Vitamin D: a new hope for chronic kidney disease?

Abstract:

:Vitamin D analogs may slow the progression of chronic kidney disease. Tan et al. report that paricalcitol has additive effects with an angiotensin-converting enzyme inhibitor (ACEI) in suppressing extracellular matrix expression, interstitial inflammation, and myofibroblast activation in obstructive nephropathy. Paricalcitol inhibited renin transcription, countering the compensatory ACEI-induced rise in renin, thus achieving a more complete blockade of the renin-angiotensin system (RAS). Vitamin D analogs may enhance the renoprotective effects of RAS inhibitors.

journal_name

Kidney Int

journal_title

Kidney international

authors

Li M,Batuman V

doi

10.1038/ki.2009.390

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1219-21

issue

12

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)53921-5

journal_volume

76

pub_type

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