Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney.

abstract：:In organ transplantation, ischemia/reperfusion (I/R) results in damage that may affect cell viability and lead to organ failure. I/R injury involves a complex cascade of events, including loss of energy, derangement of the ionic hemostasis, production of reactive oxygen species, and cell death. In this context, mitoch...

journal_title：Kidney international

authors： Jassem W,Heaton ND

更新日期：2004-08-01 00:00:00

abstract：:Adenosine is known to decrease renal blood flow and glomerular filtration rate. We have tested the hypothesis that adenosine exerts contractile effects on mesangial cells. Furthermore, we have studied, using selective agonists and antagonists for adenosine, which kind of adenosine receptor, A1 or A2, is mainly implica...

journal_title：Kidney international

authors： Olivera A,Lamas S,Rodriguez-Puyol D,López-Novoa JM

更新日期：1989-06-01 00:00:00

abstract：:For decades, ill-defined autosomal dominant renal diseases have been reported, which originate from tubular cells and lead to tubular atrophy and interstitial fibrosis. These diseases are clinically indistinguishable, but caused by mutations in at least four different genes: UMOD, HNF1B, REN, and, as recently describe...

journal_title：Kidney international

authors： Ekici AB,Hackenbeck T,Morinière V,Pannes A,Buettner M,Uebe S,Janka R,Wiesener A,Hermann I,Grupp S,Hornberger M,Huber TB,Isbel N,Mangos G,McGinn S,Soreth-Rieke D,Beck BB,Uder M,Amann K,Antignac C,Reis A,Eckardt K

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The glomerular endothelial cell is a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration. During gram-negative sepsis, glomerulonephritis, and acute renal failure, bacterial lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) may cause severe cell dam...

journal_title：Kidney international

authors： Messmer UK,Briner VA,Pfeilschifter J

更新日期：1999-06-01 00:00:00

abstract：:We explored how B-lymphocytes influence in vitro T-cell alloresponses in patients with antibody-mediated rejection (AMR), testing whether B-cells would be preferentially involved in this group of patients. Peripheral blood mononuclear cells were collected from 65 patients having biopsy: 14 patients with AMR and 5 with...

journal_title：Kidney international

authors： Shiu KY,McLaughlin L,Rebollo-Mesa I,Zhao J,Semik V,Cook HT,Roufosse C,Brookes P,Bowers RW,Galliford J,Taube D,Lechler RI,Hernandez-Fuentes MP,Dorling A

更新日期：2015-09-01 00:00:00

abstract：UNLABELLED:Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. BACKGROUND:Mutations in the gene for apolipoprotein AII (apoAII) have recently been found to cause hereditary renal amyloidosis. In each case amyloid deposition has been associated with a peptide extensio...

journal_title：Kidney international

authors： Yazaki M,Liepnieks JJ,Barats MS,Cohen AH,Benson MD

更新日期：2003-07-01 00:00:00

abstract：:Changes in macula densa intracellular pH (pHi) were used to monitor the direction of flux mediated by the apical Na:2Cl:K cotransporter. At the macula densa, a decrease in luminal [Cl] ([Cl]1) from 60 to 1 mM produced cellular alkalinization secondary to a cascade of events involving a decrease in apical Na:2Cl:K cotr...

journal_title：Kidney international

authors： Lapointe JY,Laamarti A,Hurst AM,Fowler BC,Bell PD

更新日期：1995-03-01 00:00:00

abstract：:Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocyte...

journal_title：Kidney international

authors： Simons M,Huber TB

更新日期：2009-03-01 00:00:00

abstract：:Noninvasive molecular tests of urine cells have been developed to monitor the activity of kidney diseases. We evaluate whether measurement of urinary messenger RNA (mRNA) levels of chemokine and growth factor genes could distinguish between diffuse proliferative lupus nephritis (class IV LN) and others and whether it ...

journal_title：Kidney international

authors： Avihingsanon Y,Phumesin P,Benjachat T,Akkasilpa S,Kittikowit V,Praditpornsilpa K,Wongpiyabavorn J,Eiam-Ong S,Hemachudha T,Tungsanga K,Hirankarn N

更新日期：2006-02-01 00:00:00

abstract：:Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl(-) channel activity in Xenopus oocytes. Background. Cyst expansion in autosomal-dominant polycystic kidney disease (ADPKD) is characterized by active Cl(-) secretion in excess of solute reabsorption. However, the connections between elevated epith...

journal_title：Kidney international

authors： Chernova MN,Vandorpe DH,Clark JS,Alper SL

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Cold ischemia and reperfusion during kidney transplantation are associated with release of free oxygen radicals and damage of renal tubular cells. Bioflavonoids may diminish cold storage-induced injury due to antioxidant and iron chelating activities. This study was designed to delineate the renoprotective m...

journal_title：Kidney international

authors： Ahlenstiel T,Burkhardt G,Köhler H,Kuhlmann MK

更新日期：2003-02-01 00:00:00

abstract：:The impacts of IgA nephropathy and pregnancy on each other were evaluated in 118 women who conceived 168 times between 1970 and 1988. Rates of spontaneous abortion, normal delivery, live birth and perinatal death were 9, 66, 87 and 4%, respectively. Infants born to women with glomerular filtration rates (GFR) lower th...

journal_title：Kidney international

authors： Abe S

更新日期：1991-12-01 00:00:00

abstract：:Circulating immune complexes (CIC), measured by the solid-phase Clq method, were found to be in abnormal concentration in about half of 39 patients with membranoproliferative glomerulonephritis (MPGN). In contrast, they were present, usually in higher concentration, in nearly all patients with active lupus nephritis. ...

journal_title：Kidney international

authors： Davis CA,Marder H,West CD

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the renoprotective effect as reflected by short-term changes in albuminuria of ultrahigh doses of irbesartan in type 2 diabetic patients with microalbuminuria. METHODS:This double-masked randomized crossover trial included 52 (41 males) hypertensive type 2 diabetic ...

journal_title：Kidney international

authors： Rossing K,Schjoedt KJ,Jensen BR,Boomsma F,Parving HH

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Renal anemia is an important determinant for left ventricular hypertrophy in dialysis patients and an independent prognosis parameter for the cardiovascular survival in dialysis patients. In addition, an autonomic dysfunction is associated with the uremic state and influences the cardiovascular risk in patie...

journal_title：Kidney international

authors： Frank H,Heusser K,Höffken B,Huber P,Schmieder RE,Schobel HP

更新日期：2004-08-01 00:00:00

abstract：:The addition of spironolactone or hydrochlorothiazide enhances the antialbuminuric effect of renin-angiotensin blockers. However, comparative studies on the effect of different diuretics are lacking. We conducted a prospective randomized crossover study to compare the effects of spironolactone (25 mg/day), hydrochloro...

journal_title：Kidney international

authors： Morales E,Caro J,Gutierrez E,Sevillano A,Auñón P,Fernandez C,Praga M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The renin-angiotensin system has been known to regulate blood pressure and body fluid homeostasis. Several lines of evidence have shown that renin gene expression and release are up-regulated by beta-adrenergic stimulation, sodium depletion, and angiotensin converting enzyme inhibition, but down-regulated by...

journal_title：Kidney international

authors： Chen LS,Cuddy MP,LaVallette LA

更新日期：1998-12-01 00:00:00

abstract：:The high serum fibroblast growth factor 23 (FGF23) levels in patients with acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with increased morbidity and mortality. Mice with folic acid-induced AKI had an increase in bone FGF23 mRNA expression together with an increase in serum FGF23 and severa...

journal_title：Kidney international

authors： Durlacher-Betzer K,Hassan A,Levi R,Axelrod J,Silver J,Naveh-Many T

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:During inflammation, polymorphonuclear neutrophils (PMNs) migrate into the affected tissue interacting with extracellular matrix (ECM) proteins. We tested the hypothesis that PMN-matrix interaction affects PMN apoptosis. METHODS:Apoptosis of human PMNs was detected by DNA-fragmentation assay and was quantit...

journal_title：Kidney international

authors： Kettritz R,Xu YX,Kerren T,Quass P,Klein JB,Luft FC,Haller H

更新日期：1999-02-01 00:00:00

abstract：:Podocyte injury and loss contribute to the progression of glomerular diseases, including diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 (SIRT1) is reduced in human diabetic glomeruli and that the podocyte-specific loss of SIRT1 aggravated albuminuria and worsened kidney diseas...

journal_title：Kidney international

authors： Hong Q,Zhang L,Das B,Li Z,Liu B,Cai G,Chen X,Chuang PY,He JC,Lee K

更新日期：2018-06-01 00:00:00

abstract：:The purpose of these studies was to test the hypothesis that Randall's plaque develops in unique anatomical sites of the kidney and their formation is conditioned by specific stone-forming pathophysiologies. We performed intraoperative papillary biopsies from kidneys of idiopathic-calcium oxalate (CaOx), intestinal by...

journal_title：Kidney international

authors： Evan A,Lingeman J,Coe FL,Worcester E

更新日期：2006-04-01 00:00:00

abstract：:Adiponectin levels are increased in patients with type I diabetes especially in the presence of microangiopathy. Here we determined the predictive value of serum adiponectin levels and 8 adiponectin gene polymorphisms for mortality, cardiovascular events and end-stage renal disease in type I diabetic patients. This pr...

journal_title：Kidney international

authors： Jorsal A,Tarnow L,Frystyk J,Lajer M,Flyvbjerg A,Parving HH,Vionnet N,Rossing P

更新日期：2008-09-01 00:00:00

abstract：:Polycystin-1 (PC1) and -2 (PC2), products of the PKD1 and PKD2 genes, are mutated in autosomal dominant polycystic kidney disease (ADPKD). They localize to the primary cilia; however, their ciliary function is in dispute. Loss of either the primary cilia or PC1 or PC2 causes cyst formation. However, loss of both cilia...

journal_title：Kidney international

authors： Shao L,El-Jouni W,Kong F,Ramesh J,Kumar RS,Shen X,Ren J,Devendra S,Dorschel A,Wu M,Barrera I,Tabari A,Hu K,Haque N,Yambayev I,Li S,Kumar A,Behera TR,McDonough G,Furuichi M,Xifaras M,Lu T,Alhayaza RM,Miyabaya

更新日期：2020-11-01 00:00:00

abstract：:In view of the increasing concern about methicillin-resistant Staphylococcus aureus (MRSA) infections, we studied the characteristics and outcome of MRSA nasal carriage and infections in our CAPD program. All patients entering into the CAPD program from January 1989 to December 1991 were enrolled into the study. The p...

journal_title：Kidney international

authors： Lye WC,Leong SO,Lee EJ

更新日期：1993-06-01 00:00:00

abstract：:Surgical creation of new anastomosis has been proposed as the preferred treatment for perianastomotic stenoses of fistulae. However, disadvantages of surgical approach have included (1) frequent conversion of fistula to a graft by using synthetic graft material to create a new anastomosis, (2) shortening the length of...

journal_title：Kidney international

authors： Asif A,Lenz O,Merrill D,Cherla G,Cipleu CD,Ellis R,Francois B,Epstein DL,Pennell P

更新日期：2006-05-01 00:00:00

abstract：:Systemic AA type amyloidosis with renal involvement is the major cause of morbidity and mortality in patients with familial Mediterranean fever (FMF). A histopathological examination is essential to achieve a definite diagnosis in systemic amyloidosis. The diagnostic yield of the procedure varies according to the biop...

journal_title：Kidney international

authors： Sungur C,Sungur A,Ruacan S,Arik N,Yasavul U,Turgan C,Caglar S

更新日期：1993-10-01 00:00:00

abstract：:Fatal vascular access hemorrhage is considered a rare complication of hemodialysis (HD). Ellingson et al. indicate otherwise, and their data suggest that it causes 0.4-1.6% of deaths in US HD patients. It is more common with grafts than fistulas, and many victims have had previous access hemorrhages. The widespread pr...

journal_title：Kidney international

authors： Blake PG,Quinn RR,Oliver MJ

更新日期：2012-09-01 00:00:00

abstract：:Previous studies have shown a number of different associations between major histocompatibility complex (MHC) alleles and primary systemic vasculitis. Disease heterogeneity and the lack of specificity of certain MHC typing techniques may have contributed to the lack of consistency in those studies. We therefore studie...

journal_title：Kidney international

authors： Zhang L,Jayne DR,Zhao MH,Lockwood CM,Oliveira DB

更新日期：1995-01-01 00:00:00

abstract：:The improvement in the anemia in patients with end-stage renal disease (ESRD) on continuous ambulatory peritoneal dialysis (CAPD) suggests that dialyzable substances present in the sera of uremic patients either inhibit erythropoiesis directly or inactivate erythropoietin (EPO). In the present study predialysis sera f...

journal_title：Kidney international

authors： Kushner D,Beckman B,Nguyen L,Chen S,Della Santina C,Husserl F,Rice J,Fisher JW

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Random, nontimed blood pressure (BP) measurements in the outpatient clinic may fail to provide reliable information on actual daily BP control in renal patients on chronic antihypertensive therapy. METHODS:In a cohort of 163 patients with proteinuric chronic nephropathies followed prospectively with repeate...

journal_title：Kidney international

authors： Ruggenenti P,Perna A,Lesti M,Pisoni R,Mosconi L,Arnoldi F,Ciocca I,Gaspari F,Remuzzi G

更新日期：2000-11-01 00:00:00