Meprin, a brush-border enzyme, plays an important role in hypoxic/ischemic acute renal tubular injury in rats.

abstract：:Gene expression differs substantially among individual cells of the same type. We speculate that genes that are expressed in all but a portion of cells of a given cell type would be likely essential and required for either the cell survival (housekeeping) or for the cell type's unique structure and function, enabling ...

journal_title：Kidney international

authors： Lu Y,Ye Y,Bao W,Yang Q,Wang J,Liu Z,Shi S

更新日期：2017-11-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in kidney transplant recipients in many transplant registries. An analysis of transplant recipients from the United Kingdom using propensity score matching (PSM) suggests there are limited or no benefits to cardiovascular screening before transplant listing. We sugg...

journal_title：Kidney international

authors： Rankin AJ,Mark PB

更新日期：2021-02-01 00:00:00

abstract：:The antiphospholipid syndrome is a common autoimmune disease caused by pathogenic antiphospholipid antibodies, leading to recurrent thrombosis and/or obstetrical complications. Importantly for nephrologists, antiphospholipid antibodies are associated with various renal manifestations including large renal vessel throm...

journal_title：Kidney international

authors： Bienaimé F,Legendre C,Terzi F,Canaud G

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The podocyte is the focus of much research into the mechanisms of renal disease progression, and the number of podocytes per glomerulus has thus become a parameter of much interest. When counting podocytes, the actual particle counted is the cell nucleus. The majority of published studies estimating podocyte...

journal_title：Kidney international

authors： White KE,Bilous RW

更新日期：2004-08-01 00:00:00

abstract：:The autoregulatory ability of the renal vascular system in the split hydronephrotic kidney was quantitated with intravital microscopy. The luminal diameters of the arcuate and interlobular arteries as well as the afferent and efferent arterioles were measured. Glomerular blood flow was determined by the dual slit tech...

journal_title：Kidney international

authors： Steinhausen M,Blum M,Fleming JT,Holz FG,Parekh N,Wiegman DL

更新日期：1989-05-01 00:00:00

abstract：:The Standardized Outcomes in Nephrology (SONG) initiative is designed to improve research productivity by building consensus. Stakeholders involved with peritoneal dialysis (PD) have put life participation on top of their list, along with treatment-related infection, cardiovascular complications, and patient and techn...

journal_title：Kidney international

authors： Davies SJ

更新日期：2019-09-01 00:00:00

abstract：:Intravenous conjugated estrogens reduce the prolonged bleeding time in uremic patients and in a rat model of uremia. However, estrogens have major side effects related to their hormonal activity. We investigated whether a beta-resorcylic acid lactone, zeranol (a compound with close spatial similarity to estrogens but ...

journal_title：Kidney international

authors： Zoja C,Viganò G,Corna D,Salmona M,Remuzzi G,Garattini S

更新日期：1990-07-01 00:00:00

abstract：:Vascular calcification is recognized as a major contributor to cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. Susceptibility to vascular calcification is genetically determined and actively regulated by diverse inducers and inhibitors. One of these inducers, hyperphosphatemia, promotes vascul...

journal_title：Kidney international

authors： Giachelli CM

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:To chart the epidemiology of primary glomerular disease by means of a prospective regional study in the southern part of The Netherlands. METHODS:Experienced renal technicians collected renal biopsies, blood, and 24-hour urine samples at the bed site in each of the participating hospitals. The material was ...

journal_title：Kidney international

authors： van Paassen P,van Breda Vriesman PJ,van Rie H,Tervaert JW

更新日期：2004-09-01 00:00:00

abstract：:In studying the metabolic effects of diet potassium (K+) variation in normal humans, we noted that varying diet K+ within its normal range influenced inorganic phosphorus (Pi) homeostasis and serum calcitriol (1,25-dihydroxyvitamin D) levels. In six men who ingested a constant whole-foods diet containing (per 70 kg bo...

journal_title：Kidney international

authors： Sebastian A,Hernandez RE,Portale AA,Colman J,Tatsuno J,Morris RC Jr

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Previous experiments from our laboratory have demonstrated that HKalpha(2) coimmunoprecipitated with beta(1)-Na(+),K(+)-ATPase. Although HKalpha(2) is expressed abundantly in the apical membrane of distal colon, the demonstration that beta(1) localizes to this same membrane in distal colon has not been demon...

journal_title：Kidney international

authors： Li J,Codina J,Petroske E,Werle MJ,Willingham MC,DuBose TD Jr

更新日期：2004-09-01 00:00:00

abstract：:Dopamine plays an important role in regulation of renal sodium transport. Proximal tubule cells produce dopamine after decarboxylation of L-DOPA via the enzyme aromatic L-amino acid decarboxylase (AADC). The presence and cellular localization of AADC-like immunoreactivity (-LI) and AADC mRNA were examined during pre- ...

journal_title：Kidney international

authors： Meister B,Fried G,Holgert H,Aperia A,Hökfelt T

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Hypertriglyceridemia is a result of reduced triglyceride (TG)-rich lipoprotein (TRL) catabolism and occurs in rats with nephrotic syndrome (NS) and in Nagase analbuminemic rats (NARs). While the heparin-releasable lipoprotein lipase (LpL) pool in NAR and in NS is similar, TG levels are significantly greater ...

journal_title：Kidney international

authors： Shearer GC,Stevenson FT,Atkinson DN,Jones H,Staprans I,Kaysen GA

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:We have recently demonstrated an increase in apoptosis in Han:SPRD rat kidneys with autosomal-dominant polycystic kidney disease (ADPKD). Caspase-3 and caspase-7 are major mediators of apoptosis. There are two pathways of caspase-3 and caspase-7-mediated apoptosis: (1) the "extrinsic" pathway involving the d...

journal_title：Kidney international

authors： Tao Y,Kim J,Stanley M,He Z,Faubel S,Schrier RW,Edelstein CL

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The relationship between blood pressure (BP) and mortality in hemodialysis patients has remained controversial. Some studies suggested that a lower pre- or postdialysis BP was associated with excess mortality, while others showed poorer outcome in patients with uncontrolled hypertension. We conducted a multi...

journal_title：Kidney international

authors： Shoji T,Tsubakihara Y,Fujii M,Imai E

更新日期：2004-09-01 00:00:00

abstract：:Fatal vascular access hemorrhage is considered a rare complication of hemodialysis (HD). Ellingson et al. indicate otherwise, and their data suggest that it causes 0.4-1.6% of deaths in US HD patients. It is more common with grafts than fistulas, and many victims have had previous access hemorrhages. The widespread pr...

journal_title：Kidney international

authors： Blake PG,Quinn RR,Oliver MJ

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Tubular transepithelial reabsorption of chloride along the nephron is a major determinant of body salt and water homeostasis and blood pressure regulation. About 40% of the glomerulary filtered sodium chloride are reabsorbed in the distal nephrons. Vectorial transepithelial sodium chloride transport is criti...

journal_title：Kidney international

authors： Jeck N,Waldegger P,Doroszewicz J,Seyberth H,Waldegger S

更新日期：2004-01-01 00:00:00

abstract：:The mean renal tubular diameters, number of tubules per unit of cross-sectional area, and fraction of the total volume occupied by each medullary structure were determined at various levels of the renal medulla of the rat and rabbit. Statistical estimates of anatomic variables were made using spatial sampling techniqu...

journal_title：Kidney international

authors： Knepper MA,Danielson RA,Saidel GM,Post RS

更新日期：1977-11-01 00:00:00

abstract：:Pain was surveyed via structured interview and the McGill Pain Questionnaire in 53 dialysis and 27 transplant patients. Increased patient control over the dialysis procedure was not associated with a reduction in pain though perceived control may have been. Compliance with the dialysis regimen did not predict pain and...

journal_title：Kidney international

authors： Binik YM,Baker AG,Kalogeropoulos D,Devins GM,Guttmann RD,Hollomby DJ,Barré PE,Hutchison T,Prud'Homme M,McMullen L

更新日期：1982-06-01 00:00:00

abstract：:Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl(-) channel activity in Xenopus oocytes. Background. Cyst expansion in autosomal-dominant polycystic kidney disease (ADPKD) is characterized by active Cl(-) secretion in excess of solute reabsorption. However, the connections between elevated epith...

journal_title：Kidney international

authors： Chernova MN,Vandorpe DH,Clark JS,Alper SL

更新日期：2005-08-01 00:00:00

abstract：:Polycystic renal disease was induced in rats by feeding 2-amino-4,5-diphenylthiazole. Tubular (TBM) and glomerular basement membranes (GBM) were purified and analyzed for possible structural changes that may be a factor in the development of the tubular dilations and cysts. Changes in the relative quantities of TBM po...

journal_title：Kidney international

authors： Butkowski RJ,Carone FA,Grantham JJ,Hudson BG

更新日期：1985-11-01 00:00:00

abstract：:While hemodialysis therapy in its present form is capable of sustaining life, dialysis patients are not metabolically normal and we are unable to say what technical factors contribute adequate therapy. Recent efforts to resolve these problems have led to the assumption that substances in the molecular weight range of ...

journal_title：Kidney international

authors： Lowrie EG,Steinberg SM,Galen MA,Gagneux SA,Lazarus JM,Gottlieb MN,Merrill JP

更新日期：1976-11-01 00:00:00

abstract：:The purpose of these studies was to quantitatively assess the role of endogenous angiotensin II activity in controlling transport in the proximal convoluted tubule (PCT) and whole nephron. We used the nonpeptide angiotensin II receptor antagonist DuP 753, which lacks the agonist and kinin/prostaglandin-inducing proper...

journal_title：Kidney international

authors： Xie MH,Liu FY,Wong PC,Timmermans PB,Cogan MG

更新日期：1990-09-01 00:00:00

abstract：:Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A key component in cellular adaptation to hypoxia is the hypoxia-inducibl...

journal_title：Kidney international

authors： Kobayashi H,Liu J,Urrutia AA,Burmakin M,Ishii K,Rajan M,Davidoff O,Saifudeen Z,Haase VH

更新日期：2017-12-01 00:00:00

abstract：:Patients with chronic renal failure frequently have hypogonadism. To elucidate the molecular mechanisms involved, we tested the ability of serum from these patients to inhibit recombinant human luteinizing hormone receptors. Using a cell line expressing functional human luteinizing hormone receptors, we found that ade...

journal_title：Kidney international

authors： Dunkel L,Raivio T,Laine J,Holmberg C

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Random, nontimed blood pressure (BP) measurements in the outpatient clinic may fail to provide reliable information on actual daily BP control in renal patients on chronic antihypertensive therapy. METHODS:In a cohort of 163 patients with proteinuric chronic nephropathies followed prospectively with repeate...

journal_title：Kidney international

authors： Ruggenenti P,Perna A,Lesti M,Pisoni R,Mosconi L,Arnoldi F,Ciocca I,Gaspari F,Remuzzi G

更新日期：2000-11-01 00:00:00

abstract：:The formation of the non-sulphated glycosaminoglycan hyaluronan by cells of the renal glomerulus in diabetes may contribute to altered matrix composition. We describe an increased production of hyaluronan from mesangial cell-enriched glomerular cores from diabetic animals, and further show that increased hyaluronan pr...

journal_title：Kidney international

authors： Dunlop ME,Clark S,Mahadevan P,Muggli E,Larkins RG

更新日期：1996-07-01 00:00:00

abstract：:Copy number variations associate with different developmental phenotypes and represent a major cause of congenital anomalies of the kidney and urinary tract (CAKUT). Because rare pathogenic copy number variations are often large and contain multiple genes, identification of the underlying genetic drivers has proven to...

journal_title：Kidney international

authors： Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

更新日期：2015-12-01 00:00:00

abstract：:The existence of a tissue renin-angiotensin (RAS) system independent of the circulating RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in order to explain their tissue uptake. Two receptors that bind with similar affinity mature renin and prorenin were identified, the mannose-...

journal_title：Kidney international

authors： Nguyen G

更新日期：2006-05-01 00:00:00

abstract：:Genetic deletion of the adenosine A1 receptor (A1AR) increased renal injury following ischemia-reperfusion injury suggesting that receptor activation is protective in vivo. Here we tested this hypothesis by expressing the human-A(1)AR in A(1)AR knockout mice. Renal ischemia-reperfusion was induced in knockout mice 2 d...

journal_title：Kidney international

authors： Kim M,Chen SW,Park SW,Kim M,D'Agati VD,Yang J,Lee HT

更新日期：2009-04-01 00:00:00