Abstract：
:Whole cerebral and isolated mitochondrial calcium levels were determined in normal and chronically uremic Sprague-Dawley rats. Uremia was induced by a two-stage 5/6 nephrectomy 4 weeks prior to study. Serum was obtained for urea, calcium, magnesium, phosphate, and i-PTH. Mitochondria were isolated by gradient centrifugation and calcium was determined by flameless atomic absorption spectrophotometry. The results demonstrate that mitochondrial calcium levels in uremic rats are not different from normal (8.0 +/- 2.8 vs. 7.8 +/- 1.8 nmoles/mg protein) despite an 11% increase in whole cerebral calcium concentration (17.3 +/- 2.0 vs. 15.5 +/- 2.8 nmoles/mg protein; P less than 0.005) in 24 severely uremic rats (BUN greater than 18.0 mmoles/liter). Multiple regression analysis demonstrates a significant positive correlation between cerebral calcium concentrations and both serum calcium (P less than 0.005) and serum magnesium levels (P less than 0.005). No relationship was found for urea, serum phosphate, or i-PTH. Similar analysis of mitochondrial calcium concentration demonstrated a significant positive correlation with serum calcium (P less than 0.005) and i-PTH (P less than 0.05) suggesting that increased PTH may be necessary for maintaining normal intracellular calcium levels in uremia. We conclude that uremia in the rat is associated with a small rise in whole cerebral calcium but that intracellular calcium as reflected by mitochondrial levels is not elevated.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Adler AJ,Berlyne GMdoi
10.1038/ki.1985.42subject
Has Abstractpub_date
1985-03-01 00:00:00pages
523-9issue
3eissn
0085-2538issn
1523-1755pii
S0085-2538(15)33389-5journal_volume
27pub_type
杂志文章abstract：:Acid (H+) retention appears to contribute to progressive decline in glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD), including some patients without metabolic acidosis. Identification of patients with H+ retention but without metabolic acidosis could facilitate targeted alkali therapy; h...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.11.033
更新日期：2019-05-01 00:00:00
abstract：:In his hypothesis of the evolution of renal functions Homer Smith proposed that the formation of glomerular nephron and body armor had been adequate for the appearance of primitive vertebrates in fresh water and that the adaptation of homoiotherms to terrestrial life was accompanied by the appearance of the loop of He...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.1996.220
更新日期：1996-06-01 00:00:00
abstract：:The use of the immuno-suppressant cyclosporine A (CsA) after transplantation has been associated with less favorable plasma lipid profiles, which may contribute to the high incidence of cardiovascular morbidity and mortality in transplant recipients. Recent studies have suggested that oxidative modification of LDL pla...
journal_title：Kidney international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/ki.1997.221
更新日期：1997-05-01 00:00:00
abstract：:Cells from RCCT-28A cell line, which exhibited the highest peanut-lectin binding capacity [RCCT-28A(P+)] were separated and cultured attempting to obtain a population of HCO3- secreting cells. The mechanisms of apical solution acid or base extrusion were studied in confluent monolayers. In RCCT-28A (P+) cells net H+ f...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1993.30
更新日期：1993-01-01 00:00:00
abstract：:The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. We have shown that the interaction of VDRs with VDREs is inhibited by uremic toxins. We hypothesize that uremic toxins form Schiff bases with the lysine re...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.469
更新日期：1996-11-01 00:00:00
abstract：:Prior studies showed conflicting results regarding the association between 25-hydroxyvitamin D (25(OH)D) levels and mineral metabolism in end-stage renal disease. In order to determine whether the bioavailable vitamin D (that fraction not bound to vitamin D-binding protein) associates more strongly with measures of mi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.19
更新日期：2012-07-01 00:00:00
abstract：:Aminopeptidase A is one of the most potent enzymes within the renin-angiotensin system in terms of angiotensin II degradation. Here, we examined whether there is a kidney phenotype and any compensatory changes in other renin angiotensin system enzymes involved in the metabolism of angiotensin II associated with aminop...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.11.012
更新日期：2020-12-11 00:00:00
abstract：:The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we inves...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002090
更新日期：2007-03-01 00:00:00
abstract：:One reason for the inadequacy of current renoprotective therapy and the persistent poor renal prognosis in diabetic nephropathy is the large interindividual variation in response to treatment. Genetic as well as non-genetic factors are known to influence treatment efficacy. This Commentary summarizes the impact of the...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5000283
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Current renal substitution therapy for acute or chronic renal failure with hemodialysis or hemofiltration is life sustaining, but continues to have unacceptably high morbidity and mortality rates. This therapy is not complete renal replacement therapy because it does not provide active transport nor metaboli...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1999.00486.x
更新日期：1999-06-01 00:00:00
abstract：:We examined the effect of daily cyclosporin A administration on the development and extent of tubulointerstitial nephritis produced in rats immunized with tubular basement membranes in adjuvant. Six mg/kg/day of cyclosporin A, given from the time of immunization, completely blocked the development of interstitial lesi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1988.119
更新日期：1988-06-01 00:00:00
abstract：:Previous studies have shown that nonsteroidal anti-inflammatory drug (NSAID) use might be associated with a lower risk of developing cancer in the general population. Patients on dialysis have increased risk for cancer, but there are no studies to determine the relationship between NSAID use and cancer risk in these p...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2013.79
更新日期：2013-07-01 00:00:00
abstract：:Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received increasing attention as a therapeutic target in a variety of diseases because they serve as key regulatory hubs uniquely situated at crossroads be...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2017.05.034
更新日期：2017-11-01 00:00:00
abstract：:Development of physiologically relevant cellular models with strong translatability to human pathophysiology is critical for identification and validation of novel therapeutic targets. Herein we describe a detailed protocol for generation of an advanced 3-dimensional kidney cellular model using induced pluripotent ste...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.05.003
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Normal human podocytes are terminally differentiated and quiescent cells. It is not known why podocytes fail to proliferate in response to most forms of injury. Proliferation is regulated by cell cycle proteins and their inhibitors. The Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors (p21, p27, p5...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00213.x
更新日期：2000-08-01 00:00:00
abstract：:The involvement of cysteinyl leukotrienes (LT) in the etiology of glomerulonephritis (GN) was investigated in a rat model of nephrotoxic serum nephritis in which renal function, morphology, LTC4 synthase activity and urinary cysteinyl LT excretion were monitored over seven days. Significant alterations in renal functi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1994.401
更新日期：1994-11-01 00:00:00
abstract：:NO, a simple molecule synthesized from L-arginine by NO synthases, has been identified to play an important role in cell communication, cell defense and cell injury. The half life of NO is very short because NO either reacts with superoxide anion (O2-), and/or binds to heme molecules or Fe-S groups present in proteins...
journal_title：Kidney international
pub_type： 社论,评审
doi：10.1038/ki.1995.262
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Intrauterine growth retardation (IUGR) is associated with higher morbidity and mortality not only in perinatal life but also in later life. The purpose of our study was to determine whether IUGR has any effect on the course of minimal change nephrotic syndrome (MCNS) in children. METHODS:Forty children who ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1998.00121.x
更新日期：1998-10-01 00:00:00
abstract：:Spontaneous polycystic kidney and liver disease in an inbred herd of Springbok (Antidorcas marsupialis) was studied by light microscopy, transmission electron microscopy, and microdissection. Springbok are a small species of gazelle of the family Bovidae native to South Africa. Since 1976, 18% of all live calves born ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1982.146
更新日期：1982-08-01 00:00:00
abstract：:The erythropoietin analogs have been an important advance for the treatment of the anemia of kidney disease, resulting in reduced need for blood transfusion and improved quality of life. Recent studies, however, have indicated risks associated with targeting higher levels of hemoglobin (Hb). As a result, in March 2007...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5002401
更新日期：2007-10-01 00:00:00
abstract：:Inflammation is the immune system's response to infectious or noninfectious sources of danger. Danger recognition is facilitated by various innate immune receptor families including the Toll-like receptors (TLRs), which detect danger signals in extracellular and intracellular compartments. It is an evolving concept th...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.2010.111
更新日期：2010-07-01 00:00:00
abstract：:It is no a secret that we are confronted by an alarmingly increasing number of patients with progressive renal disease. There is ample evidence for the notion that angiotensin II (Ang II) is a major culprit in progression. The vasopeptide Ang II turned out to have also multiple nonhemodynamic pathophysiologic actions ...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1111/j.1523-1755.2005.00145.x
更新日期：2005-03-01 00:00:00
abstract：:Low nephron number has been related to low birth weight and hypertension. In the southeastern United States, the estimated prevalence of chronic kidney disease due to hypertension is five times greater for African Americans than white subjects. This study investigates the relationships between total glomerular number ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000041
更新日期：2006-02-01 00:00:00
abstract：:Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4+ plasma cell-rich infiltrate, akin to the pan...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2010.342
更新日期：2010-11-01 00:00:00
abstract：:Multiple microRNAs (miRs) are implicated in muscle cell differentiation and muscle mass regulation. Pharmacological agents targeting miR-486 and other miRs, involved in muscle mass regulation, could potentially be developed into therapeutic agents for muscle wasting. Muscle wasting is prevalent among patients with chr...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2012.150
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Chronic inflammation and oxidative stress are highly prevalent in patients with chronic kidney disease and end-stage renal disease (ESRD). These conditions contribute to high mortality rates associated with cardiovascular disease, the leading cause of death in this patient population. To our knowledge, no pr...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00656.x
更新日期：2004-06-01 00:00:00
abstract：:The effect of the tricarboxylic acid (TCA) cycle precursor, pyruvate, on glutamine metabolism by isolated renal cortical mitochondria was assessed by quantitating its key nitrogen and carbon metabolites. When mitochondria from normal rats were incubated at pH 7.4, pyruvate (2 mM) inhibited ammonia production by almost...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1982.166
更新日期：1982-09-01 00:00:00
abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 (TWEAK-Fn14), are widely expressed and are involved in both injury and repair. Hotta et al. now demonstrate an important role for Fn14 in the common clamp ischemia model of acute kidney injury. Their da...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2010.435
更新日期：2011-01-01 00:00:00
abstract：:We examined the process of receptor-mediated endocytosis in A-9 lung fibroblast and chinese hamster ovary (CHO) cells transfected with the recently cloned vasopressin V1a receptor (51). We used a fluorescent labeled vasopressin analog (rhodamine-mercaptopropionic acid lysine vasopressin) and radiolabeled vasopressin t...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1993.119
更新日期：1993-04-01 00:00:00
abstract：:IgA nephropathy (IgAN) is the most prevalent primary chronic glomerular disease for which no safe disease-specific therapies currently exist. IgAN is an autoimmune disease involving the production of autoantigenic, aberrantly O-glycosylated IgA1 and ensuing deposition of nephritogenic immune complexes in the kidney. A...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2019.01.031
更新日期：2019-07-01 00:00:00
