Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease.

abstract：:Lysyl oxidase like-2 (LOXL2) is an amine oxidase with both intracellular and extracellular functions. Extracellularly, LOXL2 promotes collagen and elastin crosslinking, whereas intracellularly, LOXL2 has been reported to modify histone H3, stabilize SNAIL, and reduce cell polarity. Although LOXL2 promotes liver and lu...

journal_title：Kidney international

authors： Cosgrove D,Dufek B,Meehan DT,Delimont D,Hartnett M,Samuelson G,Gratton MA,Phillips G,MacKenna DA,Bain G

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:While the progression of renal disease to end stage is strongly correlated with tubulointerstitial changes, the control of the fibrotic process within the interstitium is poorly understood. Basic fibroblast growth factor (FGF-2) has been implicated as a major growth factor involved in fibroblast activation a...

journal_title：Kidney international

authors： Clayton A,Thomas J,Thomas GJ,Davies M,Steadman R

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

journal_title：Kidney international

authors： Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

更新日期：2003-07-01 00:00:00

abstract：:To assess in vitro erythropoietic cultures as a tool to discriminate between patients whose anemia improves with and those whose anemia fails to improve with androgens, bone marrows of 24 anemic patients receiving maintenance hemodialysis in hormone-depleted plasma clots were cultured. While erythroid colony prolifera...

journal_title：Kidney international

authors： Kalmanti M,Dainiak N,Martino J,Dewey M,Kulkarni V,Howard D

更新日期：1982-10-01 00:00:00

abstract：:Here we studied a possible association between low parathyroid hormone (PTH) status and mortality in incident patients undergoing hemodialysis . A total of 1983 patients were included at baseline and prospectively followed for 24 months. Patients were classified according to their Kidney Disease: Improving Global Outc...

journal_title：Kidney international

authors： Merle E,Roth H,London GM,Jean G,Hannedouche T,Bouchet JL,Drüeke T,Fouque D,Daugas E,French Calcium and Phosphate Observatory.

更新日期：2016-03-01 00:00:00

abstract：:Prior studies reported associations of APOL1 nephropathy risk variants with subclinical atherosclerosis. However, these findings were limited to older individuals with high comorbidities. To evaluate this in younger individuals, we calculated associations of APOL1 risk variants (high risk [2 risk variants] vs. low ris...

journal_title：Kidney international

authors： Gutiérrez OM,Limou S,Lin F,Peralta CA,Kramer HJ,Carr JJ,Bibbins-Domingo K,Winkler CA,Lewis CE,Kopp JB

更新日期：2018-03-01 00:00:00

abstract：:Renal stone disease, which affects 12% of males and 5% of females by the seventh decade, occurs as an inherited disorder in 45% of patients and is most commonly associated with hypercalciuria. The biochemical basis for hereditary nephrolithiasis and hypercalciuria is unknown, and this has therefore been investigated b...

journal_title：Kidney international

authors： Thakker RV

更新日期：2000-03-01 00:00:00

abstract：:Cilnidipine, a dual L-/N-type calcium channel blocker, dilates both efferent and afferent arterioles and is renoprotective. Our multi-center, open-labeled, and randomized trial compared the antiproteinuric effect of cilnidipine with that of amlodipine in hypertensive patients with kidney disease. A group of 339 patien...

journal_title：Kidney international

authors： Fujita T,Ando K,Nishimura H,Ideura T,Yasuda G,Isshiki M,Takahashi K,Cilnidipine versus Amlodipine Randomised Trial for Evaluation in Renal Desease(CARTER) Study Investigators.

更新日期：2007-12-01 00:00:00

abstract：:Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased elimination half-life, allowing an extended dosing interval from two to eight weeks. Here we evaluate the efficacy and safety of ravulizumab in adults with atypical hemolytic uremic syndrome presenting with thrombotic microangiopathy. ...

journal_title：Kidney international

authors： Rondeau E,Scully M,Ariceta G,Barbour T,Cataland S,Heyne N,Miyakawa Y,Ortiz S,Swenson E,Vallee M,Yoon SS,Kavanagh D,Haller H,311 Study Group.

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The peritoneum is progressively denuded of its mesothelial cell monolayer in patients on continuous ambulatory peritoneal dialysis (CAPD). These alterations of the mesothelium cause membrane dysfunction and progressive peritoneal fibrosis. Integrins regulate cell motility and play an important role in wound ...

journal_title：Kidney international

authors： Tamura M,Osajima A,Nakayamada S,Anai H,Kabashima N,Kanegae K,Ota T,Tanaka Y,Nakashima Y

更新日期：2003-02-01 00:00:00

abstract：:Nephrons possess a segmental organization where each segment is specialized for the secretion and reabsorption of particular solutes. The developmental control of nephron segment patterning remains one of the enigmas within the field of renal biology. Achieving an understanding of the mechanisms that direct nephron se...

journal_title：Kidney international

authors： Wingert RA,Davidson AJ

更新日期：2008-05-01 00:00:00

abstract：:Following 5/6 nephrectomy, 18 rats were fed a normal diet. After 30 days, serum creatinine (SCr), urine protein excretion and urine volume were increased compared to pre-nephrectomy (0.27 +/- 0.1 vs. 1.62 +/- 0.6 mg/deciliter, 17.0 +/- 10.3 vs. 257.6 +/- 13.4 mg/24 hr, and 16.6 +/- 4.4 vs. 39.2 +/- 11.7 ml/24 hr, resp...

journal_title：Kidney international

authors： Lumlertgul D,Burke TJ,Gillum DM,Alfrey AC,Harris DC,Hammond WS,Schrier RW

更新日期：1986-03-01 00:00:00

abstract：:For decades, ill-defined autosomal dominant renal diseases have been reported, which originate from tubular cells and lead to tubular atrophy and interstitial fibrosis. These diseases are clinically indistinguishable, but caused by mutations in at least four different genes: UMOD, HNF1B, REN, and, as recently describe...

journal_title：Kidney international

authors： Ekici AB,Hackenbeck T,Morinière V,Pannes A,Buettner M,Uebe S,Janka R,Wiesener A,Hermann I,Grupp S,Hornberger M,Huber TB,Isbel N,Mangos G,McGinn S,Soreth-Rieke D,Beck BB,Uder M,Amann K,Antignac C,Reis A,Eckardt K

更新日期：2014-09-01 00:00:00

abstract：:Effect of varying concentrations (0 to 800 microM) of three different light chains on sodium-dependent L-(14C)alanine and D-(14C)glucose uptake by rat renal brush border membrane vesicles were studied. One kappa and two lambda type light chains (lambda-1 and lambda-2) were isolated from urines of patients with multipl...

journal_title：Kidney international

authors： Batuman V,Sastrasinh M,Sastrasinh S

更新日期：1986-11-01 00:00:00

abstract：:The purpose of these studies was to quantitatively assess the role of endogenous angiotensin II activity in controlling transport in the proximal convoluted tubule (PCT) and whole nephron. We used the nonpeptide angiotensin II receptor antagonist DuP 753, which lacks the agonist and kinin/prostaglandin-inducing proper...

journal_title：Kidney international

authors： Xie MH,Liu FY,Wong PC,Timmermans PB,Cogan MG

更新日期：1990-09-01 00:00:00

abstract：:We investigated the effect of the potent immunosuppressive agent, FK506, on experimental glomerular thrombosis in rats by combined injections of nephrotoxic serum (NTS) and lipopolysaccharide (LPS). Either FK506 or placebo was administered intramuscularly three hours prior to injection of NTS that was followed one hou...

journal_title：Kidney international

authors： Hiromura K,Hayashi J,Tsukada Y,Ono K,Tsuchida A,Yano S,Naruse T

更新日期：1994-06-01 00:00:00

abstract：:Cardiac surgery associated-acute kidney injury (CS-AKI) occurs in 30-50% of patients undergoing surgery for congenital heart disease. Here we determine if CS-AKI is associated with chronic kidney disease (CKD) in patients with congenital heart disease. Using Danish regional population-based registries, our cohort stud...

journal_title：Kidney international

authors： Madsen NL,Goldstein SL,Frøslev T,Christiansen CF,Olsen M

更新日期：2017-09-01 00:00:00

abstract：:Class II gene products of the major histocompatibility complex (MHC) are not expressed usually in abundance on normal epithelium. The cell surface visibility of such proteins for the immune system is thought to be limited protectively in order to minimize inflammation consequent to the recognition of self-antigens in ...

journal_title：Kidney international

authors： Albert SE,Shelton K,Sun MJ,Neilson EG

更新日期：1991-07-01 00:00:00

abstract：:The effects of acidosis on renal function and morphology were examined in the isolated perfused rat kidney (IPK). Kidneys were perfused with oxygenated Krebs-Henseleit-albumin medium for 60 minutes at pH 7.4 or pH 7.0. At the lower pH, GFR was reduced by 25%, TRNa by 32% and oxygen consumption by 41% as compared to pe...

journal_title：Kidney international

authors： Shanley PF,Shapiro JI,Chan L,Burke TJ,Johnson GC

更新日期：1988-12-01 00:00:00

abstract：:The vasopressin inhibitor tolvaptan is clinically effective in slowing growth of renal cysts and reduction in estimated glomerular filtration rate (eGFR) in autosomal dominant polycystic kidney disease (ADPKD), but these effects are mitigated by the associated polyuria. Changes of total kidney volume, eGFR, and sympto...

journal_title：Kidney international

authors： Horie S

更新日期：2015-07-01 00:00:00

abstract：:Utilizing [5-15N] and [2-15N]-labeled glutamine and gas chromatography mass spectrometry methodology, we examined the pathways of ammoniagenesis under basal and acute acidotic conditions of pH 7.0 and pH 6.8, respectively. LLC-PK1 cultures were incubated for one hour with gentle rocking in a bicarbonate buffer of pH 7...

journal_title：Kidney international

authors： Nissim I,Sahai A,Sandler RS,Tannen RL

更新日期：1994-04-01 00:00:00

abstract：:Many features of chronic kidney disease may be reversed, but it is unclear whether advanced lesions, such as adhesions of sclerotic glomerular tufts to Bowman's capsule (synechiae), can resolve during treatment. We previously showed, using a renal ablation model, that the renoprotective effect of the AT-1 receptor blo...

journal_title：Kidney international

authors： Teles F,Machado FG,Ventura BH,Malheiros DM,Fujihara CK,Silva LF,Zatz R

更新日期：2009-01-01 00:00:00

abstract：:Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell survival and reaction to oxidative stress. As oxidative stress is increased in uremia and is associated with vascular calcification, we studied the role of autophagy in vascular calcification induced by phosphate. In an in vitro...

journal_title：Kidney international

authors： Dai XY,Zhao MM,Cai Y,Guan QC,Zhao Y,Guan Y,Kong W,Zhu WG,Xu MJ,Wang X

更新日期：2013-06-01 00:00:00

abstract：:The involvement of sodium/potassium-ATPase in regulating parathyroid hormone (PTH) secretion is inferred from in vitro studies. Recently, the α-klotho-dependent rapid recruitment of this ATPase to the parathyroid cell plasma membrane in response to low extracellular calcium ion was suggested to be linked to increased ...

journal_title：Kidney international

authors： Martuseviciene G,Hofman-Bang J,Clausen T,Olgaard K,Lewin E

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Recently, the in vivo pathogenic role of anti-neutrophil cytoplasm autoantibodies (ANCA) in ANCA-associated vasculitis has been challenged by Abdel-Salam et al. In their report, they observed that ANCA directed against proteinase 3 (PR3) cannot bind to their target autoantigen PR3 on circulating neutrophils ...

journal_title：Kidney international

authors： Van Rossum AP,van der Geld YM,Limburg PC,Kallenberg CG

更新日期：2005-08-01 00:00:00

abstract：:Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common....

journal_title：Kidney international

authors： Wang X,Lopez R,Luchtel RA,Hafizi S,Gartrell B,Shenoy N

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Patients on continuous ambulatory peritoneal dialysis (CAPD) are dependent on residual renal function for solute and water clearances, and this declines with time on dialysis. Loop diuretics have been postulated to slow this decline. METHODS:Sixty-one patients new to dialysis were randomly assigned to eithe...

journal_title：Kidney international

authors： Medcalf JF,Harris KP,Walls J

更新日期：2001-03-01 00:00:00

abstract：:Intrauterine growth retardation (IUGR) aggravates the course of acute mesangioproliferative glomerulonephritis (GN) in the rat. Observational studies in children suggest that IUGR may be associated with a severe course of kidney diseases such as IgA nephropathy. We tested the hypothesis that IUGR leads to aggravation ...

journal_title：Kidney international

authors： Plank C,Ostreicher I,Hartner A,Marek I,Struwe FG,Amann K,Hilgers KF,Rascher W,Dötsch J

更新日期：2006-12-01 00:00:00

abstract：:T lymphocytes modulate early ischemia-reperfusion injury in the kidney; however, their role during repair is unknown. We studied the role of TCRbeta(+)CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), known to blunt immune responses, in repair after ischemia-reperfusion injury to the kidney. Using a murine model of is...

journal_title：Kidney international

authors： Gandolfo MT,Jang HR,Bagnasco SM,Ko GJ,Agreda P,Satpute SR,Crow MT,King LS,Rabb H

更新日期：2009-10-01 00:00:00

abstract：:Podocyte injury and loss contribute to the progression of glomerular diseases, including diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 (SIRT1) is reduced in human diabetic glomeruli and that the podocyte-specific loss of SIRT1 aggravated albuminuria and worsened kidney diseas...

journal_title：Kidney international

authors： Hong Q,Zhang L,Das B,Li Z,Liu B,Cai G,Chen X,Chuang PY,He JC,Lee K

更新日期：2018-06-01 00:00:00