Surveillance of alloantibodies after transplantation identifies the risk of chronic rejection.

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：:The relationship of protein intake to urinary oxalate and glycolate excretion was examined in a large cohort (N = 101) of normal individuals on self-selected diets and in 11 individuals on controlled protein diets. On self-selected diets no correlation was detected between protein intake and urinary oxalate or glycola...

journal_title：Kidney international

authors： Holmes RP,Goodman HO,Hart LJ,Assimos DG

更新日期：1993-08-01 00:00:00

abstract：:31P NMR as a descriptive technique is of interest to nephrologists. Particular contributions of 31P NMR to our understanding of renal function may be enumerated.: "Free" metabolite levels are different from those classically accepted; in particular, ADP and Pi are low with implications for the control of renal metabol...

journal_title：Kidney international

authors： Ross B,Freeman D,Chan L

更新日期：1986-01-01 00:00:00

abstract：:Vitamin D deficiency is common in patients with chronic kidney disease after renal transplantation. Vitamin D, essential for mineral and bone metabolism, also has myriad beneficial autocrine effects on intact immune responses and defense against infection, as well as suppression of malignant changes. Supplementation w...

journal_title：Kidney international

authors： Levi R,Silver J

更新日期：2009-03-01 00:00:00

abstract：:Cell-cycle proteins influence almost all aspects of embryogenesis and differentiation. In adults, these proteins control cell division and regeneration after injury. During the past several years, their roles in controlling reaction to stress have been demonstrated in several organ systems. In the kidney, the cell typ...

journal_title：Kidney international

authors： Price PM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:High-dose folinic acid is used to accelerate methotrexate elimination to avoid renal toxicity of the drug. The present study was carried out to examine the role of the renal organic anion transporters OAT-K1 and OAT-K2 in the urinary excretion of methotrexate, especially in the methotrexate-folinic acid resc...

journal_title：Kidney international

authors： Takeuchi A,Masuda S,Saito H,Doi T,Inui K

更新日期：2001-09-01 00:00:00

abstract：:Previous studies have demonstrated that dietary potassium deprivation in healthy human subjects eating diets otherwise containing normal quantities of NaCl is accompanied by an increase in urinary calcium excretion. This increase in urinary Ca excretion occurs in association with reductions in urinary Na and Cl excret...

journal_title：Kidney international

authors： Lemann J Jr,Pleuss JA,Hornick L,Hoffman RG

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:It is not known to what extent intravascular phenotypic alterations in adhesion molecule expression induced by hemodialysis influence the recruitment of monocytes and their ability to up-regulate CD11b at the local site of inflammation in the interstitium. Using a skin suction chamber technique, we addressed...

journal_title：Kidney international

authors： Thylén P,Lundahl J,Fernvik E,Grönneberg R,Halldén G,Jacobson SH

更新日期：2000-05-01 00:00:00

abstract：:Patients with chronic renal failure frequently have hypogonadism. To elucidate the molecular mechanisms involved, we tested the ability of serum from these patients to inhibit recombinant human luteinizing hormone receptors. Using a cell line expressing functional human luteinizing hormone receptors, we found that ade...

journal_title：Kidney international

authors： Dunkel L,Raivio T,Laine J,Holmberg C

更新日期：1997-03-01 00:00:00

abstract：:Accumulation of extracellular matrix within the mesangium is an important event in the development of glomerular disease. In this report we have used indirect immunofluorescence to positively identify a number of constituents of the mesangial matrix synthesized by rat mesangial cells (RMC) in vitro including laminin, ...

journal_title：Kidney international

authors： Thomas GJ,Shewring L,McCarthy KJ,Couchman JR,Mason RM,Davies M

更新日期：1995-10-01 00:00:00

abstract：:The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...

journal_title：Kidney international

authors： Keddis MT,El Ters M,Rodrigo E,Dean P,Wohlfahrtova M,Kudva YC,Lorenz EC,Cosio FG

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Cardiovascular death continues to be a major problem in renal failure. Structural abnormalities of the heart and the vasculature contribute to the increased cardiovascular risk. They are ameliorated by angiotensin-converting enzyme (ACE) inhibitors, but because of the nonspecifity of ACE inhibition, it is un...

journal_title：Kidney international

authors： Amann K,Gassmann P,Buzello M,Orth SR,Törnig J,Gross ML,Magener A,Mall G,Ritz E

更新日期：2000-07-01 00:00:00

abstract：:The OSCAR study was a multicenter, prospective randomized open-label blinded end-point study of 1164 Japanese elderly hypertensive patients comparing the efficacy of angiotensin II receptor blocker (ARB) uptitration to an ARB plus calcium channel blocker (CCB) combination. In this prospective study, we performed presp...

journal_title：Kidney international

authors： Kim-Mitsuyama S,Ogawa H,Matsui K,Jinnouchi T,Jinnouchi H,Arakawa K

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Elimination of residual proteinuria is the novel target in renoprotection; nevertheless, whether a greater suppression of renin-angiotensin system (RAS) effectively improves the antiproteinuric response in patients with moderate proteinuria remains ill-defined. METHODS:We evaluated the effects of maximizing...

journal_title：Kidney international

authors： Iodice C,Balletta MM,Minutolo R,Giannattasio P,Tuccillo S,Bellizzi V,D'Amora M,Rinaldi G,Signoriello G,Conte G,De Nicola L

更新日期：2003-06-01 00:00:00

abstract：:Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory function of PGRN in rheumatoid arthritis encouraged us to examine the role of PGRN in acute kidney injury (AKI). We found that levels ...

journal_title：Kidney international

authors： Zhou M,Tang W,Fu Y,Xu X,Wang Z,Lu Y,Liu F,Yang X,Wei X,Zhang Y,Liu J,Geng X,Zhang C,Wan Q,Li N,Yi F

更新日期：2015-05-01 00:00:00

abstract：:Recent studies of timing of dialysis initiation have challenged the recent trend to earlier initiation of therapy. The observed outcomes though are a consequence of the balance between the risks of advanced uremia versus the inherent dangers relating to dialysis therapy itself. Many of these risks are inherent in how ...

journal_title：Kidney international

authors： McIntyre CW,Rosansky SJ

更新日期：2012-08-01 00:00:00

abstract：:We used the perfused hemicorpus preparation to measure individual rates of protein synthesis and degradation. Using fed animals, perfused either with or without insulin, muscle protein synthesis and hemicorpus protein degradation rates were similar, but myofibrillar protein degradation was clearly increased in the ure...

journal_title：Kidney international

authors： Li JB,Wassner SJ

更新日期：1986-06-01 00:00:00

abstract：:Melamine, a widely used chemical found in many products in daily use, became a public health concern due to melamine-associated urinary stone formation in children. In adults, it is still unknown whether low-dose melamine exposure may also cause urolithiasis. To address this question, we studied 211 Taiwanese patients...

journal_title：Kidney international

authors： Liu CC,Wu CF,Chen BH,Huang SP,Goggins W,Lee HH,Chou YH,Wu WJ,Huang CH,Shiea J,Lee CH,Wu KY,Wu MT

更新日期：2011-10-01 00:00:00

abstract：:Transport and metabolism of adenosine were studied in the S1, S2, and S3 segments of the rabbit proximal renal tubule. Isolated segments were perfused in vitro with uniformly labelled 14C-adenosine to measure the lumen-to-bath flux of adenosine. This flux rate was measured by the disappearance of 14C from the luminal ...

journal_title：Kidney international

authors： Barfuss DW,McCann WP,Katholi RE

更新日期：1992-05-01 00:00:00

abstract：:Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing etiologies with monogenic disease accounting for 2.9-30% in selected series. Using whole exome sequencing we sought to stratify a national population of children with SRNS into monogenic and non-monogenic forms, and further define t...

journal_title：Kidney international

authors： Bierzynska A,McCarthy HJ,Soderquest K,Sen ES,Colby E,Ding WY,Nabhan MM,Kerecuk L,Hegde S,Hughes D,Marks S,Feather S,Jones C,Webb NJ,Ognjanovic M,Christian M,Gilbert RD,Sinha MD,Lord GM,Simpson M,Koziell AB,Welsh

更新日期：2017-04-01 00:00:00

abstract：:Osteopontin (OPN) is a secreted acidic glycoprotein that has potent monocyte chemoattractant and adhesive properties. Up-regulation of tubular OPN expression is thought to promote interstitial macrophage infiltration in experimental nephritis; however, the role of OPN in glomerular lesions, particularly crescent forma...

journal_title：Kidney international

authors： Lan HY,Yu XQ,Yang N,Nikolic-Paterson DJ,Mu W,Pichler R,Johnson RJ,Atkins RC

更新日期：1998-01-01 00:00:00

abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...

journal_title：Kidney international

authors： Tian Y,Riazi S,Khan O,Klein JD,Sugimura Y,Verbalis JG,Ecelbarger CA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Strict glycemic control and antihypertensive treatment may decrease but not eliminate the risk of progressive nephropathy in diabetic patients. C-peptide has been shown to exert beneficial effects on complications, including incipient nephropathy, in type 1 diabetes. METHODS:Renal effects of 14 days of intr...

journal_title：Kidney international

authors： Samnegård B,Jacobson SH,Jaremko G,Johansson BL,Sjöquist M

更新日期：2001-10-01 00:00:00

abstract：:Chronic kidney disease (CKD) accelerates muscle protein degradation by stimulating the ubiquitin proteasome system through activation of the E3 ligases, Atrogin-1/MAFbx and MuRF-1. Forkhead transcription factors (FoxOs) can control the expression of these E3 ligases, but the contribution of individual FoxOs to muscle ...

journal_title：Kidney international

authors： Xu J,Li R,Workeneh B,Dong Y,Wang X,Hu Z

更新日期：2012-08-01 00:00:00

abstract：:Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit ...

journal_title：Kidney international

authors： Yokoi H,Yanagita M

更新日期：2016-04-01 00:00:00

abstract：:Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk...

journal_title：Kidney international

authors： Juni RP,Al-Shama R,Kuster DWD,van der Velden J,Hamer HM,Vervloet MG,Eringa EC,Koolwijk P,van Hinsbergh VWM

更新日期：2020-12-22 00:00:00

abstract：:Pulse wave velocity (PWV) was measured in the aorta, right leg and arm of 90 control subjects (CS) and 92 hemodialysis patients (HD) of the same age and mean arterial pressure (MAP). Blood chemistry, including blood lipids, and echographic dimensions of the aorta, were measured in all subjects. Presence of aortic calc...

journal_title：Kidney international

authors： London GM,Marchais SJ,Safar ME,Genest AF,Guerin AP,Metivier F,Chedid K,London AM

更新日期：1990-01-01 00:00:00

abstract：:The generation of reactive oxygen species has a pivotal role in both acute and chronic glomerular injuries in patients with lupus nephritis. As the transcription factor Nrf2 is a major regulator of the antioxidant response and is a primary cellular defense mechanism, we sought to determine a role of Nrf2 in the progre...

journal_title：Kidney international

authors： Jiang T,Tian F,Zheng H,Whitman SA,Lin Y,Zhang Z,Zhang N,Zhang DD

更新日期：2014-02-01 00:00:00

abstract：:US adults with metabolic syndrome, as defined by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, have been shown to be at increased risk of chronic kidney disease (CKD), but there is limited information in other populations. The relationship between metabolic syndrome and CKD ...

journal_title：Kidney international

authors： Kitiyakara C,Yamwong S,Cheepudomwit S,Domrongkitchaiporn S,Unkurapinun N,Pakpeankitvatana V,Sritara P

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques ...

journal_title：Kidney international

authors： Thongboonkerd V,McLeish KR,Arthur JM,Klein JB

更新日期：2002-10-01 00:00:00