当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Alleles of the alpha1 immunoglobulin gene 3' enhancer control evolution of IgA nephropathy toward renal failure.

Alleles of the alpha1 immunoglobulin gene 3' enhancer control evolution of IgA nephropathy toward renal failure.

Abstract：

BACKGROUND:IgA nephropathy is the most common glomerular disease. Mechanisms leading to its occurrence and controlling the evolution of the disease remain largely unknown. Various genetic factors have been found, mostly implicating immunologically relevant genes (IgH, TCR, human lymphocyte antigen, and complement loci). A regulatory region recently identified downstream, the alpha1 gene of the IgH locus, was a likely candidate for the control of IgA1 production in patients. Alleles of this region, differing by size, sequence, and orientation of the alpha1 hs1,2 transcriptional enhancer, were first identified through Southern blot hybridization. METHODS:We established a polymerase chain reaction (PCR) method suitable for routine testing that amplifies minisatellites within the alpha1 hs1, 2 enhancer, with variable numbers of tandem repeats (VNTR) defining the two alleles. This assay allowed the typing of 104 patients with IgAN and 83 healthy volunteers. Results from typing of alpha1 hs1,2 alleles were compared with long-term clinical outcome in patients. Enhancer alleles were compared in a luciferase reporter gene assay. RESULTS:The alpha1 hs1,2 alleles do not constitute a predictive factor for IgA nephropathy, since similar allelic frequencies were observed in healthy individuals and in unrelated European patients. In contrast, among patients, homozygosity for the weakest enhancer allele (AA genotype) was significantly correlated with a milder form of the disease, whereas the allele B was associated with severe evolution. The minisatellite region within the alpha1 hs1,2 enhancer carried potential transcription factor-binding sites, and its duplication increased the transcriptional strength of the alpha1 hs1, 2 allele B over that of allele A. CONCLUSION:Altogether, these alleles may constitute a risk factor for the prognosis of IgA nephropathy.

journal_name

Kidney Int

journal_title

Kidney international

authors

Aupetit C,Drouet M,Pinaud E,Denizot Y,Aldigier JC,Bridoux F,Cogné M

doi

10.1046/j.1523-1755.2000.00253.x

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

966-71

issue

3

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)47187-X

journal_volume

58

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Monthly access flow monitoring with increased prophylactic angioplasty did not improve fistula patency.

    abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00697.x

    authors： Shahin H,Reddy G,Sharafuddin M,Katz D,Franzwa BS,Dixon BS

    更新日期：2005-11-01 00:00:00

  • Effects of 5'-N-ethylcarboxamideadenosine (NECA) on erythropoietin production.

    abstract：:The present studies were undertaken to assess the effects of 5'-N-ethylcarboxamideadenosine (NECA), an adenosine analogue, on erythropoietin (Epo) production. NECA (0.05 and 0.1 mumol/kg i.v.) produced significant increases in serum Epo levels (368.8 +/- 56.1 and 384.6 +/- 45.9 mU/ml, respectively) in exhypoxic polycy...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.307

    authors： Nakashima J,Ohigashi T,Brookins JW,Beckman BS,Agrawal KC,Fisher JW

    更新日期：1993-10-01 00:00:00

  • IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injury.

    abstract：:Cytokines and chemokines produced by tubular epithelial and infiltrating cells are critical to inflammation in renal ischemia-reperfusion injury. IL-37, a newly described IL-1 family member, inhibits IL-18-dependent pro-inflammatory cytokine production by its binding to IL-18 receptors and IL-18 binding protein. The p...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.295

    authors： Yang Y,Zhang ZX,Lian D,Haig A,Bhattacharjee RN,Jevnikar AM

    更新日期：2015-02-01 00:00:00

  • The cost-effectiveness of lipid lowering for primary cardiovascular prevention in chronic kidney disease: moving beyond statins.

    abstract：:Because of high risk of cardiovascular disease, patients with chronic kidney disease may benefit from cholesterol-lowering therapy beyond statins. A cost-effectiveness analysis of adding ezetimibe to high-dose statins for primary cardiovascular disease prevention in patients with non-dialysis-dependent chronic kidney ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2019.02.029

    authors： Walther CP,Erickson KF

    更新日期：2019-07-01 00:00:00

  • Preserved leukocyte CD11b expression at the site of interstitial inflammation in patients with high-flux hemodiafiltration.

    abstract：:The impact of high-flux hemodialysis on clinical outcomes remains controversial. We have previously shown that in vivo transmigrated leukocytes from patients with low-flux bioincompatible hemodialysis have an impaired capacity to upregulate CD11b at the site of interstitial inflammation. In the present study, we inves...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002090

    authors： Olsson J,Dadfar E,Paulsson J,Lundahl J,Moshfegh A,Jacobson SH

    更新日期：2007-03-01 00:00:00

  • Inhibition of pressure natriuresis in mice lacking the AT2 receptor.

    abstract：UNLABELLED:Inhibition of pressure natriuresis in mice lacking the AT2 receptor. BACKGROUND:Angiotensin II type 2 (AT2) receptor knockout mice have higher blood pressures than wild-type mice; however, the hypertension is imperfectly defined. We tested the hypothesis that renal mechanisms could be contributory. METHODS...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00820.x

    authors： Gross V,Schunck WH,Honeck H,Milia AF,Kärgel E,Walther T,Bader M,Inagami T,Schneider W,Luft FC

    更新日期：2000-01-01 00:00:00

  • High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells.

    abstract：BACKGROUND:The peritoneum is progressively denuded of its mesothelial cell monolayer in patients on continuous ambulatory peritoneal dialysis (CAPD). These alterations of the mesothelium cause membrane dysfunction and progressive peritoneal fibrosis. Integrins regulate cell motility and play an important role in wound ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00772.x

    authors： Tamura M,Osajima A,Nakayamada S,Anai H,Kabashima N,Kanegae K,Ota T,Tanaka Y,Nakashima Y

    更新日期：2003-02-01 00:00:00

  • Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney.

    abstract：BACKGROUND:We aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene. METHODS:A partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enric...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00143.x

    authors： Hilgers KF,Nagaraj SK,Karginova EA,Kazakova IG,Chevalier RL,Carey RM,Pentz ES,Gomez RA

    更新日期：1998-11-01 00:00:00

  • The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes.

    abstract：:The ankyrin repeat and sterile α motif (SAM) domain-containing six gene (Anks6) is a candidate for polycystic kidney disease (PKD). Originally identified in the PKD/Mhm(cy/+) rat model of PKD, the disease is caused by a mutation (R823W) in the SAM domain of the encoded protein. Recent studies support the etiological r...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.122

    authors： Bakey Z,Bihoreau MT,Piedagnel R,Delestré L,Arnould C,de Villiers Ad,Devuyst O,Hoffmann S,Ronco P,Gauguier D,Lelongt B

    更新日期：2015-08-01 00:00:00

  • Dialysate calcium profiling during hemodialysis: use and clinical implications.

    abstract：BACKGROUND:Low dialysate calcium (LdCa) concentration is used to prevent or treat hemodialysis (HD)-induced hypercalcemia, but its use has been complicated by intradialytic hypotension in some patients. Our goal was to explore the possibility that dialysis calcium profiling (dCaP) can ameliorate intradialytic hypotensi...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1523-1755.2002.00100.x

    authors： Kyriazis J,Glotsos J,Bilirakis L,Smirnioudis N,Tripolitou M,Georgiakodis F,Grimani I

    更新日期：2002-01-01 00:00:00

  • Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression.

    abstract：:We previously demonstrated that urinary endothelin excretion is increased in rats with extensive renal mass reduction, a model of progressive renal disease. Here we explored whether the increased urinary endothelin in this model were due to induction of renal pre-pro-endothelin-1 gene and whether changes in endothelin...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.53

    authors： Orisio S,Benigni A,Bruzzi I,Corna D,Perico N,Zoja C,Benatti L,Remuzzi G

    更新日期：1993-02-01 00:00:00

  • Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.

    abstract：:An expression profile is a list based on a large scale sequencing of 1000 cDNA clones, showing the expressed genes and the abundance of their transcripts in a given cell or tissue (Okubo K et al: Nature Genet 2:173, 1992). We constructed an expression profile of mouse renal proximal tubules (PT) carefully isolated by ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00808.x

    authors： Takenaka M,Imai E,Kaneko T,Ito T,Moriyama T,Yamauchi A,Hori M,Kawamoto S,Okubo K

    更新日期：1998-03-01 00:00:00

  • Renal growth hormone--insulin-like growth factor-I system in acute renal failure.

    abstract：:The renal growth hormone--insulin-like growth factor-I system in acute ischemic renal failure. Recovery from acute tubular necrosis (ATN) is accelerated by IGF-I therapy. Furthermore, the local renal growth hormone-IGF-I system may participate in the natural repair. We examined the IGF-I system in rat kidneys subjecte...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.230

    authors： Tsao T,Wang J,Fervenza FC,Vu TH,Jin IH,Hoffman AR,Rabkin R

    更新日期：1995-06-01 00:00:00

  • Nephritogenicity of proteoglycans. III. Mechanism of immune deposit formation.

    abstract：:Administration of antibody, directed against glomerular basement membrane (GBM) heparan sulfate-proteoglycan, into a presensitized rat results in the induction of membranous nephropathy with subepithelial immune-complex deposits. In this investigation, we examined the mechanisms responsible for the formation of subepi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.166

    authors： Makino H,Lelongt B,Kanwar YS

    更新日期：1988-08-01 00:00:00

  • Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation.

    abstract：:Major features of a long-standing inflammation in the kidney are vascular proliferation, glomerulosclerosis, interstitial fibrosis and tubular atrophy, leading to a gradual deterioration of the renal function. In this study we have investigated the expression of B-type receptors for platelet-derived growth factor (PDG...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.306

    authors： Fellström B,Klareskog L,Heldin CH,Larsson E,Rönnstrand L,Terracio L,Tufveson G,Wahlberg J,Rubin K

    更新日期：1989-12-01 00:00:00

  • Expression of endothelial and inducible nitric oxide synthase in human glomerulonephritis.

    abstract：:The presence of nitric oxide (NO) in the kidney has been implicated in the pathogenesis of human glomerulonephritis. However, the exact type of glomerular cells that express NO synthase (NOS) and the NOS isoform involved in the local production of NO has not been identified in the human diseased kidney. We examined th...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00907.x

    authors： Furusu A,Miyazaki M,Abe K,Tsukasaki S,Shioshita K,Sasaki O,Miyazaki K,Ozono Y,Koji T,Harada T,Sakai H,Kohno S

    更新日期：1998-06-01 00:00:00

  • Contributions of nuclear magnetic resonance to renal biochemistry.

    abstract：:31P NMR as a descriptive technique is of interest to nephrologists. Particular contributions of 31P NMR to our understanding of renal function may be enumerated.: "Free" metabolite levels are different from those classically accepted; in particular, ADP and Pi are low with implications for the control of renal metabol...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.1986.15

    authors： Ross B,Freeman D,Chan L

    更新日期：1986-01-01 00:00:00

  • Finding the safe place between the hammer and the anvil: sounding the depth of therapeutic immunosuppression.

    abstract：:Transplanted organs express allogeneic epitopes against which a recipient's immune system mounts a destructive response. In the absence of a reliable strategy for induction of donor-specific tolerance, therapeutic immunosuppression remains the best prospect to prevent rejection, but exposes recipients to increased ris...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.268

    authors： Thaunat O

    更新日期：2015-12-01 00:00:00

  • Measurement of urinary chemokine and growth factor messenger RNAs: a noninvasive monitoring in lupus nephritis.

    abstract：:Noninvasive molecular tests of urine cells have been developed to monitor the activity of kidney diseases. We evaluate whether measurement of urinary messenger RNA (mRNA) levels of chemokine and growth factor genes could distinguish between diffuse proliferative lupus nephritis (class IV LN) and others and whether it ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000132

    authors： Avihingsanon Y,Phumesin P,Benjachat T,Akkasilpa S,Kittikowit V,Praditpornsilpa K,Wongpiyabavorn J,Eiam-Ong S,Hemachudha T,Tungsanga K,Hirankarn N

    更新日期：2006-02-01 00:00:00

  • Renal iron handling in the nephrotic syndrome.

    abstract：:Renal iron handling was characterized in three experimental models of the nephrotic syndrome: puromycin aminonucleoside, adriamycin and nephrotoxic serum. In adriamycin-induced nephrotic syndrome, which has previously been shown to result from alterations in pore size of the filtration barrier, the transferrin leak wa...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.130

    authors： Alfrey AC,Hammond WS

    更新日期：1990-06-01 00:00:00

  • Advances in renal (patho)physiology using multiphoton microscopy.

    abstract：:Multiphoton excitation fluorescence microscopy is a state-of-the-art confocal imaging technique ideal for deep optical sectioning of living tissues. It is capable of performing ultrasensitive, quantitative imaging of organ functions in health and disease with high spatial and temporal resolution which other imaging mo...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/sj.ki.5002461

    authors： Sipos A,Toma I,Kang JJ,Rosivall L,Peti-Peterdi J

    更新日期：2007-11-01 00:00:00

  • Increased expression of a brain/embryo-type myosin heavy chain isoform (MIIB2) in mesangial proliferative glomerulonephritis.

    abstract：:Proliferation of mesangial cells is frequently found in glomerulonephritis, such as IgA glomerulonephritis. Recent reports suggest that a brain/embryo-type myosin isoform (MIIB2) is involved in cell proliferation. We have studied the expression of MIIB2 in renal biopsy samples from patients with various renal diseases...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.191

    authors： Kishino M,Kimura A,Yamaguchi K,Ohtani H,Yamada Y,Takahashi T,Mune M,Mimura K,Maeda T,Matsumura S,Tsuji T,Yukawa S

    更新日期：1996-05-01 00:00:00

  • Necrosis and apoptosis of polymorphonuclear cells exposed to peritoneal dialysis fluids in vitro.

    abstract：:Conventional peritoneal dialysis (PD) fluids are known to inhibit polymorphonuclear cells (PMN) phagocytosis, oxidative burst and enzyme release. However, the relative contributions of apoptosis and/or necrosis to this dysfunction have not been examined. We investigated the effects of osmolality, glucose concentration...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.495

    authors： Cendoroglo M,Sundaram S,Groves C,Ucci AA,Jaber BL,Pereira BJ

    更新日期：1997-12-01 00:00:00

  • Platelet activating factor inhibits Cl and K transport in the medullary thick ascending limb.

    abstract：:Since the kidney medulla was reported to generate platelet activating factor (PAF), we investigated a possible effect of this agent on the reabsorptive function of in vitro microperfused medullary thick ascending limbs from mouse kidney (mTAL). PAF, 10(-7) M in the bath, significantly decreased the net chloride flux (...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.38

    authors： Bailly C,Barlet-Bas C,Amiel C

    更新日期：1992-02-01 00:00:00

  • The cell cycle and acute kidney injury.

    abstract：:Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although seemingly discrete and unrelated mechanisms, these pathways can now be shown to be connected and even to be controlled by similar pathways. The dependence of the severity of renal-cell injury on cell cycle pathways can be used ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2009.224

    authors： Price PM,Safirstein RL,Megyesi J

    更新日期：2009-09-01 00:00:00

  • Selective antagonism of the AT1 receptor inhibits angiotensin II stimulated DNA and protein synthesis in primary cultures of human proximal tubular cells.

    abstract：:The hypertrophy of renal proximal tubular cells occurs as an adaptive response to a variety of stimuli and may be involved with the progression of renal disease. Angiotensin II acting alone or in combination with other growth factors has been implicated in this process. The aims of this study were to identify the role...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.385

    authors： Chatterjee PK,Weerackody RP,Mistry SK,Hawksworth GM,McLay JS

    更新日期：1997-09-01 00:00:00

  • High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients.

    abstract：:Hyperhomocysteinemia, an arteriosclerotic risk factor, persists in 75% of dialysis patients despite routine low dose supplementation with the B-vitamin co-factors/substrates for homocysteine (Hcy) metabolism, and normal or supernormal plasma status of these vitamins (Atherosclerosis 114:93, 1995). We conducted a place...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1038/ki.1996.19

    authors： Bostom AG,Shemin D,Lapane KL,Hume AL,Yoburn D,Nadeau MR,Bendich A,Selhub J,Rosenberg IH

    更新日期：1996-01-01 00:00:00

  • The chemokine receptor 5 Delta32 mutation is associated with increased renal survival in patients with IgA nephropathy.

    abstract：BACKGROUND:Chemokine receptor 5 (CCR5) plays an important role in the recruitment of monocytes and T cells in inflammation and experimental studies suggest that CCR5 might be involved in the pathogenesis of IgA nephropathy. A mutation in the CCR5 gene (CCR5 Delta32), leading to a nonfunctional receptor, was recently de...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00057.x

    authors： Panzer U,Schneider A,Steinmetz OM,Wenzel U,Barth P,Reinking R,Becker JU,Harendza S,Zahner G,Fischereder M,Krämer BK,Schlöndorff D,Ostendorf T,Floege J,Helmchen U,Stahl RA

    更新日期：2005-01-01 00:00:00

  • Renal secretion of organic anions and cations.

    abstract：:The renal proximal tubule actively transports charged, potentially toxic xenobiotics from blood to lumen. Basolateral uptake of organic anions is indirectly coupled to the sodium gradient through Na-dicarboxylate cotransport and dicarboxylate-organic anion exchange. Upon entry, a significant fraction of intracellular ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.1996.240

    authors： Pritchard JB,Miller DS

    更新日期：1996-06-01 00:00:00

  • Chronic renal failure from lead: myth or evidence-based fact?

    abstract：:In this mini review, we would like to challenge the well-established 'fact' that lead exposure causes chronic renal failure (CRF). Even though only scarce evidence exists of the relationship between lead and renal failure, a World Health Organization Environmental Health Criteria document summarizes that 'Lead has bee...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2010.394

    authors： Evans M,Elinder CG

    更新日期：2011-02-01 00:00:00