Demonstration of plasma proteinase inhibitors in beta 2-microglobulin amyloid deposits.

abstract：:Studies were undertaken to examine the mechanism whereby changes in intraluminal flow rates after reabsorption in the isolated perfused proximal tubule of the rabbit. All protocols employed the technique of in vitro perfusion of isolated segments of the proximal convoluted tubule. Stepwise elimination of d-glucose and...

journal_title：Kidney international

authors： Imai M,Seldin DW,Kokko JP

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

journal_title：Kidney international

authors： Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Long-term graft function is the result of multiple parameters, including both immune and non-immune components, which have a beneficial or detrimental potential. Among these, despite its frequency and theoretical interest (expression of "danger signals" in the graft itself), the effects of acute graft pyelon...

journal_title：Kidney international

authors： Giral M,Pascuariello G,Karam G,Hourmant M,Cantarovich D,Dantal J,Blancho G,Coupel S,Josien R,Daguin P,Méchineau S,Soulillou JP

更新日期：2002-05-01 00:00:00

abstract：:Because the comparison of survival in patients with renal failure treated by dialysis and transplantation may be biased by pretreatment prognostic differences in the patients who receive these two therapies, we quantified the pretreatment prognosis of all 430 dialysis and transplant patients who began therapy for end-...

journal_title：Kidney international

authors： Hutchinson TA,Thomas DC,Lemieux JC,Harvey CE

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Patients initiating dialysis after a failed kidney transplant are a subgroup of chronic kidney disease (CKD) patients who have not been characterized. Exposure to immunosuppressive medications differentiates these patients from the general incident end-stage renal disease (ESRD) population. METHODS:Data fro...

journal_title：Kidney international

authors： Gill JS,Abichandani R,Khan S,Kausz AT,Pereira BJ

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Angiotensin type 1 (AT1) receptor-deficient mice (Agtr1-/-), which selectively lack both AT1A and AT1B receptor genes, are characterized by marked intrarenal vascular thickening. In the present study, we explored the possible involvement of the kinin-kallikrein system in the development of this renal vascula...

journal_title：Kidney international

authors： Tsuchida S,Miyazaki Y,Matsusaka T,Hunley TE,Inagami T,Fogo A,Ichikawa I

更新日期：1999-08-01 00:00:00

abstract：:A strong influence of urinary kallikrein excretion on the salt sensitivity of blood pressure has been recently suggested in normotensive patients. To evaluate the relationship between kallikrein and salt sensitivity in essential hypertension, active kallikrein excretion, plasma renin activity, atrial natriuretic pepti...

journal_title：Kidney international

authors： Ferri C,Bellini C,Carlomagno A,Perrone A,Santucci A

更新日期：1994-09-01 00:00:00

abstract：:Amyloidosis results from protein misfolding, and ongoing amyloid deposition can ultimately lead to organ failure and death. Historically, this is a group of diseases with limited treatment options and frequently poor prognosis. However, there are now 'targeted' therapeutics emerging in the form of stabilizers of the p...

journal_title：Kidney international

authors： Sayed RH,Hawkins PN,Lachmann HJ

更新日期：2015-03-01 00:00:00

abstract：:Noninvasive molecular tests of urine cells have been developed to monitor the activity of kidney diseases. We evaluate whether measurement of urinary messenger RNA (mRNA) levels of chemokine and growth factor genes could distinguish between diffuse proliferative lupus nephritis (class IV LN) and others and whether it ...

journal_title：Kidney international

authors： Avihingsanon Y,Phumesin P,Benjachat T,Akkasilpa S,Kittikowit V,Praditpornsilpa K,Wongpiyabavorn J,Eiam-Ong S,Hemachudha T,Tungsanga K,Hirankarn N

更新日期：2006-02-01 00:00:00

abstract：:Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk...

journal_title：Kidney international

authors： Juni RP,Al-Shama R,Kuster DWD,van der Velden J,Hamer HM,Vervloet MG,Eringa EC,Koolwijk P,van Hinsbergh VWM

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) is expressed constitutively in the adult glomerular podocytes at high levels; however, the regulation of its production is unclear. Recent data from podocyte-specific knockout mice suggest that VPF/VEGF-A is critical for the proper ...

journal_title：Kidney international

authors： Datta K,Li J,Karumanchi SA,Wang E,Rondeau E,Mukhopadhyay D

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Transforming growth factor-beta (TGF-beta) is known to play an important role in the pathophysiology of renal tubular disease. Researchers have recently identified a novel mitogen-activated protein kinase kinase kinase (MAPKKK), TAK (TGF-beta activated kinase)1, which stimulates the MKK3/6-p38K pathway. The ...

journal_title：Kidney international

authors： Terada Y,Nakashima O,Inoshita S,Kuwahara M,Sasaki S,Marumo F

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:This study examined the effects of stent placement for renal artery stenosis on the function of treated and contralateral kidneys. METHODS:Eighteen patients who underwent stent placement for unilateral renal artery stenosis presenting with hypertension and/or renal failure were studied before angiography an...

journal_title：Kidney international

authors： Leertouwer TC,Derkx FH,Pattynama PM,Deinum J,van Dijk LC,Schalekamp MA

更新日期：2002-08-01 00:00:00

abstract：:The main distal nephron segment sodium transporters are the distal tubule chlorothiazide-sensitive sodium chloride cotransporter (NCC) and the collecting duct amiloride-sensitive epithelial sodium channel (ENaC). The infusion of ghrelin into the renal interstitium stimulates distal nephron-dependent sodium reabsorptio...

journal_title：Kidney international

authors： Kemp BA,Howell NL,Gildea JJ,Keller SR,Padia SH

更新日期：2013-09-01 00:00:00

abstract：:Early graft loss (EGL) is a feared outcome of kidney transplantation. Consequently, kidneys with an anticipated risk of EGL are declined for transplantation. In the most favorable scenario, with optimal use of available donor kidneys, the donor pool size is balanced by the risk of EGL, with a tradeoff dictated by the ...

journal_title：Kidney international

authors： de Kok MJ,Schaapherder AF,Mensink JW,de Vries AP,Reinders ME,Konijn C,Bemelman FJ,van de Wetering J,van Zuilen AD,Christiaans MH,Baas MC,Nurmohamed AS,Berger SP,Ploeg RJ,Alwayn IP,Lindeman JH

更新日期：2020-06-01 00:00:00

abstract：:Renal stone disease, which affects 12% of males and 5% of females by the seventh decade, occurs as an inherited disorder in 45% of patients and is most commonly associated with hypercalciuria. The biochemical basis for hereditary nephrolithiasis and hypercalciuria is unknown, and this has therefore been investigated b...

journal_title：Kidney international

authors： Thakker RV

更新日期：2000-03-01 00:00:00

abstract：:A morphometric study was undertaken to quantitate the morphologic changes induced by ADH availability in the rat kidney. Homozygous Brattleboro rats with hereditary diabetes insipidus (DI) (no ADH) were compared to heterozygous Brattleboro control rats (HZ) and to DI rats after 5 to 6 weeks of continuous ADH infusion ...

journal_title：Kidney international

authors： Bouby N,Bankir L,Trinh-Trang-Tan MM,Minuth WW,Kriz W

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:While the most common glomerular lesion associated with human immunodeficiency virus (HIV) infection is collapsing focal segmental glomerulosclerosis (FSGS) [HIV-associated nephropathy (HIVAN)], immune complex-mediated forms of glomerulonephritis have been increasingly reported. One form of glomerulonephriti...

journal_title：Kidney international

authors： Haas M,Kaul S,Eustace JA

更新日期：2005-04-01 00:00:00

abstract：:Coronary artery stenosis induces renal inflammation and kidney injury in pigs even in the absence of myocardial infarction or clinically significant heart failure. This effect is aggravated by experimentally induced renovascular hypertension. Interestingly, oxidative stress originating from the ischemic myocardium was...

journal_title：Kidney international

authors： Rump LC,Stegbauer J

更新日期：2015-04-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) transforms endogenous glucocorticoids to their respective "biologically inert" 11-dehydro derivatives. A decrease in enzyme activity allows glucocorticoids to induce mineralocorticoid-like renal sodium retention. Since positive sodium balance is required for optimum ...

journal_title：Kidney international

authors： Brem AS,Bina B,Matheson KL,Barnes JL,Morris DJ

更新日期：1994-03-01 00:00:00

abstract：:An expression profile is a list based on a large scale sequencing of 1000 cDNA clones, showing the expressed genes and the abundance of their transcripts in a given cell or tissue (Okubo K et al: Nature Genet 2:173, 1992). We constructed an expression profile of mouse renal proximal tubules (PT) carefully isolated by ...

journal_title：Kidney international

authors： Takenaka M,Imai E,Kaneko T,Ito T,Moriyama T,Yamauchi A,Hori M,Kawamoto S,Okubo K

更新日期：1998-03-01 00:00:00

abstract：:IgA1 proteins from sera of patients with IgA nephropathy (IgAN) are galactosylated to a lesser degree than those from healthy controls. The increased reactivity of intact or de-sialylated serum IgA1 with N-acetylgalactosamine (GalNAc)-specific lectins, Helix aspersa (HAA) and Caragana arborescens (CAA) and de-sialylat...

journal_title：Kidney international

authors： Tomana M,Matousovic K,Julian BA,Radl J,Konecny K,Mestecky J

更新日期：1997-08-01 00:00:00

abstract：:Gap junctions are present in the juxtaglomerular apparatus enabling intercellular communication. Our study determined the location of different connexin subtypes within the juxtaglomerular apparatus of the rat, and the role of these subtypes in renal hemodynamics through the use of specific mimetic peptides. Immunohis...

journal_title：Kidney international

authors： Takenaka T,Inoue T,Kanno Y,Okada H,Meaney KR,Hill CE,Suzuki H

更新日期：2008-02-01 00:00:00

abstract：:The rate of myofibrillar protein degradation was measured by 3-methylhistidine (3MH) release in moderately uremic and sham-operated control rats. The rats were studied in the fed state or after 24 and 48 hours of fasting. When fed, both uremic and control rats gained weight at the same rate. During 48 hours of fasting...

journal_title：Kidney international

authors： Li JB,Wassner SJ

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) uniquely serve as conduits between innate and cognate arms of the immune system. The normal kidney contains an extensive population of interstitial DCs but their role in the pathogenesis of acute renal injury is not known. METHODS:Renal DCs were studied by flow cytometric analysis of c...

journal_title：Kidney international

authors： Dong X,Swaminathan S,Bachman LA,Croatt AJ,Nath KA,Griffin MD

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:In the United States, infection is second to cardiovascular disease as the leading cause of death in patients with end-stage renal disease (ESRD), and septicemia accounts for more than 75% of this category. This increased susceptibility to infections is partly due to uremia, old age, and comorbid conditions....

journal_title：Kidney international

authors： Sarnak MJ,Jaber BL

更新日期：2000-10-01 00:00:00

abstract：:The inactivation of physiological glucocorticoids by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) confers mineralocorticoid specificity to certain aldosterone target tissues. Both NADP, and NAD-dependent isoforms of 11 beta-HSD have been described. An NAD-dependent isoform of 11 beta-HSD (11 beta-HSD2) was recen...

journal_title：Kidney international

authors： Kyossev Z,Walker PD,Reeves WB

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Lipoprotein glomerulopathy (LPG) is characterized by intraglomerular lipoprotein thrombosis and high plasma concentrations of apolipoprotein (apo) E. An apo E variant, apo E2 (Arg145Pro) Sendai, was recently identified in three patients with LPG. We detected a novel point mutation in the apo E gene in a pati...

journal_title：Kidney international

authors： Matsunaga A,Sasaki J,Komatsu T,Kanatsu K,Tsuji E,Moriyama K,Koga T,Arakawa K,Oikawa S,Saito T,Kita T,Doi T

更新日期：1999-08-01 00:00:00

abstract：:Angiotensin II plays an important role in the regulation of blood pressure, body salt and fluid balance, and urine concentration. Mice with deletion of the AT(1a) receptor develop polyuria and urine concentration defects. We studied the mechanisms of these urine concentration defects by treating wild-type and AT(1a)-k...

journal_title：Kidney international

authors： Li XC,Shao Y,Zhuo JL

更新日期：2009-07-01 00:00:00

abstract：:Renal involvement in von Hippel-Lindau (VHL) disease has emerged as the most prevalent cause of death in this hereditary disorder. In a group of 43 VHL patients (23 unrelated families) with renal lesions we examined whether severity of renal disease is affected by parental inheritance and VHL subtype (1, without pheoc...

journal_title：Kidney international

authors： Chauveau D,Duvic C,Chrétien Y,Paraf F,Droz D,Melki P,Hélénon O,Richard S,Grünfeld JP

更新日期：1996-09-01 00:00:00