B7(+)-transfectant tubular epithelial cells induce T cell anergy, ignorance or proliferation.

abstract：:The use of the immuno-suppressant cyclosporine A (CsA) after transplantation has been associated with less favorable plasma lipid profiles, which may contribute to the high incidence of cardiovascular morbidity and mortality in transplant recipients. Recent studies have suggested that oxidative modification of LDL pla...

journal_title：Kidney international

authors： van den Dorpel MA,Ghanem H,Rischen-Vos J,Man in't Veld AJ,Jansen H,Weimar W

更新日期：1997-05-01 00:00:00

abstract：:Effect of varying concentrations (0 to 800 microM) of three different light chains on sodium-dependent L-(14C)alanine and D-(14C)glucose uptake by rat renal brush border membrane vesicles were studied. One kappa and two lambda type light chains (lambda-1 and lambda-2) were isolated from urines of patients with multipl...

journal_title：Kidney international

authors： Batuman V,Sastrasinh M,Sastrasinh S

更新日期：1986-11-01 00:00:00

abstract：:We evaluated the effects of the bisphosphonate pamidronate on bone histomorphometry, structure and strength in male rats with uninephrectomy or with chronic renal disease induced by 5/6 nephrectomy. In rats with chronic renal disease the plasma urea, phosphate and parathyroid hormone levels were significantly increase...

journal_title：Kidney international

authors： Jokihaara J,Pörsti IH,Kööbi P,Jolma PM,Mustonen JT,Saha HH,Sievänen H,Kannus P,Iwaniec UT,Turner RT,Järvinen TL

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction. The enzymatic effect of xanthine oxidase is the production of ROS and uric acid. Studies have shown that inhibiting xanthine oxidase wit...

journal_title：Kidney international

authors： Khosla UM,Zharikov S,Finch JL,Nakagawa T,Roncal C,Mu W,Krotova K,Block ER,Prabhakar S,Johnson RJ

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Inhibition of the renin-angiotensin system (RAS) prevents development of chronic allograft dysfunction in experimental animals. Whether this therapeutic approach is effective even if started when signs of allograft nephropathy are already manifested has not been investigated. METHODS:To address this issue, ...

journal_title：Kidney international

authors： Noris M,Mister M,Pezzotta A,Azzollini N,Cassis P,Benigni A,Gagliardini E,Perico N,Remuzzi G

更新日期：2003-12-01 00:00:00

abstract：:While it is known that risk of death from sepsis is higher in patients with pre-existing chronic kidney disease its mechanism is unknown. To study this we established a two-stage mouse model where renal disease was first induced by folic acid injection followed by sub-lethal cecal ligation and puncture to induce sepsi...

journal_title：Kidney international

authors： Doi K,Leelahavanichkul A,Hu X,Sidransky KL,Zhou H,Qin Y,Eisner C,Schnermann J,Yuen PS,Star RA

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Interleukin-6 (IL-6) exerts its actions through a cell-surface receptor system that consists of two transmembrane subunits: the IL-6 binding glycoprotein gp 80 (IL-6R) and the signal-transducing component (gp 130). Soluble forms of the IL-6R (sIL-6R) are generated by shedding of the membrane-associated prote...

journal_title：Kidney international

authors： Memoli B,Postiglione L,Cianciaruso B,Bisesti V,Cimmaruta C,Marzano L,Minutolo R,Cuomo V,Guida B,Andreucci M,Rossi G

更新日期：2000-07-01 00:00:00

abstract：:Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are exposed to a continuous infusion of glucose via their peritoneal cavity. We performed studies to quantitate the amount of energy derived from dialysate glucose. Net glucose absorption averaged 182 +/- (SD) 61 g/day in 19 studies with a dialysate ...

journal_title：Kidney international

authors： Grodstein GP,Blumenkrantz MJ,Kopple JD,Moran JK,Coburn JW

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:Renal disease is commonly associated with hyperlipidemia and correlates with glomerular accumulation of atherogenic lipoproteins, for example, lipoprotein(a) [Lp(a)], and mesangial hypercellularity. Specific binding of Lp(a) to mesangial cells and induction of c-myc and c-fos expression has been demonstrated...

journal_title：Kidney international

authors： Mondorf UF,Piiper A,Herrero M,Olbrich HG,Bender M,Gross W,Scheuermann E,Geiger H

更新日期：1999-04-01 00:00:00

abstract：:In the epidemiologic study of end-stage renal disease (ESRD), accurate adjustment for comorbidity is essential to controlling bias in the comparison of outcomes across groups of patients or dialysis facilities. Liu et al. derive and validate a novel comorbidity index using data from the United States Renal Data System...

journal_title：Kidney international

authors： Seliger SL

更新日期：2010-01-01 00:00:00

abstract：:Acute kidney injury (AKI) is associated with progression to advanced chronic kidney disease (CKD). We tested whether patients who survive AKI and are at higher risk for CKD progression can be identified during their hospital admission, thus providing opportunities to intervene. This was assessed in patients in the Dep...

journal_title：Kidney international

authors： Chawla LS,Amdur RL,Amodeo S,Kimmel PL,Palant CE

更新日期：2011-06-01 00:00:00

abstract：:IgA1 proteins from sera of patients with IgA nephropathy (IgAN) are galactosylated to a lesser degree than those from healthy controls. The increased reactivity of intact or de-sialylated serum IgA1 with N-acetylgalactosamine (GalNAc)-specific lectins, Helix aspersa (HAA) and Caragana arborescens (CAA) and de-sialylat...

journal_title：Kidney international

authors： Tomana M,Matousovic K,Julian BA,Radl J,Konecny K,Mestecky J

更新日期：1997-08-01 00:00:00

abstract：:Low-protein diets (LPD) increase insulin-mediated glucose disposal in chronic renal failure (CRF), but the fate of the better utilized glucose and the effect on energy production rate are unknown. Using a two-step (1 and 5 mU x kg(-1) x min(-1)) euglycemic hyperinsulinemic clamp combined with indirect calorimetry, we ...

journal_title：Kidney international

authors： Rigalleau V,Combe C,Blanchetier V,Aubertin J,Aparicio M,Gin H

更新日期：1997-04-01 00:00:00

abstract：:Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit ...

journal_title：Kidney international

authors： Yokoi H,Yanagita M

更新日期：2016-04-01 00:00:00

abstract：:Amyloidosis results from protein misfolding, and ongoing amyloid deposition can ultimately lead to organ failure and death. Historically, this is a group of diseases with limited treatment options and frequently poor prognosis. However, there are now 'targeted' therapeutics emerging in the form of stabilizers of the p...

journal_title：Kidney international

authors： Sayed RH,Hawkins PN,Lachmann HJ

更新日期：2015-03-01 00:00:00

abstract：:To analyze the role of clusterin in renal diseases involving a regenerative process, we have used a novel rodent model to compare temporal and spatial expression of clusterin mRNA. Thus, renal artery stenosis was used to induce unilateral non-infarctive renal atrophy. After several weeks, when cellular pathology of at...

journal_title：Kidney international

authors： Gobé GC,Buttyan R,Wyburn KR,Etheridge MR,Smith PJ

更新日期：1995-02-01 00:00:00

abstract：:To examine whether hypoxia-inducible factor (HIF)-1α mediates the profibrotic effects of angiotensin II, we treated cultured renal medullary interstitial cells with angiotensin II and found that it increased HIF-1α levels. This was accompanied by a significant upregulation of collagen I/III, the tissue inhibitor of me...

journal_title：Kidney international

authors： Wang Z,Tang L,Zhu Q,Yi F,Zhang F,Li PL,Li N

更新日期：2011-02-01 00:00:00

abstract：:Utilizing [5-15N] and [2-15N]-labeled glutamine and gas chromatography mass spectrometry methodology, we examined the pathways of ammoniagenesis under basal and acute acidotic conditions of pH 7.0 and pH 6.8, respectively. LLC-PK1 cultures were incubated for one hour with gentle rocking in a bicarbonate buffer of pH 7...

journal_title：Kidney international

authors： Nissim I,Sahai A,Sandler RS,Tannen RL

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Human mesothelial cells (HMCs) have an important role in maintaining an adequately functioning fibrinolytic system in the peritoneal cavity by secreting the fibrinolytic enzymes tissue-type and urokinase-type plasminogen activator (t-PA and u-PA), as well as a specific PA inhibitor, PA inhibitor type 1 (PAI-...

journal_title：Kidney international

authors： Sitter T,Toet K,Quax P,Kooistra T

更新日期：1999-01-01 00:00:00

abstract：:Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Re...

journal_title：Kidney international

authors： Ortiz C,Meneses R,Jaffe D,Fernandez JA,Perez G,Bourgoignie JJ

更新日期：1988-08-01 00:00:00

abstract：:Plasma lipid and lipoprotein concentration and high density lipoprotein (HDL) kinetics were determined in control subjects and patients with chronic renal failure (CRF). Results demonstrated that plasma triglyceride (TG) concentration was significantly higher (P less than 0.001) in patients with CRF, associated with a...

journal_title：Kidney international

authors： Fuh MM,Lee CM,Jeng CY,Shen DC,Shieh SM,Reaven GM,Chen YD

更新日期：1990-05-01 00:00:00

abstract：:Abnormalities of bone mineral metabolism and vascular calcification are prevalent in patients with kidney failure. Clinical management is based on biochemical targets, in particular parathyroid hormone (PTH) concentrations, but this has many limitations including high biological variation. A possible alternative is bo...

journal_title：Kidney international

authors： Sardiwal S,Gardham C,Coleman AE,Stevens PE,Delaney MP,Lamb EJ

更新日期：2012-07-01 00:00:00

abstract：:Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory...

journal_title：Kidney international

authors： Pepper RJ,Hamour S,Chavele KM,Todd SK,Rasmussen N,Flint S,Lyons PA,Smith KG,Pusey CD,Cook HT,Salama AD

更新日期：2013-06-01 00:00:00

abstract：:Class IV-S lupus nephritis is often associated with more necrosis and fewer subendothelial immune deposits compared to class IV-G lupus nephritis, suggestive of necrotising glomerular inflammation found in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. ANCAs are present in a significant proportion o...

journal_title：Kidney international

authors： Turner-Stokes T,Wilson HR,Morreale M,Nunes A,Cairns T,Cook HT,Pusey CD,Tarzi RM,Lightstone L

更新日期：2017-11-01 00:00:00

abstract：:The natural course of idiopathic membranous nephropathy is variable, with some patients slowly progressing to renal failure while others maintain normal renal function over the entire time. Whether to treat this disease or not is controversial due to the lack of controlled data about the long-term effects of treatment...

journal_title：Kidney international

authors： Ponticelli C,Zucchelli P,Passerini P,Cesana B,Locatelli F,Pasquali S,Sasdelli M,Redaelli B,Grassi C,Pozzi C

更新日期：1995-11-01 00:00:00

abstract：:Undecalcified sections of doubly tetracycline-labeled transiliac bone biopsy specimens obtained from ten hemodialyzed patients before and 10 to 16 months after parathyroidectomy (PTX) were analyzed. Before parathyroidectomy (total PTX with autotransplant in six patients and subtotal PTX in four patients), all the pati...

journal_title：Kidney international

authors： Charhon SA,Berland YF,Olmer MJ,Delawari E,Traeger J,Meunier PJ

更新日期：1985-02-01 00:00:00

abstract：:The improvement in the anemia in patients with end-stage renal disease (ESRD) on continuous ambulatory peritoneal dialysis (CAPD) suggests that dialyzable substances present in the sera of uremic patients either inhibit erythropoiesis directly or inactivate erythropoietin (EPO). In the present study predialysis sera f...

journal_title：Kidney international

authors： Kushner D,Beckman B,Nguyen L,Chen S,Della Santina C,Husserl F,Rice J,Fisher JW

更新日期：1991-04-01 00:00:00

abstract：:While hemodialysis therapy in its present form is capable of sustaining life, dialysis patients are not metabolically normal and we are unable to say what technical factors contribute adequate therapy. Recent efforts to resolve these problems have led to the assumption that substances in the molecular weight range of ...

journal_title：Kidney international

authors： Lowrie EG,Steinberg SM,Galen MA,Gagneux SA,Lazarus JM,Gottlieb MN,Merrill JP

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:To study the molecular mechanism responsible for cadmium-induced Fanconi syndrome, an in vitro mouse model has been used. We have previously shown that exposure of primary cultures of kidney cortical cells to micromolar concentrations of cadmium inhibited uptake of the glucose analog, [14C] methyl alpha-d-gl...

journal_title：Kidney international

authors： Tabatabai NM,Blumenthal SS,Lewand DL,Petering DH

更新日期：2003-10-01 00:00:00

abstract：:Monocyte and macrophage markers are among the most highly overexpressed genes in cpk mouse kidneys with severely progressive renal cystic disease. We show here that one of these markers, CD14, is abnormally transcribed, activated and shed in cystic kidneys. However, these abnormalities were not associated with an incr...

journal_title：Kidney international

authors： Zhou J,Ouyang X,Cui X,Schoeb TR,Smythies LE,Johnson MR,Guay-Woodford LM,Chapman AB,Mrug M

更新日期：2010-09-01 00:00:00