Abstract：
:Following 5/6 nephrectomy, 18 rats were fed a normal diet. After 30 days, serum creatinine (SCr), urine protein excretion and urine volume were increased compared to pre-nephrectomy (0.27 +/- 0.1 vs. 1.62 +/- 0.6 mg/deciliter, 17.0 +/- 10.3 vs. 257.6 +/- 13.4 mg/24 hr, and 16.6 +/- 4.4 vs. 39.2 +/- 11.7 ml/24 hr, respectively, all P less than 0.001). At this time, when serum phosphorus (SPi) and serum calcium (SCa2+) were normal, the rats were separated into two groups, matched and paired by body weight and SCr, and housed separately in metabolic cages. Animals of one group ingested a normal diet supplemented with dihydroxyaluminum aminoacetate (DHAAA), 15 g%, to induce phosphate depletion (PD). The second group ingested the same diet supplemented with 7.5% glycine and was the phosphate replete (PR) group. All rats were pair fed throughout the study to maintain similar caloric, protein, carbohydrate, vitamin, and mineral intakes. At six weeks after separation, SPi was decreased in PD vs. PR group (2.85 +/- 0.8 vs. 6.71 +/- 1.2 mg/deciliter, P less than 0.001) and SCa2+ was increased in the PD group (11.98 +/- 0.7 vs. 10.03 +/- 0.7 mg/deciliter, P less than 0.001). Urine urea nitrogen, body weight, and sodium, potassium and solute excretion were similar between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Lumlertgul D,Burke TJ,Gillum DM,Alfrey AC,Harris DC,Hammond WS,Schrier RWdoi
10.1038/ki.1986.49subject
Has Abstractpub_date
1986-03-01 00:00:00pages
658-66issue
3eissn
0085-2538issn
1523-1755pii
S0085-2538(15)33632-2journal_volume
29pub_type
杂志文章abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.04.033
更新日期：2020-07-01 00:00:00
abstract：:We studied the glomerular architecture in renal biopsies of 95 patients undergoing bariatric surgery for extreme obesity but whose renal function was normal. The comparison group was 40 control patients having protocol biopsies. These latter patients had normal weight and renal function, were non-diabetic, non-hyperte...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002796
更新日期：2008-04-01 00:00:00
abstract：:Plasma newly-synthesized cholesteryl ester transfer (NCET) rate and concentrations of lipids, lipoproteins and apolipoproteins A1 and B were measured in chronic renal failure patients (dialysis independent and dialysis dependent), patients with a functioning renal transplant and in healthy control subjects with compar...
journal_title：Kidney international
pub_type： 临床试验,杂志文章
doi：10.1038/ki.1994.378
更新日期：1994-10-01 00:00:00
abstract：:Hyperinsulinemia can contribute to hypertension through effects on sodium transport. To test whether the stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in insulin resistance, we compared the effects of insulin on abdominal adipocytes and proximal tubules in rats and humans. Insuli...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2014.351
更新日期：2015-03-01 00:00:00
abstract：:Nephropathy is among the most frequent complications of diabetes and the leading cause of end-stage renal disease. Despite the success of novel drugs in animal models, the majority of the subsequent clinical trials employing those drugs targeting diabetic nephropathy failed. This lack of translational value may in par...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2016.06.023
更新日期：2016-11-01 00:00:00
abstract：:Conventional peritoneal dialysis (PD) fluids are known to inhibit polymorphonuclear cells (PMN) phagocytosis, oxidative burst and enzyme release. However, the relative contributions of apoptosis and/or necrosis to this dysfunction have not been examined. We investigated the effects of osmolality, glucose concentration...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.495
更新日期：1997-12-01 00:00:00
abstract：:Abnormalities of bone mineral metabolism and vascular calcification are prevalent in patients with kidney failure. Clinical management is based on biochemical targets, in particular parathyroid hormone (PTH) concentrations, but this has many limitations including high biological variation. A possible alternative is bo...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.77
更新日期：2012-07-01 00:00:00
abstract：:Aboriginal dialysis patients have reduced access to kidney transplantation. The reasons for this disparity are unknown. Tonelli et al. show that in Canada, residence location does not significantly impact on an Aboriginal dialysis patient's likelihood of receiving kidney transplantation. This Commentary explores the i...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5001762
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00697.x
更新日期：2005-11-01 00:00:00
abstract：:As an alternative to classical immunosuppressants in experimental lupus nephritis, we looked at bindarit, 2-methyl-2-[[1-phenylmethyl)-1H-indazol-3-y1]methoxy]propanoic acid, a novel molecule devoid of immunosuppressive effects, which selectively reduces chronic inflammation in rat adjuvant arthritis. Two groups of NZ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1998.00804.x
更新日期：1998-03-01 00:00:00
abstract：:The nature of the light chains in mesangial IgA deposits and serum IgA was studied in patients with IgA nephropathy. Immunofluorescence (IF) studies using murine monoclonal antibodies, rabbit and goat anti-human monospecific antisera were performed in kidney sections from 15 IgA nephritic patients with only IgA isotyp...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1988.37
更新日期：1988-02-01 00:00:00
abstract：:Peptides representing potential antigenic regions of the NC-1 and 7-S domains of the human alpha 1 and alpha 2, and bovine alpha 3 chains of type IV collagen were synthesized either chemically or by the recombinant DNA technique and tested by ELISA using antibodies raised in rabbits against the whole type IV collagen ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1993.16
更新日期：1993-01-01 00:00:00
abstract：:Atherogenic lipoproteins and reactive oxygen species stimulate renin release from isolated juxtaglomerular (JG) cells. Here we assessed whether stimulation of renin release is mediated by formation of superoxide anion (O2-), and whether the effects of oxidized lipoproteins, like in many other biological systems, can b...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.30
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Peritoneal sclerosis, characterized by collagen accumulation, is a serious complication in continuous ambulatory peritoneal dialysis (CAPD) therapy. Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperon and is closely associated with collagen synthesis. METHODS:We determined the expression...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00883.x
更新日期：2000-02-01 00:00:00
abstract：:The pathogenesis of the multiple structural lesions in diabetic nephropathy remains debated, and likely is multifactorial. The uniform thickening of the renal basement membranes lining the glomerular and tubular elements appears to be a consequence of the metabolic perturbations which are directly related to hyperglyc...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.1993.19
更新日期：1993-01-01 00:00:00
abstract：:Intrauterine growth retardation (IUGR) aggravates the course of acute mesangioproliferative glomerulonephritis (GN) in the rat. Observational studies in children suggest that IUGR may be associated with a severe course of kidney diseases such as IgA nephropathy. We tested the hypothesis that IUGR leads to aggravation ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5001966
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Redox-active iron can promote oxidative stress and tissue injury by catalyzing hydroxyl radical generation and lipid peroxidation. Intravenous iron preparations are routinely administered in conjunction with erythropoietin to treat anemia in patients with chronic renal failure (CRF), a condition that is mark...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00580.x
更新日期：2004-05-01 00:00:00
abstract：:Fixed anionic sites within the glomerular capillary wall influence the permeation of serum proteins, the localization of various antigens, and the deposition of antibody in the subepithelial space. In anti-GBM nephritis antibody deposition occurs very rapidly to antigenic sites located relatively proximal in the glome...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1984.188
更新日期：1984-10-01 00:00:00
abstract：:The primary hyperoxalurias are diseases of overproduction of oxalate. The immediate precursor of oxalate is glyoxylate. Metabolism of hydroxyproline, derived from collagen turnover or the diet, appears to be a major source of glyoxylate, and a potential target for a therapeutic strategy of substrate depletion. ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5001987
更新日期：2006-12-01 00:00:00
abstract：:Leptin is an adipocyte-derived hormone that acts as a major regulator of food intake and energy homeostasis. It circulates both as a free and as a protein-bound entity. Leptin is released into the blood in proportion to the amount of body fat and exerts sustained inhibitory effects on food intake while increasing ener...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5000182
更新日期：2006-03-01 00:00:00
abstract：:Fibroblast growth factors (FGFs) regulate cell proliferation and differentiation, and are also important regulators of extracellular matrix. They are among the most potent angiogenic factors known. Evidence suggests the FGFs play a role in glomerular development and pathology. The aim of the present study was to deter...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.238
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:The debate on the association between nonphenacetin-containing combined analgesics and renal disease has lasted for several years. METHOD:A peer review committee of scientists, selected jointly by the regulatory authorities of Germany, Switzerland, and Austria and the pharmaceutical industry was asked to cr...
journal_title：Kidney international
pub_type： 共识发展会议,杂志文章,评审
doi：10.1046/j.1523-1755.2000.00410.x
更新日期：2000-12-01 00:00:00
abstract：:Hyper-activation of Rac1, a small GTPase, in glomerular podocytes has been implicated in the pathogenesis of familial proteinuric kidney diseases. However, the role of Rac1 in acquired nephrotic syndrome is unknown. To gain direct insights into this, we generated a transgenic mouse model expressing a doxycycline-induc...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2017.03.010
更新日期：2017-08-01 00:00:00
abstract：:The remnant kidney model was produced in mice by unilateral nephrectomy and partial infarction of the remaining kidney. Control mice underwent laparotomy only. The mice were studied for up to 44 weeks. No quantitative differences were noted in systolic arterial pressure, proteinuria, or histopathology between control ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1999.00527.x
更新日期：1999-07-01 00:00:00
abstract：:Acute kidney injury (AKI) is a critical condition with a mortality rate as high as 50% and significantly contributes to the burden of end-stage renal disease (ESRD) requiring renal replacement therapy. The incidence and prognosis of AKI have been shown to vary with patient age, with younger individuals being more resi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.394
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Since the cloning of the gene for autosomal dominant polycystic kidney disease type 2 (PKD2), approximately 40 different mutations of that gene have been reported to be associated with the disease. The relationship between the PKD2 genotype and phenotype, however, remains unclear. METHODS:Detailed clinical ...
journal_title：Kidney international
pub_type： 杂志文章,多中心研究
doi：10.1046/j.1523-1755.2000.00989.x
更新日期：2000-04-01 00:00:00
abstract：:The microcirculation is regulated by oxygen gradients and by endothelial release of nitric oxide, which can react with hemoglobin to form S-nitroso derivatives. Here we induced flow-mediated dilatation of the brachial artery in response to ischemia in 141 non-diabetic patients with stage 3-4 chronic kidney disease who...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2009.63
更新日期：2009-06-01 00:00:00
abstract：:Bikunin is a chondroitin-sulphate containing serum protein with a Stokes-Einstein radius and a negative net charge close to those of serum albumin. The plasma half life of bikunin is about 10 minutes, and approximately half of its clearance occurs in the kidneys. The quantitative role of glomerular filtration in the r...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.147
更新日期：1997-04-01 00:00:00
abstract：:The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in osteoarthritis (OA) an...
journal_title：Kidney international
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ki.5001766
更新日期：2006-10-01 00:00:00
abstract：:Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is lacking. Here we studied the effect of propofol anesthesia on the occurrence of acute kidney injury following heart surgery with cardiopulmonary bypass. One hundred and twelve patients who u...
journal_title：Kidney international
pub_type： 杂志文章,随机对照试验
doi：10.1038/ki.2013.532
更新日期：2014-08-01 00:00:00
