Finding the safe place between the hammer and the anvil: sounding the depth of therapeutic immunosuppression.

abstract：:Erythropoietin (EPO) therapy in hemodialysis patients may be associated with an enhanced risk of vascular access and extracorporeal thrombosis. Assessment of blood coagulation and fibrinolysis was performed monthly on a group of 21 hemodialysis patients treated with EPO, and on four iron-deficient hemodialysis patient...

journal_title：Kidney international

authors： Taylor JE,Belch JJ,McLaren M,Henderson IS,Stewart WK

更新日期：1993-07-01 00:00:00

abstract：:Osteopontin is an arginine-glycine-aspartate (RGD) containing secreted phosphoprotein recently shown to stimulate a local macrophage influx when injected subcutaneously in mice. We examined the effect of angiotensin II infusion on renal injury and osteopontin expression in the rat kidney by in situ hybridization and i...

journal_title：Kidney international

authors： Giachelli CM,Pichler R,Lombardi D,Denhardt DT,Alpers CE,Schwartz SM,Johnson RJ

更新日期：1994-02-01 00:00:00

abstract：:The risk of developing contrast media-induced acute renal failure was studied in 49 randomly selected nonazotemic type 2 adult diabetic patients subjected to IVU. There were 19 men and 30 women in the group whose mean age was 62 +/- 10 years (range, 38 to 82 years). In preparation for IVU, patients were neither dehydr...

journal_title：Kidney international

authors： Shieh SD,Hirsch SR,Boshell BR,Pino JA,Alexander LJ,Witten DM,Friedman EA

更新日期：1982-05-01 00:00:00

abstract：:Pain is a common complaint in patients with autosomal-dominant polycystic kidney disease, and a systematic approach is needed to differentiate the etiology of the pain and define an approach to management. A thorough history is the best clue to the multifactorial causes of the pain, superimposed upon an understanding ...

journal_title：Kidney international

authors： Bajwa ZH,Gupta S,Warfield CA,Steinman TI

更新日期：2001-11-01 00:00:00

abstract：:EDTA (calcium disodium edetate) lead mobilization and x-ray fluorescence (XRF) finger bone lead tests were done in 42 patients with chronic renal failure and without persisting lead intoxication. Nineteen of 23 patients with gout and 8 of 19 without gout had positive EDTA lead mobilization tests. Those patients with g...

journal_title：Kidney international

authors： Craswell PW,Price J,Boyle PD,Heazlewood VJ,Baddeley H,Lloyd HM,Thomas BJ,Thomas BW

更新日期：1984-09-01 00:00:00

abstract：:Angiotensin II plays an important role in the regulation of blood pressure, body salt and fluid balance, and urine concentration. Mice with deletion of the AT(1a) receptor develop polyuria and urine concentration defects. We studied the mechanisms of these urine concentration defects by treating wild-type and AT(1a)-k...

journal_title：Kidney international

authors： Li XC,Shao Y,Zhuo JL

更新日期：2009-07-01 00:00:00

abstract：:Renal dysfunction is a common and serious complication in multiple myeloma (MM) patients. Renal proximal tubule injury is characteristic in MM, and may result in disturbed renal handling of various vitamins. The abnormal excretion of vitamins in urine may result in their low serum levels. The goal of this study was to...

journal_title：Kidney international

authors： Gavrilov V,Yermiahu T,Gorodischer R

更新日期：2006-01-01 00:00:00

abstract：:Emerging evidence of crosstalk between glomerular cells in pathological settings provides opportunities for novel therapeutic discovery. Here we investigated underlying mechanisms of early events leading to filtration barrier defects of podocyte and glomerular endothelial cell crosstalk in the mouse models of primary ...

journal_title：Kidney international

authors： Ebefors K,Wiener RJ,Yu L,Azeloglu EU,Yi Z,Jia F,Zhang W,Baron MH,He JC,Haraldsson B,Daehn I

更新日期：2019-10-01 00:00:00

abstract：:Higher diet-dependent nonvolatile acid load is associated with faster chronic kidney disease (CKD) progression, but most studies have used estimated acid load or measured only components of the gold standard, net acid excretion (NAE). Here we measured NAE as the sum of urine ammonium and titratable acidity in 24-hour ...

journal_title：Kidney international

authors： Scialla JJ,Asplin J,Dobre M,Chang AR,Lash J,Hsu CY,Kallem RR,Hamm LL,Feldman HI,Chen J,Appel LJ,Anderson CA,Wolf M,Chronic Renal Insufficiency Cohort Study Investigators.

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy is commonly associated with renal salt and water retention and hypertension. The molecular mechanisms involved and how the kidney responds to this volume expansion, in terms of renal transporter regulation, are not understood. METHODS:Targeted proteomics employing semiquantitative immun...

journal_title：Kidney international

authors： Bickel CA,Knepper MA,Verbalis JG,Ecelbarger CA

更新日期：2002-06-01 00:00:00

abstract：INTRODUCTION:Thiazide diuretics have the unique characteristic of increasing renal Na+ excretion, while decreasing Ca2+ excretion. However, the molecular mechanism responsible for this thiazide-induced hypocalciuria remains unclear. The present study investigates the effect of thiazides on the expression of the protein...

journal_title：Kidney international

authors： Nijenhuis T,Hoenderop JG,Loffing J,van der Kemp AW,van Os CH,Bindels RJ

更新日期：2003-08-01 00:00:00

abstract：:Acid (H+) retention appears to contribute to progressive decline in glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD), including some patients without metabolic acidosis. Identification of patients with H+ retention but without metabolic acidosis could facilitate targeted alkali therapy; h...

journal_title：Kidney international

authors： Goraya N,Simoni J,Sager LN,Madias NE,Wesson DE

更新日期：2019-05-01 00:00:00

abstract：:Space medicine and new technology such as magnetic resonance imaging of tissue sodium stores (23NaMRI) have changed our understanding of human sodium homeostasis and pathophysiology. It has become evident that body sodium comprises 3 main components. Two compartments have been traditionally recognized, namely one that...

journal_title：Kidney international

authors： Canaud B,Kooman J,Selby NM,Taal M,Francis S,Kopperschmidt P,Maierhofer A,Kotanko P,Titze J

更新日期：2019-02-01 00:00:00

abstract：:Our genetic hypercalciuric (GH) rats have been selected and inbred for 29 generations to maximize urine calcium (UCa) excretion compared to identical gender controls (Ctl). To determine the effect of the increased UCa on urinary supersaturation and stone formation, we pair fed 15 GH and 15 Ctl rats a standard 1.2% cal...

journal_title：Kidney international

authors： Bushinsky DA,Grynpas MD,Nilsson EL,Nakagawa Y,Coe FL

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:The benefit of the potent chemotherapeutic agent cisplatin in treating neoplasms is limited by nephrotoxicity. We tested the hypothesis that CD54 [intercellular adhesion molecule-1 (ICAM-1)] is an important mediator in cisplatin-mediated renal failure. METHODS:The effect of a monoclonal anti-CD54 antibody w...

journal_title：Kidney international

authors： Kelly KJ,Meehan SM,Colvin RB,Williams WW,Bonventre JV

更新日期：1999-09-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive kidney disease with high genetic heterogeneity. Understanding the functions of the individual genes contributing to this disease is critical for delineating the pathomechanisms of this disorder. Here, we investigated kidney function of a novel gene associated with nephronopht...

journal_title：Kidney international

authors： Airik R,Airik M,Schueler M,Bates CM,Hildebrandt F

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:In interstitial fibrosis, monocytes and myofibroblasts have been directly implicated in scarring, apoptosis, and tissue necrosis. While much has been done to explore the role of these cell types individually in fibrosis, the interactive dependency of monocytes and myofibroblasts has been only marginally expl...

journal_title：Kidney international

authors： Rodgers KD,Rao V,Meehan DT,Fager N,Gotwals P,Ryan ST,Koteliansky V,Nemori R,Cosgrove D

更新日期：2003-04-01 00:00:00

abstract：:Although angiotensin-converting enzyme (ACE) inhibitors are well-established drugs in the treatment of hypertension, they are not supposed to be sufficient in the inhibition of aldosterone formation. The present study analyzes the effect of aldosterone receptor antagonist, spironolactone and ACE inhibitor, captopril o...

journal_title：Kidney international

authors： Pechanova O,Matuskova J,Capikova D,Jendekova L,Paulis L,Simko F

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:It has been shown that non-congenic mice strains with lower levels of renal meprin develop less renal injury following renal ischemia and reperfusion. We have demonstrated that following ischemia-reperfusion renal injury, there is a rapid shift of meprin localization and intensity from the brush border to th...

journal_title：Kidney international

authors： Carmago S,Shah SV,Walker PD

更新日期：2002-03-01 00:00:00

abstract：:Undecalcified sections of doubly tetracycline-labeled transiliac bone biopsy specimens obtained from ten hemodialyzed patients before and 10 to 16 months after parathyroidectomy (PTX) were analyzed. Before parathyroidectomy (total PTX with autotransplant in six patients and subtotal PTX in four patients), all the pati...

journal_title：Kidney international

authors： Charhon SA,Berland YF,Olmer MJ,Delawari E,Traeger J,Meunier PJ

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Proteoglycans are integral components of the mesangial matrix and glomerular permeability barrier. Recent studies have shown that changes in glomerular proteoglycan expression may play a major role in the pathogenesis of renal disease. Steroid hormones are used as first-choice therapy for the treatment of gl...

journal_title：Kidney international

authors： Kuroda M,Sasamura H,Shimizu-Hirota R,Mifune M,Nakaya H,Kobayashi E,Hayashi M,Saruta T

更新日期：2002-09-01 00:00:00

abstract：:When patients develop acute kidney injury, a small fraction of them will develop end-stage renal disease later. The severity of renal impairment in the remaining patients is uncertain because studies have not carefully examined renal function over time or the precise timing of entry into a late stage of chronic kidney...

journal_title：Kidney international

authors： Amdur RL,Chawla LS,Amodeo S,Kimmel PL,Palant CE

更新日期：2009-11-01 00:00:00

abstract：:The parathyroid hormone response to hypocalcemia was investigated in hemodialysis patients with osteomalacia and compared to those with osteitis fibrosa. Hypocalcemia was induced during hemodialysis by employing a dialysate devoid of calcium. Patients with osteomalacia had a blunted maximum amino terminal parathyroid ...

journal_title：Kidney international

authors： Andress D,Felsenfeld AJ,Voigts A,Llach F

更新日期：1983-09-01 00:00:00

abstract：:Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been proposed for these disorders, including 'Medullary Cystic Kidney Disease (MCKD) type 2', 'Familial Ju...

journal_title：Kidney international

authors： Eckardt KU,Alper SL,Antignac C,Bleyer AJ,Chauveau D,Dahan K,Deltas C,Hosking A,Kmoch S,Rampoldi L,Wiesener M,Wolf MT,Devuyst O,Kidney Disease: Improving Global Outcomes.

更新日期：2015-10-01 00:00:00

abstract：:Vitamin D analogs may slow the progression of chronic kidney disease. Tan et al. report that paricalcitol has additive effects with an angiotensin-converting enzyme inhibitor (ACEI) in suppressing extracellular matrix expression, interstitial inflammation, and myofibroblast activation in obstructive nephropathy. Paric...

journal_title：Kidney international

authors： Li M,Batuman V

更新日期：2009-12-01 00:00:00

abstract：:Carefully age-matched, purebred male beagle dogs that underwent uninephrectomy one month after they were made diabetic with alloxan were used to establish a model of rapidly developing diabetic nephropathy in a large animal. The diabetic animals, all requiring insulin, were divided into two groups: one group with cont...

journal_title：Kidney international

authors： Steffes MW,Buchwald H,Wigness BD,Groppoli TJ,Rupp WM,Rohde TD,Blackshear PJ,Mauer SM

更新日期：1982-05-01 00:00:00

abstract：:Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic disorders, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF receptors in its target ti...

journal_title：Kidney international

authors： Lanske B,Razzaque MS

更新日期：2014-12-01 00:00:00

abstract：:Short-term correction of metabolic acidosis in normal and uremic subjects has been shown to decrease protein degradation, but the long-term effects of better correction of acidosis on nutrition in ESRF are unknown. The aim of this study was to assess the possible benefits, in the nutritional state and morbidity, of im...

journal_title：Kidney international

authors： Stein A,Moorhouse J,Iles-Smith H,Baker F,Johnstone J,James G,Troughton J,Bircher G,Walls J

更新日期：1997-10-01 00:00:00

abstract：:Anthropometric measurements and circulating growth factors were studied serially in 44 prepubertal children with growth failure and chronic renal failure (GFR = 10 to 40 ml/min/1.73 m2) who were randomized to receive either recombinant human growth hormone (rhGH; N = 30) or no treatment (N = 14). RhGH was given as Nut...

journal_title：Kidney international

authors： Powell DR,Liu F,Baker BK,Hintz RL,Lee PD,Durham SK,Brewer ED,Frane JW,Watkins SL,Hogg RJ

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:A nationwide survey of urolithiasis in Japan was made in order to evaluate the chronological trend of upper urinary tract stones in the Japanese. It succeeded previous studies done in 1955, 1966, 1979, and 1990. METHODS:All outpatient visits to urologists that resulted in a diagnosis of first-episode upper ...

journal_title：Kidney international

authors： Yoshida O,Terai A,Ohkawa T,Okada Y

更新日期：1999-11-01 00:00:00