The severity of acute kidney injury predicts progression to chronic kidney disease.

abstract：:The structure of the duodenal mucosa was evaluated in duodenal biopsy samples obtained from patients with moderate renal failure (MRF) and in dialysis patients (HD) in an effort to examine the possibility that changes in duodenal mucosa may contribute to the impaired calcium absorption in renal failure (RF). The effec...

journal_title：Kidney international

authors： Goldstein DA,Horowitz RE,Petit S,Haldimann B,Massry SG

更新日期：1981-02-01 00:00:00

abstract：:Thrombotic microangiopathy (TMA) is a pattern of endothelial damage that can be found in association with diverse clinical conditions such as malignant hypertension. Although the pathophysiological mechanisms differ, accumulating evidence links complement dysregulation to various TMA syndromes and in particular the at...

journal_title：Kidney international

authors： Timmermans SAMEG,Abdul-Hamid MA,Vanderlocht J,Damoiseaux JGMC,Reutelingsperger CP,van Paassen P,Limburg Renal Registry.

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is characterized by systemic vasculitis with crescentic glomerulonephritis (CGN) and circulating autoantibodies directed against neutrophil cytoplasmic antigens (ANCA). Proteinase 3 (PR-3), a neutral serine proteinase in neutrophils implicated in the growth control of myeloid ce...

journal_title：Kidney international

authors： Schwarting A,Hagen D,Odenthal M,Brockmann H,Dienes HP,Wandel E,Rumpelt HJ,Zum Büschenfelde KH,Galle PR,Mayet W

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Assessment of mRNA levels has the potential to predict renal outcome. The objective of this study was to optimize several steps in the protocol for obtaining cDNA from routine clinical kidney biopsy material. METHODS:RNA integrity was compared between different methods for extraction of RNA, synthesis of cD...

journal_title：Kidney international

authors： Roos-van Groningen MC,Eikmans M,Baelde HJ,de Heer E,Bruijn JA

更新日期：2004-01-01 00:00:00

abstract：:Inflammation is the immune system's response to infectious or noninfectious sources of danger. Danger recognition is facilitated by various innate immune receptor families including the Toll-like receptors (TLRs), which detect danger signals in extracellular and intracellular compartments. It is an evolving concept th...

journal_title：Kidney international

authors： Anders HJ,Schlondorff DO

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

journal_title：Kidney international

authors： Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

更新日期：2003-07-01 00:00:00

abstract：:Lithium therapy frequently induces nephrogenic diabetes insipidus; amiloride appears to prevent its occurrence in some clinical cases. Amiloride blocks the epithelial sodium channel (ENaC) located in the apical membrane of principal cells; hence one possibility is that ENaC is the main entry site for lithium and the b...

journal_title：Kidney international

authors： Kortenoeven ML,Li Y,Shaw S,Gaeggeler HP,Rossier BC,Wetzels JF,Deen PM

更新日期：2009-07-01 00:00:00

abstract：:We examined the potential of in vivo linkage of plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) in the setting of endothelial injury and sclerosis following radiation injury in the rat. PAI-1 is a major physiological inhibitor of the plasminogen activator (PA)/plasmin system, a key regulator of f...

journal_title：Kidney international

authors： Oikawa T,Freeman M,Lo W,Vaughan DE,Fogo A

更新日期：1997-01-01 00:00:00

abstract：:Isolated perfused rat kidneys were passively sensitized by addition of either mouse ascitic fluid containing monoclonal IgE against dinitrophenol (DNP) or DNP-specific purified IgE. After washing the organ, defined doses of DNP-bovine serum albumin were given as bolus injection via the kidney artery. Antigen challenge...

journal_title：Kidney international

authors： Pirotzky E,Pintos-Morell G,Burtin C,Boudet J,Bidault J,Benveniste J

更新日期：1987-08-01 00:00:00

abstract：:A morphometric study was undertaken to quantitate the morphologic changes induced by ADH availability in the rat kidney. Homozygous Brattleboro rats with hereditary diabetes insipidus (DI) (no ADH) were compared to heterozygous Brattleboro control rats (HZ) and to DI rats after 5 to 6 weeks of continuous ADH infusion ...

journal_title：Kidney international

authors： Bouby N,Bankir L,Trinh-Trang-Tan MM,Minuth WW,Kriz W

更新日期：1985-09-01 00:00:00

abstract：:Multiple microRNAs (miRs) are implicated in muscle cell differentiation and muscle mass regulation. Pharmacological agents targeting miR-486 and other miRs, involved in muscle mass regulation, could potentially be developed into therapeutic agents for muscle wasting. Muscle wasting is prevalent among patients with chr...

journal_title：Kidney international

authors： Mak RH,Cheung WW

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Erythropoietin is known to improve outcomes in patients with anemia from chronic renal disease. However, there is uncertainty about the optimal timing of initiation of erythropoietin treatment in predialysis patients with non-severe anemia. METHODS:We conducted a randomized controlled trial of early versus ...

journal_title：Kidney international

authors： Gouva C,Nikolopoulos P,Ioannidis JP,Siamopoulos KC

更新日期：2004-08-01 00:00:00

abstract：:Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2(*)) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. This parameter was...

journal_title：Kidney international

authors： Michaely HJ,Metzger L,Haneder S,Hansmann J,Schoenberg SO,Attenberger UI

更新日期：2012-04-01 00:00:00

abstract：:Clinical and experimental studies have shown that serum aluminum (Al) is bound to transferrin and that cellular uptake of Al appears to be mediated by transferrin receptors. Based on these findings it is widely believed that intestinal Al absorption occurs via iron-specific, transferrin-dependent pathways and that iro...

journal_title：Kidney international

authors： Ittel TH,Kinzel S,Ortmanns A,Sieberth HG

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Rho proteins are small guanine 5'-triphosphate (GTP)-binding proteins felt to be important regulators of several aspects of cell function, including the organization of the actin cytoskeleton. The effects of Rho proteins on the regulation of renal tubular epithelial cell function are not known. METHODS:Sele...

journal_title：Kidney international

authors： Anderson RJ,Ray CJ,Popoff MR

更新日期：2000-11-01 00:00:00

abstract：:Tenascin-C is an extracellular matrix glycoprotein that plays a critical role in kidney fibrosis by orchestrating a fibrogenic niche. Here, we demonstrate that tenascin-C is a biomarker and a mediator of kidney fibrogenesis by impairing tubular integrity. Tenascin-C was found to be increased in kidney biopsies from pa...

journal_title：Kidney international

authors： Zhu H,Liao J,Zhou X,Hong X,Song D,Hou FF,Liu Y,Fu H

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:It is still unclear whether age per se is associated with preservation of renal functional reserve, that is, of the increase in glomerular filtration rate (GFR) induced by appropriate vasodilating stimulus. METHODS:To gain insights into this issue, we evaluated the renal response to a maximal vasodilating s...

journal_title：Kidney international

authors： Fuiano G,Sund S,Mazza G,Rosa M,Caglioti A,Gallo G,Natale G,Andreucci M,Memoli B,De Nicola L,Conte G

更新日期：2001-03-01 00:00:00

abstract：:The cannabinoid receptor type 2 (CB2) is a G protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the pathogenesis of kidney injury and fibrosis remains poorly understood. Here we demonstrate that CB2 was induced, predominantly in kidney tubular epithelium, i...

journal_title：Kidney international

authors： Zhou L,Zhou S,Yang P,Tian Y,Feng Z,Xie XQ,Liu Y

更新日期：2018-10-01 00:00:00

abstract：:Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure. Histologically, the classic picture of focal segmental glomerulosclerosis (FSGS) was found; males were more severely affected than females. Among the early...

journal_title：Kidney international

authors： Kriz W,Hähnel B,Rösener S,Elger M

更新日期：1995-11-01 00:00:00

abstract：:We have shown that cisplatin inhibits fatty acid oxidation, and that fibrate treatment ameliorates renal function by preventing the inhibition of fatty acid oxidation and proximal tubule cell death. Urine samples of mice treated with single injection of cisplatin (20 mg/kg body weight) were collected for 3 days and an...

journal_title：Kidney international

authors： Portilla D,Li S,Nagothu KK,Megyesi J,Kaissling B,Schnackenberg L,Safirstein RL,Beger RD

更新日期：2006-06-01 00:00:00

abstract：:Hemodynamic studies were performed at two levels of dietary sodium intake (10 mmoles/day and 100 mmoles/day for 14 days) in a group of patients (with retained kidneys) on chronic hemodialysis. Plasma renin activity and aldosterone, plasma, and extracellular fluid (ECF) volumes were measured while the patient were at r...

journal_title：Kidney international

authors： McGrath BP,Tiller DJ,Bune A,Chalmers JP,Korner PI,Uther JB

更新日期：1977-10-01 00:00:00

abstract：:The acute renal effects of hypoxemia and the ability of theophylline to prevent these effects were assessed in anesthetized and mechanically-ventilated newborn and adult rabbits. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by the clearance of para-aminohippuric acid and inulin, respecti...

journal_title：Kidney international

authors： Gouyon JB,Guignard JP

更新日期：1988-06-01 00:00:00

abstract：:beta 2-microglobulin-related amyloidosis (A beta 2M) represents a frequent complication in long-term dialysis patients. Although the pathogenetic mechanism has yet to be fully understood, it is known that amyloid fibrils usually consist of intact molecules of beta 2-microglobulin (beta 2m). Plasma proteinase inhibitor...

journal_title：Kidney international

authors： Campistol JM,Shirahama T,Abraham CR,Rodgers OG,Solé M,Cohen AS,Skinner M

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Tissue kallikrein regulates blood circulation. Low urinary kallikrein excretion was associated with hypertension and renal disease in blacks. The polymorphic KLK1 promoter includes -130 GN coupled with multiple single base substitutions. The -130 G12 allele in the KLK1 promoter was associated with lower tran...

journal_title：Kidney international

authors： Lee-Chen GJ,Liu KP,Lai YC,Juang HS,Huang SY,Lin CY

更新日期：2004-04-01 00:00:00

abstract：:Vascular sclerosis has been linked to many risk factors, including smoking, family history, low birth weight, and hypertension. In interesting studies, Goforth et al. show an increased rate of mutations in thrombophilic molecules in patients with vascular sclerosis in renal biopsies, suggesting yet another mechanism. ...

journal_title：Kidney international

authors： Fogo AB

更新日期：2006-08-01 00:00:00

abstract：:Intravenous conjugated estrogens reduce the prolonged bleeding time in uremic patients and in a rat model of uremia. However, estrogens have major side effects related to their hormonal activity. We investigated whether a beta-resorcylic acid lactone, zeranol (a compound with close spatial similarity to estrogens but ...

journal_title：Kidney international

authors： Zoja C,Viganò G,Corna D,Salmona M,Remuzzi G,Garattini S

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:This multicenter, open-label, dose-titration study assessed the safety and efficacy of RenaGel(R), a nonabsorbed calcium- and aluminum-free phosphate binder, in lowering serum phosphorus. Secondary outcomes were its effects on serum intact parathyroid hormone (iPTH) and serum lipids. METHODS:Phosphate binde...

journal_title：Kidney international

authors： Slatopolsky EA,Burke SK,Dillon MA

更新日期：1999-01-01 00:00:00

abstract：:Cell surface aminopeptidases N (APN) and A (APA) have been characterized on cultured human glomerular epithelial cells and a SV40-transformed cell line derived from them. APN had a wide substrate specificity whereas APA only attacked peptides with an acidic N terminal amino acid. Both enzymes also differed by their se...

journal_title：Kidney international

authors： Stefanovic V,Vlahovic P,Ardaillou N,Ronco P,Ardaillou R

更新日期：1992-06-01 00:00:00

abstract：:Bone marrow (BM) cells are reported to contribute to the process of regeneration following myocardial infarction. The present study examined two independent clonal studies to determine the origin of bone marrow (BM)-derived cardiomyocytes. First, we transplanted single CD34(-)c-kit(+)Sca-1(+)lineage(-) side population...

journal_title：Kidney international

authors： Fukuda K,Fujita J

更新日期：2005-11-01 00:00:00

abstract：:Erythropoietin (EPO) therapy in hemodialysis patients may be associated with an enhanced risk of vascular access and extracorporeal thrombosis. Assessment of blood coagulation and fibrinolysis was performed monthly on a group of 21 hemodialysis patients treated with EPO, and on four iron-deficient hemodialysis patient...

journal_title：Kidney international

authors： Taylor JE,Belch JJ,McLaren M,Henderson IS,Stewart WK

更新日期：1993-07-01 00:00:00