4-Hydroxyproline metabolism and glyoxylate production: A target for substrate depletion in primary hyperoxaluria?

abstract：:Recent studies including the current article by Sawinski et al. demonstrate that hepatitis C virus (HCV) infection is associated with worse outcomes in kidney transplant recipients with and without HIV infection. We comment on the significance of these findings in the context of newer options for the treatment of HCV ...

journal_title：Kidney international

authors： Del Bello D,Ross MJ,Huprikar SS

更新日期：2015-08-01 00:00:00

abstract：:When the endotoxin-lipopolysaccharide (LPS) derived from the cell wall of gram-negative bacteria is given to the rat in vivo, there are prompt, marked decreases in glomerular filtration rate (GFR), renal blood flow (RBF) and % Na+ reabsorption (%T-Na+). However, it has not been determined whether the endotoxin itself ...

journal_title：Kidney international

authors： Cohen JJ,Black AJ,Wertheim SJ

更新日期：1990-05-01 00:00:00

abstract：:PDGF and TGF-beta are known mediators of mesangial cell proliferation and matrix expansion. The presence of these regulatory factors was examined in 30 renal biopsies from patients with IgA glomerulonephritis (IgA-GN) at the mRNA and protein level. Normal renal tissue served as control. The mRNA expression of PDGF A/B...

journal_title：Kidney international

authors： Niemir ZI,Stein H,Noronha IL,Krüger C,Andrassy K,Ritz E,Waldherr R

更新日期：1995-11-01 00:00:00

abstract：:Tubular function studies have shown that nephrectomy leads to a sharp increase in potassium secretion by initial collecting tubules. The aim of this study was to examine the relationship between potassium transport and the cellular morphology of the distal nephron. Clearance and ultrastructural studies were conducted ...

journal_title：Kidney international

authors： Zalups RK,Stanton BA,Wade JB,Giebisch G

更新日期：1985-04-01 00:00:00

abstract：:The metabolism of phenylalanine and tyrosine was evaluated in six normal men, five chronically uremic men, and three men undergoing maintenance hemodialysis. Phenylalanine, tyrosine, and 13 acidic metabolites of those amino acids were measured in plasma postabsorptively and in plasma and urine after a phenylalanine lo...

journal_title：Kidney international

authors： Jones MR,Kopple JD,Swendseid ME

更新日期：1978-08-01 00:00:00

abstract：:Cytomegalovirus (CMV) seropositivity is associated with increased risk for atherosclerotic disease in patients with end-stage renal disease. This association is due to a unique peripheral blood CD4(+) T cell population which lack CD28 (CD4(+)CD28(-) T cells). Here we found that this patient population has a significan...

journal_title：Kidney international

authors： Betjes MG,Huisman M,Weimar W,Litjens NH

更新日期：2008-09-01 00:00:00

abstract：:The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we inves...

journal_title：Kidney international

authors： Olsson J,Dadfar E,Paulsson J,Lundahl J,Moshfegh A,Jacobson SH

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that a high concentration of phosphate directly stimulates parathyroid hormone (PTH) secretion. High serum levels of phosphate are usually observed in patients with end-stage renal disease. The aim of the present study was to evaluate whether serum phosphate concentration had...

journal_title：Kidney international

authors： de Francisco AL,Cobo MA,Setien MA,Rodrigo E,Fresnedo GF,Unzueta MT,Amado JA,Ruiz JC,Arias M,Rodriguez M

更新日期：1998-12-01 00:00:00

abstract：:Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix (ECM) glycoprotein that has been recently isolated and cloned from the rabbit kidney. It is an integral component of the basal lamina, and unlike other basement membrane proteins it is exclusively expressed in the tubular basement membranes (TBMs...

journal_title：Kidney international

authors： Kumar A,Ota K,Wada J,Wallner EI,Charonis AS,Carone FA,Kanwar YS

更新日期：1997-09-01 00:00:00

abstract：:The present studies were undertaken to assess the effects of 5'-N-ethylcarboxamideadenosine (NECA), an adenosine analogue, on erythropoietin (Epo) production. NECA (0.05 and 0.1 mumol/kg i.v.) produced significant increases in serum Epo levels (368.8 +/- 56.1 and 384.6 +/- 45.9 mU/ml, respectively) in exhypoxic polycy...

journal_title：Kidney international

authors： Nakashima J,Ohigashi T,Brookins JW,Beckman BS,Agrawal KC,Fisher JW

更新日期：1993-10-01 00:00:00

abstract：:Clinical and experimental studies have shown that serum aluminum (Al) is bound to transferrin and that cellular uptake of Al appears to be mediated by transferrin receptors. Based on these findings it is widely believed that intestinal Al absorption occurs via iron-specific, transferrin-dependent pathways and that iro...

journal_title：Kidney international

authors： Ittel TH,Kinzel S,Ortmanns A,Sieberth HG

更新日期：1996-12-01 00:00:00

abstract：:There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chro...

journal_title：Kidney international

authors： Leibler C,Thiolat A,Elsner RA,El Karoui K,Samson C,Grimbert P

更新日期：2019-04-01 00:00:00

abstract：:The application of our evolving knowledge of adhesion receptors to experimental models of immune complex glomerulonephritis has led to substantial advances in our understanding of how leukocytes emigrate from the vasculature into glomeruli and produce glomerular dysfunction. With respect to neutrophil (PMN) migration ...

journal_title：Kidney international

authors： Lefkowith JB

更新日期：1997-05-01 00:00:00

abstract：:The circumstances under which furosemide increases renal blood flow was examined in mongrel dogs as it may relate to a tubuloglomerular feedback mechanism. Two maneuvers, desoxycorticosterone (DOCA) plus salt treatment and inhibition of tubular fluid flow, were used in the dogs to evaluate the renal vascular effects o...

journal_title：Kidney international

authors： Gerber JG,Nies AS

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:Hypertriglyceridemia is a result of reduced triglyceride (TG)-rich lipoprotein (TRL) catabolism and occurs in rats with nephrotic syndrome (NS) and in Nagase analbuminemic rats (NARs). While the heparin-releasable lipoprotein lipase (LpL) pool in NAR and in NS is similar, TG levels are significantly greater ...

journal_title：Kidney international

authors： Shearer GC,Stevenson FT,Atkinson DN,Jones H,Staprans I,Kaysen GA

更新日期：2001-01-01 00:00:00

abstract：:Antibody responses to antigens are impaired in humans and animals with chronic renal failure (CRF), and parathyroid hormone (PTH) inhibits Staphylococcus aureus Cowan I (SAC) or pokeweed mitogen (PWM)-induced antibody production by B cells from normal subjects. Since CRF is associated with secondary hyperparathyroidis...

journal_title：Kidney international

authors： Gaciong Z,Alexiewicz JM,Massry SG

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:It is known that inhibition of cyclooxygenase (COX) impairs the renal actions of loop diuretics. Recently, we found that cyclosporine A (CsA) inhibits renal COX-2 expression. Therefore, we examined the interferences of CsA with the renal actions of loop diuretics. METHOD:We investigated the renal effects of...

journal_title：Kidney international

authors： Höcherl K,Kees F,Krämer BK,Kurtz A

更新日期：2004-06-01 00:00:00

abstract：:Cell surface aminopeptidases N (APN) and A (APA) have been characterized on cultured human glomerular epithelial cells and a SV40-transformed cell line derived from them. APN had a wide substrate specificity whereas APA only attacked peptides with an acidic N terminal amino acid. Both enzymes also differed by their se...

journal_title：Kidney international

authors： Stefanovic V,Vlahovic P,Ardaillou N,Ronco P,Ardaillou R

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Low urinary pH is the commonest and by far the most important factor in uric acid nephrolithiasis but the reason(s) for this defect is (are) unknown. Patients with uric acid nephrolithaisis have normal acid-base parameters according conventional clinical tests. METHODS:We studied steady-state plasma and uri...

journal_title：Kidney international

authors： Sakhaee K,Adams-Huet B,Moe OW,Pak CY

更新日期：2002-09-01 00:00:00

abstract：:Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2(*)) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. This parameter was...

journal_title：Kidney international

authors： Michaely HJ,Metzger L,Haneder S,Hansmann J,Schoenberg SO,Attenberger UI

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis and afferent arteriolar hyalinosis. L-arginine (L-Arg), the substrate for nitric oxide (NO) synthase and N-nitro-L-arginine-methyl ester (L-NAME), the NO synthase inhibitor, were shown to modulate acute CsA nephrotoxicity. Ho...

journal_title：Kidney international

authors： Shihab FS,Yi H,Bennett WM,Andoh TF

更新日期：2000-09-01 00:00:00

abstract：:Long-term outcomes of kidney allografts have shown only marginal improvement over the last three decades, despite the remarkable improvement in acute rejection and one-year graft survival. Novel biomarkers of tubular injury may prevent irreversible damage to the tubulointerstitial compartment and improve allograft sur...

journal_title：Kidney international

authors： Abulezz S

更新日期：2008-03-01 00:00:00

abstract：:For reasons that are not well understood, Aboriginal people with end-stage renal disease (ESRD) have lower rates of kidney transplantation. We hypothesized that distance between residence location and the closest transplant center was greater in Aboriginal dialysis patients and would partially explain the lower rate o...

journal_title：Kidney international

authors： Tonelli M,Hemmelgarn B,Kim AK,Bertazzon S,Klarenbach S,Manns B,Wiebe N,Culleton B,Gill JS,Alberta Kidney Disease Network.

更新日期：2006-09-01 00:00:00

abstract：:Pathologic calcification is a significant cause of increased morbidity and mortality in patients with chronic kidney disease. The precise mechanisms of ectopic calcification are not fully elucidated, but it is known to be caused by an imbalance of procalcific and anticalcific factors. In the chronic kidney disease pop...

journal_title：Kidney international

authors： Paloian NJ,Leaf EM,Giachelli CM

更新日期：2016-05-01 00:00:00

abstract：:Suzuki et al. analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene. The authors show that excess iron decreases levels of hypoxia-inducible transcription f...

journal_title：Kidney international

authors： Ganz T

更新日期：2018-11-01 00:00:00

abstract：:Serum calcitriol and the free calcitriol index together with factors considered to regulate calcitriol production were measured in eleven patients with moderate chronic renal failure (MCRF) and eleven age- and sex-matched normal subjects. Although the serum dialysable calcium levels were similar in the two groups, the...

journal_title：Kidney international

authors： Prince RL,Hutchison BG,Kent JC,Kent GN,Retallack RW

更新日期：1988-03-01 00:00:00

abstract：:Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results...

journal_title：Kidney international

authors： Ooi YM,Vallota EH,West CD

更新日期：1976-01-01 00:00:00

abstract：:Fibroblasts in parenchymal organs potentially contribute extracellular matrix to local fibrogenic processes. This contribution, in some circumstances, may be initiated by cytokines disseminated from inflammatory lesions. Different populations of fibroblasts, however, might respond distinctively to this cytokine bath d...

journal_title：Kidney international

authors： Alvarez RJ,Sun MJ,Haverty TP,Iozzo RV,Myers JC,Neilson EG

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Non-(1-84) parathyroid hormone (PTH) fragments are large circulating carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. hPTH (7-84), a synthetic surrogate, has been demonstrated to exert biologic effects in vivo and in vitro which are opposite to those of hPTH (1-34) on ...

journal_title：Kidney international

authors： D'Amour P,Brossard JH,Rousseau L,Nguyen-Yamamoto L,Nassif E,Lazure C,Gauthier D,Lavigne JR,Zahradnik RJ

更新日期：2005-09-01 00:00:00

abstract：:Osteocytes within the mineralized bone matrix control bone remodeling by regulating osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the functional role of this protein in skeletal homeostasis is unknown. Here we identify Klotho expression in osteocytes as a potent regulator of b...

journal_title：Kidney international

authors： Komaba H,Kaludjerovic J,Hu DZ,Nagano K,Amano K,Ide N,Sato T,Densmore MJ,Hanai JI,Olauson H,Bellido T,Larsson TE,Baron R,Lanske B

更新日期：2017-09-01 00:00:00