Microangiographic evaluation of the effects of heparin on progressive Masugi nephritis.

abstract：BACKGROUND:High-dose folinic acid is used to accelerate methotrexate elimination to avoid renal toxicity of the drug. The present study was carried out to examine the role of the renal organic anion transporters OAT-K1 and OAT-K2 in the urinary excretion of methotrexate, especially in the methotrexate-folinic acid resc...

journal_title：Kidney international

authors： Takeuchi A,Masuda S,Saito H,Doi T,Inui K

更新日期：2001-09-01 00:00:00

abstract：:This NIH-funded multicenter randomized study of focal segmental glomerulosclerosis (FSGS) treatment compared the efficacy of a 12-month course of cyclosporine to a combination of oral pulse dexamethasone and mycophenolate mofetil in children and adults with steroid-resistant primary FSGS. Of the 192 patients enrolled,...

journal_title：Kidney international

authors： Gipson DS,Trachtman H,Kaskel FJ,Greene TH,Radeva MK,Gassman JJ,Moxey-Mims MM,Hogg RJ,Watkins SL,Fine RN,Hogan SL,Middleton JP,Vehaskari VM,Flynn PA,Powell LM,Vento SM,McMahan JL,Siegel N,D'Agati VD,Friedman AL

更新日期：2011-10-01 00:00:00

abstract：:The possibility that hypercalciuria could cause calcium stone formation through a mechanism other than by increasing urinary saturation of stone-forming calcium salts was explored. The effect of increasing calcium concentration on the inhibitor activity against the spontaneous precipitation of calcium oxalate was exam...

journal_title：Kidney international

authors： Zerwekh JE,Hwang TI,Poindexter J,Hill K,Wendell G,Pak CY

更新日期：1988-05-01 00:00:00

abstract：:Diabetic kidney disease is the leading cause of kidney failure. However, studies of molecular mechanisms of early kidney damage are lacking. Here we examined for possible linkage between transcriptional regulation and quantitative structural damage in early diabetic kidney disease in Pima Indians with type 2 diabetes....

journal_title：Kidney international

authors： Nair V,Komorowsky CV,Weil EJ,Yee B,Hodgin J,Harder JL,Godfrey B,Ju W,Boustany-Kari CM,Schwarz M,Lemley KV,Nelson PJ,Nelson RG,Kretzler M

更新日期：2018-02-01 00:00:00

abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

journal_title：Kidney international

authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

更新日期：2009-10-01 00:00:00

abstract：:Effect of varying concentrations (0 to 800 microM) of three different light chains on sodium-dependent L-(14C)alanine and D-(14C)glucose uptake by rat renal brush border membrane vesicles were studied. One kappa and two lambda type light chains (lambda-1 and lambda-2) were isolated from urines of patients with multipl...

journal_title：Kidney international

authors： Batuman V,Sastrasinh M,Sastrasinh S

更新日期：1986-11-01 00:00:00

abstract：:From August 1987 through February 1995 we performed 42 surgical procedures in 29 patients with occluded or stenotic radiocephalic arteriovenous fistulae. Operations were designed to preserve native veins for cannulation (Group I) or to preserve access in the same forearm, bypassing the failed fistula (Group II). For 2...

journal_title：Kidney international

authors： Oakes DD,Sherck JP,Cobb LF

更新日期：1998-02-01 00:00:00

abstract：:Hypoalbuminemia is the most powerful predictor of mortality in end-stage renal disease. Since protein-calorie malnutrition can decrease albumin synthesis it is assumed that hypoalbuminemia results principally from malnutrition in these patients, but albumin synthesis may also be decreased as part of the acute-phase re...

journal_title：Kidney international

authors： Kaysen GA,Rathore V,Shearer GC,Depner TA

更新日期：1995-08-01 00:00:00

abstract：:This very brief summary of the various possible contributions of PG to normal and abnormal renal function should highlight the problem of assigning a specific role to PG in overall renal physiology and pathophysiology. PG produced in specific segments of the nephron will affect specific functions occurring in this seg...

journal_title：Kidney international

authors： Schlondorff D,Ardaillou R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Advanced glycation end products (AGEs) accumulate in patients with diabetes, particularly at sites of vascular damage and within atherosclerotic lesions, but whether they have direct actions on vascular smooth muscle cells (VSMCs) is controversial. METHODS:AGEs were constructed and characterized by protein ...

journal_title：Kidney international

authors： Ballinger ML,Thomas MC,Nigro J,Ivey ME,Dilley RJ,Little PJ

更新日期：2005-12-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that metabolic clearance rate (MCR) of calcitriol is decreased in experimental renal failure. In this experiment, we examined the effects of calcitriol, 25-hydroxyvitamin D3 (25(OH)D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) on the MCR of calcitriol in renal ...

journal_title：Kidney international

authors： Patel S,Simpson RU,Hsu CH

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Both high glucose (HG) and angiotensin II (Ang II) causes glomerular mesangial cell (GMC) growth and increased synthesis of matrix proteins like collagen IV contributing to diabetic nephropathy. We have recently found that exposure of vascular smooth muscle cells to HG augments the Ang II activation of the g...

journal_title：Kidney international

authors： Amiri F,Shaw S,Wang X,Tang J,Waller JL,Eaton DC,Marrero MB

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Cardiovascular death continues to be a major problem in renal failure. Structural abnormalities of the heart and the vasculature contribute to the increased cardiovascular risk. They are ameliorated by angiotensin-converting enzyme (ACE) inhibitors, but because of the nonspecifity of ACE inhibition, it is un...

journal_title：Kidney international

authors： Amann K,Gassmann P,Buzello M,Orth SR,Törnig J,Gross ML,Magener A,Mall G,Ritz E

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction. The enzymatic effect of xanthine oxidase is the production of ROS and uric acid. Studies have shown that inhibiting xanthine oxidase wit...

journal_title：Kidney international

authors： Khosla UM,Zharikov S,Finch JL,Nakagawa T,Roncal C,Mu W,Krotova K,Block ER,Prabhakar S,Johnson RJ

更新日期：2005-05-01 00:00:00

abstract：:The purpose of this prospective, angiographically controlled study was to determine the diagnostic value of color Doppler sonography with two differing approaches of scanning in patients with clinical clues for renal artery stenosis (RAS). In 135 hypertensive patients peak systolic velocity in the main renal arteries ...

journal_title：Kidney international

authors： Krumme B,Blum U,Schwertfeger E,Flügel P,Höllstin F,Schollmeyer P,Rump LC

更新日期：1996-10-01 00:00:00

abstract：:We reviewed the diagnostic features and clinical course of 140 patients with idiopathic membranous nephropathy who had their index renal biopsies performed at the Mayo Clinic between 1972 and 1984. There were 93 males and 47 females (average age, 50.8 +/- 17 years); 116 patients (83%) had the nephrotic syndrome and 42...

journal_title：Kidney international

authors： Donadio JV Jr,Torres VE,Velosa JA,Wagoner RD,Holley KE,Okamura M,Ilstrup DM,Chu CP

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Cisplatin (CP) induced polyuria in rats is associated with a reduction in medullary hypertonicity, normally generated by the thick ascending limb (TAL) salt transporters, and the collecting duct urea transporters (UT). To investigate the molecular basis of this abnormality, we determined the protein abundanc...

journal_title：Kidney international

authors： Ecelbarger CA,Sands JM,Doran JJ,Cacini W,Kishore BK

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:High blood glucose levels play major roles in the pathogenesis of renal diabetic complications through non-enzymatic glycation. For long-lived molecules this leads to formation of advanced glycation end products (AGE), and the renal extracellular matrix appears to be one of the targets for such processes. Us...

journal_title：Kidney international

authors： Bendayan M

更新日期：1998-08-01 00:00:00

abstract：:Intrarenal angiotensin II is increased in kidney diseases independently of plasma angiotensin II and is thought to promote progressive deterioration of renal architecture. Here we investigated the mechanism of enhanced renal angiotensin II generation in kidney glomerular diseases. For this, kidney- or liver-specific a...

journal_title：Kidney international

authors： Matsusaka T,Niimura F,Pastan I,Shintani A,Nishiyama A,Ichikawa I

更新日期：2014-05-01 00:00:00

abstract：:We previously demonstrated that urinary endothelin excretion is increased in rats with extensive renal mass reduction, a model of progressive renal disease. Here we explored whether the increased urinary endothelin in this model were due to induction of renal pre-pro-endothelin-1 gene and whether changes in endothelin...

journal_title：Kidney international

authors： Orisio S,Benigni A,Bruzzi I,Corna D,Perico N,Zoja C,Benatti L,Remuzzi G

更新日期：1993-02-01 00:00:00

abstract：:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. ...

journal_title：Kidney international

authors： Alexander JJ,Chaves LD,Chang A,Jacob A,Ritchie M,Quigg RJ

更新日期：2015-05-01 00:00:00

abstract：:Low density lipoprotein (LDL) deposition and local oxidation play a key role in the pathogenesis of atherosclerosis and may likewise contribute to glomerular injury. These studies were designed to determine whether cultured human mesangial cells oxidize homologous LDL and to compare the effects of unmodified and oxidi...

journal_title：Kidney international

authors： Wheeler DC,Chana RS,Topley N,Petersen MM,Davies M,Williams JD

更新日期：1994-06-01 00:00:00

abstract：:Aminopeptidase A is one of the most potent enzymes within the renin-angiotensin system in terms of angiotensin II degradation. Here, we examined whether there is a kidney phenotype and any compensatory changes in other renin angiotensin system enzymes involved in the metabolism of angiotensin II associated with aminop...

journal_title：Kidney international

authors： Marahrens B,Schulze A,Wysocki J,Lin MH,Ye M,Kanwar YS,Bader M,Velez JCQ,Miner JH,Batlle D

更新日期：2020-12-11 00:00:00

abstract：:This study examined the expression of EPO, VEGF and VEGF receptor gene under conditions of reduced oxygen supply in primary cultures of rat hepatocytes, and compared it with the expression of these genes in hypoxic rat livers in vivo. To this end we exposed male Sprague-Dawley rats to hypoxia (10% and 8% O2), carbon m...

journal_title：Kidney international

authors： Sandner P,Wolf K,Bergmaier U,Gess B,Kurtz A

更新日期：1997-02-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-1) is a peptide growth factor that is synthesized in cultured mesangial cells and induces hyperplasia. We tested whether incubation with IGF-1 at concentrations of 7 nM, 70 nM, and 350 nM stimulates mesangial cell extracellular matrix mRNA and protein levels, and whether it influences...

journal_title：Kidney international

authors： Feld SM,Hirschberg R,Artishevsky A,Nast C,Adler SG

更新日期：1995-07-01 00:00:00

abstract：:Intrauterine growth retardation (IUGR) aggravates the course of acute mesangioproliferative glomerulonephritis (GN) in the rat. Observational studies in children suggest that IUGR may be associated with a severe course of kidney diseases such as IgA nephropathy. We tested the hypothesis that IUGR leads to aggravation ...

journal_title：Kidney international

authors： Plank C,Ostreicher I,Hartner A,Marek I,Struwe FG,Amann K,Hilgers KF,Rascher W,Dötsch J

更新日期：2006-12-01 00:00:00

abstract：:Cells from RCCT-28A cell line, which exhibited the highest peanut-lectin binding capacity [RCCT-28A(P+)] were separated and cultured attempting to obtain a population of HCO3- secreting cells. The mechanisms of apical solution acid or base extrusion were studied in confluent monolayers. In RCCT-28A (P+) cells net H+ f...

journal_title：Kidney international

authors： Bello-Reuss E

更新日期：1993-01-01 00:00:00

abstract：:The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. In mice, Kir4.2 was present exclusively at t...

journal_title：Kidney international

authors： Bignon Y,Pinelli L,Frachon N,Lahuna O,Figueres L,Houillier P,Lourdel S,Teulon J,Paulais M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Determinants of inter-individual variation in blood pressure (BP) response to antihypertensive therapy remain largely unknown. Although differences in race, age and measures of the renin-angiotensin-aldosterone system (RAAS) have been associated with variation in blood pressure response to hydrochlorothiazid...

journal_title：Kidney international

authors： Chapman AB,Schwartz GL,Boerwinkle E,Turner ST

更新日期：2002-03-01 00:00:00

abstract：:Residual kidney function (RKF) may confer a variety of benefits to patients on maintenance dialysis. RKF provides continuous clearance of middle molecules and protein-bound solutes. Whereas the definition of RKF varies across studies, interdialytic urine volume may emerge as a pragmatic alternative to more cumbersome ...

journal_title：Kidney international

authors： Mathew AT,Fishbane S,Obi Y,Kalantar-Zadeh K

更新日期：2016-08-01 00:00:00