当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Estradiol suppresses type I collagen synthesis in mesangial cells via activation of activator protein-1.

Estradiol suppresses type I collagen synthesis in mesangial cells via activation of activator protein-1.

Abstract：

BACKGROUND:Estradiol suppresses the synthesis of type I collagen by murine mesangial cells. However, neither the alpha 1(I) nor the alpha 2(I) collagen gene contains an estrogen-response element. Because estradiol modulates the transcription of several genes that lack an estrogen-response element but contain a regulatory activator protein-1 (AP-1) binding motif, we hypothesized that AP-1 may mediate estradiol-induced suppression of type I collagen synthesis. METHODS:We measured type I collagen synthesis in murine mesangial cells exposed to estradiol, phorbol 12-myristate 13-acetate (an activator of AP-1), or curcumin (an inhibitor of AP-1). We also assessed the effects of estradiol on the steady-state level of c-fos and c-jun mRNA and on the binding of mesangial cell nuclear extracts to an AP-1 consensus binding site oligonucleotide. RESULTS:Estradiol (10(-10) M to 10(-7) M) suppressed type I collagen synthesis by murine mesangial cells in a dose-dependent manner (10(-7) M, 43.7 +/- 8.2% of control values, P < 0.001). Phorbol 12-myristate 13-acetate (10 microM, four-hr exposure) also decreased type I collagen in the media. In contrast, curcumin (1 microM) increased type I collagen. Estradiol increased the steady-state level of c-fos mRNA twofold at 30 minutes, with a return to basal levels at one hour. This was associated with a greater than threefold increase in the binding of nuclear extracts from estradiol-treated mesangial cells to an AP-1 consensus binding site oligonucleotide. Estradiol-enhanced binding of nuclear extracts to the AP-1 oligonucleotide was reversed by cycloheximide. CONCLUSIONS:These data suggest that estradiol suppresses collagen I synthesis by murine mesangial cells via enhanced AP-1 activity.

journal_name

Kidney Int

journal_title

Kidney international

authors

Silbiger S,Lei J,Neugarten J

doi

10.1046/j.1523-1755.1999.00376.x

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

1268-76

issue

4

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)46079-X

journal_volume

55

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Cardiac hypertrophy and remodeling in relation to ACE and angiotensinogen genes genotypes in Chinese dialysis patients.

    abstract：BACKGROUND:Genetic polymorphisms of the angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes are associated with increased risk of hypertension and left ventricular hypertrophy (LVH) in hypertensive subjects. However, the extent to which these polymorphisms are related to LVH and remodeling in dialysis p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00933.x

    authors： Wang AY,Chan JC,Wang M,Poon E,Lui SF,Li PK,Sanderson J

    更新日期：2003-05-01 00:00:00

  • Pro-resolution properties of macrophages in renal injury.

    abstract：:Macrophages are inflammatory cells with important roles in the propagation of renal injury. More recently they have also been shown to be important in the resolution of inflammation. Wang et al. show that macrophages can be modulated ex vivo by cytokine stimulation, localize to renal tissue, and slow progression of ex...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5002332

    authors： Kluth DC

    更新日期：2007-08-01 00:00:00

  • T-cell transcriptome analysis points up a thymic disorder in idiopathic nephrotic syndrome.

    abstract：BACKGROUND:Idiopathic nephrotic syndrome is a proteinuric disease secondary to the release of a nonidentified circulating glomerular permeability factor by T cells. Because specificities of T-cell activation in idiopathic nephrotic syndrome remain unknown, we evaluated transcriptional activation of T cells in nephrotic...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00322.x

    authors： Mansour H,Cheval L,Elalouf JM,Aude JC,Alyanakian MA,Mougenot B,Doucet A,Deschênes G

    更新日期：2005-06-01 00:00:00

  • Prolongation of canine allograft survival with donor pretreatment.

    abstract：:Donor pretreatment of 100 mg/kg each of cyclophosphamide (CY) and methylprednisolone (P) infused 5 hours before nephrectomy invariably prolongs the survival of DLA mismatched, MLC incompatible nonlittermate Beagle renal allografts as well as the survival of mongrel renal allografts. The effect of donor pretreatment ap...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.25

    authors： Brom HL,van Breda Vriesman PJ,Terpstra JL

    更新日期：1982-02-01 00:00:00

  • Effects of pentoxifylline in experimental acute renal failure.

    abstract：:The beneficial effects of post-insult administration of pentoxifylline, a novel hemorheologic agent experimentally studied in various ischemic diseases, were evaluated in two models of acute renal failure (ARF): direct nephrotoxicity (mercuric chloride 4 mg/kg via femoral vein) and hemoglobinuria (glycerol 10 ml/kg i....

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.218

    authors： Vadiei K,Brunner LJ,Luke DR

    更新日期：1989-09-01 00:00:00

  • Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities.

    abstract：:Many transgenic and knockout mice with increased urine flow have structural abnormalities of the renal pelvis and inner medulla. Here, we used high resolution contrast enhanced T1-weighted magnetic resonance imaging of mice whose urea transporters UT-A1 and UT-A3 were deleted (UT-A1/3(-/-) mice) as a model for the in ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.392

    authors： Jacob VA,Harbaugh CM,Dietz JR,Fenton RA,Kim SM,Castrop H,Schnermann J,Knepper MA,Chou CL,Anderson SA

    更新日期：2008-11-01 00:00:00

  • Hypoalbuminemia and proteinuria contribute separately to reduced lipoprotein catabolism in the nephrotic syndrome.

    abstract：BACKGROUND:Hypertriglyceridemia is a result of reduced triglyceride (TG)-rich lipoprotein (TRL) catabolism and occurs in rats with nephrotic syndrome (NS) and in Nagase analbuminemic rats (NARs). While the heparin-releasable lipoprotein lipase (LpL) pool in NAR and in NS is similar, TG levels are significantly greater ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00478.x

    authors： Shearer GC,Stevenson FT,Atkinson DN,Jones H,Staprans I,Kaysen GA

    更新日期：2001-01-01 00:00:00

  • Diabetic nephropathy in the uninephrectomized dog: microscopic lesions after one year.

    abstract：:Carefully age-matched, purebred male beagle dogs that underwent uninephrectomy one month after they were made diabetic with alloxan were used to establish a model of rapidly developing diabetic nephropathy in a large animal. The diabetic animals, all requiring insulin, were divided into two groups: one group with cont...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.88

    authors： Steffes MW,Buchwald H,Wigness BD,Groppoli TJ,Rupp WM,Rohde TD,Blackshear PJ,Mauer SM

    更新日期：1982-05-01 00:00:00

  • Changes in bone structure and the muscle-bone unit in children with chronic kidney disease.

    abstract：:The impact of pediatric chronic kidney disease (CKD) on acquisition of volumetric bone mineral density (BMD) and cortical dimensions is lacking. To address this issue, we obtained tibia quantitative computed tomography scans from 103 patients aged 5-21 years with CKD (26 on dialysis) at baseline and 12 months later. G...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.347

    authors： Tsampalieros A,Kalkwarf HJ,Wetzsteon RJ,Shults J,Zemel BS,Foster BJ,Foerster DL,Leonard MB

    更新日期：2013-03-01 00:00:00

  • The metabolic syndrome and chronic kidney disease in a Southeast Asian cohort.

    abstract：:US adults with metabolic syndrome, as defined by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, have been shown to be at increased risk of chronic kidney disease (CKD), but there is limited information in other populations. The relationship between metabolic syndrome and CKD ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002128

    authors： Kitiyakara C,Yamwong S,Cheepudomwit S,Domrongkitchaiporn S,Unkurapinun N,Pakpeankitvatana V,Sritara P

    更新日期：2007-04-01 00:00:00

  • Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients.

    abstract：:Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. Kidney biopsy is required to establish the diagnosis. Recent studies have identified abundant glomerular deposition of DNAJB9 as a unique histological marker of FGN. We developed an immunoprecipitation-based multiple reaction monitoring method to measur...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.01.024

    authors： Nasr SH,Dasari S,Lieske JC,Benson LM,Vanderboom PM,Holtz-Heppelmann CJ,Giesen CD,Snyder MR,Erickson SB,Fervenza FC,Leung N,Kurtin PJ,Alexander MP

    更新日期：2019-05-01 00:00:00

  • CD154-CD40 T-cell co-stimulation pathway is a key mechanism in kidney ischemia-reperfusion injury.

    abstract：:Ischemia-reperfusion occurs in a great many clinical settings and contributes to organ failure or dysfunction. CD154-CD40 signaling in leukocyte-endothelial cell interactions or T-cell activation facilitates tissue inflammation and injury. Here we tested a siRNA anti-CD40 in rodent warm and cold ischemia models to che...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.146

    authors： de Ramon L,Ripoll E,Merino A,Lúcia M,Aran JM,Pérez-Rentero S,Lloberas N,Cruzado JM,Grinyó JM,Torras J

    更新日期：2015-09-01 00:00:00

  • Growth hormone receptor abundance in tibial growth plates of uremic rats: GH/IGF-I treatment.

    abstract：BACKGROUND:Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH or GH/IGF-I can partially restore linear growth. The molecular basis for decreased longitudinal growth is not known but may ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00141.x

    authors： Edmondson SR,Baker NL,Oh J,Kovacs G,Werther GA,Mehls O

    更新日期：2000-07-01 00:00:00

  • Intrarenal ghrelin receptors regulate ENaC-dependent sodium reabsorption by a cAMP-dependent pathway.

    abstract：:The main distal nephron segment sodium transporters are the distal tubule chlorothiazide-sensitive sodium chloride cotransporter (NCC) and the collecting duct amiloride-sensitive epithelial sodium channel (ENaC). The infusion of ghrelin into the renal interstitium stimulates distal nephron-dependent sodium reabsorptio...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.187

    authors： Kemp BA,Howell NL,Gildea JJ,Keller SR,Padia SH

    更新日期：2013-09-01 00:00:00

  • Nucleation of calcium oxalate crystals by albumin: involvement in the prevention of stone formation.

    abstract：BACKGROUND:Urine is supersaturated in calcium oxalate, which means that it will contain calcium oxalate crystals that form spontaneously. Their size must be controlled to prevent retention in ducts and the eventual development of a lithiasis. This is achieved, in part, by specific inhibitors of crystal growth. We inves...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00426.x

    authors： Cerini C,Geider S,Dussol B,Hennequin C,Daudon M,Veesler S,Nitsche S,Boistelle R,Berthézène P,Dupuy P,Vazi A,Berland Y,Dagorn JC,Verdier JM

    更新日期：1999-05-01 00:00:00

  • Cytoprotective effects of adrenomedullin in glomerular cell injury: central role of cAMP signaling pathway.

    abstract：:Activation of cAMP signaling pathway was shown to inhibit some pathobiologic processes in mesangial cells (MC). We investigated whether adrenomedullin (ADM), a potent agonist of adenylate cyclase, is synthesized in MC and whether it can, via cAMP, suppress the generation of reactive oxygen metabolites (ROM) and prolif...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.413

    authors： Chini EN,Chini CC,Bolliger C,Jougasaki M,Grande JP,Burnett JC Jr,Dousa TP

    更新日期：1997-10-01 00:00:00

  • Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney.

    abstract：BACKGROUND:Unilateral ureteral obstruction (UUO) leads to interstitial fibrosis of the obstructed kidney, and TGF-beta is considered to play an important role in this fibrotic process. Smad7 has been recently identified as an antagonist of TGF-beta signaling. To investigate whether this novel molecule can be exploited ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.0610s1094.x

    authors： Terada Y,Hanada S,Nakao A,Kuwahara M,Sasaki S,Marumo F

    更新日期：2002-01-01 00:00:00

  • Genetic complexity in Joubert syndrome and related disorders.

    abstract：:The recent identification of RPGRIP1L as a Joubert syndrome gene brings the total of known genes to five. Three of these are also associated with the lethal Meckel syndrome, and two with Senior-Løken syndrome; both of these disorders share Joubert syndrome phenotypes, illustrating the genetic complexity of this. ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/sj.ki.5002577

    authors： Harris PC

    更新日期：2007-12-01 00:00:00

  • Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats.

    abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000076

    authors： Tian Y,Riazi S,Khan O,Klein JD,Sugimura Y,Verbalis JG,Ecelbarger CA

    更新日期：2006-01-01 00:00:00

  • Effect of loop diuretics on organic osmolytes and cell electrolytes in the renal outer medulla.

    abstract：:Electron microprobe analysis on freeze-dried cryosections was used to determine the effect of the loop diuretics torasemide and furosemide on intracellular electrolyte concentrations in individual cells of the outer and inner stripe of the outer medulla and on cell rubidium uptake, the latter a measure of basolateral ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.359

    authors： Beck FX,Sone M,Dörge A,Thurau K

    更新日期：1992-10-01 00:00:00

  • Morphometric study of glomerular slit diaphragms fixed by rapid-freezing and freeze-substitution.

    abstract：:The widths of slit diaphragms in rat glomeruli were quantitatively measured on electron micrographs obtained by the rapid-freezing and freeze-substitution (FS) fixation method and compared to those prepared by conventional chemical fixation procedures, such as tannic acid, glutaraldehyde and osmium tetroxide (TGO) or ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.253

    authors： Furukawa T,Ohno S,Oguchi H,Hora K,Tokunaga S,Furuta S

    更新日期：1991-10-01 00:00:00

  • Theophylline prevents the hypoxemia-induced renal hemodynamic changes in rabbits.

    abstract：:The acute renal effects of hypoxemia and the ability of theophylline to prevent these effects were assessed in anesthetized and mechanically-ventilated newborn and adult rabbits. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by the clearance of para-aminohippuric acid and inulin, respecti...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.114

    authors： Gouyon JB,Guignard JP

    更新日期：1988-06-01 00:00:00

  • Interleukin-1 beta up-regulates the plasminogen activator/plasmin system in human mesangial cells.

    abstract：:The plasminogen activators (PA), which are regulated by their specific inhibitor, PAI-1, convert the zymogen plasminogen to plasmin, a protease involved in fibrinolysis and extracellular matrix turnover. Interleukin 1 beta (IL-1) is a key cytokine released from infiltrating monocytes/macrophages during the initial sta...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.159

    authors： Wilson HM,Haites NE,Reid FJ,Booth NA

    更新日期：1996-04-01 00:00:00

  • Glutathione S-transferase polymorphisms and skin cancer after renal transplantation.

    abstract：BACKGROUND:Susceptibility to skin cancer after transplantation is multifactorial, and risk factors include skin type, sun exposure, and level of immunosuppression. A major mechanism of carcinogenesis is ultraviolet radiation-induced free radical damage, and genetically determined ability to metabolize free radicals may...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2000.00392.x

    authors： Marshall SE,Bordea C,Haldar NA,Mullighan CG,Wojnarowska F,Morris PJ,Welsh KI

    更新日期：2000-11-01 00:00:00

  • Effects of C-peptide on renal function at the early stage of experimental diabetes.

    abstract：BACKGROUND:C-peptide has been reported to have biological effects on renal function early in the course of diabetes. This investigation was initiated to elucidate and amplify these findings with respect to protein leakage, hyperfiltration and renal functional reserve in diabetic rats. METHODS:Acute effects of 140 minu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00074.x

    authors： Sjöquist M,Huang W,Johansson BL

    更新日期：1998-09-01 00:00:00

  • Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation.

    abstract：:Major features of a long-standing inflammation in the kidney are vascular proliferation, glomerulosclerosis, interstitial fibrosis and tubular atrophy, leading to a gradual deterioration of the renal function. In this study we have investigated the expression of B-type receptors for platelet-derived growth factor (PDG...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.306

    authors： Fellström B,Klareskog L,Heldin CH,Larsson E,Rönnstrand L,Terracio L,Tufveson G,Wahlberg J,Rubin K

    更新日期：1989-12-01 00:00:00

  • Risk factors for chronic allograft nephropathy after renal transplantation: a protocol biopsy study.

    abstract：BACKGROUND:Chronic allograft nephropathy (CAN) leads to chronic allograft dysfunction and loss. Regular renal transplant biopsies may be useful to find risk factors for CAN. METHODS:We carried out 688 protocol biopsies in 258 patients at 6, 12, and 26 weeks after renal transplantation. Patients with signs of CAN in th...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00087.x

    authors： Schwarz A,Mengel M,Gwinner W,Radermacher J,Hiss M,Kreipe H,Haller H

    更新日期：2005-01-01 00:00:00

  • Mechanistic aspects of mineralocorticoid receptor activation.

    abstract：:Aldosterone exerts its biological effects through binding to mineralocorticoid receptor (MR). Ligand binding induces a receptor transconformation within the ligand-binding domain and dissociation of associated proteins from the receptor. The ligand-activated receptor binds as a dimer to the response elements present i...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.2000.00958.x

    authors： Hellal-Levy C,Fagart J,Souque A,Rafestin-Oblin ME

    更新日期：2000-04-01 00:00:00

  • Breaking the ice: urine proteomics of medullary sponge kidney disease.

    abstract：:Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinicall...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.10.032

    authors： Chutipongtanate S

    更新日期：2017-02-01 00:00:00

  • Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure.

    abstract：:Reliable estimates of the long-term outcomes of acute kidney injury (AKI) are needed to inform clinical practice and guide allocation of health care resources. This systematic review and meta-analysis aimed to quantify the association between AKI and chronic kidney disease (CKD), end-stage kidney disease (ESKD), and d...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.kint.2018.08.036

    authors： See EJ,Jayasinghe K,Glassford N,Bailey M,Johnson DW,Polkinghorne KR,Toussaint ND,Bellomo R

    更新日期：2019-01-01 00:00:00