The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury.

abstract：:The distribution of precursor nitrogen between urea and glutamine was studied in control and acidotic rats. Acidosis, either acutely induced with hydrochloric acid or chronically induced with ammonium chloride, resulted in a rise in ammonia and a fall in urinary urea excretion; the percent of urinary nitrogen excreted...

journal_title：Kidney international

authors： Phromphetcharat V,Jackson A,Dass PD,Welbourne TC

更新日期：1981-11-01 00:00:00

abstract：:Plasma newly-synthesized cholesteryl ester transfer (NCET) rate and concentrations of lipids, lipoproteins and apolipoproteins A1 and B were measured in chronic renal failure patients (dialysis independent and dialysis dependent), patients with a functioning renal transplant and in healthy control subjects with compar...

journal_title：Kidney international

authors： Corboy J,Sutherland WH,Walker RJ,Robertson MC,Cox CM

更新日期：1994-10-01 00:00:00

abstract：:Urinary peptidomics focuses on endogenous urinary peptide content. Many studies now show the usefulness of this approach for the discovery and validation of biomarkers in kidney diseases that are as varied as chronic kidney disease, acute kidney injury, congenital anomalies of the kidney and the urinary tract, and pol...

journal_title：Kidney international

authors： Klein J,Bascands JL,Mischak H,Schanstra JP

更新日期：2016-03-01 00:00:00

abstract：:Gain-of-function variants in CFB encoding factor B (FB), a component of the alternative pathway C3 convertase, have been reported in a minority of patients with aHUS and result in massive C3 activation. Zhang et al. describe the functional characterization of a novel FB variant (p.Ser367Arg) that they identified in 2 ...

journal_title：Kidney international

authors： Noris M,Remuzzi G

更新日期：2020-11-01 00:00:00

abstract：:In uremic patients resistance to the action of insulin has been documented, but it is not known at what stage of renal disease it appears. We therefore examined 29 patients with IgA glomerulonephritis (IgAGN) and 21 patients with adult polycystic kidney disease (ADPKD) in different stages of renal failure, and in addi...

journal_title：Kidney international

authors： Fliser D,Pacini G,Engelleiter R,Kautzky-Willer A,Prager R,Franek E,Ritz E

更新日期：1998-05-01 00:00:00

abstract：:Vascular sclerosis is often seen in renal biopsies. It is usually associated with diabetes mellitus, hypertension, smoking, etc. However, whether inherited thrombophilic states such as factor V gene mutation, prothrombin gene mutation, and methylenetetrahydrofolate reductase (MTHFR) gene mutation are associated with t...

journal_title：Kidney international

authors： Goforth RL,Rennke H,Sethi S

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Low birth weight is an important risk factor for hypertension and unfavorable prognoses of a number of renal diseases. It is also associated with reduced kidney size and nephron number. A differentiation between the effects of low birth weight versus being born premature or small for gestational age has, how...

journal_title：Kidney international

authors： Schmidt IM,Chellakooty M,Boisen KA,Damgaard IN,Mau Kai C,Olgaard K,Main KM

更新日期：2005-08-01 00:00:00

abstract：:Following 5/6 nephrectomy, 18 rats were fed a normal diet. After 30 days, serum creatinine (SCr), urine protein excretion and urine volume were increased compared to pre-nephrectomy (0.27 +/- 0.1 vs. 1.62 +/- 0.6 mg/deciliter, 17.0 +/- 10.3 vs. 257.6 +/- 13.4 mg/24 hr, and 16.6 +/- 4.4 vs. 39.2 +/- 11.7 ml/24 hr, resp...

journal_title：Kidney international

authors： Lumlertgul D,Burke TJ,Gillum DM,Alfrey AC,Harris DC,Hammond WS,Schrier RW

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Cyclosporine (CsA) is effective for the treatment of children with steroid-dependent and -resistant nephrotic syndrome (NS), but it can result in chronic CsA nephrotoxicity including CsA-induced tubulointerstitial lesions. The factors responsible for the development of CsA-induced tubulointerstitial lesions ...

journal_title：Kidney international

authors： Iijima K,Hamahira K,Tanaka R,Kobayashi A,Nozu K,Nakamura H,Yoshikawa N

更新日期：2002-05-01 00:00:00

abstract：:Before hemodialysis, patients have an intraerythrocytic pH (pHi) and an extracellular pH, measured in whole blood (pHo), which are lower than those of healthy controls. During bicarbonate hemodialysis, pHi values continuously increase, approaching a normal value at the end of the session. Concomitantly, pHo values fol...

journal_title：Kidney international

authors： Monti JP,Gallice P,Baz M,Murisasco A,Crevat A,Elsen R

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:In interstitial fibrosis, monocytes and myofibroblasts have been directly implicated in scarring, apoptosis, and tissue necrosis. While much has been done to explore the role of these cell types individually in fibrosis, the interactive dependency of monocytes and myofibroblasts has been only marginally expl...

journal_title：Kidney international

authors： Rodgers KD,Rao V,Meehan DT,Fager N,Gotwals P,Ryan ST,Koteliansky V,Nemori R,Cosgrove D

更新日期：2003-04-01 00:00:00

abstract：:Chronic kidney disease (CKD) accelerates muscle protein degradation by stimulating the ubiquitin proteasome system through activation of the E3 ligases, Atrogin-1/MAFbx and MuRF-1. Forkhead transcription factors (FoxOs) can control the expression of these E3 ligases, but the contribution of individual FoxOs to muscle ...

journal_title：Kidney international

authors： Xu J,Li R,Workeneh B,Dong Y,Wang X,Hu Z

更新日期：2012-08-01 00:00:00

abstract：:In landmark clinical trials, pharmacological inhibition of the renin-angiotensin system (RAS) with angiotensin-converting enzyme inhibitors (ACEIs) attenuated the decline in renal function associated with chronic renal disease (CRD). Hemodynamic and nonhemodynamic effects of angiotensin II (Ang II) attest to its centr...

journal_title：Kidney international

authors： Taal MW,Brenner BM

更新日期：2000-05-01 00:00:00

abstract：:Cilnidipine, a dual L-/N-type calcium channel blocker, dilates both efferent and afferent arterioles and is renoprotective. Our multi-center, open-labeled, and randomized trial compared the antiproteinuric effect of cilnidipine with that of amlodipine in hypertensive patients with kidney disease. A group of 339 patien...

journal_title：Kidney international

authors： Fujita T,Ando K,Nishimura H,Ideura T,Yasuda G,Isshiki M,Takahashi K,Cilnidipine versus Amlodipine Randomised Trial for Evaluation in Renal Desease(CARTER) Study Investigators.

更新日期：2007-12-01 00:00:00

abstract：:The present study examined the effect of elevated glucose on glomerular cell membrane lipid peroxidation. Glomeruli were isolated from male Sprague-Dawley rat kidneys utilizing a standard sieving method and incubated in medium containing different concentrations of glucose at 37 degrees C for one and 48 hours. The lev...

journal_title：Kidney international

authors： Ha H,Yoon SJ,Kim KH

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Current renal substitution therapy for acute or chronic renal failure with hemodialysis or hemofiltration is life sustaining, but continues to have unacceptably high morbidity and mortality rates. This therapy is not complete renal replacement therapy because it does not provide active transport nor metaboli...

journal_title：Kidney international

authors： Humes HD,MacKay SM,Funke AJ,Buffington DA

更新日期：1999-06-01 00:00:00

abstract：:Progressive renal vascular sclerosis is a key feature of chronic kidney disease (CKD). Adiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease. In this study, we evaluated the predictive value of adip...

journal_title：Kidney international

authors： Kollerits B,Fliser D,Heid IM,Ritz E,Kronenberg F,MMKD Study Group.

更新日期：2007-06-01 00:00:00

abstract：:Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit ...

journal_title：Kidney international

authors： Yokoi H,Yanagita M

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Glucose degradation products (GDPs) are cytotoxic in vitro and potentially toxic in vivo during peritoneal dialysis (PD). We are presenting the results of a two-year randomized clinical trial of a new PD fluid, produced in a two-compartment bag and designed to minimize heat-induced glucose degradation while ...

journal_title：Kidney international

authors： Rippe B,Simonsen O,Heimbürger O,Christensson A,Haraldsson B,Stelin G,Weiss L,Nielsen FD,Bro S,Friedberg M,Wieslander A

更新日期：2001-01-01 00:00:00

abstract：:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. ...

journal_title：Kidney international

authors： Alexander JJ,Chaves LD,Chang A,Jacob A,Ritchie M,Quigg RJ

更新日期：2015-05-01 00:00:00

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：:The release of cytokines and prostaglandins (PG) by peritoneal macrophages (PM luminal diameter of) may influence the cytokine network controlling peritoneal inflammation and in the long-term the function of the peritoneum as a dialysis membrane. In the present study, an evaluation of the long-term effects of peritone...

journal_title：Kidney international

authors： McGregor SJ,Topley N,Jörres A,Speekenbrink AB,Gordon A,Gahl GM,Junor BJ,Briggs JD,Brock JH

更新日期：1996-02-01 00:00:00

abstract：:The presence of CR1 mRNA in podocytes was investigated using a 35S-labeled CR1 cDNA probe and in situ hybridization in sections from fetal and adult human kidneys. CR1 mRNA was only detected in immature podocytes at early stages of glomerular differentiation in the fetal kidney. In contrast, CR1 antigen was abundantly...

journal_title：Kidney international

authors： Appay MD,Kazatchkine MD,Levi-Strauss M,Hinglais N,Bariety J

更新日期：1990-08-01 00:00:00

abstract：:Endostatin (EST), an antiangiogenic factor, is enriched in aging kidneys. EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whether EST and TG2 play a role in the fibrosis of aging. In wild-type mice, aging kidneys exhibited a 2- to...

journal_title：Kidney international

authors： Lin CH,Chen J,Zhang Z,Johnson GV,Cooper AJ,Feola J,Bank A,Shein J,Ruotsalainen HJ,Pihlajaniemi TA,Goligorsky MS

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Nephrologists report that patients' choice should play an important role in the selection of renal replacement therapy (RRT) for end-stage renal disease (ESRD). In the United States, kidney transplant rates remain low and <10% of patients utilize home dialysis therapies. This study examined the effect of pre...

journal_title：Kidney international

authors： Mehrotra R,Marsh D,Vonesh E,Peters V,Nissenson A

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...

journal_title：Kidney international

authors： Shahin H,Reddy G,Sharafuddin M,Katz D,Franzwa BS,Dixon BS

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Acute renal failure (ARF) has a high morbidity and mortality. Many therapies have worked in animals but were unsuccessful in clinical trials. The inability to diagnose ARF early may have impaired the success of these trials. METHOD:We screened a subtraction library to search for potential disease markers th...

journal_title：Kidney international

authors： Muramatsu Y,Tsujie M,Kohda Y,Pham B,Perantoni AO,Zhao H,Jo SK,Yuen PS,Craig L,Hu X,Star RA

更新日期：2002-11-01 00:00:00

abstract：:Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received increasing attention as a therapeutic target in a variety of diseases because they serve as key regulatory hubs uniquely situated at crossroads be...

journal_title：Kidney international

authors： Galvan DL,Green NH,Danesh FR

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Renal anemia is an important determinant for left ventricular hypertrophy in dialysis patients and an independent prognosis parameter for the cardiovascular survival in dialysis patients. In addition, an autonomic dysfunction is associated with the uremic state and influences the cardiovascular risk in patie...

journal_title：Kidney international

authors： Frank H,Heusser K,Höffken B,Huber P,Schmieder RE,Schobel HP

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Estradiol suppresses the synthesis of type I collagen by murine mesangial cells. However, neither the alpha 1(I) nor the alpha 2(I) collagen gene contains an estrogen-response element. Because estradiol modulates the transcription of several genes that lack an estrogen-response element but contain a regulato...

journal_title：Kidney international

authors： Silbiger S,Lei J,Neugarten J

更新日期：1999-04-01 00:00:00