Bone-specific alkaline phosphatase concentrations are less variable than those of parathyroid hormone in stable hemodialysis patients.

abstract：:Isolated perfused rat kidneys were passively sensitized by addition of either mouse ascitic fluid containing monoclonal IgE against dinitrophenol (DNP) or DNP-specific purified IgE. After washing the organ, defined doses of DNP-bovine serum albumin were given as bolus injection via the kidney artery. Antigen challenge...

journal_title：Kidney international

authors： Pirotzky E,Pintos-Morell G,Burtin C,Boudet J,Bidault J,Benveniste J

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:The beneficial effect of blood transfusions before cadaveric renal transplantation on allograft survival, although previously well documented, has become controversial in light of their adverse effects. Recently, it has been suggested that their clinical benefits are due to HLA-DR sharing between the blood d...

journal_title：Kidney international

authors： Hiesse C,Busson M,Buisson C,Farahmand H,Bierling P,Benbunan M,Bedrossian J,Aubert P,Glotz D,Loirat C,Rondeau E,Viron B,Bleux H,Lang P

更新日期：2001-07-01 00:00:00

abstract：:Accumulation of extracellular matrix within the mesangium is an important event in the development of glomerular disease. In this report we have used indirect immunofluorescence to positively identify a number of constituents of the mesangial matrix synthesized by rat mesangial cells (RMC) in vitro including laminin, ...

journal_title：Kidney international

authors： Thomas GJ,Shewring L,McCarthy KJ,Couchman JR,Mason RM,Davies M

更新日期：1995-10-01 00:00:00

abstract：:Disasters result in a substantial number of renal challenges, either by the creation of crush injury in victims trapped in collapsed buildings or by the destruction of existing dialysis facilities, leaving chronic dialysis patients without access to their dialysis units, medications, or medical care. Over the past two...

journal_title：Kidney international

authors： Gibney RT,Sever MS,Vanholder RC

更新日期：2014-05-01 00:00:00

abstract：:Micropuncture studies were carried out in surface nephrons of rats with nephrotoxic-serum (NTS)-induced nephrotic syndrome during a period of active sodium and water retention. It was found that hydrostatic pressure and tubular diameter were increased in the proximal tubules (13.4 +/- 0.2 vs. 10.4 +/- 0.2 mm Hg; 31.3 ...

journal_title：Kidney international

authors： Kuroda S,Aynedjian HS,Bank N

更新日期：1979-11-01 00:00:00

abstract：:Vascular calcification is a recognized risk factor for cardiovascular mortality in patients with end-stage renal disease. The aim of this study was to identify risk factors for vascular access calcification and to determine if patients with this disorder are at increased risk of death. Vascular access calcification wa...

journal_title：Kidney international

authors： Schlieper G,Krüger T,Djuric Z,Damjanovic T,Markovic N,Schurgers LJ,Brandenburg VM,Westenfeld R,Dimkovic S,Ketteler M,Grootendorst DC,Dekker FW,Floege J,Dimkovic N

更新日期：2008-12-01 00:00:00

abstract：:Proliferation of mesangial cells is frequently found in glomerulonephritis, such as IgA glomerulonephritis. Recent reports suggest that a brain/embryo-type myosin isoform (MIIB2) is involved in cell proliferation. We have studied the expression of MIIB2 in renal biopsy samples from patients with various renal diseases...

journal_title：Kidney international

authors： Kishino M,Kimura A,Yamaguchi K,Ohtani H,Yamada Y,Takahashi T,Mune M,Mimura K,Maeda T,Matsumura S,Tsuji T,Yukawa S

更新日期：1996-05-01 00:00:00

abstract：:Acute phosphate nephropathy (APhN) is a clinical pathological entity characterized by acute and subsequent chronic renal failure following exposure to oral sodium phosphate (OSP) bowel purgatives. Renal biopsy findings include acute and chronic tubular injury with prominent tubular and interstitial calcium phosphate d...

journal_title：Kidney international

authors： Markowitz GS,Perazella MA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:In the United States, infection is second to cardiovascular disease as the leading cause of death in patients with end-stage renal disease (ESRD), and septicemia accounts for more than 75% of this category. This increased susceptibility to infections is partly due to uremia, old age, and comorbid conditions....

journal_title：Kidney international

authors： Sarnak MJ,Jaber BL

更新日期：2000-10-01 00:00:00

abstract：:Cell surface aminopeptidases N (APN) and A (APA) have been characterized on cultured human glomerular epithelial cells and a SV40-transformed cell line derived from them. APN had a wide substrate specificity whereas APA only attacked peptides with an acidic N terminal amino acid. Both enzymes also differed by their se...

journal_title：Kidney international

authors： Stefanovic V,Vlahovic P,Ardaillou N,Ronco P,Ardaillou R

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Renal inflammation is regulated by a network of local and systemic mediators. Of them, transforming growth factor-beta1 (TGF-beta 1) and glucocorticoids play an important role in deactivating monocytes/macrophages. We examined the hypothesis that TGF-beta 1 effects may be partially achieved through modulatio...

journal_title：Kidney international

authors： Peltier J,Perez J,Bellocq A,Escoubet B,Fouqueray B,Baud L

更新日期：2003-06-01 00:00:00

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

journal_title：Kidney international

authors： Zager RA

更新日期：2005-10-01 00:00:00

abstract：:The circumstances under which furosemide increases renal blood flow was examined in mongrel dogs as it may relate to a tubuloglomerular feedback mechanism. Two maneuvers, desoxycorticosterone (DOCA) plus salt treatment and inhibition of tubular fluid flow, were used in the dogs to evaluate the renal vascular effects o...

journal_title：Kidney international

authors： Gerber JG,Nies AS

更新日期：1980-10-01 00:00:00

abstract：:In early clinical testing, acute addition of alanyl-glutamine (AlaGln) to glucose-based peritoneal dialysis (PD) fluids restored peritoneal cellular stress responses and leukocyte function. This study was designed to test the effect of extended treatment with AlaGln-supplemented PD fluid on biomarkers of peritoneal he...

journal_title：Kidney international

authors： Vychytil A,Herzog R,Probst P,Ribitsch W,Lhotta K,Machold-Fabrizii V,Wiesholzer M,Kaufmann M,Salmhofer H,Windpessl M,Rosenkranz AR,Oberbauer R,König F,Kratochwill K,Aufricht C

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:We determined the effect of regional citrate versus systemic heparin anticoagulation for continuous renal replacement therapy in critically ill subjects suffering from acute renal failure who were not at high risk for hemorrhagic complications. METHODS:Between April 1999 and June 2002, 30 critically ill sub...

journal_title：Kidney international

authors： Kutsogiannis DJ,Gibney RT,Stollery D,Gao J

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Protein-calorie malnutrition is common in chronic hemodialysis (CHD) patients and correlates with morbidity and mortality in these patients. There are limited trials evaluating the efficacy of oral nutritional supplementation in malnourished CHD patients. METHODS:Eighty-five CHD patients with evidence of ma...

journal_title：Kidney international

authors： Caglar K,Fedje L,Dimmitt R,Hakim RM,Shyr Y,Ikizler TA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The fibrinolytic system plays an important role in degrading fibrin-rich thrombi and in vascular and tissue remodeling. Elevated levels of plasminogen activator inhibitor-1 (PAI-1) can reduce the efficiency of the endogenous fibrinolytic system. Angiotensin (Ang) has been shown to regulate PAI-1 expression v...

journal_title：Kidney international

authors： Nakamura S,Nakamura I,Ma L,Vaughan DE,Fogo AB

更新日期：2000-07-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in about half of patients in septic shock and the mortality of AKI with sepsis is extremely high. An effective therapeutic intervention is urgently required. Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors that also have pleiotropic actions. They have been report...

journal_title：Kidney international

authors： Yasuda H,Yuen PS,Hu X,Zhou H,Star RA

更新日期：2006-05-01 00:00:00

abstract：:Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

journal_title：Kidney international

authors： Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

更新日期：2011-04-01 00:00:00

abstract：:The monitoring of the levels of alloantibodies following transplantation might facilitate early diagnosis of chronic rejection (CR), the leading cause of renal allograft failure. Here, we used serial alloantibody surveillance to monitor patients with preoperative positive flow cytometric crossmatch (FCXM). Sixty-nine ...

journal_title：Kidney international

authors： Kimball PM,Baker MA,Wagner MB,King A

更新日期：2011-05-01 00:00:00

abstract：:Renal iron handling was characterized in three experimental models of the nephrotic syndrome: puromycin aminonucleoside, adriamycin and nephrotoxic serum. In adriamycin-induced nephrotic syndrome, which has previously been shown to result from alterations in pore size of the filtration barrier, the transferrin leak wa...

journal_title：Kidney international

authors： Alfrey AC,Hammond WS

更新日期：1990-06-01 00:00:00

abstract：:The recent identification of RPGRIP1L as a Joubert syndrome gene brings the total of known genes to five. Three of these are also associated with the lethal Meckel syndrome, and two with Senior-Løken syndrome; both of these disorders share Joubert syndrome phenotypes, illustrating the genetic complexity of this. ...

journal_title：Kidney international

authors： Harris PC

更新日期：2007-12-01 00:00:00

abstract：:This study was done to investigate the mechanisms that underly the changes of renal renin gene expression upon hypoperfusion of one kidney. To this end the left renal arteries of male Sprague-Dawley rats were clipped with 0.2 mm silver clips and renal renin mRNA levels were assayed by RNase protection during the first...

journal_title：Kidney international

authors： Schricker K,Holmer S,Krämer BK,Riegger G,Kurtz A

更新日期：1994-12-01 00:00:00

abstract：:Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic disorders, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF receptors in its target ti...

journal_title：Kidney international

authors： Lanske B,Razzaque MS

更新日期：2014-12-01 00:00:00

abstract：:This study examined the expression of EPO, VEGF and VEGF receptor gene under conditions of reduced oxygen supply in primary cultures of rat hepatocytes, and compared it with the expression of these genes in hypoxic rat livers in vivo. To this end we exposed male Sprague-Dawley rats to hypoxia (10% and 8% O2), carbon m...

journal_title：Kidney international

authors： Sandner P,Wolf K,Bergmaier U,Gess B,Kurtz A

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:We have recently demonstrated an increase in apoptosis in Han:SPRD rat kidneys with autosomal-dominant polycystic kidney disease (ADPKD). Caspase-3 and caspase-7 are major mediators of apoptosis. There are two pathways of caspase-3 and caspase-7-mediated apoptosis: (1) the "extrinsic" pathway involving the d...

journal_title：Kidney international

authors： Tao Y,Kim J,Stanley M,He Z,Faubel S,Schrier RW,Edelstein CL

更新日期：2005-03-01 00:00:00

abstract：:More than two isoforms have been identified for angiotensin receptors based on their ligand selectivity. The objective of this study is to determine the molecular structure of angiotensin type 2 receptor (AT2), whose physiological functions are still an enigma despite extensive studies on its distribution in fetal tis...

journal_title：Kidney international

authors： Kambayashi Y,Takahashi K,Bardhan S,Inagami T

更新日期：1994-12-01 00:00:00

abstract：:Proteinuric diabetic patients have an increased risk of cardiovascular disease and almost always have hypertension. In the early stages of diabetic renal disease (microalbuminuria) when renal function is well preserved, systemic arterial blood pressure is already elevated compared to insulin-dependent diabetic patient...

journal_title：Kidney international

authors： Earle K,Viberti GC

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Although the existence of multiple isoforms of plasma membrane calcium ATPase (PMCA) is now well documented, their biological functions are not yet known. In this study, we set out to investigate the potential role of PMCA isoforms, previously identified in renal cortical tissue, in tubular reabsorption of c...

journal_title：Kidney international

authors： Caride AJ,Chini EN,Penniston JT,Dousa TP

更新日期：1999-11-01 00:00:00