Circulating luteinizing hormone receptor inhibitor(s) in boys with chronic renal failure.

abstract：:The current study was undertaken to examine the effects of dithiothreitol (DDT), a sulfhydryl-reducing agent and heavy metal chelator, on the course of heavy metal-induced acute renal failure in the rat. Groups of rats in metabolic cages received uranyl nitrate (UN) alone, UN plus DTT, mercuric chloride (HgCl2) alone,...

journal_title：Kidney international

authors： Kleinman JG,McNeil JS,Schwartz JH,Hamburger RJ,Flamenbaum W

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

journal_title：Kidney international

authors： Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:The clinical use of cyclosporine (CsA) is limited by its nephrotoxicity. Apoptosis, perhaps instigated by increased nitric oxide synthase (NOS) activity, may play a role in such toxicity. METHODS:Human mesangial cells, human tubular cells, human umbilical vein endothelial cells, or murine endothelial cells ...

journal_title：Kidney international

authors： Amore A,Emancipator SN,Cirina P,Conti G,Ricotti E,Bagheri N,Coppo R

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Acute renal failure (ARF) has a high morbidity and mortality. Many therapies have worked in animals but were unsuccessful in clinical trials. The inability to diagnose ARF early may have impaired the success of these trials. METHOD:We screened a subtraction library to search for potential disease markers th...

journal_title：Kidney international

authors： Muramatsu Y,Tsujie M,Kohda Y,Pham B,Perantoni AO,Zhao H,Jo SK,Yuen PS,Craig L,Hu X,Star RA

更新日期：2002-11-01 00:00:00

abstract：:Cultures of human proximal tubule cells were exposed to elevated concentrations of glucose and dome formation was assessed over a 22 day period of growth. Cultures grown on 5.5 mM glucose formed five domes per microscopic field while those exposed to elevated glucose concentrations (11.0 mM to 27.5 mM) formed only two...

journal_title：Kidney international

authors： Hazen-Martin DJ,Sens MA,Detrisac CJ,Blackburn JG,Sens DA

更新日期：1989-01-01 00:00:00

abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...

journal_title：Kidney international

authors： Ooi YM,Ooi BS

更新日期：1983-06-01 00:00:00

abstract：:Data from the national French Renal Epidemiology and Information Network (REIN) registry were used to compare survival between transplant recipients under age 65 who resumed dialysis after graft failure during 2007-2009 and transplant-naïve incident dialysis patients matched for age, gender, diabetes mellitus, and yea...

journal_title：Kidney international

authors： Mourad G,Minguet J,Pernin V,Garrigue V,Peraldi MN,Kessler M,Jacquelinet C,Couchoud C,Duny Y,Daurès JP

更新日期：2014-07-01 00:00:00

abstract：:Methods for estimating glomerular volume were compared in Zenker-fixed, paraffin-embedded biopsies from 10 patients with insulin-dependent diabetes mellitus and 6 normal kidney donors. Two methods of measurement of individual glomerular volumes were used: the Cavalieri method (considered the "gold standard") and the m...

journal_title：Kidney international

authors： Lane PH,Steffes MW,Mauer SM

更新日期：1992-04-01 00:00:00

abstract：:The effects of two models of chronic hypercalcemia on renal acid-base metabolism were studied in rats. In the first series of experiments, rats were rendered hyperparathyroid by the autologous grafting of 20 to 24 parathyroid glands into a single recipient. Hypercalcemia (5.48 +/- 0.03 mEq/liter in high PTH animals, 4...

journal_title：Kidney international

authors： Mitnick P,Greenberg A,Coffman T,Kelepouris E,Wolf CJ,Goldfarb S

更新日期：1982-04-01 00:00:00

abstract：:Copy number variations associate with different developmental phenotypes and represent a major cause of congenital anomalies of the kidney and urinary tract (CAKUT). Because rare pathogenic copy number variations are often large and contain multiple genes, identification of the underlying genetic drivers has proven to...

journal_title：Kidney international

authors： Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:Correlation of histology to rejection reversal: A Thymoglobulin Multicenter Trial report BACKGROUND:Histology may provide a link between clinical response to antirejection therapy and graft function. In a subset of centers, renal biopsy was a secondary end point for the Thymoglobulin Multicenter Trial. MET...

journal_title：Kidney international

authors： Gaber LW,Moore LW,Gaber AO,Tesi RJ,Meyer J,Schroeder TJ

更新日期：1999-06-01 00:00:00

abstract：:The inner medullary collecting duct (IMCD) is a major target site of atrial natriuretic peptide (ANP) for diuresis and natriuresis, and it is in a hypertonic condition made by the renal countercurrent multiplication system. We investigated the effects of hyperosmolality on ANP-stimulated cGMP generation in IMCD and gl...

journal_title：Kidney international

authors： Shinohara M,Nonoguchi H,Ujiie K,Terada Y,Owada A,Tomita K,Marumo F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Epithelial cells in the renal inner medulla accumulate osmolytes such as betaine to maintain normal cell volume during prolonged extracellular hypertonic stress. Betaine accumulation is the result of activation of transcription of the BGT1 transporter gene followed by increased betaine transport. METHODS:We...

journal_title：Kidney international

authors： Basham JC,Chabrerie A,Kempson SA

更新日期：2001-06-01 00:00:00

abstract：:Alterations in myocardial wall texture stand out among ADPKD cardiovascular manifestations in hypertensive and normotensive patients. To elucidate their pathogenesis, we analyzed the cardiac phenotype in Pkd1(cond/cond)Nestin(cre) (CYG+) cystic mice exposed to increased blood pressure, at 5 to 6 and 20 to 24 weeks of ...

journal_title：Kidney international

authors： Balbo BE,Amaral AG,Fonseca JM,de Castro I,Salemi VM,Souza LE,Dos Santos F,Irigoyen MC,Qian F,Chammas R,Onuchic LF

更新日期：2016-09-01 00:00:00

abstract：:Sodium depletion has a protective effect on target-organ damage in hypertension independent of blood pressure. Here we tested whether chronic dietary sodium restriction may prevent the development of renal alterations associated with insulin resistance by reducing the inflammatory and oxidant state. Rats were fed norm...

journal_title：Kidney international

authors： Oudot C,Lajoix AD,Jover B,Rugale C

更新日期：2013-04-01 00:00:00

abstract：:The hormonal responsiveness profile of the cortical collecting duct varies from one species to another. To identify the hormones and agonists that modulate the functions of this tubule segment in the human species, we generated a cell line (HCD) immortalized by SV40 virus. The tubular origin of this cell line was asse...

journal_title：Kidney international

authors： Prié D,Friedlander G,Coureau C,Vandewalle A,Cassingéna R,Ronco PM

更新日期：1995-05-01 00:00:00

abstract：:Spontaneous polycystic kidney and liver disease in an inbred herd of Springbok (Antidorcas marsupialis) was studied by light microscopy, transmission electron microscopy, and microdissection. Springbok are a small species of gazelle of the family Bovidae native to South Africa. Since 1976, 18% of all live calves born ...

journal_title：Kidney international

authors： Iverson WO,Fetterman GH,Jacobson ER,Olsen JH,Senior DF,Schobert EE

更新日期：1982-08-01 00:00:00

abstract：:Prior studies reported associations of APOL1 nephropathy risk variants with subclinical atherosclerosis. However, these findings were limited to older individuals with high comorbidities. To evaluate this in younger individuals, we calculated associations of APOL1 risk variants (high risk [2 risk variants] vs. low ris...

journal_title：Kidney international

authors： Gutiérrez OM,Limou S,Lin F,Peralta CA,Kramer HJ,Carr JJ,Bibbins-Domingo K,Winkler CA,Lewis CE,Kopp JB

更新日期：2018-03-01 00:00:00

abstract：:The inactivation of physiological glucocorticoids by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) confers mineralocorticoid specificity to certain aldosterone target tissues. Both NADP, and NAD-dependent isoforms of 11 beta-HSD have been described. An NAD-dependent isoform of 11 beta-HSD (11 beta-HSD2) was recen...

journal_title：Kidney international

authors： Kyossev Z,Walker PD,Reeves WB

更新日期：1996-01-01 00:00:00

abstract：:The relationship of protein intake to urinary oxalate and glycolate excretion was examined in a large cohort (N = 101) of normal individuals on self-selected diets and in 11 individuals on controlled protein diets. On self-selected diets no correlation was detected between protein intake and urinary oxalate or glycola...

journal_title：Kidney international

authors： Holmes RP,Goodman HO,Hart LJ,Assimos DG

更新日期：1993-08-01 00:00:00

abstract：:We examined the circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 alpha, IL-6, granulocyte macrophage-colony stimulating factor (GM-CSF), and the anti-inflammatory cytokine IL-10, and their expression in kidneys acutely infected with murine malaria parasite...

journal_title：Kidney international

authors： Rui-Mei L,Kara AU,Sinniah R

更新日期：1998-04-01 00:00:00

abstract：:Whole-genome microarrays identify large numbers of gene expression changes that appear specifically related to disease states such as antineutrophil cytoplasmic autoantibody (ANCA) and systemic lupus erythematosus. Although understanding this enormous volume of esoteric data is difficult, a few basic concepts regardin...

journal_title：Kidney international

authors： Stegall MD,Park W

更新日期：2007-10-01 00:00:00

abstract：:The Standardized Outcomes in Nephrology (SONG) initiative is designed to improve research productivity by building consensus. Stakeholders involved with peritoneal dialysis (PD) have put life participation on top of their list, along with treatment-related infection, cardiovascular complications, and patient and techn...

journal_title：Kidney international

authors： Davies SJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Hypertriglyceridemia is a result of reduced triglyceride (TG)-rich lipoprotein (TRL) catabolism and occurs in rats with nephrotic syndrome (NS) and in Nagase analbuminemic rats (NARs). While the heparin-releasable lipoprotein lipase (LpL) pool in NAR and in NS is similar, TG levels are significantly greater ...

journal_title：Kidney international

authors： Shearer GC,Stevenson FT,Atkinson DN,Jones H,Staprans I,Kaysen GA

更新日期：2001-01-01 00:00:00

abstract：:Acute kidney injury (AKI) is associated with progression to advanced chronic kidney disease (CKD). We tested whether patients who survive AKI and are at higher risk for CKD progression can be identified during their hospital admission, thus providing opportunities to intervene. This was assessed in patients in the Dep...

journal_title：Kidney international

authors： Chawla LS,Amdur RL,Amodeo S,Kimmel PL,Palant CE

更新日期：2011-06-01 00:00:00

abstract：:Plasma lipid and lipoprotein concentration and high density lipoprotein (HDL) kinetics were determined in control subjects and patients with chronic renal failure (CRF). Results demonstrated that plasma triglyceride (TG) concentration was significantly higher (P less than 0.001) in patients with CRF, associated with a...

journal_title：Kidney international

authors： Fuh MM,Lee CM,Jeng CY,Shen DC,Shieh SM,Reaven GM,Chen YD

更新日期：1990-05-01 00:00:00

abstract：:[Arg(8)]-vasopressin (AVP) has several functions via its three distinct receptors, V1a, V1b, and V2. The V1a vasopressin receptor (V1aR) is expressed in blood vessels and involved in vascular contraction. Recently, we generated V1a receptor-deficient (V1aR(-/-)) mice and found that they were hypotensive. In addition, ...

journal_title：Kidney international

authors： Aoyagi T,Koshimizu TA,Tanoue A

更新日期：2009-11-01 00:00:00

abstract：:The mean renal tubular diameters, number of tubules per unit of cross-sectional area, and fraction of the total volume occupied by each medullary structure were determined at various levels of the renal medulla of the rat and rabbit. Statistical estimates of anatomic variables were made using spatial sampling techniqu...

journal_title：Kidney international

authors： Knepper MA,Danielson RA,Saidel GM,Post RS

更新日期：1977-11-01 00:00:00

abstract：:Suzuki et al. analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene. The authors show that excess iron decreases levels of hypoxia-inducible transcription f...

journal_title：Kidney international

authors： Ganz T

更新日期：2018-11-01 00:00:00

abstract：:Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients ...

journal_title：Kidney international

authors： McAdoo SP,Tanna A,Hrušková Z,Holm L,Weiner M,Arulkumaran N,Kang A,Satrapová V,Levy J,Ohlsson S,Tesar V,Segelmark M,Pusey CD

更新日期：2017-09-01 00:00:00