipoproteins, like in many other biological systems, can b...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.30

    authors： Galle J,Heinloth A,Schwedler S,Wanner C

    更新日期：1997-01-01 00:00:00

  • T-cell transcriptome analysis points up a thymic disorder in idiopathic nephrotic syndrome.

    abstract：BACKGROUND:Idiopathic nephrotic syndrome is a proteinuric disease secondary to the release of a nonidentified circulating glomerular permeability factor by T cells. Because specificities of T-cell activation in idiopathic nephrotic syndrome remain unknown, we evaluated transcriptional activation of T cells in nephrotic...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00322.x

    authors： Mansour H,Cheval L,Elalouf JM,Aude JC,Alyanakian MA,Mougenot B,Doucet A,Deschênes G

    更新日期：2005-06-01 00:00:00

  • The clot thickens.

    abstract：:Vascular sclerosis has been linked to many risk factors, including smoking, family history, low birth weight, and hypertension. In interesting studies, Goforth et al. show an increased rate of mutations in thrombophilic molecules in patients with vascular sclerosis in renal biopsies, suggesting yet another mechanism. ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5001721

    authors： Fogo AB

    更新日期：2006-08-01 00:00:00

  • Necrosis and apoptosis of polymorphonuclear cells exposed to peritoneal dialysis fluids in vitro.

    abstract：:Conventional peritoneal dialysis (PD) fluids are known to inhibit polymorphonuclear cells (PMN) phagocytosis, oxidative burst and enzyme release. However, the relative contributions of apoptosis and/or necrosis to this dysfunction have not been examined. We investigated the effects of osmolality, glucose concentration...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.495

    authors： Cendoroglo M,Sundaram S,Groves C,Ucci AA,Jaber BL,Pereira BJ

    更新日期：1997-12-01 00:00:00

  • The podocyte's response to injury: role in proteinuria and glomerulosclerosis.

    abstract：:The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are highly specialized cells. They function as a critical size and charge barrier to prevent proteinuria. Podocytes are injured in diabetic and non-diabetic renal diseases. The clinical signature of podocyte injury is proteinuria,...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/sj.ki.5000410

    authors： Shankland SJ

    更新日期：2006-06-01 00:00:00

  • MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation.

    abstract：:Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2018.12.028

    authors： Bai M,Chen H,Ding D,Song R,Lin J,Zhang Y,Guo Y,Chen S,Ding G,Zhang Y,Jia Z,Huang S,He JC,Yang L,Zhang A

    更新日期：2019-06-01 00:00:00

  • Dual RAAS blockade is desirable in kidney disease: con.

    abstract：:Dual renin-angiotensin aldosterone (RAAS) blockade is associated with higher risk of hyperkalemia and has not been shown, in any outcome trial of validated renal end points, that is, doubling of creatinine, time to dialysis, or death, to be superior over other approaches. It shows promise in advanced proteinuric nephr...

    journal_title：Kidney international

    pub_type： 评论,杂志文章,评审

    doi：10.1038/ki.2010.226

    authors： Bakris GL

    更新日期：2010-09-01 00:00:00

  • Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis.

    abstract：:Mutations in the inverted formin 2 gene (INF2) have recently been identified as the most common cause of autosomal dominant focal and segmental glomerulosclerosis (FSGS). To quantify the contribution of various genes contributing to FSGS, we sequenced INF2 where all mutations have previously been described (exons 2 to...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.349

    authors： Barua M,Brown EJ,Charoonratana VT,Genovese G,Sun H,Pollak MR

    更新日期：2013-02-01 00:00:00

  • Classical pathway of complement activation in normal and diseased human glomeruli.

    abstract：:Monoclonal antibodies (mAb) reactive against complement components involved in the classical activation pathway were applied in an indirect immunoperoxidase technique for the histological study of normal and diseased human renal tissues. Prominent staining with antibodies against the C4d fragment was seen in all glome...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.302

    authors： Zwirner J,Felber E,Herzog V,Riethmüller G,Feucht HE

    更新日期：1989-12-01 00:00:00

  • Changes in cancer incidence and outcomes among kidney transplant recipients in the United States over a thirty-year period.

    abstract：:Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.10.018

    authors： Blosser CD,Haber G,Engels EA

    更新日期：2020-11-04 00:00:00

  • Characterization of glycosaminoglycans in tubular epithelial cells: calcium oxalate and oxalate ions effects.

    abstract：BACKGROUND:The interaction between tubular epithelial cells and calcium oxalate crystals or oxalate ions is a very precarious event in the lithogenesis. Urine contains ions, glycoproteins and glycosaminoglycans that inhibit the crystallization process and may protect the kidney against lithogenesis. We examined the eff...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00577.x

    authors： Borges FT,Michelacci YM,Aguiar JA,Dalboni MA,Garófalo AS,Schor N

    更新日期：2005-10-01 00:00:00

  • Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate.

    abstract：:Vitamin D receptor activation has been associated with increased serum creatinine and reduced estimated glomerular filtration rates, raising concerns that its use may be detrimental to kidney function. Here we studied the effect of vitamin D receptor activation on serum creatinine, creatinine generation, and its clear...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.2011.207

    authors： Agarwal R,Hynson JE,Hecht TJ,Light RP,Sinha AD

    更新日期：2011-11-01 00:00:00

  • Real-time monitoring of mesangial cell-macrophage cross-talk using SEAP in vitro and ex vivo.

    abstract：BACKGROUND:Macrophage-mesangial cell interaction plays a crucial role in the pathogenesis of glomerulonephritis. We established a novel system for continuous, real-time monitoring of cross-talk between macrophages and mesangial cells in vitro and ex vivo. METHODS:Rat mesangial cells were genetically engineered to prod...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00471.x

    authors： Meng Y,Kasai A,Hiramatsu N,Hayakawa K,Takeda M,Shimizu F,Kawachi H,Yao J,Kitamura M

    更新日期：2005-08-01 00:00:00

  • Cardiovascular disease in pediatric chronic dialysis patients.

    abstract：BACKGROUND:Little information is available regarding cardiac morbidity and mortality in children with end-stage renal disease. We sought to determine the incidence of cardiac morbidity and mortality in pediatric chronic dialysis patients. METHODS:Medicare incident pediatric (0 to 19 years) dialysis patients from 1991 ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00472.x

    authors： Chavers BM,Li S,Collins AJ,Herzog CA

    更新日期：2002-08-01 00:00:00