当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > The soluble urokinase receptor is not a clinical marker for focal segmental glomerulosclerosis.

The soluble urokinase receptor is not a clinical marker for focal segmental glomerulosclerosis.

Abstract：

:The soluble urokinase receptor (suPAR) promotes proteinuria and induces focal segmental glomerulosclerosis (FSGS)-like lesions in mice. A serum suPAR concentration cutoff of 3000 pg/ml has been proposed as a clinical biomarker for patients with FSGS. Interestingly, several studies in patients with glomerulopathy found an inverse correlation between the estimated glomerular filtration rate (eGFR) and suPAR. As patients with FSGS present at different eGFRs, we studied the relationship between eGFR and suPAR in a cohort of 476 non-FSGS patients and 54 patients with biopsy-proven idiopathic FSGS. In the non-FSGS patients, eGFR was the strongest significant determinant of suPAR. The proposed cutoff for suPAR in FSGS patients was exceeded in 17%, 39%, and 88% in patients with eGFRs of more than 60, 45-60, and 30-45 ml/min per 1.73 m(2), respectively. In patients with eGFR of <30 ml/min per 1.73 m(2), suPAR exceeded the cutoff in 95% of patients. Levels of suPAR in patients with idiopathic FSGS overlapped with non-FSGS controls and for any given eGFR did not discriminate FSGS cases from non-FSGS controls. In the overall cohort, there was a negative association between idiopathic FSGS and suPAR, and idiopathic FSGS was not an independent predictor of FSGS concentration over 3000 pg/ml. Thus, this study does not support an absolute, eGFR-independent, suPAR concentration cutoff as a biomarker for underlying FSGS pathology and questions the validity of relative, eGFR-dependent suPAR cutoff values.

journal_name

Kidney Int

journal_title

Kidney international

authors

Meijers B,Maas RJ,Sprangers B,Claes K,Poesen R,Bammens B,Naesens M,Deegens JK,Dietrich R,Storr M,Wetzels JF,Evenepoel P,Kuypers D

doi

10.1038/ki.2013.505

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

636-40

issue

3

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)56249-2

journal_volume

85

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality.

    abstract：:Patients receiving hemodialysis have high rates of cardiovascular morbidity and mortality that may be related to the hemodynamic effects of rapid ultrafiltration. Here we tested whether higher dialytic ultrafiltration rates are associated with greater all-cause and cardiovascular mortality, and hospitalization for car...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/ki.2010.383

    authors： Flythe JE,Kimmel SE,Brunelli SM

    更新日期：2011-01-01 00:00:00

  • The effects of iron dextran on the oxidative stress in cardiovascular tissues of rats with chronic renal failure.

    abstract：BACKGROUND:Redox-active iron can promote oxidative stress and tissue injury by catalyzing hydroxyl radical generation and lipid peroxidation. Intravenous iron preparations are routinely administered in conjunction with erythropoietin to treat anemia in patients with chronic renal failure (CRF), a condition that is mark...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00580.x

    authors： Lim CS,Vaziri ND

    更新日期：2004-05-01 00:00:00

  • Aortic and large artery compliance in end-stage renal failure.

    abstract：:Pulse wave velocity (PWV) was measured in the aorta, right leg and arm of 90 control subjects (CS) and 92 hemodialysis patients (HD) of the same age and mean arterial pressure (MAP). Blood chemistry, including blood lipids, and echographic dimensions of the aorta, were measured in all subjects. Presence of aortic calc...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.19

    authors： London GM,Marchais SJ,Safar ME,Genest AF,Guerin AP,Metivier F,Chedid K,London AM

    更新日期：1990-01-01 00:00:00

  • Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats.

    abstract：BACKGROUND:Tamm-Horsfall glycoprotein (THP) is a unique protein that is produced exclusively by cells of the thick ascending limb of Henle's loop (TALH). This study examined whether dietary salt altered renal THP production. METHODS:Male Sprague-Dawley rats were examined on days 1, 4, and 15 following placement in met...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00117.x

    authors： Ying WZ,Sanders PW

    更新日期：1998-10-01 00:00:00

  • Importance of angiogenic action of angiotensin II in the glomerular growth of maturing kidneys.

    abstract：:We studied the effect of three antihypertensive drugs on the growth of glomeruli in four- to five-week-old Munich-Wistar rats (N = 24), which were undergoing rapid maturation processes. Young rats were given an angiotensin converting enzyme inhibitor (ACEI, enalapril, 50 mg/liter drinking water), verapamil (50 mg/lite...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.314

    authors： Fogo A,Yoshida Y,Yared A,Ichikawa I

    更新日期：1990-12-01 00:00:00

  • Acetate and bicarbonate hemodialysis in patients with and without autonomic dysfunction.

    abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.1984.134

    authors： Velez RL,Woodard TD,Henrich WL

    更新日期：1984-07-01 00:00:00

  • Plasma alpha 2 macroglobulin is increased in nephrotic patients as a result of increased synthesis alone.

    abstract：BACKGROUND:alpha 2 Macroglobulin (alpha 2M), a protease inhibitor, is often increased in plasma of patients with the nephrotic syndrome. Although it has been speculated that synthesis is increased, no direct measurements have been performed. METHODS:alpha 2M synthesis in both normal subjects (N = 4) and nephrotic pati...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00018.x

    authors： de Sain-van der Velden MG,Rabelink TJ,Reijngoud DJ,Gadellaa MM,Voorbij HA,Stellaard F,Kaysen GA

    更新日期：1998-08-01 00:00:00

  • Incidence of latent mesangial IgA deposition in renal allograft donors in Japan.

    abstract：BACKGROUND:Mesangial immunoglobulin A (IgA) deposition is incidentally encountered in asymptomatic individuals, but its precise frequency and significance had not been clarified. The background of the latent IgA deposition is related to the epidemiology and pathogenesis of IgA nephropathy. METHODS:Zero-hour allograft ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.63.6s.2.x

    authors： Suzuki K,Honda K,Tanabe K,Toma H,Nihei H,Yamaguchi Y

    更新日期：2003-06-01 00:00:00

  • FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis.

    abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis involves innate and adaptive immune cells in the induction of autoimmunity and in autoimmune effector responses. Most Fcγ receptors (FcγRs) activate immune cells, but FcγRIIB, found in humans and mice on B cells and innate cells, is an inhibitor...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.189

    authors： Ooi JD,Gan PY,Chen T,Eggenhuizen PJ,Chang J,Alikhan MA,Odobasic D,Holdsworth SR,Kitching AR

    更新日期：2014-12-01 00:00:00

  • The role of hyperparathyroidism, erythropoietin therapy, and CMV infection in the failure of arteriovenous fistula in hemodialysis.

    abstract：BACKGROUND:Vascular access failure is the main cause of morbidity in hemodialysis. Venous stenosis and subsequent thrombosis, as the result of intimal hyperplasia, is the major cause of vascular access failure. Intimal hyperplasia of the arteriovenous fistula (AVF) closely resembles the main histopathologic feature of ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00120.x

    authors： Grandaliano G,Teutonico A,Allegretti A,Losappio R,Mancini A,Gesualdo L,Schena FP,Pertosa G

    更新日期：2003-08-01 00:00:00

  • Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

    abstract：:Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.2

    authors： Pepper RJ,Hamour S,Chavele KM,Todd SK,Rasmussen N,Flint S,Lyons PA,Smith KG,Pusey CD,Cook HT,Salama AD

    更新日期：2013-06-01 00:00:00

  • Contribution of dietary oxalate to urinary oxalate excretion.

    abstract：BACKGROUND:The amount of oxalate excreted in urine has a significant impact on calcium oxalate supersaturation and stone formation. Dietary oxalate is believed to make only a minor (10 to 20%) contribution to the amount of oxalate excreted in urine, but the validity of the experimental observations that support this co...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00488.x

    authors： Holmes RP,Goodman HO,Assimos DG

    更新日期：2001-01-01 00:00:00

  • Von Willebrand factor regulates complement on endothelial cells.

    abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.03.023

    authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

    更新日期：2016-07-01 00:00:00

  • Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy.

    abstract：:Hydrogen sulfide has recently been found decreased in chronic kidney disease. Here we determined the effect and underlying mechanisms of hydrogen sulfide on a rat model of unilateral ureteral obstruction. Compared with normal rats, obstructive injury decreased the plasma hydrogen sulfide level. Cystathionine-β-synthas...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.449

    authors： Song K,Wang F,Li Q,Shi YB,Zheng HF,Peng H,Shen HY,Liu CF,Hu LF

    更新日期：2014-06-01 00:00:00

  • PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells.

    abstract：:Renal cell carcinoma (RCC) is the most common kidney malignancy and has a poor prognosis owing to its resistance to chemotherapy. RCC cells overexpress the transcription factor, PAX2, normally expressed in fetal kidney but downregulated at birth. Since Pax2 suppresses apoptosis during renal development, we reasoned th...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000136

    authors： Hueber PA,Waters P,Clark P,Eccles M,Goodyer P

    更新日期：2006-04-01 00:00:00

  • The proto-oncogene c-Fos transcriptionally regulates VEGF production during peritoneal inflammation.

    abstract：:Vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) are key mediators of adverse peritoneal membrane remodeling in peritoneal dialysis eventually leading to ultrafiltration failure. Both are pleiotropic growth factors with cell type-dependent regulation of expression and biological eff...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.217

    authors： Catar R,Witowski J,Wagner P,Annett Schramm I,Kawka E,Philippe A,Dragun D,Jörres A

    更新日期：2013-12-01 00:00:00

  • Role of hyperpolarization-activated cation channels in pyeloureteric peristalsis.

    abstract：:Although it has been recognized for more than 140 years that the pacemaker driving pyeloureteric peristalsis resides within the kidney, the cellular mechanisms underlying this autorhythmicity have been little investigated. The demonstration by Hurtado et al. of a role of hyperpolarization-activated cation channels in ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2009.485

    authors： Lang RJ

    更新日期：2010-03-01 00:00:00

  • Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats.

    abstract：:Renal proximal tubule cells from spontaneously hypertensive rats (SHR), compared with normotensive Wistar-Kyoto rats (WKY), have increased oxidative stress. The contribution of mitochondrial oxidative phosphorylation to the subsequent hypertensive phenotype remains unclear. We found that renal proximal tubule cells fr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.397

    authors： Lee H,Abe Y,Lee I,Shrivastav S,Crusan AP,Hüttemann M,Hopfer U,Felder RA,Asico LD,Armando I,Jose PA,Kopp JB

    更新日期：2014-03-01 00:00:00

  • Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury.

    abstract：:Anemia can contribute to chronic allograft injury by limiting oxygen delivery to tissues, particularly in the tubulointerstitium. To determine mechanisms by which erythropoietin (EPO) prevents chronic allograft injury we utilized a rat model of full MHC-mismatched kidney transplantation (Wistar Furth donor and Lewis r...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.473

    authors： Cassis P,Gallon L,Benigni A,Mister M,Pezzotta A,Solini S,Gagliardini E,Cugini D,Abbate M,Aiello S,Rocchetta F,Scudeletti P,Perico N,Noris M,Remuzzi G

    更新日期：2012-05-01 00:00:00

  • Effects of acute ureteral obstruction on glomerular hemodynamics in rat kidney.

    abstract：:In order to study the effects of acute ureteral obstruction on glomerular hemodynamics, glomerular hydrostatic capillary pressure (PG), pressure in the first-order peritubular capillaries (EAP), and intratubular pressure (PT) were directly measured in superficial nephrons on Munich-Wistar rats by micropuncture with a ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1977.131

    authors： Dal Canton A,Stanziale R,Corradi A,Andreucci VE,Migone L

    更新日期：1977-12-01 00:00:00

  • Increased Na/H antiport activity and abundance in uremic red blood cells.

    abstract：:Alterations in red blood cell sodium (Na) transport have been described in chronic renal failure. This study examines the possible impact of uremia on two ouabain-insensitive pathways, the Na/H antiporter and the Cl-/NaCO3- anion exchanger. The Vmax of Na/H antiporter measured as Na influx driven by outward H gradient...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.283

    authors： Corry DB,Tuck ML,Nicholas S,Weinman EJ

    更新日期：1993-09-01 00:00:00

  • Improving human kidney function in renovascular disease with mesenchymal stem cell therapy.

    abstract：:A dose escalation study of adipose-derived human mesenchymal stem cell (MSC) therapy was studied in 21 subjects. This dose escalation study confirmed no significant cellular toxicity, but it showed improvement in renal oxygenation and glomerular filtration rate. No significant renal toxicity from cell therapy was show...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2019.12.020

    authors： Sivanathan KN,Coates PT

    更新日期：2020-04-01 00:00:00

  • Circulating soluble receptor of advanced glycation end product inversely correlates with atherosclerosis in patients with chronic kidney disease.

    abstract：:The soluble receptor of advanced glycation end product (sRAGE) prevents vascular damage in experimental animal models, and observational studies in the general population support the hypothesis that sRAGE may exert a protective role on the vasculature. To test this in patients with chronic kidney disease, we determine...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.419

    authors： Basta G,Leonardis D,Mallamaci F,Cutrupi S,Pizzini P,Gaetano L,Tripepi R,Tripepi G,De Caterina R,Zoccali C

    更新日期：2010-02-01 00:00:00

  • Metabolic acidosis inhibits soft tissue calcification in uremic rats.

    abstract：:Metabolic acidosis is common in patients with chronic kidney disease, which is known to affect bone metabolism. We examined the effect of metabolic acidosis on the development of vascular and other soft-tissue calcifications in uremic rats treated with calcitriol. Extraskeletal calcification was measured in vivo, in c...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002646

    authors： Mendoza FJ,Lopez I,Montes de Oca A,Perez J,Rodriguez M,Aguilera-Tejero E

    更新日期：2008-02-01 00:00:00

  • DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition.

    abstract：BACKGROUND:Tubulointerstitial inflammation and fibrosis are pathologic hallmarks of end-stage renal disease (ESRD). Here we have used DNA microarray technology to monitor the transcriptomic responses to murine unilateral ureteral obstruction (UUO) with a view to identifying molecular modulators of tubulointerstitial fi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00306.x

    authors： Higgins DF,Lappin DW,Kieran NE,Anders HJ,Watson RW,Strutz F,Schlondorff D,Haase VH,Fitzpatrick JM,Godson C,Brady HR

    更新日期：2003-12-01 00:00:00

  • Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry.

    abstract：:The glomerular response to injury displays astonishingly uniform features that include infiltration with professional immune cells, activation and proliferation of resident glomerular cells and matrix expansion. Cross-communication of intrinsic mesangial cells with invading immune cells is crucial for the fate of glom...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.2002.00225.x

    authors： Pfeilschifter J,Beck KF,Eberhardt W,Huwiler A

    更新日期：2002-03-01 00:00:00

  • Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils.

    abstract：BACKGROUND:Recently, the in vivo pathogenic role of anti-neutrophil cytoplasm autoantibodies (ANCA) in ANCA-associated vasculitis has been challenged by Abdel-Salam et al. In their report, they observed that ANCA directed against proteinase 3 (PR3) cannot bind to their target autoantigen PR3 on circulating neutrophils ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00431.x

    authors： Van Rossum AP,van der Geld YM,Limburg PC,Kallenberg CG

    更新日期：2005-08-01 00:00:00

  • A role for novel cell-cycle proteins in podocyte biology.

    abstract：:Cell-cycle proteins influence almost all aspects of embryogenesis and differentiation. In adults, these proteins control cell division and regeneration after injury. During the past several years, their roles in controlling reaction to stress have been demonstrated in several organ systems. In the kidney, the cell typ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2009.562

    authors： Price PM

    更新日期：2010-04-01 00:00:00

  • Urine citrate excretion as a marker of acid retention in patients with chronic kidney disease without overt metabolic acidosis.

    abstract：:Acid (H+) retention appears to contribute to progressive decline in glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD), including some patients without metabolic acidosis. Identification of patients with H+ retention but without metabolic acidosis could facilitate targeted alkali therapy; h...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2018.11.033

    authors： Goraya N,Simoni J,Sager LN,Madias NE,Wesson DE

    更新日期：2019-05-01 00:00:00

  • Selective antagonism of the AT1 receptor inhibits angiotensin II stimulated DNA and protein synthesis in primary cultures of human proximal tubular cells.

    abstract：:The hypertrophy of renal proximal tubular cells occurs as an adaptive response to a variety of stimuli and may be involved with the progression of renal disease. Angiotensin II acting alone or in combination with other growth factors has been implicated in this process. The aims of this study were to identify the role...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.385

    authors： Chatterjee PK,Weerackody RP,Mistry SK,Hawksworth GM,McLay JS

    更新日期：1997-09-01 00:00:00