The emerging role of phosphate in vascular calcification.


:Vascular calcification is recognized as a major contributor to cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. Susceptibility to vascular calcification is genetically determined and actively regulated by diverse inducers and inhibitors. One of these inducers, hyperphosphatemia, promotes vascular calcification and is a nontraditional risk factor for CVD mortality in ESRD patients. Vascular smooth muscle cells (SMCs) respond to elevated phosphate levels by undergoing an osteochondrogenic phenotype change and mineralizing their extracellular matrix through a mechanism requiring sodium-dependent phosphate cotransporters. Disease states and cytokines can increase expression of sodium-dependent phosphate cotransporters in SMCs, thereby increasing susceptibility to calcification even at phosphate concentrations that are in the normal range.


Kidney Int


Kidney international


Giachelli CM




Has Abstract


2009-05-01 00:00:00














  • MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice.

    abstract::Murine double minute (MDM)-2, an E3 ubiquitin ligase, promotes cancer cell survival and growth, by degrading the cell cycle regulator p53. Antagonism of MDM2 by the small-molecule cis-imidazoline nutlin analogs is under current study for cancer therapy. To test whether MDM2 also promotes regenerative cell growth, we d...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Mulay SR,Thomasova D,Ryu M,Anders HJ

    更新日期:2012-06-01 00:00:00

  • Renal blood flow measurement by positron emission tomography using 15O-labeled water.

    abstract:BACKGROUND:Only few noninvasive methods have the potential to quantitate renal blood flow (RBF) in humans. Positron emission tomography (PET) is a clinical imaging method that can be used to measure the tissue blood flow noninvasively. The purpose of this study was to validate PET measurement of RBF using 15O-labeled w...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Juillard L,Janier MF,Fouque D,Lionnet M,Le Bars D,Cinotti L,Barthez P,Gharib C,Laville M

    更新日期:2000-06-01 00:00:00

  • Expression of CR1 (CD35) mRNA in podocytes from adult and fetal human kidneys.

    abstract::The presence of CR1 mRNA in podocytes was investigated using a 35S-labeled CR1 cDNA probe and in situ hybridization in sections from fetal and adult human kidneys. CR1 mRNA was only detected in immature podocytes at early stages of glomerular differentiation in the fetal kidney. In contrast, CR1 antigen was abundantly...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Appay MD,Kazatchkine MD,Levi-Strauss M,Hinglais N,Bariety J

    更新日期:1990-08-01 00:00:00

  • Role of HSD11B2 polymorphisms in essential hypertension and the diuretic response to thiazides.

    abstract:BACKGROUND:The renal 11beta-hydroxysteroid dehydrogenase type 2 (11beta HSD2) enzyme inactivates 11-hydroxy steroids in the kidney, thereby protecting the nonselective mineralocorticoid (MR) receptor from occupation by glucocorticoids. Loss-of-function mutations in the gene encoding 11beta HSD2 (HSD11B2) result in over...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Williams TA,Mulatero P,Filigheddu F,Troffa C,Milan A,Argiolas G,Parpaglia PP,Veglio F,Glorioso N

    更新日期:2005-02-01 00:00:00

  • A controlled trial of cyclosporine in patients with progressive membranous nephropathy. Canadian Glomerulonephritis Study Group.

    abstract::A controlled trial of cyclosporine in patients diagnosed with progressive membranous nephropathy (MGN) was carried out to determine whether cyclosporine (D) would be more effective than placebo (P) in reducing the rate of deterioration in renal function. Patients (N = 64) with MGN were placed on a restricted protein d...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cattran DC,Greenwood C,Ritchie S,Bernstein K,Churchill DN,Clark WF,Morrin PA,Lavoie S

    更新日期:1995-04-01 00:00:00

  • Angiotensin-converting enzyme gene polymorphism and reversibility of uremic left ventricular hypertrophy following long-term antihypertensive therapy.

    abstract:BACKGROUND:Prolonged antihypertensive therapy might be less effective in reversing the left ventricular hypertrophy (LVH) in uremics bearing the deleted (DD) allele of the angiotensin converting enzyme (ACE) gene than in patients with the inserted (II) allele or in those heterozygous (ID) for the gene. METHODS:Thirtee...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Cannella G,Paoletti E,Barocci S,Massarino F,Delfino R,Ravera G,Di Maio G,Nocera A,Patrone P,Rolla D

    更新日期:1998-08-01 00:00:00

  • Extracellular matrix regulates apoptosis in human neutrophils.

    abstract:BACKGROUND:During inflammation, polymorphonuclear neutrophils (PMNs) migrate into the affected tissue interacting with extracellular matrix (ECM) proteins. We tested the hypothesis that PMN-matrix interaction affects PMN apoptosis. METHODS:Apoptosis of human PMNs was detected by DNA-fragmentation assay and was quantit...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kettritz R,Xu YX,Kerren T,Quass P,Klein JB,Luft FC,Haller H

    更新日期:1999-02-01 00:00:00

  • The pathobiology of subclinical pyelonephritis--an experimental evaluation.

    abstract::Clinical studies have demonstrated a poor correlation between localization tests, which are designed to determine the site of urinary tract infection, and symptoms of upper urinary tract infection. One explanation is that microorganisms may be present in the kidney but not initiate an inflammatory response with associ...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Miller TE,Findon G,Rainer SP,Gavin JB

    更新日期:1992-05-01 00:00:00

  • Circulating bone morphogenetic protein-7 and transforming growth factor-β1 are better predictors of renal end points in patients with type 2 diabetes mellitus.

    abstract::Albuminuria and a reduced glomerular filtration rate are conventional predictors of a future decline in kidney function in patients with type 2 diabetes mellitus. Using a nested case-control study we assessed whether circulating transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) levels mor...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Wong MG,Perkovic V,Woodward M,Chalmers J,Li Q,Hillis GS,Yaghobian Azari D,Jun M,Poulter N,Hamet P,Williams B,Neal B,Mancia G,Cooper M,Pollock CA

    更新日期:2013-02-01 00:00:00

  • Endogenous ouabain: role in the pathogenesis of hypertension.

    abstract::Substantial evidence implicates impaired renal excretion of sodium as the major culprit in the pathogenesis of hypertension. The key question is: How does the impairment of Na+ excretion lead to increased peripheral vascular resistance and elevation of the blood pressure? Here we describe the evidence that elevated le...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Blaustein MP

    更新日期:1996-06-01 00:00:00

  • Effects of C-peptide on renal function at the early stage of experimental diabetes.

    abstract:BACKGROUND:C-peptide has been reported to have biological effects on renal function early in the course of diabetes. This investigation was initiated to elucidate and amplify these findings with respect to protein leakage, hyperfiltration and renal functional reserve in diabetic rats. METHODS:Acute effects of 140 minu...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Sjöquist M,Huang W,Johansson BL

    更新日期:1998-09-01 00:00:00

  • Effect of calcium and phosphate on bicarbonate and fluid transport by proximal tubules in vitro.

    abstract::Previous studies in living animals have suggested that variations in the serum concentrations of calcium and phosphate directly affect renal tubular bicarbonate transport. To examine this area more directly, we measured the bicarbonate and the fluid transport in isolated rabbit proximal convoluted and straight tubules...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: McKinney TD,Myers P

    更新日期:1982-03-01 00:00:00

  • Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate.

    abstract::Vitamin D receptor activation has been associated with increased serum creatinine and reduced estimated glomerular filtration rates, raising concerns that its use may be detrimental to kidney function. Here we studied the effect of vitamin D receptor activation on serum creatinine, creatinine generation, and its clear...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章


    authors: Agarwal R,Hynson JE,Hecht TJ,Light RP,Sinha AD

    更新日期:2011-11-01 00:00:00

  • Early hospital readmission among hemodialysis patients in the United States is associated with subsequent mortality.

    abstract::Dialysis providers in the United States may soon be held accountable for their patients' 30-day hospital readmissions. However, few studies have evaluated the timing of readmissions, which determines the window in which dialysis providers could act to prevent readmission. We therefore examined the timing of readmissio...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Plantinga LC,King L,Patzer RE,Lea JP,Burkart JM,Hockenberry JM,Jaar BG

    更新日期:2017-10-01 00:00:00

  • Parathyroid hormone and bone histology: response to hypocalcemia in osteitis fibrosa.

    abstract::The parathyroid hormone (PTH) response to hypocalcemia was studied in 18 hemodialysis patients with osteitis fibrosa, and the relationship with PTH and bone histology in 26 hemodialysis patients. Hypocalcemia was produced during hemodialysis by the use of a dialysate devoid of calcium. Both amino (N) (P less than 0.05...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Voigts A,Felsenfeld AJ,Andress D,Llach F

    更新日期:1984-02-01 00:00:00

  • Regulatory interactions of alphabeta and gammadelta T cells in glomerulonephritis.

    abstract:BACKGROUND:Several lines of evidence suggest that cellular immune mechanisms contribute to glomerulonephritis. METHODS:The roles of alphabeta and gammadelta T cells in the pathogenesis of glomerulonephritis were investigated in a model of nephrotoxic nephritis in mice deficient in either T-cell population [T-cell rece...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Rosenkranz AR,Knight S,Sethi S,Alexander SI,Cotran RS,Mayadas TN

    更新日期:2000-09-01 00:00:00

  • Endothelial nitric oxide synthase: from structure to function in one aspartic substitution.

    abstract::Cherney and co-workers examine the functional phenotype of the G894T eNOS polymorphism in a selected group of apparently healthy subjects. The investigators used L-arginine infusion and induced changes in renal hemodynamics. While L-arginine increased effective plasma flow and glomerular filtration rate in GG subjects...

    journal_title:Kidney international

    pub_type: 评论,杂志文章


    authors: Goligorsky MS

    更新日期:2009-02-01 00:00:00

  • Protection from toxicant-mediated renal injury in the rat with anti-CD54 antibody.

    abstract:BACKGROUND:The benefit of the potent chemotherapeutic agent cisplatin in treating neoplasms is limited by nephrotoxicity. We tested the hypothesis that CD54 [intercellular adhesion molecule-1 (ICAM-1)] is an important mediator in cisplatin-mediated renal failure. METHODS:The effect of a monoclonal anti-CD54 antibody w...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Kelly KJ,Meehan SM,Colvin RB,Williams WW,Bonventre JV

    更新日期:1999-09-01 00:00:00

  • Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines.

    abstract::Fibroblasts in parenchymal organs potentially contribute extracellular matrix to local fibrogenic processes. This contribution, in some circumstances, may be initiated by cytokines disseminated from inflammatory lesions. Different populations of fibroblasts, however, might respond distinctively to this cytokine bath d...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Alvarez RJ,Sun MJ,Haverty TP,Iozzo RV,Myers JC,Neilson EG

    更新日期:1992-01-01 00:00:00

  • HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases.

    abstract:BACKGROUND:While the most common glomerular lesion associated with human immunodeficiency virus (HIV) infection is collapsing focal segmental glomerulosclerosis (FSGS) [HIV-associated nephropathy (HIVAN)], immune complex-mediated forms of glomerulonephritis have been increasingly reported. One form of glomerulonephriti...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Haas M,Kaul S,Eustace JA

    更新日期:2005-04-01 00:00:00

  • Pathogenesis of vascular calcification in chronic kidney disease.

    abstract::Pathogenesis of vascular calcification in chronic kidney disease. Background. Hyperphosphatemia and hypercalcemia are independent risk factors for higher incidence of cardiovascular events in patients with chronic kidney disease. In addition to increased calcium-phosphate product, hyperphosphatemia accelerates the pro...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Cozzolino M,Brancaccio D,Gallieni M,Slatopolsky E

    更新日期:2005-08-01 00:00:00

  • Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities.

    abstract::Tenofovir, a widely prescribed antiretroviral medication for treatment of HIV-1 infection, is infrequently associated with renal dysfunction and biopsy findings of acute tubular necrosis. We examined the clinical and pathological findings in 13 cases of tenofovir nephrotoxicity (7 men and 6 women, mean age of 51.1±9.6...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Herlitz LC,Mohan S,Stokes MB,Radhakrishnan J,D'Agati VD,Markowitz GS

    更新日期:2010-12-01 00:00:00

  • Recombinant human growth hormone exacerbates chronic puromycin aminonucleoside nephropathy in rats.

    abstract::Growth failure is a cardinal feature of chronic renal failure in children. Administration of recombinant human growth hormone (rhGH) ameliorates this problem but may adversely affect the kidney and hasten the progression to end-stage renal disease. We conducted experiments to examine the impact of rhGH on the severity...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Trachtman H,Futterweit S,Schwob N,Maesaka J,Valderrama E

    更新日期:1993-12-01 00:00:00

  • The potential for renoprotection with incretin-based drugs.

    abstract::Incretin-based drugs, i.e., glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, are widely used for the treatment of type 2 diabetes. In addition to the primary role of incretins in stimulating insulin secretion from pancreatic β-cells, they have extra pancreatic functions ...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Tanaka T,Higashijima Y,Wada T,Nangaku M

    更新日期:2014-10-01 00:00:00

  • Mechanistic aspects of mineralocorticoid receptor activation.

    abstract::Aldosterone exerts its biological effects through binding to mineralocorticoid receptor (MR). Ligand binding induces a receptor transconformation within the ligand-binding domain and dissociation of associated proteins from the receptor. The ligand-activated receptor binds as a dimer to the response elements present i...

    journal_title:Kidney international

    pub_type: 杂志文章,评审


    authors: Hellal-Levy C,Fagart J,Souque A,Rafestin-Oblin ME

    更新日期:2000-04-01 00:00:00

  • Proteinuria in rats induced by serum from patients with collapsing glomerulopathy.

    abstract:BACKGROUND:Primary collapsing glomerulopathy recurs postransplant, raising the possibility of circulating factors implicated in the pathogenesis of the disease. METHODS:To determine the presence of circulating factors in collapsing glomerulopathy patients, we tested serum from those patients in an in vivo assay. Eleve...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Avila-Casado Mdel C,Perez-Torres I,Auron A,Soto V,Fortoul TI,Herrera-Acosta J

    更新日期:2004-07-01 00:00:00

  • Toward a working definition of C3 glomerulopathy by immunofluorescence.

    abstract::Precise immunofluorescence criteria for C3 glomerulopathy remain to be defined. Here we tested hierarchical immunofluorescence criteria with varying stringency for C3 glomerulopathy in a cohort with dense deposit disease as the gold standard and then applied these criteria to analyze the incidence of C3 glomerulopathy...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Hou J,Markowitz GS,Bomback AS,Appel GB,Herlitz LC,Barry Stokes M,D'Agati VD

    更新日期:2014-02-01 00:00:00

  • Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis.

    abstract::The involvement of cysteinyl leukotrienes (LT) in the etiology of glomerulonephritis (GN) was investigated in a rat model of nephrotoxic serum nephritis in which renal function, morphology, LTC4 synthase activity and urinary cysteinyl LT excretion were monitored over seven days. Significant alterations in renal functi...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Petric R,Ford-Hutchinson AW

    更新日期:1994-11-01 00:00:00

  • Nature of glomerular dysfunction in pre-eclampsia.

    abstract:BACKGROUND:Pre-eclampsia is characterized by hypertension, proteinuria and edema. Simultaneous studies of kidney function and structure have not been reported. We wished to explore the degree and nature of glomerular dysfunction in pre-eclampsia. METHODS:Physiologic techniques were used to estimate glomerular filtrati...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Lafayette RA,Druzin M,Sibley R,Derby G,Malik T,Huie P,Polhemus C,Deen WM,Myers BD

    更新日期:1998-10-01 00:00:00

  • Impaired renal acidification following acute renal ischemia in the dog.

    abstract::Transient renal tubular acidosis may complicate acute renal failure (ARF). To clarify this phenomenon, the present study examined tubular H+ ion secretory capacity in an ischemic model of ARF. Clearance studies were performed in dogs subjected to 60 minutes, unilateral renal artery clamping. The contralateral kidney s...

    journal_title:Kidney international

    pub_type: 杂志文章


    authors: Winaver J,Agmon D,Harari R,Better OS

    更新日期:1986-12-01 00:00:00