Serum homocysteine level and protein intake are related to risk of microalbuminuria: the Hoorn Study.


BACKGROUND:Microalbuminuria (MA) is a strong predictor of cardiovascular disease, but its causes are incompletely understood. Hyperhomocysteinemia is a recently recognized risk factor for cardiovascular disease independent of established risk factors. It is not known whether hyperhomocysteinemia is associated with MA, and thus could be a possible cause of microalbuminuria. METHODS:We studied an age-, sex- and glucose-tolerance-stratified random sample of a 50- to 75-year old general Caucasian population (N = 680). The urinary albumin-to-creatinine ratio (ACR) was measured in an early morning spot urine sample. MA was defined as an ACR > 3.0 mg/mmol. RESULTS:The prevalence of MA was 4.3% (13 of 304) in subjects with normal glucose tolerance, 9.2% (17 of 185) in impaired glucose tolerance and 18.3% (30 of 164) in non-insulin-dependent diabetes mellitus (NIDDM); it was 3.7% (15 of 402) in subjects without hypertension and 17.9% (45 of 251) in those with hypertension. After adjusting for age, sex, glucose tolerance category, hypertension, dyslipidemia and smoking, the odds ratio [OR; 95% confidence interval (95%CI)] for MA per 5 mumol/liter total homocysteine increment was 1.33 (1.08 to 1.63). Additional adjustment for HbA1c, waist-hip ratio, protein intake and serum creatinine did not attenuate the association between MA and total homocysteine. A 0.1 g/ increment of protein intake was also associated with an increased risk for MA after adjustment for age, sex, classical risk factors and serum total homocysteine [OR (95% CI); 1.20 (1.08 to 1.32)]. CONCLUSION:Both hyperhomocysteinemia and protein intake are related to microalbuminuria independent of NIDDM and hypertension. Hyperhomocysteinemia may partly explain the link between MA and increased risk of cardiovascular disease.


Kidney Int


Kidney international


Hoogeveen EK,Kostense PJ,Jager A,Heine RJ,Jakobs C,Bouter LM,Donker AJ,Stehouwer CD




Has Abstract


1998-07-01 00:00:00














  • Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.

    abstract::Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Here we provide evidence ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Rashmi P,Colussi G,Ng M,Wu X,Kidwai A,Pearce D

    更新日期:2017-05-01 00:00:00

  • Evaluation of renal Kt/V as a marker of renal function in predialysis patients.

    abstract:BACKGROUND:The use of renal Kt/V (r-Kt/V) as an indicator for the need of dialysis initiation has been recommended in the NKF-DOQI guidelines. In analogy to clinical practice in peritoneal dialysis, a fall of r-Kt/V below a threshold of 2.0 per week may indicate inadequate renal toxin elimination. However, there are no...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kuhlmann MK,Heckmann M,Riegel W,Köhler H

    更新日期:2001-10-01 00:00:00

  • Pathogenesis of vascular calcification in chronic kidney disease.

    abstract::Pathogenesis of vascular calcification in chronic kidney disease. Background. Hyperphosphatemia and hypercalcemia are independent risk factors for higher incidence of cardiovascular events in patients with chronic kidney disease. In addition to increased calcium-phosphate product, hyperphosphatemia accelerates the pro...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Cozzolino M,Brancaccio D,Gallieni M,Slatopolsky E

    更新日期:2005-08-01 00:00:00

  • Diagnosis of renovascular disease by intra- and extrarenal Doppler scanning.

    abstract::The purpose of this prospective, angiographically controlled study was to determine the diagnostic value of color Doppler sonography with two differing approaches of scanning in patients with clinical clues for renal artery stenosis (RAS). In 135 hypertensive patients peak systolic velocity in the main renal arteries ...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章


    authors: Krumme B,Blum U,Schwertfeger E,Flügel P,Höllstin F,Schollmeyer P,Rump LC

    更新日期:1996-10-01 00:00:00

  • Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes.

    abstract::Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms underlying these roles are not well understood. Here, we performed a single-cell RNA-sequence (RNA-seq) analysis of mouse mesangial cells using the Fluidigm C1 platform. We found that gene expression in individual mesangial c...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Lu Y,Ye Y,Yang Q,Shi S

    更新日期:2017-08-01 00:00:00

  • Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.

    abstract::Progressive kidney fibrosis precedes end-stage renal failure in up to a third of patients with diabetes mellitus. Elevated intra-renal transforming growth factor-beta (TGF-beta) is thought to underlie disease progression by promoting deposition of extracellular matrix and epithelial-mesenchymal transition. GW788388 is...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Petersen M,Thorikay M,Deckers M,van Dinther M,Grygielko ET,Gellibert F,de Gouville AC,Huet S,ten Dijke P,Laping NJ

    更新日期:2008-03-01 00:00:00

  • LECT2 amyloidosis.

    abstract::LECT2 amyloidosis is the latest systemic type of amyloidosis to be described. It was discovered in patients with nephrotic syndrome and renal failure and is characterized by amyloid deposition in glomeruli, renal vessels, and interstitium. Clinical and pathological features of earlier phases of this type of amyloidosi...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Benson MD

    更新日期:2010-05-01 00:00:00

  • Dialysis costs: results of a diverse sample study.

    abstract::A study of dialysis costs in five major dialysis centers throughout the United States was conducted in 1973. When available, home, home training, limited care, satellite and in-hospital-full-care dialysis were included. The study's objective was to determine the cost per dialysis for each separate dialysis modality. A...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Hoffstein PA,Krueger KK,Wineman RJ

    更新日期:1976-03-01 00:00:00

  • T-cell exhaustion correlates with improved outcomes in kidney transplant recipients.

    abstract::Continuous antigen stimulation during chronic infection or malignancy can promote functional T cell silencing, a phenomenon called T cell exhaustion. The prevalence and impact of T cell exhaustion following organ transplantation, another immune stimulus with persistently high antigen load, are unknown. Here, we charac...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Fribourg M,Anderson L,Fischman C,Cantarelli C,Perin L,La Manna G,Rahman A,Burrell BE,Heeger PS,Cravedi P

    更新日期:2019-08-01 00:00:00

  • Myeloproliferative neoplasms cause glomerulopathy.

    abstract::Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. To better characterize the glomerular disease associated with myeloproliferative neoplasms, we evaluated features of 11 patients with myeloproliferative neoplasm-related glomerulopathy that included ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Said SM,Leung N,Sethi S,Cornell LD,Fidler ME,Grande JP,Herrmann S,Tefferi A,D'Agati VD,Nasr SH

    更新日期:2011-10-01 00:00:00

  • Solitary functioning kidney and diverse genital tract malformations associated with hepatocyte nuclear factor-1beta mutations.

    abstract:BACKGROUND:Renal tract malformations are, on occasion, associated with uterine malformations. The transcription factor hepatocyte nuclear factor (HNF)-1beta is expressed from the earliest stages of development of the Wolffian duct, the mesonephros and metanephros, and the Müllerian ducts in the mouse. In adult mice HNF...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Bingham C,Ellard S,Cole TR,Jones KE,Allen LI,Goodship JA,Goodship TH,Bakalinova-Pugh D,Russell GI,Woolf AS,Nicholls AJ,Hattersley AT

    更新日期:2002-04-01 00:00:00

  • The course of the remnant kidney model in mice.

    abstract::The remnant kidney model was produced in mice by unilateral nephrectomy and partial infarction of the remaining kidney. Control mice underwent laparotomy only. The mice were studied for up to 44 weeks. No quantitative differences were noted in systolic arterial pressure, proteinuria, or histopathology between control ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kren S,Hostetter TH

    更新日期:1999-07-01 00:00:00

  • Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes.

    abstract:BACKGROUND:The glomerular podocyte is the kidney cell most affected during the development of nephrotic syndrome, and mutations in podocyte proteins are responsible for a variety of inherited forms of nephrotic syndrome. Although glucocorticoids are a primary treatment for nephrotic syndrome, neither their target cell ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Ransom RF,Vega-Warner V,Smoyer WE,Klein J

    更新日期:2005-04-01 00:00:00

  • Renal bradykinin and vasopressin receptors: ligand selectivity and classification.

    abstract::We studied the specific binding of radiolabeled bradykinin ([3H]BK) and vasopressin ([3H]AVP) to membrane preparations of bovine and porcine kidney medulla. [3H]BK reversibly labeled a single site (Kd = 1.06 nM) in bovine kidney medulla independently of [Mg2+]. The number of BK receptors in bovine kidney medulla, Bmax...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Howl J,Yarwood NJ,Davies AR,Wheatley M

    更新日期:1996-08-01 00:00:00

  • Von Willebrand factor regulates complement on endothelial cells.

    abstract::Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

    更新日期:2016-07-01 00:00:00

  • Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4-dependent pathway and limits sensitivity to fluid therapy in mice.

    abstract::Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the proximal tubular lumen into the interstitium, thus disturbing the recovery of urine output during the...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Nakano D,Kitada K,Wan N,Zhang Y,Wiig H,Wararat K,Yanagita M,Lee S,Jia L,Titze JM,Nishiyama A

    更新日期:2020-05-01 00:00:00

  • Cardiac dysfunction in Pkd1-deficient mice with phenotype rescue by galectin-3 knockout.

    abstract::Alterations in myocardial wall texture stand out among ADPKD cardiovascular manifestations in hypertensive and normotensive patients. To elucidate their pathogenesis, we analyzed the cardiac phenotype in Pkd1(cond/cond)Nestin(cre) (CYG+) cystic mice exposed to increased blood pressure, at 5 to 6 and 20 to 24 weeks of ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Balbo BE,Amaral AG,Fonseca JM,de Castro I,Salemi VM,Souza LE,Dos Santos F,Irigoyen MC,Qian F,Chammas R,Onuchic LF

    更新日期:2016-09-01 00:00:00

  • Role of vasopressin in the impaired water excretion of glucocorticoid deficiency.

    abstract::The mechanism whereby glucocorticoid deficiency impairs renal water excretion was studied in the conscious mineralocorticoid-replaced, adrenalectomized rat. Control animals received physiologic replacement with prednisolone, and experimental animals were deprived of glucocorticoid hormone for either 1 or 14 days. The ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Linas SL,Berl T,Robertson GL,Aisenbrey GA,Schrier RW,Anderson RJ

    更新日期:1980-07-01 00:00:00

  • PGF2 alpha activation of Na/H antiporter and ammoniagenesis in parent/variant LLC-PK1 cells.

    abstract::A novel variant of the LLC-PK1 cell line was used to examine directly the mechanism whereby PGF2 alpha and TPA inhibit renal ammoniagenesis. The variant cells, which exhibit a growth pattern and morphology similar to the parent cell line, were isolated by a self selection process utilizing long-term cultures of parent...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Sahai A,Fadda GZ,Sandler RS,Tannen RL

    更新日期:1994-10-01 00:00:00

  • Effect of prolonged bicarbonate administration on plasma potassium in terminal renal failure.

    abstract::In hemodialysis patients with hyperkalemia, i.v. sodium bicarbonate has recently been found to be ineffective in lowering plasma potassium within one hour. In the present study the effect of a prolonged bicarbonate infusion on plasma potassium was investigated. Twelve patients with terminal renal failure who were on h...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Blumberg A,Weidmann P,Ferrari P

    更新日期:1992-02-01 00:00:00

  • Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients.

    abstract::In recent times, therapy for renal anemia has changed dramatically in that iron administration has increased and doses of erythropoiesis-stimulating agents (ESAs) have decreased. Here we used a prospective, observational, multicenter design and measured the serum ferritin and hemoglobin levels every 3 months for 2 yea...

    journal_title:Kidney international

    pub_type: 杂志文章,多中心研究


    authors: Kuragano T,Matsumura O,Matsuda A,Hara T,Kiyomoto H,Murata T,Kitamura K,Fujimoto S,Hase H,Joki N,Fukatsu A,Inoue T,Itakura I,Nakanishi T

    更新日期:2014-10-01 00:00:00

  • Acid and mineral balances and bone in familial proximal renal tubular acidosis.

    abstract:BACKGROUND:Metabolic acidosis caused by increased rates of fixed acid production is associated with increased urinary excretion of Ca and negative Ca balances. Metabolic acidosis caused by a reduced capacity of the kidneys to excrete acid contributes to the development of bone disease in the course of chronic renal fai...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Lemann J Jr,Adams ND,Wilz DR,Brenes LG

    更新日期:2000-09-01 00:00:00

  • Theophylline prevents the hypoxemia-induced renal hemodynamic changes in rabbits.

    abstract::The acute renal effects of hypoxemia and the ability of theophylline to prevent these effects were assessed in anesthetized and mechanically-ventilated newborn and adult rabbits. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by the clearance of para-aminohippuric acid and inulin, respecti...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Gouyon JB,Guignard JP

    更新日期:1988-06-01 00:00:00

  • Surveillance of alloantibodies after transplantation identifies the risk of chronic rejection.

    abstract::The monitoring of the levels of alloantibodies following transplantation might facilitate early diagnosis of chronic rejection (CR), the leading cause of renal allograft failure. Here, we used serial alloantibody surveillance to monitor patients with preoperative positive flow cytometric crossmatch (FCXM). Sixty-nine ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kimball PM,Baker MA,Wagner MB,King A

    更新日期:2011-05-01 00:00:00

  • Are vitamin D receptor agonists like angiotensin-converting enzyme inhibitors without side effects?

    abstract::Vitamin D receptor agonists (VDRAs) inhibit the renin-angiotensin system (RAS) and reduce podocyte loss and fibrosis over and above RAS blockade. Several studies in humans show that VDRAs are antiproteinuric and have the potential to delay the progression of renal disease. Whether VDRAs will accomplish this goal among...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Agarwal R

    更新日期:2010-06-01 00:00:00

  • Thrombomodulin is synthesized by human mesangial cells.

    abstract::Thrombomodulin (TM), an endothelial receptor for thrombin, endowed with a powerful anticoagulant activity, plays an important role in the antithrombogenicity of the vascular endothelium. Its presence within the human renal glomerulus is already known but was thought to be only endothelial. We looked for TM expression ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Pruna A,Peyri N,Berard M,Boffa MC

    更新日期:1997-03-01 00:00:00

  • Renal blood flow measurement by positron emission tomography using 15O-labeled water.

    abstract:BACKGROUND:Only few noninvasive methods have the potential to quantitate renal blood flow (RBF) in humans. Positron emission tomography (PET) is a clinical imaging method that can be used to measure the tissue blood flow noninvasively. The purpose of this study was to validate PET measurement of RBF using 15O-labeled w...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Juillard L,Janier MF,Fouque D,Lionnet M,Le Bars D,Cinotti L,Barthez P,Gharib C,Laville M

    更新日期:2000-06-01 00:00:00

  • Time course studies on phosphate transfer in frog urinary bladder.

    abstract::Unidirectional 32P-phosphate and 3H-mannitol fluxes were simultaneously measured, at two minutes intervals, in frog urinary bladders. The spontaneous or externally imposed transepithelial potential (PD) and short circuit current (SCC) were also recorded in most experiments. It was observed that: (1) Phosphate transfer...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Parisi M,Cancela L

    更新日期:1988-01-01 00:00:00

  • The renal action of atrial natriuretic peptide during control of glomerular filtration.

    abstract::Studies were performed in anesthetized dogs (N = 7) to determine the effects of synthetic atrial natriuretic peptide (ANP) on sodium excretion in the presence and absence of control of glomerular filtration rate produced by suprarenal aortic clamping. Intrarenal infusion of synthetic atrial natriuretic peptide (0.3 mi...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Burnett JC Jr,Opgenorth TJ,Granger JP

    更新日期:1986-07-01 00:00:00

  • Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature.

    abstract:BACKGROUND:Angiotensin type 1 (AT1) receptor-deficient mice (Agtr1-/-), which selectively lack both AT1A and AT1B receptor genes, are characterized by marked intrarenal vascular thickening. In the present study, we explored the possible involvement of the kinin-kallikrein system in the development of this renal vascula...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Tsuchida S,Miyazaki Y,Matsusaka T,Hunley TE,Inagami T,Fogo A,Ichikawa I

    更新日期:1999-08-01 00:00:00