当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition.

Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition.

Abstract：

:We examined the potential of in vivo linkage of plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) in the setting of endothelial injury and sclerosis following radiation injury in the rat. PAI-1 is a major physiological inhibitor of the plasminogen activator (PA)/plasmin system, a key regulator of fibrinolysis and extracellular matrix (ECM) turnover. PAI-1 mRNA expression in the kidney was markedly increased (9-fold) at 12 weeks after irradiation (P < 1.001 vs. normal control). In situ hybridization revealed significant association of PAI-1 expression with sites of glomerular injury (signal intensity in injured vs. intact glomeruli, P < 0.001). Angiotensin converting enzyme inhibitors (ACEI, captopril or enalapril) or angiotensin II receptor antagonist (AIIRA, L158,809) markedly reduced glomerular lesions (thrombosis, mesangiolysis, and sclerosis; sclerosis index, 0 to 4+ scale, 0.49 +/- 0.20 in untreated vs. 0.05 +/- 0.02, 0.02 +/- 0.01, 0.04 +/- 0.02 in captopril, enalapril and AIIRA, respectively, all P < 0.01 vs untreated). Further, ACEI and AIIRA markedly attenuated increased PAI-1 mRNA expression in the irradiated kidney (36, 19 and 20% expression, respectively, for captopril, enalapril and AIIRA, compared to untreated irradiated kidney, P < 0.05, < 0.01, < 0.01). This effect was selective in that neither tissue-type nor urokinase-type PA mRNA expression was affected by these interventions. Thus, we speculate that inhibition of the renin-angiotensin system may ameliorate injury following radiation by accelerating fibrinolysis and ECM degradation, at least in part, via suppression of PAI-1 expression. In summary, inhibition of Ang II, in addition to its known effects on vascular sclerosis, may also by its novel effect to inhibit PAI-1, lessen fibrosis following endothelial/thrombotic injury.

journal_name

Kidney Int

journal_title

Kidney international

authors

Oikawa T,Freeman M,Lo W,Vaughan DE,Fogo A

doi

10.1038/ki.1997.20

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

164-72

issue

1

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)59852-9

journal_volume

51

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Analysis of renal tubular electrolyte transporter genes in seven patients with hypokalemic metabolic alkalosis.

    abstract：BACKGROUND:Disorders that manifest hypokalemic metabolic alkalosis, such as Bartter's syndrome and Gitelman's syndrome, are caused by the malfunction of renal tubular electrolyte transporters. Bartter's syndrome may be linked to dysfunction of Na-K-2Cl cotransporter (NKCC2), renal outer medullary K channel (ROMK), or C...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00163.x

    authors： Fukuyama S,Okudaira S,Yamazato S,Yamazato M,Ohta T

    更新日期：2003-09-01 00:00:00

  • Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican.

    abstract：BACKGROUND:Among the members of the small leucine-rich proteoglycan family, decorin, biglycan, and fibromodulin have been proposed to be potent modulators of transforming growth factor-beta (TGF-beta) activity, thereby playing an important role in the pathogenesis of fibrotic kidney diseases. Furthermore, decorin expre...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00317.x

    authors： Schaefer L,Gröne HJ,Raslik I,Robenek H,Ugorcakova J,Budny S,Schaefer RM,Kresse H

    更新日期：2000-10-01 00:00:00

  • Dysregulation of cytokine expression in tubulointerstitial nephritis associated with murine malaria.

    abstract：:We examined the circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 alpha, IL-6, granulocyte macrophage-colony stimulating factor (GM-CSF), and the anti-inflammatory cytokine IL-10, and their expression in kidneys acutely infected with murine malaria parasite...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.1998.00848.x

    authors： Rui-Mei L,Kara AU,Sinniah R

    更新日期：1998-04-01 00:00:00

  • Predominant synthesis of IgA with lambda light chain in IgA nephropathy.

    abstract：:The nature of the light chains in mesangial IgA deposits and serum IgA was studied in patients with IgA nephropathy. Immunofluorescence (IF) studies using murine monoclonal antibodies, rabbit and goat anti-human monospecific antisera were performed in kidney sections from 15 IgA nephritic patients with only IgA isotyp...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.37

    authors： Lai KN,Chui SH,Lai FM,Lam CW

    更新日期：1988-02-01 00:00:00

  • Progranulin protects against renal ischemia/reperfusion injury in mice.

    abstract：:Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory function of PGRN in rheumatoid arthritis encouraged us to examine the role of PGRN in acute kidney injury (AKI). We found that levels ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.403

    authors： Zhou M,Tang W,Fu Y,Xu X,Wang Z,Lu Y,Liu F,Yang X,Wei X,Zhang Y,Liu J,Geng X,Zhang C,Wan Q,Li N,Yi F

    更新日期：2015-05-01 00:00:00

  • Thrombomodulin ameliorates transforming growth factor-β1-mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway.

    abstract：:Kidney fibrosis is the common consequence of chronic kidney diseases that inexorably progresses to end-stage kidney disease with organ failure treatable only with replacement therapy. Since transforming growth factor-β1 is the main player in the pathogenesis of kidney fibrosis, we posed the hypothesis that recombinant...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.05.041

    authors： Takeshita A,Yasuma T,Nishihama K,D'Alessandro-Gabazza CN,Toda M,Totoki T,Okano Y,Uchida A,Inoue R,Qin L,Wang S,D'Alessandro VF,Kobayashi T,Takei Y,Mizoguchi A,Yano Y,Gabazza EC

    更新日期：2020-11-01 00:00:00

  • Effects of 1,25(OH)2D3 in experimental mesangial proliferative nephritis in rats.

    abstract：BACKGROUND:1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D3, is a potent immunomodulatory agent on several cell types such as monocytes and mesangial cells. Recruitment of inflammatory cells, as well as stimulation of resident cells and mesangial matrix accumulation are key features of various expe...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00775.x

    authors： Panichi V,Migliori M,Taccola D,Filippi C,De Nisco L,Giovannini L,Palla R,Tetta C,Camussi G

    更新日期：2001-07-01 00:00:00

  • TNF-alpha--accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism.

    abstract：BACKGROUND:Tumor necrosis factor (TNF)-alpha rapidly primes neutrophils (PMN) for an anti-neutrophil cytoplasmic antibody (ANCA)-induced respiratory burst and is thus proinflammatory. TNF-alpha also progressively accelerates apoptosis. We investigated the effect of TNF-alpha-mediated apoptosis on ANCA antigen expressio...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00161.x

    authors： Kettritz R,Scheumann J,Xu Y,Luft FC,Haller H

    更新日期：2002-02-01 00:00:00

  • Cognitive function before and after dialysis initiation in adults with chronic kidney disease-a new perspective on an old problem?

    abstract：:The impact of dialysis on cognitive trends is uncertain. Kurella Tamura et al. evaluated cognitive trajectories in 212 participants from the Chronic Renal Insufficiency Cohort study and found that dialysis initiation was associated with a decline in executive function. This is consistent with a cerebrovascular basis f...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2017.01.022

    authors： Iyasere O,Brown EA

    更新日期：2017-04-01 00:00:00

  • Amylin deposition in the kidney of patients with diabetic nephropathy.

    abstract：:Amylin (islet amyloid peptide) plays a critical role in islet amyloidosis and in the development of beta-cell dysfunction in patients with diabetes; however, the involvement of amylin in renal amyloidosis has not been studied. For this reason, we surveyed 149 patients with biopsy-proven diabetic nephropathy (DN). The ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002305

    authors： Gong W,Liu ZH,Zeng CH,Peng A,Chen HP,Zhou H,Li LS

    更新日期：2007-07-01 00:00:00

  • ANCA in anti-GBM disease: moving beyond a one-dimensional clinical phenotype.

    abstract：:McAdoo et al. propose that patients with both circulating antiglomerular basement membrane antibody and antineutrophil cytoplasm antibody demonstrate a phenotype that lies between that of single-positive antiglomerular basement membrane disease and antineutrophil cytoplasm antibody-associated vasculitis. Specifically,...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2017.04.024

    authors： Canney M,Little MA

    更新日期：2017-09-01 00:00:00

  • What is the place of peritoneal dialysis in the integrated treatment of renal failure?

    abstract：:The role of peritoneal dialysis (PD) in renal replacement therapy (RRT) remains unclear. There are no controlled trials to provide hard evidence of its efficacy. Comparative studies with haemodialysis from different centres and countries have given conflicting results even when allowing for case mix. Data from the Uni...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.1998.00183.x

    authors： Coles GA,Williams JD

    更新日期：1998-12-01 00:00:00

  • TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells.

    abstract：BACKGROUND:Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (M...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00900.x

    authors： Nee LE,McMorrow T,Campbell E,Slattery C,Ryan MP

    更新日期：2004-10-01 00:00:00

  • Selective antagonism of the AT1 receptor inhibits angiotensin II stimulated DNA and protein synthesis in primary cultures of human proximal tubular cells.

    abstract：:The hypertrophy of renal proximal tubular cells occurs as an adaptive response to a variety of stimuli and may be involved with the progression of renal disease. Angiotensin II acting alone or in combination with other growth factors has been implicated in this process. The aims of this study were to identify the role...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.385

    authors： Chatterjee PK,Weerackody RP,Mistry SK,Hawksworth GM,McLay JS

    更新日期：1997-09-01 00:00:00

  • Vascular function of the peripheral circulation in patients with nephrosis.

    abstract：BACKGROUND:Nephrotic syndrome is associated with abnormal lipoprotein metabolism and increased risk of coronary heart disease. Endothelial dysfunction, an early phase of atherogenesis that manifests as impaired flow-mediated dilation (FMD) of the peripheral circulation, may link these associations. METHODS:We examined...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00785.x

    authors： Watts GF,Herrmann S,Dogra GK,Playford DA,Best JD,Thomas MA,Irish A

    更新日期：2001-07-01 00:00:00

  • Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.

    abstract：:Progressive kidney fibrosis precedes end-stage renal failure in up to a third of patients with diabetes mellitus. Elevated intra-renal transforming growth factor-beta (TGF-beta) is thought to underlie disease progression by promoting deposition of extracellular matrix and epithelial-mesenchymal transition. GW788388 is...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002717

    authors： Petersen M,Thorikay M,Deckers M,van Dinther M,Grygielko ET,Gellibert F,de Gouville AC,Huet S,ten Dijke P,Laping NJ

    更新日期：2008-03-01 00:00:00

  • Role of excess volume in the pathophysiology of hypertension in chronic kidney disease.

    abstract：BACKGROUND:The pathophysiology of hypertension in patients with chronic kidney disease (CKD) is largely attributed to positive sodium balance. It is unclear how loop diuretics affect fluid volume compartments, especially with respect to their antihypertensive effect. METHODS:Subjects with CKD were administered a singl...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1523-1755.2003.00273.x

    authors： Vasavada N,Agarwal R

    更新日期：2003-11-01 00:00:00

  • Endothelial cell adhesion molecule and PMNL response to inflammatory stimuli and AGE-modified fibronectin.

    abstract：BACKGROUND:Atherosclerotic vascular disease is the leading cause of death in patients with diabetes mellitus and end-stage renal disease. Advanced glycation end products (AGEs) are strongly suggested to be involved in the pathogenesis of atherosclerosis in these patients who also frequently experience infectious compli...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00157.x

    authors： Sengoelge G,Födinger M,Skoupy S,Ferrara I,Zangerle C,Rogy M,Hörl WH,Sunder-Plassmann G,Menzel J

    更新日期：1998-11-01 00:00:00

  • Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response.

    abstract：:The generation of reactive oxygen species has a pivotal role in both acute and chronic glomerular injuries in patients with lupus nephritis. As the transcription factor Nrf2 is a major regulator of the antioxidant response and is a primary cellular defense mechanism, we sought to determine a role of Nrf2 in the progre...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.343

    authors： Jiang T,Tian F,Zheng H,Whitman SA,Lin Y,Zhang Z,Zhang N,Zhang DD

    更新日期：2014-02-01 00:00:00

  • Stimulation of renin secretion by non-diuretic sulfhydryl reagents.

    abstract：:Organomercurial diuretics stimulate renin secretion although the underlying cellular mechanisms remain undefined. Since organomercurials are also known to react with sulfhydryl groups, the present studies determined the effects of sulfhydryl reagents on renin secretion. The effects of the non-diuretic mercurial agent,...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.57

    authors： Lee DY,Cho KW,Lee JS,Honeyman TW,Park CS

    更新日期：1989-03-01 00:00:00

  • Osteoblastic intracellular pH and calcium in metabolic and respiratory acidosis.

    abstract：:In vitro metabolic acidosis (Met) induces greater bone mineral resorption than respiratory acidosis (Resp). Met, but not Resp, inhibits osteoblasts which control many aspects of osteoclastic function. To determine whether at a similar decrement in extracellular pH, Met and Resp would induce different changes in intrac...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.247

    authors： Ori Y,Lee SG,Krieger NS,Bushinsky DA

    更新日期：1995-06-01 00:00:00

  • Metabolic acidosis inhibits soft tissue calcification in uremic rats.

    abstract：:Metabolic acidosis is common in patients with chronic kidney disease, which is known to affect bone metabolism. We examined the effect of metabolic acidosis on the development of vascular and other soft-tissue calcifications in uremic rats treated with calcitriol. Extraskeletal calcification was measured in vivo, in c...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002646

    authors： Mendoza FJ,Lopez I,Montes de Oca A,Perez J,Rodriguez M,Aguilera-Tejero E

    更新日期：2008-02-01 00:00:00

  • Coronary artery stenosis: a new risk factor for chronic kidney injury?

    abstract：:Coronary artery stenosis induces renal inflammation and kidney injury in pigs even in the absence of myocardial infarction or clinically significant heart failure. This effect is aggravated by experimentally induced renovascular hypertension. Interestingly, oxidative stress originating from the ischemic myocardium was...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2014.431

    authors： Rump LC,Stegbauer J

    更新日期：2015-04-01 00:00:00

  • Acute renal failure independently predicts mortality after myeloablative allogeneic hematopoietic cell transplant.

    abstract：BACKGROUND:Patients undergoing myeloablative allogeneic hematopoietic cell transplantation (HCT) have a high incidence of acute renal failure (ARF). However, it is unclear if ARF is independently associated with mortality after this procedure. METHODS:We performed meta-analysis of published reports on ARF after myeloa...

    journal_title：Kidney international

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1523-1755.2005.00301.x

    authors： Parikh CR,McSweeney P,Schrier RW

    更新日期：2005-05-01 00:00:00

  • Classical pathway of complement activation in normal and diseased human glomeruli.

    abstract：:Monoclonal antibodies (mAb) reactive against complement components involved in the classical activation pathway were applied in an indirect immunoperoxidase technique for the histological study of normal and diseased human renal tissues. Prominent staining with antibodies against the C4d fragment was seen in all glome...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.302

    authors： Zwirner J,Felber E,Herzog V,Riethmüller G,Feucht HE

    更新日期：1989-12-01 00:00:00

  • Tunneled catheters' outcome optimization among diabetics on dialysis through antibiotic-lock placement.

    abstract：:Efficacy and safety of antibiotic 'locks', in prevention of thrombotic and infectious complication-related morbidity and mortality, among diabetics dialyzed through tunneled-cuffed catheters (TCCs) has not been effectively investigated. This trial was designed to investigate the outcome of TCCs (n = 109), inserted amo...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/sj.ki.5001776

    authors： Saxena AK,Panhotra BR,Sundaram DS,Al-Hafiz A,Naguib M,Venkateshappa CK,Abu-Oun BA,Hussain SM,Al-Ghamdi AA

    更新日期：2006-11-01 00:00:00

  • Diverse diuretics regimens differentially enhance the antialbuminuric effect of renin-angiotensin blockers in patients with chronic kidney disease.

    abstract：:The addition of spironolactone or hydrochlorothiazide enhances the antialbuminuric effect of renin-angiotensin blockers. However, comparative studies on the effect of different diuretics are lacking. We conducted a prospective randomized crossover study to compare the effects of spironolactone (25 mg/day), hydrochloro...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.249

    authors： Morales E,Caro J,Gutierrez E,Sevillano A,Auñón P,Fernandez C,Praga M

    更新日期：2015-12-01 00:00:00

  • Starting dialysis at eGFR >5 ml/min per1.73 m(2): are we barking up the wrong tree?

    abstract：:Although the goal glomerular filtration rate (GFR) for chronic dialysis initiation is currently above 5 ml/min per 1.73 m(2), there is no convincing evidence that patients will benefit from this approach. With close follow-up of advanced chronic kidney disease patients, aiming to start dialysis at an estimated GFR (eG...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2014.164

    authors： Rosansky SJ,Durkin MW

    更新日期：2014-10-01 00:00:00

  • Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis.

    abstract：UNLABELLED:Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis. BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis, tubular dropout, and loss of cellularity in areas of fibrosis. Apoptosis was found to play a role in CsA-induced f...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00794.x

    authors： Shihab FS,Andoh TF,Tanner AM,Yi H,Bennett WM

    更新日期：1999-12-01 00:00:00

  • Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease.

    abstract：:Neutrophil gelatinase-associated lipocalin (Ngal) is a biomarker for acute and chronic renal injuries, including polycystic kidney disease (PKD). However, the effect of Ngal on PKD progression remains unexplored. To study this, we generated 3 strains of mice with different expression levels of Ngal within an establish...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.09.005

    authors： Wang E,Chiou YY,Jeng WY,Lin HK,Lin HH,Chin HJ,Leo Wang CK,Yu SS,Tsai SC,Chiang CY,Cheng PH,Lin HJ,Jiang ST,Chiu ST,Hsieh-Li HM

    更新日期：2017-02-01 00:00:00