Correlation of histology to clinical rejection reversal: a thymoglobulin multicenter trial report.

abstract：:We examined the potential of in vivo linkage of plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) in the setting of endothelial injury and sclerosis following radiation injury in the rat. PAI-1 is a major physiological inhibitor of the plasminogen activator (PA)/plasmin system, a key regulator of f...

journal_title：Kidney international

authors： Oikawa T,Freeman M,Lo W,Vaughan DE,Fogo A

更新日期：1997-01-01 00:00:00

abstract：:beta 2-microglobulin-related amyloidosis (A beta 2M) represents a frequent complication in long-term dialysis patients. Although the pathogenetic mechanism has yet to be fully understood, it is known that amyloid fibrils usually consist of intact molecules of beta 2-microglobulin (beta 2m). Plasma proteinase inhibitor...

journal_title：Kidney international

authors： Campistol JM,Shirahama T,Abraham CR,Rodgers OG,Solé M,Cohen AS,Skinner M

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Inbred miniature swine treated for 12 days with high-dose cyclosporine A develop tolerance to histocompatibility complex (MHC) class I-mismatched renal allografts. When this protocol was modified by adding thymectomy before transplant, all animals developed acute rejection. Thereafter, by day 100, one half d...

journal_title：Kidney international

authors： Shimizu A,Yamada K,Sachs DH,Colvin RB

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Evaluation of beta2-microglobulin (beta2m) removal during hemodialysis using predialysis and immediate postdialysis plasma concentrations is only valid in the absence of postdialysis rebound. Postdialysis rebound of beta2m has not been studied extensively, and its importance in the determination of beta2m cl...

journal_title：Kidney international

authors： Leypoldt JK,Cheung AK,Deeter RB

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Several examinations have been performed to identify the genes involved in chronic renal failure using 5/6 nephrectomized rats. Recently, many systematic techniques for examining molecular expression have been developed. They might also be effective in elucidating the molecular mechanism of progressive renal...

journal_title：Kidney international

authors： Horiba N,Masuda S,Takeuchi A,Saito H,Okuda M,Inui K

更新日期：2004-07-01 00:00:00

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Torsemide has predictable absorption compared to furosemide. Thereby, torsemide results in more constant exposure to active drug. Our hypothesis was that this pharmacokinetic difference between these commonly used loop diuretics may translate into disparate antihypertensive responses in patients with chronic...

journal_title：Kidney international

authors： Vasavada N,Saha C,Agarwal R

更新日期：2003-08-01 00:00:00

abstract：:Hypocalcemia, hyperphosphatemia, and resistance to the action of PTH are well characterized features in the setting of advanced chronic renal failure (CRF). Although the underlying mechanisms are ill-understood, clinical and experimental evidence points to both PTH receptor down-regulation and post-receptor abnormalit...

journal_title：Kidney international

authors： Ureña P,Kubrusly M,Mannstadt M,Hruby M,Trinh MM,Silve C,Lacour B,Abou-Samra AB,Segre GV,Drüeke T

更新日期：1994-02-01 00:00:00

abstract：:Recently, 4 new risk scores for the prediction of mortality and cardiovascular events were especially tailored for hemodialysis patients; these scores performed much better than previous scores. Tripepi et al. found that these risk scores were even more predictive for all-cause and cardiovascular death than the measur...

journal_title：Kidney international

authors： Kronenberg F,Schwaiger JP

更新日期：2017-03-01 00:00:00

abstract：:As the worldwide prevalence of end-stage renal disease increases it is important to evaluate the rate of living kidney donation in various countries; however there is no comprehensive global assessment of these rates. To measure this, we compiled data from representatives, renal registries, transplant networks, publis...

journal_title：Kidney international

authors： Horvat LD,Shariff SZ,Garg AX,Donor Nephrectomy Outcomes Research (DONOR) Network.

更新日期：2009-05-01 00:00:00

abstract：:We have studied acid-base balance in 32 patients attending the renal clinic of Mount Sinai Hospital. The parameters of acid-base balance measured included acid production measured as urinary sulfate and organic anions, net acid excretion measured as urinary ammonia plus titratable acid minus bicarbonate, and net GI ab...

journal_title：Kidney international

authors： Uribarri J,Douyon H,Oh MS

更新日期：1995-02-01 00:00:00

abstract：:The role of immunoglobulin (Ig) Fc-macrophage cell surface receptor affinity (macrophage Fc-affinity) in determining the mediation systems responsible for immune glomerular injury has been studied. Glomerular injury was initiated in rabbits by the passive administration of immunoglobulin preparations directed against ...

journal_title：Kidney international

authors： Boyce NW,Holdsworth SR

更新日期：1989-10-01 00:00:00

abstract：:Patients with chronic kidney disease have elevated circulating asymmetric dimethylarginine (ADMA). Recent studies have suggested that ADMA impairs endothelial nitric oxide synthase (eNOS) by effects other than competition with the substrate L-arginine. Here, we sought to identify the molecular mechanism by which incre...

journal_title：Kidney international

authors： Kajimoto H,Kai H,Aoki H,Yasuoka S,Anegawa T,Aoki Y,Ueda S,Okuda S,Imaizumi T

更新日期：2012-04-01 00:00:00

abstract：:Whole cerebral and isolated mitochondrial calcium levels were determined in normal and chronically uremic Sprague-Dawley rats. Uremia was induced by a two-stage 5/6 nephrectomy 4 weeks prior to study. Serum was obtained for urea, calcium, magnesium, phosphate, and i-PTH. Mitochondria were isolated by gradient centrifu...

journal_title：Kidney international

authors： Adler AJ,Berlyne GM

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Although atherosclerotic renovascular disease is increasingly recognized in chronic kidney disease, few national level studies have examined its clinical epidemiology. METHODS:Claims data from a 5% random sample of the United States Medicare population were used to select patients without atherosclerotic re...

journal_title：Kidney international

authors： Kalra PA,Guo H,Kausz AT,Gilbertson DT,Liu J,Chen SC,Ishani A,Collins AJ,Foley RN

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Mast cells are growth factor-rich, bone marrow-derived cells that infiltrate injured tissue where they have been implicated in the pathogenesis of progressive fibrosis. METHODS:Mast cell infiltration and the expression of related chemoattractants was examined following 5/6 nephrectomy, a model of progressiv...

journal_title：Kidney international

authors： Jones SE,Kelly DJ,Cox AJ,Zhang Y,Gow RM,Gilbert RE

更新日期：2003-09-01 00:00:00

abstract：:Early identification of kidney transplant recipients at risk of progressive allograft dysfunction may allow clinicians to provide closer monitoring and more aggressive risk factor modification. In this issue, Raynaud et al. presented a latent class model that clustered kidney transplant recipients into 8 risk categori...

journal_title：Kidney international

authors： Dinh A,McCulloch CE,Ku E

更新日期：2021-01-01 00:00:00

abstract：:We evaluated the contribution of intrarenal factors in the increased renal accumulation of bovine serum albumin (BSA) in chronic serum sickness (CSS). Renal transplantation was used to study 125I BSA uptake (single and paired label techniques) in normal and CSS kidneys exposed to the same immunologic milieu. In CSS, t...

journal_title：Kidney international

authors： Ward DM,Lee S,Wilson CB

更新日期：1986-11-01 00:00:00

abstract：:To date direct evidence for the presence of a H-K-ATPase in the medulla comes from proton and potassium transport studies performed on K-restricted animals and K dependent ATP hydrolysis and Rb uptake in both normal and K-depleted animals. The present work examines K-dependent acidification in the medulla of rabbits o...

journal_title：Kidney international

authors： Curran KA,Hebert MJ,Cain BD,Wingo CS

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Chronic allograft nephropathy (CAN) leads to chronic allograft dysfunction and loss. Regular renal transplant biopsies may be useful to find risk factors for CAN. METHODS:We carried out 688 protocol biopsies in 258 patients at 6, 12, and 26 weeks after renal transplantation. Patients with signs of CAN in th...

journal_title：Kidney international

authors： Schwarz A,Mengel M,Gwinner W,Radermacher J,Hiss M,Kreipe H,Haller H

更新日期：2005-01-01 00:00:00

abstract：:The purpose of these studies was to test the hypothesis that Randall's plaque develops in unique anatomical sites of the kidney and their formation is conditioned by specific stone-forming pathophysiologies. We performed intraoperative papillary biopsies from kidneys of idiopathic-calcium oxalate (CaOx), intestinal by...

journal_title：Kidney international

authors： Evan A,Lingeman J,Coe FL,Worcester E

更新日期：2006-04-01 00:00:00

abstract：:Segerer et al. report the expression and localization of macrophage and dendritic-cell markers in human renal biopsies and indicate that both cell types express CD68, findings that resonate with murine studies. The functional and phenotypic distinction between macrophages and dendritic cells is discussed. ...

journal_title：Kidney international

authors： Ferenbach D,Hughes J

更新日期：2008-07-01 00:00:00

abstract：:Autophagy is a conserved multistep pathway that degrades and recycles damaged organelles and macromolecules to maintain intracellular homeostasis. The autophagy pathway is upregulated under stress conditions including cell starvation, hypoxia, nutrient and growth-factor deprivation, endoplasmic reticulum stress, and o...

journal_title：Kidney international

authors： Kaushal GP,Shah SV

更新日期：2016-04-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is an inherited, progressive nephropathy accounting for 4-10% of end stage renal disease worldwide. PKD1 and PKD2 are the most common disease loci, but even accounting for other genetic causes, about 7% of families remain unresolved. Typically, these unsolved cases ...

journal_title：Kidney international

authors： Hopp K,Cornec-Le Gall E,Senum SR,Te Paske IBAW,Raj S,Lavu S,Baheti S,Edwards ME,Madsen CD,Heyer CM,Ong ACM,Bae KT,Fatica R,Steinman TI,Chapman AB,Gitomer B,Perrone RD,Rahbari-Oskoui FF,Torres VE,HALT Progression of

更新日期：2020-02-01 00:00:00

abstract：:Abnormalities of bone mineral metabolism and vascular calcification are prevalent in patients with kidney failure. Clinical management is based on biochemical targets, in particular parathyroid hormone (PTH) concentrations, but this has many limitations including high biological variation. A possible alternative is bo...

journal_title：Kidney international

authors： Sardiwal S,Gardham C,Coleman AE,Stevens PE,Delaney MP,Lamb EJ

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The National Kidney Foundation Dialysis Outcomes Quality Initiative (DOQI) clinical practice guidelines have suggested minimal weekly Kt/V urea and creatinine clearance goals for peritoneal dialysis patients maintained on continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD...

journal_title：Kidney international

authors： Juergensen PH,Murphy AL,Pherson KA,Kliger AS,Finkelstein FO

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Studies in animal models have shown that the alternative pathway of complement is activated in the kidney after ischemia/reperfusion. In addition, mice deficient in complement factor B, a necessary component of the alternative pathway, are protected from ischemic acute renal failure. The purpose of this stud...

journal_title：Kidney international

authors： Thurman JM,Lucia MS,Ljubanovic D,Holers VM

更新日期：2005-02-01 00:00:00

abstract：:To assess the comparative effects of hemodialysis with acetate versus bicarbonate base on left ventricular systolic function, we performed M-mode echocardiography on 36 patients prior to and immediately following 4-hr maintenance hemodialysis. Patients were initially dialyzed against either sodium acetate or sodium bi...

journal_title：Kidney international

authors： Ruder MA,Alpert MA,Van Stone J,Selmon MR,Kelly DL,Haynie JD,Perkins SK

更新日期：1985-05-01 00:00:00

abstract：:There are two fundamentally different growth responses for cells comprising the nephron: hyperplasia or hypertrophy. Cells that progress through the normal cell cycle double their DNA content and eventually divide during mitosis. Those cells that hypertrophy stop the growth process in the G1-phase of the cell cycle; w...

journal_title：Kidney international

authors： Wolf G

更新日期：1999-10-01 00:00:00

abstract：:The antiphospholipid syndrome is a common autoimmune disease caused by pathogenic antiphospholipid antibodies, leading to recurrent thrombosis and/or obstetrical complications. Importantly for nephrologists, antiphospholipid antibodies are associated with various renal manifestations including large renal vessel throm...

journal_title：Kidney international

authors： Bienaimé F,Legendre C,Terzi F,Canaud G

更新日期：2017-01-01 00:00:00