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Idiopathic retroperitoneal fibrosis: clinicopathologic features and differential diagnosis.

Abstract：

:Idiopathic retroperitoneal fibrosis (IRF) is a rare disease often causing obstructive uropathy. We evaluated the clinicopathologic features of 24 patients with IRF to characterize the histopathology of the disease and to provide a framework for the differential diagnosis with other retroperitoneal fibrosing conditions. Retroperitoneal specimens were analyzed by light and electron microscopy and by immunohistochemistry. Most patients presented with abdominal/lumbar pain, constitutional symptoms, and high acute-phase reactants. Overall, 20 had ureteral involvement and 13 developed acute renal failure. The retroperitoneal tissue consisted of a fibrous component and a chronic inflammatory infiltrate with the former characterized by myofibroblasts within a type-I collagen matrix. The infiltrate displayed perivascular and diffuse patterns containing lymphocytes, macrophages, plasma cells, and eosinophils. The perivascular aggregates had a central core of CD20(+) cells and a mantle of CD3(+) cells in equal proportions. In the areas of diffuse infiltrate, CD3(+) cells outnumbered the CD20(+) cells. Most plasma cells were positive for the IgG4 isotype. Small vessel vasculitis was found in the specimens of 11 patients. Our study indicates that a sclerotic background with myofibroblasts associated with a diffuse and perivascular infiltrate mainly consisting of T and B lymphocytes may be a pathological hallmark of IRF.

journal_name

Kidney Int

journal_title

Kidney international

authors

Corradi D,Maestri R,Palmisano A,Bosio S,Greco P,Manenti L,Ferretti S,Cobelli R,Moroni G,Dei Tos AP,Buzio C,Vaglio A

doi

10.1038/sj.ki.5002427

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

742-53

issue

6

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)52725-7

journal_volume

72

pub_type

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