Chronic renal failure with gout: a marker of chronic lead poisoning.

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia emerged in Wuhan, China in December 2019. Unfortunately, there is a lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), and even less is available in patients on maintenance hemodialysis therapy than in the g...

journal_title：Kidney international

authors： Goicoechea M,Sánchez Cámara LA,Macías N,Muñoz de Morales A,Rojas ÁG,Bascuñana A,Arroyo D,Vega A,Abad S,Verde E,García Prieto AM,Verdalles Ú,Barbieri D,Delgado AF,Carbayo J,Mijaylova A,Acosta A,Melero R,Tejedor A,Ben

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:It is still unclear whether age per se is associated with preservation of renal functional reserve, that is, of the increase in glomerular filtration rate (GFR) induced by appropriate vasodilating stimulus. METHODS:To gain insights into this issue, we evaluated the renal response to a maximal vasodilating s...

journal_title：Kidney international

authors： Fuiano G,Sund S,Mazza G,Rosa M,Caglioti A,Gallo G,Natale G,Andreucci M,Memoli B,De Nicola L,Conte G

更新日期：2001-03-01 00:00:00

abstract：:Acute kidney injury (AKI) severe enough to require dialysis is increasing and associated with high mortality, yet robust information about temporal epidemiology of AKI requiring dialysis in England is lacking. In this retrospective observational study of the Hospital Episode Statistics (HES) data set covering the enti...

journal_title：Kidney international

authors： Kolhe NV,Muirhead AW,Wilkes SR,Fluck RJ,Taal MW

更新日期：2015-11-01 00:00:00

abstract：:The following bone density measurements have limited utility in determining bone strength because they do not include bone quality: microarchitecture, mineralization, ability to repair damage, collagen structure, crystal size, or marrow composition. Patients with kidney disease have poor bone quality. Newman et al. no...

journal_title：Kidney international

authors： Ott SM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Previous experiments from our laboratory have demonstrated that HKalpha(2) coimmunoprecipitated with beta(1)-Na(+),K(+)-ATPase. Although HKalpha(2) is expressed abundantly in the apical membrane of distal colon, the demonstration that beta(1) localizes to this same membrane in distal colon has not been demon...

journal_title：Kidney international

authors： Li J,Codina J,Petroske E,Werle MJ,Willingham MC,DuBose TD Jr

更新日期：2004-09-01 00:00:00

abstract：:Albuminuria and a reduced glomerular filtration rate are conventional predictors of a future decline in kidney function in patients with type 2 diabetes mellitus. Using a nested case-control study we assessed whether circulating transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) levels mor...

journal_title：Kidney international

authors： Wong MG,Perkovic V,Woodward M,Chalmers J,Li Q,Hillis GS,Yaghobian Azari D,Jun M,Poulter N,Hamet P,Williams B,Neal B,Mancia G,Cooper M,Pollock CA

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:In a prior study the 21-aminosteroid (lazaroid) U74389F provided in vivo protection from oxidative stress when used as a preventive therapy in ischemia-reperfusion injury in the kidney. As the cell membrane is the principal site for lipoperoxidation, in the current study the very lipophilic 2-methylaminochro...

journal_title：Kidney international

authors： De Vecchi E,Lubatti L,Beretta C,Ferrero S,Rinaldi P,Galli Kienle M,Trazzi R,Paroni R

更新日期：1998-09-01 00:00:00

abstract：:Vascular calcification is a recognized risk factor for cardiovascular mortality in patients with end-stage renal disease. The aim of this study was to identify risk factors for vascular access calcification and to determine if patients with this disorder are at increased risk of death. Vascular access calcification wa...

journal_title：Kidney international

authors： Schlieper G,Krüger T,Djuric Z,Damjanovic T,Markovic N,Schurgers LJ,Brandenburg VM,Westenfeld R,Dimkovic S,Ketteler M,Grootendorst DC,Dekker FW,Floege J,Dimkovic N

更新日期：2008-12-01 00:00:00

abstract：:The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we inves...

journal_title：Kidney international

authors： Olsson J,Dadfar E,Paulsson J,Lundahl J,Moshfegh A,Jacobson SH

更新日期：2007-03-01 00:00:00

abstract：:The candidacidal activity of kidneys, liver, and spleen's phagocytic systems was studied in mouse. Different strains of mice were inoculated intravenously (i.v.) with 1 to 2.6 x 10(4) viable Candida albicans. Elimination of the microorganisms from the kidneys, liver, and spleen were evaluated by enumeration of colony ...

journal_title：Kidney international

authors： Baghian A,Lee KW

更新日期：1991-09-01 00:00:00

abstract：:The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure, an important risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, it is unclear whether adherence to a DASH diet confers protection against future ESRD, especially among those with pre-existing CKD and h...

journal_title：Kidney international

authors： Banerjee T,Crews DC,Tuot DS,Pavkov ME,Burrows NR,Stack AG,Saran R,Bragg-Gresham J,Powe NR,Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team.

更新日期：2019-06-01 00:00:00

abstract：:The present study was undertaken to: (a) clarify the comparative renal potency of bolus injection of the natriuretic peptides urodilatin and ANF99-126 in the rat; (b) establish whether or not intravenous (i.v.) infusion of urodilatin (200 ng/min) combined with dopamine (UD) to maintain mean arterial pressure could imp...

journal_title：Kidney international

authors： Shaw S,Weidmann P,Zimmermann A

更新日期：1992-11-01 00:00:00

abstract：:The main distal nephron segment sodium transporters are the distal tubule chlorothiazide-sensitive sodium chloride cotransporter (NCC) and the collecting duct amiloride-sensitive epithelial sodium channel (ENaC). The infusion of ghrelin into the renal interstitium stimulates distal nephron-dependent sodium reabsorptio...

journal_title：Kidney international

authors： Kemp BA,Howell NL,Gildea JJ,Keller SR,Padia SH

更新日期：2013-09-01 00:00:00

abstract：:Residual renal function is a major survival determinant for peritoneal dialysis patients. Hypovolemia can cause acute kidney injury and loss of residual renal function, and it has been suggested that patients receiving peritoneal dialysis should preferably be maintained hypervolemic to preserve residual renal function...

journal_title：Kidney international

authors： McCafferty K,Fan S,Davenport A

更新日期：2014-01-01 00:00:00

abstract：:Increasing evidence points to the importance of aberrant O-glycosylated immunoglobulin A1 (IgA1) in the pathogenesis of IgA nephropathy (IgAN), a disease widely considered to be a polygenic disorder. We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with sus...

journal_title：Kidney international

authors： Zhu L,Tang W,Li G,Lv J,Ding J,Yu L,Zhao M,Li Y,Zhang X,Shen Y,Zhang H,Wang H

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:It is known that chronic renal insufficiency (CRI) patients with gout may have subtle lead poisoning. In addition, gout episodes frequently aggravate progressive renal insufficiency because of the use of nephrotoxic drugs and urate deposition. Our study was arranged to evaluate the causal effect of environme...

journal_title：Kidney international

authors： Lin JL,Yu CC,Lin-Tan DT,Ho HH

更新日期：2001-07-01 00:00:00

abstract：:The effect of the tricarboxylic acid (TCA) cycle precursor, pyruvate, on glutamine metabolism by isolated renal cortical mitochondria was assessed by quantitating its key nitrogen and carbon metabolites. When mitochondria from normal rats were incubated at pH 7.4, pyruvate (2 mM) inhibited ammonia production by almost...

journal_title：Kidney international

authors： Tannen RL,Kunin AS

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Patients initiating dialysis after a failed kidney transplant are a subgroup of chronic kidney disease (CKD) patients who have not been characterized. Exposure to immunosuppressive medications differentiates these patients from the general incident end-stage renal disease (ESRD) population. METHODS:Data fro...

journal_title：Kidney international

authors： Gill JS,Abichandani R,Khan S,Kausz AT,Pereira BJ

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Bone marrow reconstitution using genetically-modified hematopoietic stem cells has been reported to confer resistance to inflammation and prevent renal injury in glomerulonephritis. Although this strategy has potentials for clinical use, taking hematopoietic stem cells from bone marrow is highly stressful fo...

journal_title：Kidney international

authors： Yokoo T,Ohashi T,Utsunomiya Y,Okamoto A,Suzuki T,Shen JS,Tanaka T,Kawamura T,Hosoya T

更新日期：2003-07-01 00:00:00

abstract：:Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), an enzyme that exists in several isoforms. Some studies found that a polymorphism (G894T) in the endothelial NOS gene was associated with decreased nitric oxide bioactivity and vascular complications. However, it is not known whether the enzyme ...

journal_title：Kidney international

authors： Cherney DZ,Scholey JW,Zhou J,Zimpelmann J,Kennedy C,Burns KD,Lai V,Miller JA

更新日期：2009-02-01 00:00:00

abstract：:The renal effects of a single intravenous dose of two different E. coli lipopolysaccharides (LPS 0111:B4 and LPS 0127:B8), at the same dose of 100 micrograms/kg, were evaluated in euvolemic Munich-Wistar (MW) rats by whole kidney clearance techniques and micropuncture studies. Following LPS infusion, a significant dec...

journal_title：Kidney international

authors： Lugon JR,Boim MA,Ramos OL,Ajzen H,Schor N

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Lanthanum carbonate has been shown to be a safe, effective phosphate-binding agent. We have shown that an impaired mineralization in chronic renal failure rats treated with high doses of lanthanum carbonate develops secondary to phosphate depletion and is therefore pharmacologically mediated rather than a di...

journal_title：Kidney international

authors： Behets GJ,Verberckmoes SC,Oste L,Bervoets AR,Salomé M,Cox AG,Denton J,De Broe ME,D'Haese PC

更新日期：2005-05-01 00:00:00

abstract：:Macrophages are inflammatory cells with important roles in the propagation of renal injury. More recently they have also been shown to be important in the resolution of inflammation. Wang et al. show that macrophages can be modulated ex vivo by cytokine stimulation, localize to renal tissue, and slow progression of ex...

journal_title：Kidney international

authors： Kluth DC

更新日期：2007-08-01 00:00:00

abstract：:Class IV-S lupus nephritis is often associated with more necrosis and fewer subendothelial immune deposits compared to class IV-G lupus nephritis, suggestive of necrotising glomerular inflammation found in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. ANCAs are present in a significant proportion o...

journal_title：Kidney international

authors： Turner-Stokes T,Wilson HR,Morreale M,Nunes A,Cairns T,Cook HT,Pusey CD,Tarzi RM,Lightstone L

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The induction of stress response (heat shock) proteins (HSPs) is a highly conserved response that protects many cell types from diverse physiological and environmental stressors. We tested the hypothesis that the induction of HSPs is protective in experimental renal ischemia/reperfusion injury. METHODS:The ...

journal_title：Kidney international

authors： Kelly KJ,Baird NR,Greene AL

更新日期：2001-05-01 00:00:00

abstract：:The initiation of peritonitis is accompanied by a massive increase in intraperitoneal levels of IL-6. The source of this cytokine and the mechanism by which its levels are increased so dramatically are unknown. We examined the mechanism of IL-6 secretion by HPMC exposed to the milicu present in the peritoneal cavity d...

journal_title：Kidney international

authors： Witowski J,Jörres A,Coles GA,Williams JD,Topley N

更新日期：1996-10-01 00:00:00

abstract：:Kidney transplant patients receiving phenytoin or phenobarbital may have decreased graft survival. These drugs have been shown to enhance the metabolism of glucocorticoids. We determined the disposition of total and unbound prednisolone in six stable kidney transplant patients receiving prednisone for immunosuppressio...

journal_title：Kidney international

authors： Gambertoglio JG,Holford NH,Kapusnik JE,Nishikawa R,Saltiel M,Stanik-Lizak P,Birnbaum JL,Hau T,Amend WJ Jr

更新日期：1984-01-01 00:00:00

abstract：:The present studies were undertaken to assess the effects of 5'-N-ethylcarboxamideadenosine (NECA), an adenosine analogue, on erythropoietin (Epo) production. NECA (0.05 and 0.1 mumol/kg i.v.) produced significant increases in serum Epo levels (368.8 +/- 56.1 and 384.6 +/- 45.9 mU/ml, respectively) in exhypoxic polycy...

journal_title：Kidney international

authors： Nakashima J,Ohigashi T,Brookins JW,Beckman BS,Agrawal KC,Fisher JW

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:High blood glucose levels play major roles in the pathogenesis of renal diabetic complications through non-enzymatic glycation. For long-lived molecules this leads to formation of advanced glycation end products (AGE), and the renal extracellular matrix appears to be one of the targets for such processes. Us...

journal_title：Kidney international

authors： Bendayan M

更新日期：1998-08-01 00:00:00

abstract：:Elevated serum levels of uric acid consistently correlate with hypertension, but the directionality of the association remains debated. To help define this relationship, we used a controlled setting within a homogeneous Amish community and the Mendelian randomization of a nonsynonymous coding single-nucleotide polymor...

journal_title：Kidney international

authors： Parsa A,Brown E,Weir MR,Fink JC,Shuldiner AR,Mitchell BD,McArdle PF

更新日期：2012-03-01 00:00:00