Abstract：
:The microcirculation is regulated by oxygen gradients and by endothelial release of nitric oxide, which can react with hemoglobin to form S-nitroso derivatives. Here we induced flow-mediated dilatation of the brachial artery in response to ischemia in 141 non-diabetic patients with stage 3-4 chronic kidney disease who had no history of smoking, cardiovascular events or use of erythropoietin-based agents. Patients with hemoglobin concentrations above the cohort median of 11.6 g/dl were found to have significant reductions in flow-mediated dilatation compared to those below the median. This inverse relationship remained significant after adjustment for potential confounders, including insulin sensitivity, glomerular filtration rate, proteinuria, body mass index, serum urate, etiology of underlying renal disease, treatment with anti-hypertensive drugs, and traditional Framingham risk factors. Given that hemoglobin can act as an important nitric oxide carrier and buffer, our studies suggest that the mechanism by which hemoglobin influences the endothelium-dependent microcirculation requires its nitrosylation; however, more direct studies need to be performed.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Yilmaz MI,Sonmez A,Saglam M,Gulec M,Kilic S,Eyileten T,Caglar K,Oguz Y,Vural A,Yenicesu M,Zoccali Cdoi
10.1038/ki.2009.63subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1316-1321issue
12eissn
0085-2538issn
1523-1755pii
S0085-2538(15)53643-0journal_volume
75pub_type
杂志文章abstract：:Australia's Indigenous people have high rates of chronic kidney disease and kidney failure. To define renal disease among these people, we reviewed 643 renal biopsies on Indigenous people across Australia, and compared them with 249 biopsies of non-Indigenous patients. The intent was to reach a consensus on pathologic...
journal_title：Kidney international
pub_type： 杂志文章,多中心研究
doi：10.1038/ki.2012.307
更新日期：2012-12-01 00:00:00
abstract：:Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are exposed to a continuous infusion of glucose via their peritoneal cavity. We performed studies to quantitate the amount of energy derived from dialysate glucose. Net glucose absorption averaged 182 +/- (SD) 61 g/day in 19 studies with a dialysate ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1981.53
更新日期：1981-04-01 00:00:00
abstract：:The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is thought to be a protective enzyme of the mineralocorticoid receptor (MR). We have previously demonstrated (Bonvalet et al, J Clin Invest 86:832-837, 1990) that 11 beta-OHSD is colocalized with MR along the rabbit nephron. In the present study, we examin...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.260
更新日期：1992-07-01 00:00:00
abstract：:Diabetes mellitus is associated with natriuresis, whereas estrogen has been shown to be renoprotective in diabetic nephropathy and may independently regulate renal sodium reabsorption. The aim of this study was to determine the effects of 17-beta estradiol (E(2)) replacement to diabetic, ovariectomized (OVX) female ra...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000140
更新日期：2006-02-01 00:00:00
abstract：:The goals of the present study were twofold: first, to assess the renal excretory and hormonal responses to chronic water restriction in dogs whose sodium retaining mechanisms had been stimulated through dietary sodium (Na+) deprivation; second, to determine the mediator(s) of the natriuresis which was observed with w...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1986.121
更新日期：1986-06-01 00:00:00
abstract：:It is well established that nocturnal hypoxemia in sleep apnea causes an inversion of the circadian arterial pressure rhythm and triggers nocturnal hypertension. Since sleep apnea is very frequent in dialysis patients, we hypothesized that nocturnal hypoxemia may be a factor that contributes to alter the 24-hour arter...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.1998.00853.x
更新日期：1998-04-01 00:00:00
abstract：:Macrophages are inflammatory cells with important roles in the propagation of renal injury. More recently they have also been shown to be important in the resolution of inflammation. Wang et al. show that macrophages can be modulated ex vivo by cytokine stimulation, localize to renal tissue, and slow progression of ex...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5002332
更新日期：2007-08-01 00:00:00
abstract：:Multiphoton excitation fluorescence microscopy is a state-of-the-art confocal imaging technique ideal for deep optical sectioning of living tissues. It is capable of performing ultrasensitive, quantitative imaging of organ functions in health and disease with high spatial and temporal resolution which other imaging mo...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5002461
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2003.00051.x
更新日期：2003-07-01 00:00:00
abstract：:Endostatin (EST), an antiangiogenic factor, is enriched in aging kidneys. EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whether EST and TG2 play a role in the fibrosis of aging. In wild-type mice, aging kidneys exhibited a 2- to...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2016.01.030
更新日期：2016-06-01 00:00:00
abstract：:We sought to determine whether artherosclerosis may be accelerated in uremic patients on maintenance hemodialysis and investigated the risk factors for carotid and femoral atherosclerosis in such patients. High-resolution B-mode ultrasonography was used to determine the intima-media thickness (IMT) of the carotid and ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.356
更新日期：1995-09-01 00:00:00
abstract：:Leukocytes play a major role in the development and progression of autoimmune diseases. We measured gene expression differences in leukocytes from patients that were antineutrophil cytoplasmic autoantibody (ANCA) positive, patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA), and healthy donor...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002371
更新日期：2007-10-01 00:00:00
abstract：:Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease N...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.11.011
更新日期：2019-03-01 00:00:00
abstract：:The involvement of cysteinyl leukotrienes (LT) in the etiology of glomerulonephritis (GN) was investigated in a rat model of nephrotoxic serum nephritis in which renal function, morphology, LTC4 synthase activity and urinary cysteinyl LT excretion were monitored over seven days. Significant alterations in renal functi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1994.401
更新日期：1994-11-01 00:00:00
abstract：:Monoclonal antibodies (mAb) reactive against complement components involved in the classical activation pathway were applied in an indirect immunoperoxidase technique for the histological study of normal and diseased human renal tissues. Prominent staining with antibodies against the C4d fragment was seen in all glome...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1989.302
更新日期：1989-12-01 00:00:00
abstract：BACKGROUND:Microalbuminuria (MA) is a strong predictor of cardiovascular disease, but its causes are incompletely understood. Hyperhomocysteinemia is a recently recognized risk factor for cardiovascular disease independent of established risk factors. It is not known whether hyperhomocysteinemia is associated with MA, ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.4495353
更新日期：1998-07-01 00:00:00
abstract：:The prevalence of raised Na+/Li+ countertransport (CT) activity (greater than 0.41 mmol/liter RBC/hr) was assessed in 185 consecutive insulin-dependent diabetic patients attending an outpatient diabetic clinic. Normoalbuminuria was defined as an overnight albumin excretion rate (AER) of less than 20 micrograms/min (N ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.134
更新日期：1992-04-01 00:00:00
abstract：:One of the challenges of treating patients with glomerulonephritis is to accurately assess disease activity. As renal biopsies are routinely stained for deposits of C3 activation fragments and glomerular C3 deposits are found in most forms of glomerulonephritis, we sought to determine whether a relatively noninvasive ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.332
更新日期：2012-01-01 00:00:00
abstract：:With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major health problem worldwide. Approximately, 80% of kidney stones are composed of calcium and hypercalciuria is found in up to 40% of stone-formers. Although the mechanisms resulting in precipitation and growth of calcium crystals in...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5002441
更新日期：2007-11-01 00:00:00
abstract：:Vascular calcification (VC) is an important reason for the high burden of vascular disease among chronic dialysis patients. Chronic kidney disease (CKD) is associated with increased promoters and decreased inhibitors of VC. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the c...
journal_title：Kidney international
pub_type： 评论,杂志文章,评审
doi：10.1038/sj.ki.5002355
更新日期：2007-07-01 00:00:00
abstract：:Carefully age-matched, purebred male beagle dogs that underwent uninephrectomy one month after they were made diabetic with alloxan were used to establish a model of rapidly developing diabetic nephropathy in a large animal. The diabetic animals, all requiring insulin, were divided into two groups: one group with cont...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1982.88
更新日期：1982-05-01 00:00:00
abstract：:Amylin (islet amyloid peptide) plays a critical role in islet amyloidosis and in the development of beta-cell dysfunction in patients with diabetes; however, the involvement of amylin in renal amyloidosis has not been studied. For this reason, we surveyed 149 patients with biopsy-proven diabetic nephropathy (DN). The ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002305
更新日期：2007-07-01 00:00:00
abstract：:Among Canadians starting dialysis, patients of East Asian and Indo Asian background are less likely than whites to receive a renal allograft. Although the reasons for such variation are complex, less living donation may contribute significantly. More studies are needed to confirm these differences and to evaluate stra...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5002437
更新日期：2007-08-01 00:00:00
abstract：:Pathologic calcification is a significant cause of increased morbidity and mortality in patients with chronic kidney disease. The precise mechanisms of ectopic calcification are not fully elucidated, but it is known to be caused by an imbalance of procalcific and anticalcific factors. In the chronic kidney disease pop...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2015.12.046
更新日期：2016-05-01 00:00:00
abstract：:Intravital multiphoton microscopy is a powerful tool to study kidney physiology in living animals. However, certain technical issues have curbed its usage to date, including limited depth of tissue penetration and high background emission of endogenous signals. Most previous studies have used the excitation range 700–...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2015.323
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Familial nephrotic syndrome (NS) has both autosomal dominant and recessive forms of inheritance. Recent studies in families with an autosomal dominant form of focal segmental glomerulosclerosis (FSGS) have been at odds concerning linkage to chromosome 19q13 (Mathis et al, Kidney Int 53:282-286, 1998; Winn et...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.057003875.x
更新日期：2000-03-01 00:00:00
abstract：:Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure. Histologically, the classic picture of focal segmental glomerulosclerosis (FSGS) was found; males were more severely affected than females. Among the early...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.433
更新日期：1995-11-01 00:00:00
abstract：:Many subjects nowadays present with end-stage renal failure and its attendant cardiovascular complications without known prior renal damage. In this report we review the evidence available to strongly suggest that the present practice of secondary prevention in those with known prior renal disease should be extended t...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1111/j.1523-1755.2004.66001.x
更新日期：2004-12-01 00:00:00
abstract：:The hypertrophy of renal proximal tubular cells occurs as an adaptive response to a variety of stimuli and may be involved with the progression of renal disease. Angiotensin II acting alone or in combination with other growth factors has been implicated in this process. The aims of this study were to identify the role...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.385
更新日期：1997-09-01 00:00:00
abstract：:There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chro...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2018.10.028
更新日期：2019-04-01 00:00:00
