Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats.

abstract：BACKGROUND:Little information is available regarding cardiac morbidity and mortality in children with end-stage renal disease. We sought to determine the incidence of cardiac morbidity and mortality in pediatric chronic dialysis patients. METHODS:Medicare incident pediatric (0 to 19 years) dialysis patients from 1991 ...

journal_title：Kidney international

authors： Chavers BM,Li S,Collins AJ,Herzog CA

更新日期：2002-08-01 00:00:00

abstract：:In rats undergoing renal mass reduction (RMR) oral supplementation with the nitric oxide (NO) precursor L-arginine increases glomerular filtration rate and ameliorates signs of glomerular injury, suggesting that chronic renal failure in the rats is a condition of low NO formation in the kidney. On the contrary, data a...

journal_title：Kidney international

authors： Aiello S,Noris M,Todeschini M,Zappella S,Foglieni C,Benigni A,Corna D,Zoja C,Cavallotti D,Remuzzi G

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH or GH/IGF-I can partially restore linear growth. The molecular basis for decreased longitudinal growth is not known but may ...

journal_title：Kidney international

authors： Edmondson SR,Baker NL,Oh J,Kovacs G,Werther GA,Mehls O

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:The obstructed kidney in unilateral ureteral obstruction (UUO) is characterized by renal atrophy and tissue loss, which is mediated by renal tubular apoptosis. We sought to determine whether NO is involved in renal tubular apoptosis in vitro and in vivo. METHODS:Rat renal tubular epithelial cells (NRK-52E) ...

journal_title：Kidney international

authors： Miyajima A,Chen J,Poppas DP,Vaughan ED Jr,Felsen D

更新日期：2001-04-01 00:00:00

abstract：:Renal toxicity, possibly due to vasoconstriction and vascular injury, is the most relevant side-effect of chronic cyclosporine (CsA) therapy given to prevent graft rejection. In kidney transplant recipients each oral dose of CsA is invariably followed by a transient reduction in renal plasma flow (RPF) and glomerular ...

journal_title：Kidney international

authors： Ruggenenti P,Perico N,Mosconi L,Gaspari F,Benigni A,Amuchastegui CS,Bruzzi I,Remuzzi G

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:The continuous chemical, physical, and inflammatory insults of prolonged continuous ambulatory peritoneal dialysis (CAPD) incite mesothelial cell responses, which may result in peritoneal fibrosis. The transforming growth factor-beta (TGF-beta), especially the isoform TGF-beta 1, has long been known to play ...

journal_title：Kidney international

authors： Yang AH,Chen JY,Lin JK

更新日期：2003-04-01 00:00:00

abstract：:The study by Rieg et al. is the first to examine potassium handling in BK(-/-) mice, thereby addressing many unanswered questions regarding the separate roles of BK and ROMK channels in renal potassium secretion. This Commentary is an interpretation and opinion of their results, by two researchers who have been studyi...

journal_title：Kidney international

authors： Sansom SC,Welling PA

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Increased venous pressure (VP) and decreased access flow (Qa) are predictors of dialysis access graft thrombosis. VP is easily obtainable. Qa assessment requires a special device and takes more time. The aims of our randomized multicenter studies were to compare outcome in patients with grafts monitored by V...

journal_title：Kidney international

authors： Smits JH,van der Linden J,Hagen EC,Modderkolk-Cammeraat EC,Feith GW,Koomans HA,van den Dorpel MA,Blankestijn PJ

更新日期：2001-04-01 00:00:00

abstract：:Adynamic bone disease (ABD) is increasingly recognized, especially in dialysis patients treated with oral calcium carbonate, vitamin D supplements, or supraphysiological dialysate calcium. We undertook this study to assess the effect of lowering dialysate calcium on episodes of hypercalcemia, serum parathyroid hormone...

journal_title：Kidney international

authors： Haris A,Sherrard DJ,Hercz G

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest that cellular immune mechanisms contribute to glomerulonephritis. METHODS:The roles of alphabeta and gammadelta T cells in the pathogenesis of glomerulonephritis were investigated in a model of nephrotoxic nephritis in mice deficient in either T-cell population [T-cell rece...

journal_title：Kidney international

authors： Rosenkranz AR,Knight S,Sethi S,Alexander SI,Cotran RS,Mayadas TN

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Proteoglycans are integral components of the mesangial matrix and glomerular permeability barrier. Recent studies have shown that changes in glomerular proteoglycan expression may play a major role in the pathogenesis of renal disease. Steroid hormones are used as first-choice therapy for the treatment of gl...

journal_title：Kidney international

authors： Kuroda M,Sasamura H,Shimizu-Hirota R,Mifune M,Nakaya H,Kobayashi E,Hayashi M,Saruta T

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The pathogenesis of progressive nephropathies involves hemodynamic and inflammatory factors. In the 5/6 nephrectomy model, a selective increase of cyclooxygenase-2 (COX-2) expression was shown, whereas treatment with a nonsteroidal anti-inflammatory or a specific COX-2 inhibitor was renoprotective. We invest...

journal_title：Kidney international

authors： Fujihara CK,Antunes GR,Mattar AL,Andreoli N,Malheiros DM,Noronha IL,Zatz R

更新日期：2003-12-01 00:00:00

abstract：:The present study was undertaken to evaluate some pathophysiological mechanisms of edema formation in diabetic nephropathy. Sixty-three subjects were investigated: 9 normal subjects (I), 9 normoalbuminuric Type 1 (insulin-dependent) diabetic patients (II), 15 microalbuminuric Type 1 diabetic patients (III), 16 Type 1 ...

journal_title：Kidney international

authors： Hommel E,Mathiesen ER,Aukland K,Parving HH

更新日期：1990-12-01 00:00:00

abstract：:The effects of chronic respiratory alkalosis on divalent ion homeostasis have not been reported in any species. We studied four normal male subjects during a four-day control period (residence at 500 m), during six days of chronic respiratory alkalosis induced by hypobaric hypoxia (residence at 3450 m), followed by a ...

journal_title：Kidney international

authors： Krapf R,Jaeger P,Hulter HN

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:The impact of obesity on survival in end-stage renal disease (ESRD) patients as related to dialysis modality (i.e., a direct comparison of hemodialysis with peritoneal dialysis) has not been assessed adjusting for differences in medication use, follow-up > or =2 years, or accounting for changes in dialysis m...

journal_title：Kidney international

authors： Abbott KC,Glanton CW,Trespalacios FC,Oliver DK,Ortiz MI,Agodoa LY,Cruess DF,Kimmel PL

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:In renal cells, hyperosmolarity has been shown to induce the accumulation of myo-inositol, via the Na+/myo-inositol cotransporter (SMIT). Previously we showed that SMIT mRNA in the kidney is localized in the medullary thick ascending limb of Henle (TALH). Here we used renal cells derived from the rabbit oute...

journal_title：Kidney international

authors： Yorek MA,Dunlap JA,Lowe WL Jr

更新日期：1999-01-01 00:00:00

abstract：:Atherogenic lipoproteins and reactive oxygen species stimulate renin release from isolated juxtaglomerular (JG) cells. Here we assessed whether stimulation of renin release is mediated by formation of superoxide anion (O2-), and whether the effects of oxidized lipoproteins, like in many other biological systems, can b...

journal_title：Kidney international

authors： Galle J,Heinloth A,Schwedler S,Wanner C

更新日期：1997-01-01 00:00:00

abstract：:Mutations in the complement regulatory proteins are associated with several different diseases. Although these mutations cause dysregulated alternative pathway activation throughout the body, the kidneys are the most common site of injury. The susceptibility of the kidney to alternative pathway-mediated injury may be ...

journal_title：Kidney international

authors： Laskowski J,Renner B,Le Quintrec M,Panzer S,Hannan JP,Ljubanovic D,Ruseva MM,Borza DB,Antonioli AH,Pickering MC,Holers VM,Thurman JM

更新日期：2016-07-01 00:00:00

abstract：:A number of clinical laboratory and biopsy-derived parameters were assessed for their prognostic significance in the short (24 months), intermediate (60 months) and long terms in 45 patients (43 female, 2 male) with diffuse proliferative lupus glomerulonephritis (DPGN). The factors evaluated were serum creatinine (SCr...

journal_title：Kidney international

authors： Magil AB,Puterman ML,Ballon HS,Chan V,Lirenman DS,Rae A,Sutton RA

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy is commonly associated with renal salt and water retention and hypertension. The molecular mechanisms involved and how the kidney responds to this volume expansion, in terms of renal transporter regulation, are not understood. METHODS:Targeted proteomics employing semiquantitative immun...

journal_title：Kidney international

authors： Bickel CA,Knepper MA,Verbalis JG,Ecelbarger CA

更新日期：2002-06-01 00:00:00

abstract：:beta 2-microglobulin-related amyloidosis (A beta 2M) represents a frequent complication in long-term dialysis patients. Although the pathogenetic mechanism has yet to be fully understood, it is known that amyloid fibrils usually consist of intact molecules of beta 2-microglobulin (beta 2m). Plasma proteinase inhibitor...

journal_title：Kidney international

authors： Campistol JM,Shirahama T,Abraham CR,Rodgers OG,Solé M,Cohen AS,Skinner M

更新日期：1992-10-01 00:00:00

abstract：:Large epidemiological studies clearly demonstrate that multiple episodes of acute kidney injury contribute to the development and progression of kidney fibrosis. Although our understanding of kidney fibrosis has improved in the past two decades, we have limited therapeutic strategies to halt its progression. Myofibrob...

journal_title：Kidney international

authors： Gu X,Mallipattu SK,Guo Y,Revelo MP,Pace J,Miller T,Gao X,Jain MK,Bialkowska AB,Yang VW,He JC,Mei C

更新日期：2017-11-01 00:00:00

abstract：:Utilizing [5-15N] and [2-15N]-labeled glutamine and gas chromatography mass spectrometry methodology, we examined the pathways of ammoniagenesis under basal and acute acidotic conditions of pH 7.0 and pH 6.8, respectively. LLC-PK1 cultures were incubated for one hour with gentle rocking in a bicarbonate buffer of pH 7...

journal_title：Kidney international

authors： Nissim I,Sahai A,Sandler RS,Tannen RL

更新日期：1994-04-01 00:00:00

abstract：:Vascular sclerosis has been linked to many risk factors, including smoking, family history, low birth weight, and hypertension. In interesting studies, Goforth et al. show an increased rate of mutations in thrombophilic molecules in patients with vascular sclerosis in renal biopsies, suggesting yet another mechanism. ...

journal_title：Kidney international

authors： Fogo AB

更新日期：2006-08-01 00:00:00

abstract：:Tuberous sclerosis complex is a genetic disorder characterized by hamartomatous lesions in multiple organs, frequently involving the kidney. We conducted a retrospective review of the clinical and radiographic records of 167 patients with tuberous sclerosis to determine the frequency of renal disease, the likelihood o...

journal_title：Kidney international

authors： Rakowski SK,Winterkorn EB,Paul E,Steele DJ,Halpern EF,Thiele EA

更新日期：2006-11-01 00:00:00

abstract：:The recent identification of RPGRIP1L as a Joubert syndrome gene brings the total of known genes to five. Three of these are also associated with the lethal Meckel syndrome, and two with Senior-Løken syndrome; both of these disorders share Joubert syndrome phenotypes, illustrating the genetic complexity of this. ...

journal_title：Kidney international

authors： Harris PC

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Only few noninvasive methods have the potential to quantitate renal blood flow (RBF) in humans. Positron emission tomography (PET) is a clinical imaging method that can be used to measure the tissue blood flow noninvasively. The purpose of this study was to validate PET measurement of RBF using 15O-labeled w...

journal_title：Kidney international

authors： Juillard L,Janier MF,Fouque D,Lionnet M,Le Bars D,Cinotti L,Barthez P,Gharib C,Laville M

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Adiponectin is an adipocyte-derived cytokine that has anti-inflammatory properties. A preliminary proteomic evaluation of urine for biomarkers of systemic lupus erythematosus (SLE) nephritis demonstrated high levels of adiponectin in SLE urine. This prompted investigation of adiponectin expression in human S...

journal_title：Kidney international

authors： Rovin BH,Song H,Hebert LA,Nadasdy T,Nadasdy G,Birmingham DJ,Yung Yu C,Nagaraja HN

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Urea kinetic modeling (UKM) and food records are widely used to assess the dialysis adequacy. Clinicians use these methods in individual patients to decide whether the dialysis prescription should be adjusted. We determined the variation in UKM parameters and dietary intake within individual patients in orde...

journal_title：Kidney international

authors： Kloppenburg WD,Stegeman CA,Hooyschuur M,van der Ven J,de Jong PE,Huisman RM

更新日期：1999-05-01 00:00:00

abstract：:Previously, uremic toxins were sometimes regarded as a large, mysterious, but also anonymous group of factors potentially contributing to morbidity and mortality in end-stage renal disease. By identifying the protein-bound solute p-cresol as a risk factor for mortality in dialysis patients, Bammens and colleagues for ...

journal_title：Kidney international

authors： Ketteler M

更新日期：2006-03-01 00:00:00