当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Positive antineutrophil cytoplasmic antibody serology in patients with lupus nephritis is associated with distinct histopathologic features on renal biopsy.

Positive antineutrophil cytoplasmic antibody serology in patients with lupus nephritis is associated with distinct histopathologic features on renal biopsy.

Abstract：

:Class IV-S lupus nephritis is often associated with more necrosis and fewer subendothelial immune deposits compared to class IV-G lupus nephritis, suggestive of necrotising glomerular inflammation found in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. ANCAs are present in a significant proportion of patients with lupus nephritis. Here we determine whether ANCAs are associated with distinct clinical and histopathologic features of lupus nephritis. Thirty-two ANCA-positive biopsies were compared to 222 ANCA-negative biopsies from patients with lupus nephritis. The majority (82%) of ANCA-positive patients had antimyeloperoxidase antibodies. Class IV-S lupus nephritis and glomerular necrosis were significantly more common (36% vs. 16% and 35% vs. 15%, respectively) and isolated Class V lupus nephritis significantly less common (10% vs. 29%) in the ANCA-positive group. ANCA-positive patients had significantly higher dsDNA titers (335u/ml vs. 52u/ml), significantly lower serum C4 concentrations (0.125g/L vs. 0.15g/L) and significantly higher serum creatinine (130μmol/L vs. 84μmol/L) at the time of biopsy. Hence ANCAs appear to influence the histological pattern of lupus nephritis and are associated with worse baseline renal function and more active lupus serology. There was no significant difference in outcome between groups when matched for severity of disease and treatment using propensity scoring. Thus, further studies are needed to examine whether ANCAs in patients with lupus nephritis have a pathogenic role and whether they are associated with worse renal outcomes or are simply a marker of more severe disease.

journal_name

Kidney Int

journal_title

Kidney international

authors

Turner-Stokes T,Wilson HR,Morreale M,Nunes A,Cairns T,Cook HT,Pusey CD,Tarzi RM,Lightstone L

doi

10.1016/j.kint.2017.04.029

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1223-1231

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(17)30324-1

journal_volume

92

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • T-cell transcriptome analysis points up a thymic disorder in idiopathic nephrotic syndrome.

    abstract：BACKGROUND:Idiopathic nephrotic syndrome is a proteinuric disease secondary to the release of a nonidentified circulating glomerular permeability factor by T cells. Because specificities of T-cell activation in idiopathic nephrotic syndrome remain unknown, we evaluated transcriptional activation of T cells in nephrotic...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00322.x

    authors： Mansour H,Cheval L,Elalouf JM,Aude JC,Alyanakian MA,Mougenot B,Doucet A,Deschênes G

    更新日期：2005-06-01 00:00:00

  • Apoptosis in parathyroid hyperplasia of patients with primary or secondary uremic hyperparathyroidism.

    abstract：BACKGROUND:Chronic oversecretion of parathyroid hormone (PTH) is associated with parathyroid hyperplasia, reflecting a disturbed balance between cell proliferation and apoptosis. This study addressed the unsolved issue of apoptosis in hyperparathyroidism. METHODS:Parathyroid glands from 19 patients with primary (1 deg...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00863.x

    authors： Zhang P,Duchambon P,Gogusev J,Nabarra B,Sarfati E,Bourdeau A,Drüeke TB

    更新日期：2000-02-01 00:00:00

  • Phosphate depletion arrests progression of chronic renal failure independent of protein intake.

    abstract：:Following 5/6 nephrectomy, 18 rats were fed a normal diet. After 30 days, serum creatinine (SCr), urine protein excretion and urine volume were increased compared to pre-nephrectomy (0.27 +/- 0.1 vs. 1.62 +/- 0.6 mg/deciliter, 17.0 +/- 10.3 vs. 257.6 +/- 13.4 mg/24 hr, and 16.6 +/- 4.4 vs. 39.2 +/- 11.7 ml/24 hr, resp...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.49

    authors： Lumlertgul D,Burke TJ,Gillum DM,Alfrey AC,Harris DC,Hammond WS,Schrier RW

    更新日期：1986-03-01 00:00:00

  • The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury.

    abstract：:Acute kidney injury (AKI) is a critical condition with a mortality rate as high as 50% and significantly contributes to the burden of end-stage renal disease (ESRD) requiring renal replacement therapy. The incidence and prognosis of AKI have been shown to vary with patient age, with younger individuals being more resi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.394

    authors： Fan H,Yang HC,You L,Wang YY,He WJ,Hao CM

    更新日期：2013-03-01 00:00:00

  • Increased renal tubular expression of transforming growth factor beta in human allografts correlates with cyclosporine toxicity.

    abstract：:Cyclosporine A (CsA) is a potent immunosuppressive drug that inhibits the transcription of several proinflammatory cytokines including interleukin-2. In contrast, CsA stimulates transcription of the pleuripotent cytokine, transforming growth factor-beta (TGF beta). Since the effect of CsA in transplant recipients is u...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.1996.479

    authors： Pankewycz OG,Miao L,Isaacs R,Guan J,Pruett T,Haussmann G,Sturgill BC

    更新日期：1996-11-01 00:00:00

  • Progressive renal disease: role of race and antihypertensive medications.

    abstract：:Hypertension is associated with an accelerated rate of decline in renal function in patients with chronic renal disease. To identify factors that might alter the rate of decline in renal function, we reviewed records of 200 patients from the Nephrology Clinic of the Durham VA Medical Center who had chronic progressive...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.93

    authors： Brazy PC,Fitzwilliam JF

    更新日期：1990-04-01 00:00:00

  • The role of mitochondria in ischemia/reperfusion injury in organ transplantation.

    abstract：:In organ transplantation, ischemia/reperfusion (I/R) results in damage that may affect cell viability and lead to organ failure. I/R injury involves a complex cascade of events, including loss of energy, derangement of the ionic hemostasis, production of reactive oxygen species, and cell death. In this context, mitoch...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1111/j.1523-1755.2004.761_9.x

    authors： Jassem W,Heaton ND

    更新日期：2004-08-01 00:00:00

  • Pressure diuresis and natriuresis in DOCA-salt mice.

    abstract：:The increasing use of mice in renal and cardiovascular studies has necessitated adapting physiological methods used for rats to mice, which are far smaller in size. We have adapted measurements of continuous renal blood flow, pressure natriuresis and diuresis, and laser-Doppler cortical and medullary flow to 40 g mice...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.462

    authors： Gross V,Lippoldt A,Luft FC

    更新日期：1997-11-01 00:00:00

  • Higher hemoglobin levels and quality of life in patients with advanced chronic kidney disease: no longer a moving target?

    abstract：:International clinical practice guidelines for the management of anemia in chronic kidney disease suggest target hemoglobin levels ≤ 11.5 g/dl (115 g/l), with individualized consideration of slightly higher hemoglobin targets to improve quality of life. An updated meta-analysis of randomized trials demonstrates no sig...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.03.001

    authors： Wyatt CM,Drueke TB

    更新日期：2016-05-01 00:00:00

  • The body composition and excretory burden of lean, obese, and severely obese individuals has implications for the assessment of chronic kidney disease.

    abstract：:Obesity could affect associations between creatinine generation, estimated body surface area, and excretory burden, with effects on chronic kidney disease assessment. We therefore examined the impact of obesity on the performances of estimated glomerular filtration rate (eGFR), the urine albumin:creatinine ratio (ACR)...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.112

    authors： Fotheringham J,Weatherley N,Kawar B,Fogarty DG,Ellam T

    更新日期：2014-12-01 00:00:00

  • Vintage, nutritional status, and survival in hemodialysis patients.

    abstract：BACKGROUND:The link between dialysis "vintage" (length of time on dialysis in months to years) and survival has been difficult to define, largely because of selection effects. End-stage renal disease (ESRD) is thought to be a wasting illness, but there are no published reports describing the associations between vintag...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00945.x

    authors： Chertow GM,Johansen KL,Lew N,Lazarus JM,Lowrie EG

    更新日期：2000-03-01 00:00:00

  • Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization.

    abstract：BACKGROUND:In renal cells, hyperosmolarity has been shown to induce the accumulation of myo-inositol, via the Na+/myo-inositol cotransporter (SMIT). Previously we showed that SMIT mRNA in the kidney is localized in the medullary thick ascending limb of Henle (TALH). Here we used renal cells derived from the rabbit oute...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00235.x

    authors： Yorek MA,Dunlap JA,Lowe WL Jr

    更新日期：1999-01-01 00:00:00

  • Functional thiamine deficiency in end-stage renal disease: malnutrition despite ample nutrients.

    abstract：:Zhang et al. found that plasma concentrations of the thiamine antimetabolite oxythiamine are significantly increased in patients with end-stage renal disease. These investigators discuss the potential sources of oxythiamine and the consequences of its plasma elevation. This commentary addresses the significance of the...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.04.017

    authors： Moradi H,Said HM

    更新日期：2016-08-01 00:00:00

  • Effects of recombinant human erythropoietin on HLA sensitization and cell mediated immunity.

    abstract：:Highly presensitized patients wait longer for a renal allograft than unsensitized patients and have a poorer allograft survival rate. Repeated blood transfusions have been implicated in the induction and maintenance of sensitization. To determine the effect of recombinant human erythropoietin (rHuEPO) therapy on five ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.161

    authors： Grimm PC,Sinai-Trieman L,Sekiya NM,Robertson LS,Robinson BJ,Fine RN,Ettenger RB

    更新日期：1990-07-01 00:00:00

  • Effects of C-peptide on renal function at the early stage of experimental diabetes.

    abstract：BACKGROUND:C-peptide has been reported to have biological effects on renal function early in the course of diabetes. This investigation was initiated to elucidate and amplify these findings with respect to protein leakage, hyperfiltration and renal functional reserve in diabetic rats. METHODS:Acute effects of 140 minu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00074.x

    authors： Sjöquist M,Huang W,Johansson BL

    更新日期：1998-09-01 00:00:00

  • Long-term clinical effects of a peritoneal dialysis fluid with less glucose degradation products.

    abstract：BACKGROUND:Glucose degradation products (GDPs) are cytotoxic in vitro and potentially toxic in vivo during peritoneal dialysis (PD). We are presenting the results of a two-year randomized clinical trial of a new PD fluid, produced in a two-compartment bag and designed to minimize heat-induced glucose degradation while ...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1523-1755.2001.00497.x

    authors： Rippe B,Simonsen O,Heimbürger O,Christensson A,Haraldsson B,Stelin G,Weiss L,Nielsen FD,Bro S,Friedberg M,Wieslander A

    更新日期：2001-01-01 00:00:00

  • High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients.

    abstract：:Hyperhomocysteinemia, an arteriosclerotic risk factor, persists in 75% of dialysis patients despite routine low dose supplementation with the B-vitamin co-factors/substrates for homocysteine (Hcy) metabolism, and normal or supernormal plasma status of these vitamins (Atherosclerosis 114:93, 1995). We conducted a place...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1038/ki.1996.19

    authors： Bostom AG,Shemin D,Lapane KL,Hume AL,Yoburn D,Nadeau MR,Bendich A,Selhub J,Rosenberg IH

    更新日期：1996-01-01 00:00:00

  • Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes.

    abstract：BACKGROUND:Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) is expressed constitutively in the adult glomerular podocytes at high levels; however, the regulation of its production is unclear. Recent data from podocyte-specific knockout mice suggest that VPF/VEGF-A is critical for the proper ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00910.x

    authors： Datta K,Li J,Karumanchi SA,Wang E,Rondeau E,Mukhopadhyay D

    更新日期：2004-10-01 00:00:00

  • Expression of fibroblast growth factors and their receptors in rat glomeruli.

    abstract：:Fibroblast growth factors (FGFs) regulate cell proliferation and differentiation, and are also important regulators of extracellular matrix. They are among the most potent angiogenic factors known. Evidence suggests the FGFs play a role in glomerular development and pathology. The aim of the present study was to deter...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.238

    authors： Ford MD,Cauchi J,Greferath U,Bertram JF

    更新日期：1997-06-01 00:00:00

  • C1q-binding donor-specific antibody assays help define risk and prognosis in antibody-mediated rejection.

    abstract：:Antibody-mediated rejection represents the first cause of graft loss in renal transplant recipients, and it is imperative to identify appropriate tools to enable risk stratification of such patients. Lately, the usefulness of measuring complement-binding anti-human leukocyte antigen (HLA) donor-specific antibodies (DS...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2018.06.032

    authors： Cozzi E,Biancone L

    更新日期：2018-10-01 00:00:00

  • Dysregulation of renal salt and water transport proteins in diabetic Zucker rats.

    abstract：BACKGROUND:Diabetic nephropathy is commonly associated with renal salt and water retention and hypertension. The molecular mechanisms involved and how the kidney responds to this volume expansion, in terms of renal transporter regulation, are not understood. METHODS:Targeted proteomics employing semiquantitative immun...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00353.x

    authors： Bickel CA,Knepper MA,Verbalis JG,Ecelbarger CA

    更新日期：2002-06-01 00:00:00

  • Renal vascular sclerosis is associated with inherited thrombophilias.

    abstract：:Vascular sclerosis is often seen in renal biopsies. It is usually associated with diabetes mellitus, hypertension, smoking, etc. However, whether inherited thrombophilic states such as factor V gene mutation, prothrombin gene mutation, and methylenetetrahydrofolate reductase (MTHFR) gene mutation are associated with t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5001551

    authors： Goforth RL,Rennke H,Sethi S

    更新日期：2006-08-01 00:00:00

  • Klotho upregulation by rapamycin protects against vascular disease in CKD.

    abstract：:Medial arterial calcification involves chondrogenic/osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). Zhao et al. report that phosphate activates the mammalian target of rapamycin (mTOR) cascade in VSMCs, leading to downregulation of Klotho. Furthermore, rapamycin was shown to halt medial calcif...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2015.223

    authors： Hamano T

    更新日期：2015-10-01 00:00:00

  • Roscovitine blocks collecting duct cyst growth in Cep164-deficient kidneys.

    abstract：:Nephronophthisis is an autosomal recessive kidney disease with high genetic heterogeneity. Understanding the functions of the individual genes contributing to this disease is critical for delineating the pathomechanisms of this disorder. Here, we investigated kidney function of a novel gene associated with nephronopht...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.04.014

    authors： Airik R,Airik M,Schueler M,Bates CM,Hildebrandt F

    更新日期：2019-08-01 00:00:00

  • An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes.

    abstract：:A genome-wide association scan of the Genetics of Kidneys in Diabetes (GoKinD) collections identified four novel susceptibility loci, located on chromosomes 7p14.3, 9q21.32, 11p15.4, and 13q33.3 associated with type 1 diabetic nephropathy. A recent evaluation of these loci in Japanese patients with type 2 diabetes sup...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1038/ki.2011.64

    authors： Pezzolesi MG,Poznik GD,Skupien J,Smiles AM,Mychaleckyj JC,Rich SS,Warram JH,Krolewski AS

    更新日期：2011-07-01 00:00:00

  • N-acetylcysteine attenuates the progression of chronic renal failure.

    abstract：BACKGROUND:Lipid peroxidation impairs renal function. Aldosterone contributes to renal injury in the remnant kidney model. This study aimed to determine the effects of the antioxidant N-acetylcysteine (NAC) on renal function and aldosterone levels in chronic renal failure. METHODS:Adult male Wistar rats were submitted...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00677.x

    authors： Shimizu MH,Coimbra TM,de Araujo M,Menezes LF,Seguro AC

    更新日期：2005-11-01 00:00:00

  • Examination of Hardy-Weinberg equilibrium in papers of Kidney International: an underused tool.

    abstract：BACKGROUND:Population-genetic studies investigating genetic polymorphisms of Mendelian inheritance should always test whether the measured genotype frequencies deviate from the expected one. For this purpose Hardy-Weinberg (HW) criteria are generally used. If genotype distribution of control population misses HW equili...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00596.x

    authors： Kocsis I,Györffy B,Németh E,Vásárhelyi B

    更新日期：2004-05-01 00:00:00

  • Activation of Na:2Cl:K cotransport by luminal chloride in macula densa cells.

    abstract：:Changes in macula densa intracellular pH (pHi) were used to monitor the direction of flux mediated by the apical Na:2Cl:K cotransporter. At the macula densa, a decrease in luminal [Cl] ([Cl]1) from 60 to 1 mM produced cellular alkalinization secondary to a cascade of events involving a decrease in apical Na:2Cl:K cotr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.115

    authors： Lapointe JY,Laamarti A,Hurst AM,Fowler BC,Bell PD

    更新日期：1995-03-01 00:00:00

  • Incidence of latent mesangial IgA deposition in renal allograft donors in Japan.

    abstract：BACKGROUND:Mesangial immunoglobulin A (IgA) deposition is incidentally encountered in asymptomatic individuals, but its precise frequency and significance had not been clarified. The background of the latent IgA deposition is related to the epidemiology and pathogenesis of IgA nephropathy. METHODS:Zero-hour allograft ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.63.6s.2.x

    authors： Suzuki K,Honda K,Tanabe K,Toma H,Nihei H,Yamaguchi Y

    更新日期：2003-06-01 00:00:00

  • Blood pressure and long-term mortality in United States hemodialysis patients: USRDS Waves 3 and 4 Study.

    abstract：BACKGROUND:The long-term prognostic associations of pre- and post-dialysis blood pressures, interdialytic weight gain, and antihypertensive use in hemodialysis patients are unclear. METHODS:The United States Renal Data System (USRDS) Dialysis Morbidity and Mortality Waves 3 and 4 Study, a randomly generated sample of ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00636.x

    authors： Foley RN,Herzog CA,Collins AJ,United States Renal Data System.

    更新日期：2002-11-01 00:00:00