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Metabolic acidosis inhibits soft tissue calcification in uremic rats.

Abstract：

:Metabolic acidosis is common in patients with chronic kidney disease, which is known to affect bone metabolism. We examined the effect of metabolic acidosis on the development of vascular and other soft-tissue calcifications in uremic rats treated with calcitriol. Extraskeletal calcification was measured in vivo, in control rats and rats with a remnant kidney model of uremia with or without ammonium chloride-induced acidosis. Soft-tissue calcification was assessed histologically, by measurement of the expression of the sodium-dependent phosphate cotransporter Pit-1 and by quantification of tissue calcium and phosphorus. Calcitriol administration to uremic rats resulted in significant deposition of material positive for von Kossa stain in the aorta, stomach, and kidney, elevated aortic calcium and phosphorus, increased aortic Pit-1 expression, and high mortality. Calcitriol-treated uremic rats with acidosis did not develop aortic or soft-tissue calcification, did not increase aortic Pit-1 expression, and had significantly lower mortality. Additionally, an acidotic environment prevented calcification of vascular smooth muscle cells in vitro. Our study shows that metabolic acidosis inhibits extraskeletal calcification.

journal_name

Kidney Int

journal_title

Kidney international

authors

Mendoza FJ,Lopez I,Montes de Oca A,Perez J,Rodriguez M,Aguilera-Tejero E

doi

10.1038/sj.ki.5002646

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

407-14

issue

4

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)53000-7

journal_volume

73

pub_type

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