Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate.

abstract：UNLABELLED:Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. BACKGROUND:Mutations in the gene for apolipoprotein AII (apoAII) have recently been found to cause hereditary renal amyloidosis. In each case amyloid deposition has been associated with a peptide extensio...

journal_title：Kidney international

authors： Yazaki M,Liepnieks JJ,Barats MS,Cohen AH,Benson MD

更新日期：2003-07-01 00:00:00

abstract：:Unidirectional 32P-phosphate and 3H-mannitol fluxes were simultaneously measured, at two minutes intervals, in frog urinary bladders. The spontaneous or externally imposed transepithelial potential (PD) and short circuit current (SCC) were also recorded in most experiments. It was observed that: (1) Phosphate transfer...

journal_title：Kidney international

authors： Parisi M,Cancela L

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:There is accumulating evidence that adult bone marrow (BM) cells show unexpected plasticity, and can differentiate into a wide range of specialized cells. In the case of intrinsic renal glomerular cells, BM-derived cells have been reported to differentiate into both mesangial cells and podocytes. However, th...

journal_title：Kidney international

authors： Ikarashi K,Li B,Suwa M,Kawamura K,Morioka T,Yao J,Khan F,Uchiyama M,Oite T

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a relatively new calcineurin inhibitor that has been increasingly used in transplant medicine. The objective of the current work is to report our preliminary experience with tacrolimus in the treatment of diffuse proliferative glomerulonephritis in systemic lupus erythematosus (SLE). METHODS:N...

journal_title：Kidney international

authors： Mok CC,Tong KH,To CH,Siu YP,Au TC

更新日期：2005-08-01 00:00:00

abstract：:Tubulointerstitial fibrosis is one of the most important histologic features that predicts progression in kidney disease. Thrombospondin 1 is an extracellular matrix protein that can activate latent TGF-beta, a cytokine implicated in the pathogenesis of tubulointerstitial fibrosis. We examined the expression of thromb...

journal_title：Kidney international

authors： Hugo C,Shankland SJ,Pichler RH,Couser WG,Johnson RJ

更新日期：1998-02-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) have a high risk of hyperkalemia, which increases mortality and can lead to renin-angiotensin-aldosterone system inhibitor (RAASi) dose reduction or discontinuation. Patiromer, a nonabsorbed potassium binder, has been shown to normalize serum potassium in patients with CKD an...

journal_title：Kidney international

authors： Bushinsky DA,Williams GH,Pitt B,Weir MR,Freeman MW,Garza D,Stasiv Y,Li E,Berman L,Bakris GL

更新日期：2015-12-01 00:00:00

abstract：:A major factor contributing to failure of arteriovenous fistulas (AVFs) is migration of smooth muscle cells into the forming neointima. To identify the source of smooth muscle cells in neointima, we created end-to-end AVFs by anastomosing the common carotid artery to the jugular vein and studied neural crest-derived s...

journal_title：Kidney international

authors： Liang M,Wang Y,Liang A,Mitch WE,Roy-Chaudhury P,Han G,Cheng J

更新日期：2015-09-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive kidney disease with high genetic heterogeneity. Understanding the functions of the individual genes contributing to this disease is critical for delineating the pathomechanisms of this disorder. Here, we investigated kidney function of a novel gene associated with nephronopht...

journal_title：Kidney international

authors： Airik R,Airik M,Schueler M,Bates CM,Hildebrandt F

更新日期：2019-08-01 00:00:00

abstract：:The family of bone morphogenetic proteins. Bone morphogenetic proteins (BMPs) are secreted signaling molecules belonging to the transforming growth factor-beta (TGF-beta) superfamily of growth factors. The first BMPs were originally identified by their ability to induce ectopic bone formation when implanted under the ...

journal_title：Kidney international

authors： Ducy P,Karsenty G

更新日期：2000-06-01 00:00:00

abstract：:Large epidemiological studies clearly demonstrate that multiple episodes of acute kidney injury contribute to the development and progression of kidney fibrosis. Although our understanding of kidney fibrosis has improved in the past two decades, we have limited therapeutic strategies to halt its progression. Myofibrob...

journal_title：Kidney international

authors： Gu X,Mallipattu SK,Guo Y,Revelo MP,Pace J,Miller T,Gao X,Jain MK,Bialkowska AB,Yang VW,He JC,Mei C

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Tubular transepithelial reabsorption of chloride along the nephron is a major determinant of body salt and water homeostasis and blood pressure regulation. About 40% of the glomerulary filtered sodium chloride are reabsorbed in the distal nephrons. Vectorial transepithelial sodium chloride transport is criti...

journal_title：Kidney international

authors： Jeck N,Waldegger P,Doroszewicz J,Seyberth H,Waldegger S

更新日期：2004-01-01 00:00:00

abstract：:Protein misfolding in the endoplasmic reticulum (ER) leads to ER stress. The unfolded protein response and ER-associated degradation (ERAD) interact in a coordinated manner with the ubiquitin-proteasome system and autophagy to alleviate protein misfolding or its consequences. The intersecting actions of these processe...

journal_title：Kidney international

authors： Cybulsky AV

更新日期：2013-07-01 00:00:00

abstract：:Protein and mRNA expression of TGF-beta isoforms, TGF-beta 1, -beta 2 and -beta 3, and deposition of fibronectin containing extra domain A (fibronectin EDA+) and plasminogen activator inhibitor-1 (PAI-1) were studied in human chronic glomerulonephritis and diabetic nephropathy. Normal kidneys showed similar, weak immu...

journal_title：Kidney international

authors： Yamamoto T,Noble NA,Cohen AH,Nast CC,Hishida A,Gold LI,Border WA

更新日期：1996-02-01 00:00:00

abstract：:The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absence of exogenous bicarbonate ions (HCO3-), we explored the permeability characteristics in the presence ...

journal_title：Kidney international

authors： Finn JT,Cohen LH,Steinmetz PR

更新日期：1977-04-01 00:00:00

abstract：:The aging process in humans and in the rat is associated with an impairment in renal tubular reabsorption of Pi and renal tubular adaptation to a low Pi diet. The purposes of the present study were to determine whether changes in the abundance of type II Na-Pi contransporter (NaPi-2) protein and/or mRNA play a role in...

journal_title：Kidney international

authors： Sorribas V,Lötscher M,Loffing J,Biber J,Kaissling B,Murer H,Levi M

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Cellular and molecular mechanisms responsible for cisplatin-induced nephrotoxicity to renal tubular epithelial cells are not well understood. Although caspases play a critical role in the execution of the cell death pathway, their specific role in toxic injury to renal tubular epithelial cells has not been e...

journal_title：Kidney international

authors： Kaushal GP,Kaushal V,Hong X,Shah SV

更新日期：2001-11-01 00:00:00

abstract：:Before hemodialysis, patients have an intraerythrocytic pH (pHi) and an extracellular pH, measured in whole blood (pHo), which are lower than those of healthy controls. During bicarbonate hemodialysis, pHi values continuously increase, approaching a normal value at the end of the session. Concomitantly, pHo values fol...

journal_title：Kidney international

authors： Monti JP,Gallice P,Baz M,Murisasco A,Crevat A,Elsen R

更新日期：1989-03-01 00:00:00

abstract：:Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory function of PGRN in rheumatoid arthritis encouraged us to examine the role of PGRN in acute kidney injury (AKI). We found that levels ...

journal_title：Kidney international

authors： Zhou M,Tang W,Fu Y,Xu X,Wang Z,Lu Y,Liu F,Yang X,Wei X,Zhang Y,Liu J,Geng X,Zhang C,Wan Q,Li N,Yi F

更新日期：2015-05-01 00:00:00

abstract：:Parathyroid suppression by intraperitoneal calcitriol (1,25(OH)2D3) during peritoneal dialysis. The purpose of this study was to determine if parathyroid hormone (PTH) suppression could be achieved by increasing calcium mass transfer (Ca MT) with high dialysate Ca (4 mEq/liter) or via intraperitoneal (i.p.) 1,25(OH)2D...

journal_title：Kidney international

authors： Delmez JA,Dougan CS,Gearing BK,Rothstein M,Windus DW,Rapp N,Slatopolsky E

更新日期：1987-03-01 00:00:00

abstract：:Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation d...

journal_title：Kidney international

authors： Ferrara N

更新日期：1999-09-01 00:00:00

abstract：:Isotomic fluid reabsorption (JV) of rat renal proximal tubules was examined by the shrinking droplet method in combination with simulatneous perfusion of blood capillaries. Sensitivity of JV measurement was improved by using each punctured tubule for control measurements: 1) Parathyroid hormoen (PTH) on the contralumi...

journal_title：Kidney international

authors： Baumann K,Chan YL,Bode F,Papavassiliou F

更新日期：1977-02-01 00:00:00

abstract：:In male Wistar rats, renal adenosine triphosphate (ATP), inorganic phosphate (Pi) and intracellular pH were measured by 31phosphorus nuclear magnetic resonance (31P NMR) and correlated with renal function before, during, and for one hour after a period of 30 to 40 minutes hemorrhagic hypotension. In animals which suff...

journal_title：Kidney international

authors： Ratcliffe PJ,Moonen CT,Holloway PA,Ledingham JG,Radda GK

更新日期：1986-09-01 00:00:00

abstract：:The inner medullary collecting duct (IMCD) is a major target site of atrial natriuretic peptide (ANP) for diuresis and natriuresis, and it is in a hypertonic condition made by the renal countercurrent multiplication system. We investigated the effects of hyperosmolality on ANP-stimulated cGMP generation in IMCD and gl...

journal_title：Kidney international

authors： Shinohara M,Nonoguchi H,Ujiie K,Terada Y,Owada A,Tomita K,Marumo F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease. METHODS:Stereologic studies were performed 10 weeks afte...

journal_title：Kidney international

authors： Rasch R,Nyengaard JR,Marcussen N,Meyer TW

更新日期：2002-08-01 00:00:00

abstract：:While hemodialysis therapy in its present form is capable of sustaining life, dialysis patients are not metabolically normal and we are unable to say what technical factors contribute adequate therapy. Recent efforts to resolve these problems have led to the assumption that substances in the molecular weight range of ...

journal_title：Kidney international

authors： Lowrie EG,Steinberg SM,Galen MA,Gagneux SA,Lazarus JM,Gottlieb MN,Merrill JP

更新日期：1976-11-01 00:00:00

abstract：:Phagocyte-derived interleukin-12 (IL-12) is a key cytokine that induces the development of an effective Th1 type immune response in various inflammatory and infectious disorders. To determine the importance of IL-12 in the pathogenesis of autoimmune renal injury we examined the renal production of this heterodimeric c...

journal_title：Kidney international

authors： Fan X,Oertli B,Wüthrich RP

更新日期：1997-01-01 00:00:00

abstract：:A novel variant of the LLC-PK1 cell line was used to examine directly the mechanism whereby PGF2 alpha and TPA inhibit renal ammoniagenesis. The variant cells, which exhibit a growth pattern and morphology similar to the parent cell line, were isolated by a self selection process utilizing long-term cultures of parent...

journal_title：Kidney international

authors： Sahai A,Fadda GZ,Sandler RS,Tannen RL

更新日期：1994-10-01 00:00:00

abstract：:Osteopontin is an arginine-glycine-aspartate (RGD) containing secreted phosphoprotein recently shown to stimulate a local macrophage influx when injected subcutaneously in mice. We examined the effect of angiotensin II infusion on renal injury and osteopontin expression in the rat kidney by in situ hybridization and i...

journal_title：Kidney international

authors： Giachelli CM,Pichler R,Lombardi D,Denhardt DT,Alpers CE,Schwartz SM,Johnson RJ

更新日期：1994-02-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) regulate cell proliferation and differentiation, and are also important regulators of extracellular matrix. They are among the most potent angiogenic factors known. Evidence suggests the FGFs play a role in glomerular development and pathology. The aim of the present study was to deter...

journal_title：Kidney international

authors： Ford MD,Cauchi J,Greferath U,Bertram JF

更新日期：1997-06-01 00:00:00

abstract：:The inactivation of physiological glucocorticoids by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) confers mineralocorticoid specificity to certain aldosterone target tissues. Both NADP, and NAD-dependent isoforms of 11 beta-HSD have been described. An NAD-dependent isoform of 11 beta-HSD (11 beta-HSD2) was recen...

journal_title：Kidney international

authors： Kyossev Z,Walker PD,Reeves WB

更新日期：1996-01-01 00:00:00