Immune evasion in renal cell carcinoma: biology, clinical translation, future directions.

abstract：:Sodium thiosulfate, a reversible oxidation product of hydrogen sulfide, has vasodilating and anti-oxidative properties, making it an attractive agent to alleviate damaging effects of hypertension. In experimental settings, inhibition of nitric oxide synthase causes hypertension, renal dysfunction and damage. We hypoth...

journal_title：Kidney international

authors： Nguyen ITN,Klooster A,Minnion M,Feelisch M,Verhaar MC,van Goor H,Joles JA

更新日期：2020-08-01 00:00:00

abstract：:Renal proximal tubule cells from spontaneously hypertensive rats (SHR), compared with normotensive Wistar-Kyoto rats (WKY), have increased oxidative stress. The contribution of mitochondrial oxidative phosphorylation to the subsequent hypertensive phenotype remains unclear. We found that renal proximal tubule cells fr...

journal_title：Kidney international

authors： Lee H,Abe Y,Lee I,Shrivastav S,Crusan AP,Hüttemann M,Hopfer U,Felder RA,Asico LD,Armando I,Jose PA,Kopp JB

更新日期：2014-03-01 00:00:00

abstract：:Osteonectin (SPARC, culture shock protein, BM-40) is a widely distributed glycoprotein which binds calcium and several extracellular matrix proteins, including interstitial collagens and thrombospondin, but whose physiologic role remains undefined. In the present studies, we have demonstrated that immunoreactive osteo...

journal_title：Kidney international

authors： Kopp JB,Bianco P,Young MF,Termine JD,Robey PG

更新日期：1992-01-01 00:00:00

abstract：:The glomerular response to injury displays astonishingly uniform features that include infiltration with professional immune cells, activation and proliferation of resident glomerular cells and matrix expansion. Cross-communication of intrinsic mesangial cells with invading immune cells is crucial for the fate of glom...

journal_title：Kidney international

authors： Pfeilschifter J,Beck KF,Eberhardt W,Huwiler A

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Elevated glucose levels and glomerular hypertension (Pgc) are considered to contribute to the elaboration of matrix protein by mesangial cells (MCs) in diabetic glomeruli. MCs grown in 30 mM of glucose produce excessive matrix protein, as do MCs exposed to cyclic strain, and the combination of the two exacer...

journal_title：Kidney international

authors： Ingram AJ,Ly H,Thai K,Kang MJ,Scholey JW

更新日期：1999-11-01 00:00:00

abstract：:The role of calcitonin on the calcemic response to parathyroid hormone (PTH) in renal failure has not been evaluated previously. Often animal studies evaluating the calcemic response to PTH in renal failure are performed in thyroparathyroidectomized (TPTX) animals, and thus eliminate any potential physiologic effect o...

journal_title：Kidney international

authors： Rodriguez M,Felsenfeld AJ,Torres A,Pederson L,Llach F

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:This study evaluated the effects of dietary sodium manipulation in dogs on the regulation of canine angiotensin receptors (cAT1 and cAT2) in the kidney and adrenal. METHODS:Isolated glomeruli and membranes from renal medulla and the adrenal gland were used in radioligand binding assays from two groups of do...

journal_title：Kidney international

authors： Zheng W,Ji H,Szabo Z,Brown PR,Yoo SE,Sandberg K

更新日期：2001-05-01 00:00:00

abstract：:Low-density lipoprotein was derived from carbamyl (carbamyl-LDL) by incubating LDL in potassium cyanate (KCNO). The proportion of free amino groups in the carbamyl-LDL was negatively correlated (r = -0.95) with the time of incubation in potassium cyanate (ranged from 5 to 360 min). The carbamylation did not change the...

journal_title：Kidney international

authors： Hörkkö S,Savolainen MJ,Kervinen K,Kesäniemi YA

更新日期：1992-05-01 00:00:00

abstract：:Pain was surveyed via structured interview and the McGill Pain Questionnaire in 53 dialysis and 27 transplant patients. Increased patient control over the dialysis procedure was not associated with a reduction in pain though perceived control may have been. Compliance with the dialysis regimen did not predict pain and...

journal_title：Kidney international

authors： Binik YM,Baker AG,Kalogeropoulos D,Devins GM,Guttmann RD,Hollomby DJ,Barré PE,Hutchison T,Prud'Homme M,McMullen L

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Systematic studies on safety and efficacy of enteral nutrition in patients with acute renal failure (ARF) are lacking. METHODS:We studied enteral nutrition-related complications and adequacy of nutrient administration during 2525 days of artificial nutrition in 247 consecutive patients fed exclusively by th...

journal_title：Kidney international

authors： Fiaccadori E,Maggiore U,Giacosa R,Rotelli C,Picetti E,Sagripanti S,Melfa L,Meschi T,Borghi L,Cabassi A

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Dialysis efficiency has a great influence on the outcome of patients. Few data are available on the removal of solutes with molecular weights higher than urea and creatinine. The aim of our study was to assess the transport and the removal of substances with molecular weights up to 15 kD and to evaluate the ...

journal_title：Kidney international

authors： Montini G,Amici G,Milan S,Mussap M,Naturale M,Rätsch IM,Ammenti A,Sorino P,Verrina E,Andreetta B,Zacchello G,Italian Registry of Pediatric Peritoneal Dialysis.

更新日期：2002-03-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) upregulation occurs in virtually all chronic kidney diseases and is associated with podocyte injury and proteinuria; however, the mechanisms contributing to this in vivo are ambiguous. In vitro, incubation of podocytes with TGF-β1 induced Wnt1 expression, β-catenin activation, an...

journal_title：Kidney international

authors： Wang D,Dai C,Li Y,Liu Y

更新日期：2011-12-01 00:00:00

abstract：:We studied binding and degradation of vasoactive intestinal peptide (VIP) by highly purified brush border and basolateral membranes from rabbit kidney cortex. Brush border and basolateral membranes were capable of 73 and 49% degradation of VIP after 20 minutes, and the degradation was totally prevented by bacitracin. ...

journal_title：Kidney international

authors： Kniaz D,Pahlavan P,Valaitis D,Arruda JA

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Erythropoietin is known to improve outcomes in patients with anemia from chronic renal disease. However, there is uncertainty about the optimal timing of initiation of erythropoietin treatment in predialysis patients with non-severe anemia. METHODS:We conducted a randomized controlled trial of early versus ...

journal_title：Kidney international

authors： Gouva C,Nikolopoulos P,Ioannidis JP,Siamopoulos KC

更新日期：2004-08-01 00:00:00

abstract：:The following bone density measurements have limited utility in determining bone strength because they do not include bone quality: microarchitecture, mineralization, ability to repair damage, collagen structure, crystal size, or marrow composition. Patients with kidney disease have poor bone quality. Newman et al. no...

journal_title：Kidney international

authors： Ott SM

更新日期：2016-01-01 00:00:00

abstract：:Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here the role of α-Klotho, a protein expressed predominantly in distal convoluted tubules that has a role in calcium reabsorption. We studied 31 patients with early diabetic nephropathy and compared them with 31 patients with IgA ne...

journal_title：Kidney international

authors： Asai O,Nakatani K,Tanaka T,Sakan H,Imura A,Yoshimoto S,Samejima K,Yamaguchi Y,Matsui M,Akai Y,Konishi N,Iwano M,Nabeshima Y,Saito Y

更新日期：2012-03-01 00:00:00

abstract：:Many approaches to blocking profibrotic TGFbeta overexpression are under way. Therapeutic targeting of TGFbeta-Smad signaling holds promise for slowing or halting progressive renal disease. In this issue, Fukasawa et al., using the unilateral ureteral obstruction model, provide a new target for therapeutic interventio...

journal_title：Kidney international

authors： Huang Y,Border WA,Noble NA

更新日期：2006-05-01 00:00:00

abstract：:Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix (ECM) glycoprotein that has been recently isolated and cloned from the rabbit kidney. It is an integral component of the basal lamina, and unlike other basement membrane proteins it is exclusively expressed in the tubular basement membranes (TBMs...

journal_title：Kidney international

authors： Kumar A,Ota K,Wada J,Wallner EI,Charonis AS,Carone FA,Kanwar YS

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Altered mineral metabolism contributes to bone disease, cardiovascular disease, and other clinical problems in patients with end-stage renal disease. METHODS:This study describes the recent status, significant predictors, and potential consequences of abnormal mineral metabolism in representative groups of ...

journal_title：Kidney international

authors： Young EW,Albert JM,Satayathum S,Goodkin DA,Pisoni RL,Akiba T,Akizawa T,Kurokawa K,Bommer J,Piera L,Port FK

更新日期：2005-03-01 00:00:00

abstract：:Idiopathic retroperitoneal fibrosis (IRF) is a rare disease often causing obstructive uropathy. We evaluated the clinicopathologic features of 24 patients with IRF to characterize the histopathology of the disease and to provide a framework for the differential diagnosis with other retroperitoneal fibrosing conditions...

journal_title：Kidney international

authors： Corradi D,Maestri R,Palmisano A,Bosio S,Greco P,Manenti L,Ferretti S,Cobelli R,Moroni G,Dei Tos AP,Buzio C,Vaglio A

更新日期：2007-09-01 00:00:00

abstract：:The family of bone morphogenetic proteins. Bone morphogenetic proteins (BMPs) are secreted signaling molecules belonging to the transforming growth factor-beta (TGF-beta) superfamily of growth factors. The first BMPs were originally identified by their ability to induce ectopic bone formation when implanted under the ...

journal_title：Kidney international

authors： Ducy P,Karsenty G

更新日期：2000-06-01 00:00:00

abstract：:McAdoo et al. propose that patients with both circulating antiglomerular basement membrane antibody and antineutrophil cytoplasm antibody demonstrate a phenotype that lies between that of single-positive antiglomerular basement membrane disease and antineutrophil cytoplasm antibody-associated vasculitis. Specifically,...

journal_title：Kidney international

authors： Canney M,Little MA

更新日期：2017-09-01 00:00:00

abstract：:Membranous nephropathy is a major cause of nephrotic syndrome in adults where podocyte injuries were found to mediate the development of proteinuria. Triptolide, a major active component of Tripterygium wilfordii Hook F, has potent immunosuppressive, anti-inflammatory and antiproteinuric effects. To study its antiprot...

journal_title：Kidney international

authors： Chen ZH,Qin WS,Zeng CH,Zheng CX,Hong YM,Lu YZ,Li LS,Liu ZH

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:It is currently impossible to reliably predict which diabetic patients will develop nephropathy and progress to kidney failure. Microalbuminuria, often regarded as a predictor of overt diabetic renal disease is, in fact, an indicator of established glomerular damage. We have shown that glomerular expression ...

journal_title：Kidney international

authors： Riser BL,Cortes P,DeNichilo M,Deshmukh PV,Chahal PS,Mohammed AK,Yee J,Kahkonen D

更新日期：2003-08-01 00:00:00

abstract：:The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absence of exogenous bicarbonate ions (HCO3-), we explored the permeability characteristics in the presence ...

journal_title：Kidney international

authors： Finn JT,Cohen LH,Steinmetz PR

更新日期：1977-04-01 00:00:00

abstract：:Polycystic kidney disease progresses more rapidly in men than in women. To investigate the basis for this sexual dimorphism, we exposed Madin-Darby canine kidney (MDCK) cells grown on collagen-coated cell culture inserts to control media, or to estradiol or testosterone (1 nM-1 microM). Compared to control and estradi...

journal_title：Kidney international

authors： Sandhu S,Silbiger SR,Lei J,Neugarten J

更新日期：1997-05-01 00:00:00

abstract：:A major problem in cyclosporine A (CsA) therapy is its nephrotoxicity, characterized by a marked fall in glomerular filtration rate (GFR). Since the glomerular ultrafiltration area is an important determinant of GFR and has been proposed to be regulated by mesangial (MS) cell contraction, we examined the effect of CsA...

journal_title：Kidney international

authors： Meyer-Lehnert H,Schrier RW

更新日期：1988-07-01 00:00:00

abstract：:This NIH-funded multicenter randomized study of focal segmental glomerulosclerosis (FSGS) treatment compared the efficacy of a 12-month course of cyclosporine to a combination of oral pulse dexamethasone and mycophenolate mofetil in children and adults with steroid-resistant primary FSGS. Of the 192 patients enrolled,...

journal_title：Kidney international

authors： Gipson DS,Trachtman H,Kaskel FJ,Greene TH,Radeva MK,Gassman JJ,Moxey-Mims MM,Hogg RJ,Watkins SL,Fine RN,Hogan SL,Middleton JP,Vehaskari VM,Flynn PA,Powell LM,Vento SM,McMahan JL,Siegel N,D'Agati VD,Friedman AL

更新日期：2011-10-01 00:00:00

abstract：:T lymphocytes modulate early ischemia-reperfusion injury in the kidney; however, their role during repair is unknown. We studied the role of TCRbeta(+)CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), known to blunt immune responses, in repair after ischemia-reperfusion injury to the kidney. Using a murine model of is...

journal_title：Kidney international

authors： Gandolfo MT,Jang HR,Bagnasco SM,Ko GJ,Agreda P,Satpute SR,Crow MT,King LS,Rabb H

更新日期：2009-10-01 00:00:00

abstract：:X-linked Alport syndrome (AS) associated with diffuse esophageal leiomyomatosis (DL) has been reported to be due to deletions removing the 5' ends of both the COL4A5 and COL4A6 genes, encoding the alpha 5 and alpha 6 chains of type IV collagen, respectively, whereas a variety of mutations in COL4A5 has been identified...

journal_title：Kidney international

authors： Dahan K,Heidet L,Zhou J,Mettler G,Leppig KA,Proesmans W,David A,Roussel B,Mongeau JG,Gould JM

更新日期：1995-12-01 00:00:00