Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen.

abstract：:We evaluated short- and long-term effects of high-dose recombinant human erythropoietin (rHuEPO) in kidney transplantation in a prospective double-blind, placebo-controlled study. Patients with chronic kidney disease following receipt of a deceased donor kidney allograft were randomized to 3 doses of 40,000 units rHuE...

journal_title：Kidney international

authors： Hafer C,Becker T,Kielstein JT,Bahlmann E,Schwarz A,Grinzoff N,Drzymala D,Bonnard I,Richter N,Lehner F,Klempnauer J,Haller H,Traeder J,Fliser D

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The obstructed kidney in unilateral ureteral obstruction (UUO) is characterized by renal atrophy and tissue loss, which is mediated by renal tubular apoptosis. We sought to determine whether NO is involved in renal tubular apoptosis in vitro and in vivo. METHODS:Rat renal tubular epithelial cells (NRK-52E) ...

journal_title：Kidney international

authors： Miyajima A,Chen J,Poppas DP,Vaughan ED Jr,Felsen D

更新日期：2001-04-01 00:00:00

abstract：:Lithium therapy frequently induces nephrogenic diabetes insipidus; amiloride appears to prevent its occurrence in some clinical cases. Amiloride blocks the epithelial sodium channel (ENaC) located in the apical membrane of principal cells; hence one possibility is that ENaC is the main entry site for lithium and the b...

journal_title：Kidney international

authors： Kortenoeven ML,Li Y,Shaw S,Gaeggeler HP,Rossier BC,Wetzels JF,Deen PM

更新日期：2009-07-01 00:00:00

abstract：:With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major health problem worldwide. Approximately, 80% of kidney stones are composed of calcium and hypercalciuria is found in up to 40% of stone-formers. Although the mechanisms resulting in precipitation and growth of calcium crystals in...

journal_title：Kidney international

authors： Devuyst O,Pirson Y

更新日期：2007-11-01 00:00:00

abstract：:The members of the matrix metalloproteinase gene family play critical roles in numerous physiologic events, including cellular migration, tissue remodeling in wound healing and development, as well as in the evolution of the inflammatory process. The 72 kDa gelatinase A (formerly denoted 72 kDa Type IV collagenase) is...

journal_title：Kidney international

authors： Turck J,Pollock AS,Lovett DH

更新日期：1997-05-01 00:00:00

abstract：:Vascular calcification is recognized as a major contributor to cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. Susceptibility to vascular calcification is genetically determined and actively regulated by diverse inducers and inhibitors. One of these inducers, hyperphosphatemia, promotes vascul...

journal_title：Kidney international

authors： Giachelli CM

更新日期：2009-05-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of acute kidney injury (AKI) when used in triple combination with renin-angiotensin system inhibitors and diuretics, but previous research reported that NSAIDs in dual combinations with either renin-angiotensin system inhibitors or diu...

journal_title：Kidney international

authors： Dreischulte T,Morales DR,Bell S,Guthrie B

更新日期：2015-08-01 00:00:00

abstract：:As new components of the renin-angiotensin system (RAS) are elucidated, our understanding of the complexities of their interactions also advances. Previous studies have determined that podocytes possess a local RAS that can generate angiotensin II. Podocytes have also been shown to express angiotensin-converting enzym...

journal_title：Kidney international

authors： Harris RC

更新日期：2012-08-01 00:00:00

abstract：:Targeted therapies and immune checkpoint inhibitors have advanced the treatment landscape of Renal Cell Carcinoma (RCC) over the last decade. While checkpoint inhibitors have demonstrated survival benefit and are currently approved in the front-line and second-line settings, primary and secondary resistance is common....

journal_title：Kidney international

authors： Wang X,Lopez R,Luchtel RA,Hafizi S,Gartrell B,Shenoy N

更新日期：2021-01-01 00:00:00

abstract：:Serum fibroblast growth factor 23 (FGF23) is a novel phosphaturic factor and important for the regulation of inorganic phosphate (Pi) homeostasis. In this study, we examined an acute effect of oral Pi loading on serum FGF23 levels to clarify the role in rapid adjustment of serum Pi level. We performed a randomized, do...

journal_title：Kidney international

authors： Nishida Y,Taketani Y,Yamanaka-Okumura H,Imamura F,Taniguchi A,Sato T,Shuto E,Nashiki K,Arai H,Yamamoto H,Takeda E

更新日期：2006-12-01 00:00:00

abstract：:Increasing evidence points to the importance of aberrant O-glycosylated immunoglobulin A1 (IgA1) in the pathogenesis of IgA nephropathy (IgAN), a disease widely considered to be a polygenic disorder. We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with sus...

journal_title：Kidney international

authors： Zhu L,Tang W,Li G,Lv J,Ding J,Yu L,Zhao M,Li Y,Zhang X,Shen Y,Zhang H,Wang H

更新日期：2009-07-01 00:00:00

abstract：:Nephropathy is among the most frequent complications of diabetes and the leading cause of end-stage renal disease. Despite the success of novel drugs in animal models, the majority of the subsequent clinical trials employing those drugs targeting diabetic nephropathy failed. This lack of translational value may in par...

journal_title：Kidney international

authors： Klein J,Ramirez-Torres A,Ericsson A,Huang Y,Breuil B,Siwy J,Mischak H,Peng XR,Bascands JL,Schanstra JP

更新日期：2016-11-01 00:00:00

abstract：:In this study, we have evaluated 50 children (30 girls and 20 boys; mean age, 10.1 years) with a variety of renal diseases in whom renal biopsy specimens showed crescents in greater than or equal to 50% of glomeruli. Initial clinical features included edema in 61%; hypertension in 51%; gross hematuria in 73%; 3 to 4+ ...

journal_title：Kidney international

authors：

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor (EGF) plays an important role in renal tubular regeneration after ischemic injury in kidney. The present study reports the association between the renin-angiotensin system (RAS) and EGF, and the effect of angiotensin II blockade with losartan (LSRT) on EGF expression in an experimenta...

journal_title：Kidney international

authors： Yang CW,Ahn HJ,Kim WY,Shin MJ,Kim SK,Park JH,Kim YO,Kim YS,Kim J,Bang BK

更新日期：2001-09-01 00:00:00

abstract：:Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in chil...

journal_title：Kidney international

authors： Wedenoja S,Ormälä T,Berg UB,Halling SF,Jalanko H,Karikoski R,Kere J,Holmberg C,Höglund P

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Tubular transepithelial reabsorption of chloride along the nephron is a major determinant of body salt and water homeostasis and blood pressure regulation. About 40% of the glomerulary filtered sodium chloride are reabsorbed in the distal nephrons. Vectorial transepithelial sodium chloride transport is criti...

journal_title：Kidney international

authors： Jeck N,Waldegger P,Doroszewicz J,Seyberth H,Waldegger S

更新日期：2004-01-01 00:00:00

abstract：:Dihydrotestosterone (DHT) binding studies and the effects of DHT on the expression of beta-glucuronidase (Gus) and kidney androgen-regulated protein (KAP) genes and cell growth were investigated in immortalized early PKSV-PCT and late PKSV-PR proximal tubule cells, derived from transgenic mice carrying the L-pyruvate ...

journal_title：Kidney international

authors： Ouar Z,Solé E,Bens M,Rafestin-Oblin ME,Meseguer A,Vandewalle A

更新日期：1998-01-01 00:00:00

abstract：:We designed a study to provide reversibility and comparative injury data for several candidate urinary biomarkers of kidney injury in the United States Food and Drug Administration biomarker qualification process. The nephrotoxin gentamicin was given to rats once on each of three days and the animals were killed durin...

journal_title：Kidney international

authors： Rouse RL,Zhang J,Stewart SR,Rosenzweig BA,Espandiari P,Sadrieh NK

更新日期：2011-06-01 00:00:00

abstract：:To investigate the direct toxicity of human Bence Jones protein (BJP), individual nephrons of male Sprague-Dawley rats were perfused in vivo at 20 nl/min with an artificial tubule fluid (ATF) that contained no protein, a human kappa BJP (5 g/dl), or bovine serum albumin (5 g/dl), and proximal convoluted tubule functio...

journal_title：Kidney international

authors： Sanders PW,Herrera GA,Galla JH

更新日期：1987-12-01 00:00:00

abstract：:Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient reduction or cessation of blood flow, followed by re-establishment of perfusion. In the clinical setting, IRI contributes to significant acute kidney injury, patient morbidity and mortality...

journal_title：Kidney international

authors： Pefanis A,Ierino FL,Murphy JM,Cowan PJ

更新日期：2019-08-01 00:00:00

abstract：:Hypertriglyceridemia in nephrotic (NS) and Nagase analbuminemic rats (Analb) results from reduced triglyceride clearance. NS and Analb have reduced or absent albumin, reduced plasma oncotic pressure (pi), but Analb lack proteinuria. The heparin releasable lipoprotein lipase (LpL) pool in both models is greatly reduced...

journal_title：Kidney international

authors： Shearer GC,Kaysen GA

更新日期：2006-08-01 00:00:00

abstract：:Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer ...

journal_title：Kidney international

authors： Blosser CD,Haber G,Engels EA

更新日期：2020-11-04 00:00:00

abstract：:The homocysteine hypothesis states that circulating homocysteine is a vascular toxin in concentrations that occur in the general population and in renal failure. This hypothesis is currently being tested in the Kidney and End State Renal Disease Study (HOST), but data have emerged since the HOST began that suggest its...

journal_title：Kidney international

authors： Hoffer LJ

更新日期：2006-05-01 00:00:00

abstract：:Intravascular hemolysis is relatively rare but can lead to acute kidney injury (AKI), from increased destruction of erythrocytes and release of free hemoglobin. Since hemolysis and hemoglobinuria are known causes of acute kidney injury we sought to define clinicopathologic findings and outcomes of patients with hemoly...

journal_title：Kidney international

authors： Dvanajscak Z,Walker PD,Cossey LN,Messias NC,Boils CL,Kuperman MB,Larsen CP

更新日期：2019-12-01 00:00:00

abstract：:Polycystic renal disease was induced in rats by feeding 2-amino-4,5-diphenylthiazole. Tubular (TBM) and glomerular basement membranes (GBM) were purified and analyzed for possible structural changes that may be a factor in the development of the tubular dilations and cysts. Changes in the relative quantities of TBM po...

journal_title：Kidney international

authors： Butkowski RJ,Carone FA,Grantham JJ,Hudson BG

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent scavenger of free radicals and has the antioxidant ability to inhibit lipid peroxidation. Its protective effect on brain ischemia has been shown. This study aimed to elucidate its possible therapeutic effects on renal oxidative stress in a rat ische...

journal_title：Kidney international

authors： Doi K,Suzuki Y,Nakao A,Fujita T,Noiri E

更新日期：2004-05-01 00:00:00

abstract：:Stimulation of proximal tubule cell (PTC) growth in a variety of physiological and pathological renal conditions is preceded by increased renal production of transforming growth factor-beta 1 (TGF-beta 1) and by augmented tubular sodium transport via activated sodium hydrogen exchange (NHE). Since TGF-beta 1 has been ...

journal_title：Kidney international

authors： Johnson DW,Saunders HJ,Brew BK,Poronnik P,Cook DI,Field MJ,Pollock CA

更新日期：1998-06-01 00:00:00

abstract：:Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A key component in cellular adaptation to hypoxia is the hypoxia-inducibl...

journal_title：Kidney international

authors： Kobayashi H,Liu J,Urrutia AA,Burmakin M,Ishii K,Rajan M,Davidoff O,Saifudeen Z,Haase VH

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:An imbalance between protein load and folding capacity is referred to as endoplasmic reticulum (ER) stress. As a defense mechanism, cells express ER stress inducible chaperons, such as oxygen-regulated proteins 150 (ORP150) and glucose-regulated proteins (GRPs). While ER stress is important in various diseas...

journal_title：Kidney international

authors： Inagi R,Nangaku M,Onogi H,Ueyama H,Kitao Y,Nakazato K,Ogawa S,Kurokawa K,Couser WG,Miyata T

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:A nationwide survey of urolithiasis in Japan was made in order to evaluate the chronological trend of upper urinary tract stones in the Japanese. It succeeded previous studies done in 1955, 1966, 1979, and 1990. METHODS:All outpatient visits to urologists that resulted in a diagnosis of first-episode upper ...

journal_title：Kidney international

authors： Yoshida O,Terai A,Ohkawa T,Okada Y

更新日期：1999-11-01 00:00:00