Presence of an anti-viral factor in peritoneal dialysis effluent.

abstract：:Fibroblasts in parenchymal organs potentially contribute extracellular matrix to local fibrogenic processes. This contribution, in some circumstances, may be initiated by cytokines disseminated from inflammatory lesions. Different populations of fibroblasts, however, might respond distinctively to this cytokine bath d...

journal_title：Kidney international

authors： Alvarez RJ,Sun MJ,Haverty TP,Iozzo RV,Myers JC,Neilson EG

更新日期：1992-01-01 00:00:00

abstract：:Protein misfolding in the endoplasmic reticulum (ER) leads to ER stress. The unfolded protein response and ER-associated degradation (ERAD) interact in a coordinated manner with the ubiquitin-proteasome system and autophagy to alleviate protein misfolding or its consequences. The intersecting actions of these processe...

journal_title：Kidney international

authors： Cybulsky AV

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is known to be the most important complication among patients with renal failure, and oxidative stress has been proposed to play a major role as the source of such complications. Human serum albumin (HSA) is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing...

journal_title：Kidney international

authors： Terawaki H,Yoshimura K,Hasegawa T,Matsuyama Y,Negawa T,Yamada K,Matsushima M,Nakayama M,Hosoya T,Era S

更新日期：2004-11-01 00:00:00

abstract：:Proteinuric diabetic patients have an increased risk of cardiovascular disease and almost always have hypertension. In the early stages of diabetic renal disease (microalbuminuria) when renal function is well preserved, systemic arterial blood pressure is already elevated compared to insulin-dependent diabetic patient...

journal_title：Kidney international

authors： Earle K,Viberti GC

更新日期：1994-02-01 00:00:00

abstract：:Activation of cAMP signaling pathway was shown to inhibit some pathobiologic processes in mesangial cells (MC). We investigated whether adrenomedullin (ADM), a potent agonist of adenylate cyclase, is synthesized in MC and whether it can, via cAMP, suppress the generation of reactive oxygen metabolites (ROM) and prolif...

journal_title：Kidney international

authors： Chini EN,Chini CC,Bolliger C,Jougasaki M,Grande JP,Burnett JC Jr,Dousa TP

更新日期：1997-10-01 00:00:00

abstract：:Cytokines and chemokines produced by tubular epithelial and infiltrating cells are critical to inflammation in renal ischemia-reperfusion injury. IL-37, a newly described IL-1 family member, inhibits IL-18-dependent pro-inflammatory cytokine production by its binding to IL-18 receptors and IL-18 binding protein. The p...

journal_title：Kidney international

authors： Yang Y,Zhang ZX,Lian D,Haig A,Bhattacharjee RN,Jevnikar AM

更新日期：2015-02-01 00:00:00

abstract：:In this mini review, we would like to challenge the well-established 'fact' that lead exposure causes chronic renal failure (CRF). Even though only scarce evidence exists of the relationship between lead and renal failure, a World Health Organization Environmental Health Criteria document summarizes that 'Lead has bee...

journal_title：Kidney international

authors： Evans M,Elinder CG

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Susceptibility to skin cancer after transplantation is multifactorial, and risk factors include skin type, sun exposure, and level of immunosuppression. A major mechanism of carcinogenesis is ultraviolet radiation-induced free radical damage, and genetically determined ability to metabolize free radicals may...

journal_title：Kidney international

authors： Marshall SE,Bordea C,Haldar NA,Mullighan CG,Wojnarowska F,Morris PJ,Welsh KI

更新日期：2000-11-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphate-regulating hormone that acts primarily on the kidney and parathyroid. With declining kidney function there is an increase in circulating FGF23 levels, which is associated with vascular calcification and mortality in chronic kidney disease. Whether FGF23 exerts direct ...

journal_title：Kidney international

authors： Jimbo R,Kawakami-Mori F,Mu S,Hirohama D,Majtan B,Shimizu Y,Yatomi Y,Fukumoto S,Fujita T,Shimosawa T

更新日期：2014-05-01 00:00:00

abstract：:Besides its procoagulant activity, thrombin has been shown to stimulate cell proliferation and to regulate the fibrinolytic pathway. We report here the effect of purified human alpha thrombin on the synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) by cultured human me...

journal_title：Kidney international

authors： Villamediana LM,Rondeau E,He CJ,Medcalf RL,Peraldi MN,Lacave R,Delarue F,Sraer JD

更新日期：1990-11-01 00:00:00

abstract：:It is unknown whether the association between body mass index (BMI) and chronic kidney disease (CKD) is mediated by genetic confounding or obesity-associated diabetes. We investigated the association between BMI and incident CKD in 29,136 Swedish twins with no history of CKD or diabetes, first using traditional Cox re...

journal_title：Kidney international

authors： Xu H,Kuja-Halkola R,Chen X,Magnusson PKE,Svensson P,Carrero JJ

更新日期：2019-05-01 00:00:00

abstract：:The Institute of Medicine's recent report, Organ Donation: Opportunities for Action, studies the current problems facing organ donation in the USA, making suggestions for quality improvement and analyzing various proposals of incentivized donation and presumed consent (PC). Although the report deals with the donation ...

journal_title：Kidney international

authors： Das KK,Lerner BH

更新日期：2007-04-01 00:00:00

abstract：:Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell survival and reaction to oxidative stress. As oxidative stress is increased in uremia and is associated with vascular calcification, we studied the role of autophagy in vascular calcification induced by phosphate. In an in vitro...

journal_title：Kidney international

authors： Dai XY,Zhao MM,Cai Y,Guan QC,Zhao Y,Guan Y,Kong W,Zhu WG,Xu MJ,Wang X

更新日期：2013-06-01 00:00:00

abstract：:We have sought to determine the mechanisms driving fluid secretion by the cystic epithelium in autosomal dominant polycystic kidney disease (ADPKD). We have performed in vitro experiments on intact cysts dissected from discarded ADPKD kidneys, on monolayers of cells cultured from the cystic epithelium and on microcyst...

journal_title：Kidney international

authors： Sullivan LP,Grantham JJ

更新日期：1996-06-01 00:00:00

abstract：:Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the development of hypertension and chronic kidney disease. A 2-hit model has been proposed to explain the role of urate in hypertension. The first hit entails activation of the renin-angiotensin system and inhibition of nitric oxide synthe...

journal_title：Kidney international

authors： Ponticelli C,Podestà MA,Moroni G

更新日期：2020-11-01 00:00:00

abstract：:The effects of acidosis on renal function and morphology were examined in the isolated perfused rat kidney (IPK). Kidneys were perfused with oxygenated Krebs-Henseleit-albumin medium for 60 minutes at pH 7.4 or pH 7.0. At the lower pH, GFR was reduced by 25%, TRNa by 32% and oxygen consumption by 41% as compared to pe...

journal_title：Kidney international

authors： Shanley PF,Shapiro JI,Chan L,Burke TJ,Johnson GC

更新日期：1988-12-01 00:00:00

abstract：:beta 2-microglobulin-related amyloidosis (A beta 2M) represents a frequent complication in long-term dialysis patients. Although the pathogenetic mechanism has yet to be fully understood, it is known that amyloid fibrils usually consist of intact molecules of beta 2-microglobulin (beta 2m). Plasma proteinase inhibitor...

journal_title：Kidney international

authors： Campistol JM,Shirahama T,Abraham CR,Rodgers OG,Solé M,Cohen AS,Skinner M

更新日期：1992-10-01 00:00:00

abstract：:Tamm-Horsfall protein (THP), a monomeric glycoprotein (M(r) 80 to 100 kDa), is produced by the mammalian kidney's thick ascending limb of Henle cells and excreted into the urine. The function of THP is uncertain. Here we report that a high molecular weight contaminant in sheep THP (sTHP) preparations was identified as...

journal_title：Kidney international

authors： Rhodes DC,Hinsman EJ,Rhodes JA

更新日期：1993-11-01 00:00:00

abstract：:Atherogenic lipoproteins and reactive oxygen species stimulate renin release from isolated juxtaglomerular (JG) cells. Here we assessed whether stimulation of renin release is mediated by formation of superoxide anion (O2-), and whether the effects of oxidized lipoproteins, like in many other biological systems, can b...

journal_title：Kidney international

authors： Galle J,Heinloth A,Schwedler S,Wanner C

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Transforming growth factor-beta (TGF-beta) is known to play a pivotal role in the regulation of extracellular matrix (ECM) accumulation. Since diabetic nephropathy (DMN) is characterized by basement membrane thickening and mesangial expansion, control of ECM deposition is believed to be important in the pa...

journal_title：Kidney international

authors： Wong TY,Poon P,Chow KM,Szeto CC,Cheung MK,Li PK

更新日期：2003-05-01 00:00:00

abstract：:We analyzed clinical and pathologic data from 36 recipients of 38 renal allografts who developed nephrotic syndrome following transplantation. Three groups were identified on the basis of histologic changes in the graft, and each group had a distinct clinical course. Nine grafts (23.7%) had recurrent glomerulonephriti...

journal_title：Kidney international

authors： Cheigh JS,Mouradian J,Susin M,Stubenbord WT,Tapia L,Riggio RR,Stenzel KH,Rubin AL

更新日期：1980-09-01 00:00:00

abstract：:Although APOL1 high-risk genotype partially accounts for the increased susceptibility of blacks to chronic kidney disease (CKD), whether APOL1 associates differentially with mortality risk remains controversial. Here we evaluate the association between APOL1 genotype and risk of death and determine whether APOL1 statu...

journal_title：Kidney international

authors： Ku E,Lipkowitz MS,Appel LJ,Parsa A,Gassman J,Glidden DV,Smogorzewski M,Hsu CY

更新日期：2017-02-01 00:00:00

abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

journal_title：Kidney international

authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

更新日期：2009-10-01 00:00:00

abstract：:The mechanism whereby glucocorticoid deficiency impairs renal water excretion was studied in the conscious mineralocorticoid-replaced, adrenalectomized rat. Control animals received physiologic replacement with prednisolone, and experimental animals were deprived of glucocorticoid hormone for either 1 or 14 days. The ...

journal_title：Kidney international

authors： Linas SL,Berl T,Robertson GL,Aisenbrey GA,Schrier RW,Anderson RJ

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonu...

journal_title：Kidney international

authors： Gencik M,Meller S,Borgmann S,Fricke H

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Although renal protective effect of interrupting the inflammatory process is well established, it is still controversial if it also prevents the glomerular hemodynamic disturbances that initiate renal injury. We investigated the effects of suppressing inflammation with mycophenolate mofetil (MMF) on glomerul...

journal_title：Kidney international

authors： Tapia E,Franco M,Sánchez-Lozada LG,Soto V,Avila-Casado C,Santamaría J,Quiroz Y,Rodríguez-Iturbe B,Herrera-Acosta J

更新日期：2003-03-01 00:00:00

abstract：:Monoclonal antibodies (mAb) reactive against complement components involved in the classical activation pathway were applied in an indirect immunoperoxidase technique for the histological study of normal and diseased human renal tissues. Prominent staining with antibodies against the C4d fragment was seen in all glome...

journal_title：Kidney international

authors： Zwirner J,Felber E,Herzog V,Riethmüller G,Feucht HE

更新日期：1989-12-01 00:00:00

abstract：:Kidney transplant patients receiving phenytoin or phenobarbital may have decreased graft survival. These drugs have been shown to enhance the metabolism of glucocorticoids. We determined the disposition of total and unbound prednisolone in six stable kidney transplant patients receiving prednisone for immunosuppressio...

journal_title：Kidney international

authors： Gambertoglio JG,Holford NH,Kapusnik JE,Nishikawa R,Saltiel M,Stanik-Lizak P,Birnbaum JL,Hau T,Amend WJ Jr

更新日期：1984-01-01 00:00:00

abstract：:To investigate whether alpha (alpha)-adrenoceptor agonists have a stimulatory effect on the expression of the angiotensinogen (Ang) gene in opossum kidney (OK) cells, we used OK 27 cells with a fusion gene containing the 5'-flanking regulatory sequence of the rat angiotensinogen gene fused with a human growth hormone ...

journal_title：Kidney international

authors： Wang TT,Lachance S,Delalandre A,Carrière S,Chan JS

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a relatively new calcineurin inhibitor that has been increasingly used in transplant medicine. The objective of the current work is to report our preliminary experience with tacrolimus in the treatment of diffuse proliferative glomerulonephritis in systemic lupus erythematosus (SLE). METHODS:N...

journal_title：Kidney international

authors： Mok CC,Tong KH,To CH,Siu YP,Au TC

更新日期：2005-08-01 00:00:00