Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.

abstract：:Stimulation of proximal tubule cell (PTC) growth in a variety of physiological and pathological renal conditions is preceded by increased renal production of transforming growth factor-beta 1 (TGF-beta 1) and by augmented tubular sodium transport via activated sodium hydrogen exchange (NHE). Since TGF-beta 1 has been ...

journal_title：Kidney international

authors： Johnson DW,Saunders HJ,Brew BK,Poronnik P,Cook DI,Field MJ,Pollock CA

更新日期：1998-06-01 00:00:00

abstract：:Patients with chronic kidney disease have elevated circulating asymmetric dimethylarginine (ADMA). Recent studies have suggested that ADMA impairs endothelial nitric oxide synthase (eNOS) by effects other than competition with the substrate L-arginine. Here, we sought to identify the molecular mechanism by which incre...

journal_title：Kidney international

authors： Kajimoto H,Kai H,Aoki H,Yasuoka S,Anegawa T,Aoki Y,Ueda S,Okuda S,Imaizumi T

更新日期：2012-04-01 00:00:00

abstract：:Unilateral progressive Masugi nephritis was produced in rabbits and studied by microangiography as well as light and immunofluorescence microscopy. The following five groups were studied: Group 1. Heparin was started simultaneously with nephrotoxic serum (NTS) and was given for one week. The animals were then sacrific...

journal_title：Kidney international

authors： Nakamoto Y,Dohi K,Fujike H,Yuri T,Shinoda A,Takeuchi J

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:In a prior study the 21-aminosteroid (lazaroid) U74389F provided in vivo protection from oxidative stress when used as a preventive therapy in ischemia-reperfusion injury in the kidney. As the cell membrane is the principal site for lipoperoxidation, in the current study the very lipophilic 2-methylaminochro...

journal_title：Kidney international

authors： De Vecchi E,Lubatti L,Beretta C,Ferrero S,Rinaldi P,Galli Kienle M,Trazzi R,Paroni R

更新日期：1998-09-01 00:00:00

abstract：:Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell survival and reaction to oxidative stress. As oxidative stress is increased in uremia and is associated with vascular calcification, we studied the role of autophagy in vascular calcification induced by phosphate. In an in vitro...

journal_title：Kidney international

authors： Dai XY,Zhao MM,Cai Y,Guan QC,Zhao Y,Guan Y,Kong W,Zhu WG,Xu MJ,Wang X

更新日期：2013-06-01 00:00:00

abstract：:The high serum fibroblast growth factor 23 (FGF23) levels in patients with acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with increased morbidity and mortality. Mice with folic acid-induced AKI had an increase in bone FGF23 mRNA expression together with an increase in serum FGF23 and severa...

journal_title：Kidney international

authors： Durlacher-Betzer K,Hassan A,Levi R,Axelrod J,Silver J,Naveh-Many T

更新日期：2018-08-01 00:00:00

abstract：:In adults on chronic hemodialysis, achieving a hemoglobin concentration of 12g/dl and above with erythropoiesis stimulating agents leads to increased cardiovascular events and mortality, but this may not be true in children. Therefore, we conducted a retrospective cohort study of pediatric patients (under 18) from the...

journal_title：Kidney international

authors： Rheault MN,Molony JT,Nevins T,Herzog CA,Chavers BM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Disorders that manifest hypokalemic metabolic alkalosis, such as Bartter's syndrome and Gitelman's syndrome, are caused by the malfunction of renal tubular electrolyte transporters. Bartter's syndrome may be linked to dysfunction of Na-K-2Cl cotransporter (NKCC2), renal outer medullary K channel (ROMK), or C...

journal_title：Kidney international

authors： Fukuyama S,Okudaira S,Yamazato S,Yamazato M,Ohta T

更新日期：2003-09-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

journal_title：Kidney international

authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

更新日期：2016-07-01 00:00:00

abstract：:Extracellular fluid volume expansion is known to produce exaggerated natriuresis in essential hypertension. In order to assess the role of hemodynamic and intrarenal physical factors upon natriuretic response to central volume expansion, two hour water immersion (WI) experiments were made in six uncomplicated essentia...

journal_title：Kidney international

authors： Coruzzi P,Musiari L,Biggi A,Ravanetti C,Vallisa D,Montanari A,Novarini A

更新日期：1988-04-01 00:00:00

abstract：:Renal dysfunction is a common and serious complication in multiple myeloma (MM) patients. Renal proximal tubule injury is characteristic in MM, and may result in disturbed renal handling of various vitamins. The abnormal excretion of vitamins in urine may result in their low serum levels. The goal of this study was to...

journal_title：Kidney international

authors： Gavrilov V,Yermiahu T,Gorodischer R

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Familial nephrotic syndrome (NS) has both autosomal dominant and recessive forms of inheritance. Recent studies in families with an autosomal dominant form of focal segmental glomerulosclerosis (FSGS) have been at odds concerning linkage to chromosome 19q13 (Mathis et al, Kidney Int 53:282-286, 1998; Winn et...

journal_title：Kidney international

authors： Vats A,Nayak A,Ellis D,Randhawa PS,Finegold DN,Levinson KL,Ferrell RE

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:IgA nephropathy is the most common glomerular disease. Mechanisms leading to its occurrence and controlling the evolution of the disease remain largely unknown. Various genetic factors have been found, mostly implicating immunologically relevant genes (IgH, TCR, human lymphocyte antigen, and complement loci)...

journal_title：Kidney international

authors： Aupetit C,Drouet M,Pinaud E,Denizot Y,Aldigier JC,Bridoux F,Cogné M

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Podocytes are highly differentiated glomerular epithelial cells with limited potential to divide. They are responsible for maintaining and supporting the glomerular basement membrane so as to facilitate efficient filtration. The hypothesis tested was whether the development of glomerulosclerosis in the purom...

journal_title：Kidney international

authors： Kim YH,Goyal M,Kurnit D,Wharram B,Wiggins J,Holzman L,Kershaw D,Wiggins R

更新日期：2001-09-01 00:00:00

abstract：:For reasons that are not well understood, Aboriginal people with end-stage renal disease (ESRD) have lower rates of kidney transplantation. We hypothesized that distance between residence location and the closest transplant center was greater in Aboriginal dialysis patients and would partially explain the lower rate o...

journal_title：Kidney international

authors： Tonelli M,Hemmelgarn B,Kim AK,Bertazzon S,Klarenbach S,Manns B,Wiebe N,Culleton B,Gill JS,Alberta Kidney Disease Network.

更新日期：2006-09-01 00:00:00

abstract：:An open, randomized trial study on the therapeutic effect of recombinant alpha-interferon (IFN alpha) in 40 patients with hepatitis B virus membranous nephropathy (HBVMN) was conducted. All were pathologically proven to have HBVMN which showed no response to corticosteroid treatment represented by persistent heavy pro...

journal_title：Kidney international

authors： Lin CY

更新日期：1995-01-01 00:00:00

abstract：:Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein markers of renal dysfunction and structural injury. We studied methods for collection, storage, and preservation of urinary exosomal proteins. We collected urine fro...

journal_title：Kidney international

authors： Zhou H,Yuen PS,Pisitkun T,Gonzales PA,Yasuda H,Dear JW,Gross P,Knepper MA,Star RA

更新日期：2006-04-01 00:00:00

abstract：:Intrarenal artery infusions of hypertonic saline can activate tubuloglomerular feedback (TGF), decreasing renal blood flow (RBF) and glomerular filtration rate (GFR). The response to infusion of hypertonic saline is enhanced by salt depletion and attenuated by salt loading, but has not previously been investigated in ...

journal_title：Kidney international

authors： Heidemann HT,Jackson EK,Gerkens JF,Branch RA

更新日期：1987-10-01 00:00:00

abstract：:Previous work has documented an acceleration of proteolysis and branched-chain amino acid oxidation when muscles from rats with chronic metabolic acidosis were incubated in vitro. The present study examines the impact of chronic metabolic acidosis on whole body amino acid turnover and oxidation in chronically catheter...

journal_title：Kidney international

authors： May RC,Masud T,Logue B,Bailey J,England B

更新日期：1992-06-01 00:00:00

abstract：:The present experiments were performed to examine the effect of variation in protein intake on renal function and morphology in the non-clipped kidneys of Goldblatt hypertensive rats. After renal artery clipping, rats were put on diets containing 5 (LP), 17.5 (NP), or 51% (HP) protein. After 4 to 5 weeks, all rats had...

journal_title：Kidney international

authors： Schnermann J,Gokel M,Weber PC,Schubert G,Briggs JP

更新日期：1986-02-01 00:00:00

abstract：:Loss of hypoxic vasodilation has been proposed as a causative factor in the development of hypertension in dialysis patients treated with recombinant human erythropoietin (rHuEPO). Venous occlusion plethysmography was therefore performed on 22 dialysis patients (aged 23 to 71 years, dialysis duration 6 to 260 months, ...

journal_title：Kidney international

authors： Roger SD,Grasty MS,Baker LR,Raine AE

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:It has been shown that non-congenic mice strains with lower levels of renal meprin develop less renal injury following renal ischemia and reperfusion. We have demonstrated that following ischemia-reperfusion renal injury, there is a rapid shift of meprin localization and intensity from the brush border to th...

journal_title：Kidney international

authors： Carmago S,Shah SV,Walker PD

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Macrophages have been regarded as "blackguards" in the generation of glomerular injury. However, it is still unclear what kind of cellular machinery is responsible for their pathogenic actions. To explore this issue, this investigation aims at developing a novel strategy using adoptive transfer of "loss-of-f...

journal_title：Kidney international

authors： Kitamura M

更新日期：2000-02-01 00:00:00

abstract：:The homocysteine hypothesis states that circulating homocysteine is a vascular toxin in concentrations that occur in the general population and in renal failure. This hypothesis is currently being tested in the Kidney and End State Renal Disease Study (HOST), but data have emerged since the HOST began that suggest its...

journal_title：Kidney international

authors： Hoffer LJ

更新日期：2006-05-01 00:00:00

abstract：:Insulin and growth factors activate the phosphatidylinositide-3-kinase pathway, leading to stimulation of several kinases including serum- and glucocorticoid-inducible kinase isoform SGK3, a transport regulating kinase. Here, we explored the contribution of SGK3 to the regulation of renal tubular phosphate transport. ...

journal_title：Kidney international

authors： Bhandaru M,Kempe DS,Rotte A,Capuano P,Pathare G,Sopjani M,Alesutan I,Tyan L,Huang DY,Siraskar B,Judenhofer MS,Stange G,Pichler BJ,Biber J,Quintanilla-Martinez L,Wagner CA,Pearce D,Föller M,Lang F

更新日期：2011-07-01 00:00:00

abstract：:Viral peritonitis is an exceptionally rare occurrence in peritoneal dialysis. In fact, up to now, only one case report has been documented in the literature. In a prospective study, peritoneal dialysis effluent (PDE) was specifically cultured for the following viruses: the herpes group of viruses, including herpes sim...

journal_title：Kidney international

authors： Pomeranz A,Korzets Z,Smetana O,Yuhas Y,Elan I,Bernheim J

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Hypertriglyceridemia is a result of reduced triglyceride (TG)-rich lipoprotein (TRL) catabolism and occurs in rats with nephrotic syndrome (NS) and in Nagase analbuminemic rats (NARs). While the heparin-releasable lipoprotein lipase (LpL) pool in NAR and in NS is similar, TG levels are significantly greater ...

journal_title：Kidney international

authors： Shearer GC,Stevenson FT,Atkinson DN,Jones H,Staprans I,Kaysen GA

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:A family history increases the risk of kidney stone passage independent of dietary risk factors. However, the metabolic basis for familial aggregation of urolithiasis is unknown. METHODS:We evaluated metabolic risk factors in families with at least two sibs with a history of calcium stones. Sibs underwent o...

journal_title：Kidney international

authors： Tessier J,Petrucci M,Trouvé ML,Valiquette L,Guay G,Ouimet D,Bonnardeaux A

更新日期：2001-09-01 00:00:00

abstract：:The acutely injured mammalian kidney mounts a cellular and molecular response to repair itself. However, in patchy regions such intrinsic processes are impaired and dysregulated leading to chronic kidney disease. Currently, no therapy exists to treat established acute kidney injury per se. Strategies to augment human ...

journal_title：Kidney international

authors： Kumar S

更新日期：2018-01-01 00:00:00

abstract：:In this study, we have evaluated 50 children (30 girls and 20 boys; mean age, 10.1 years) with a variety of renal diseases in whom renal biopsy specimens showed crescents in greater than or equal to 50% of glomeruli. Initial clinical features included edema in 61%; hypertension in 51%; gross hematuria in 73%; 3 to 4+ ...

journal_title：Kidney international

authors：

更新日期：1985-02-01 00:00:00