Elimination of Candida albicans from kidneys of mice during short-term systemic infections.

abstract：BACKGROUND:Interleukin-6 (IL-6) exerts its actions through a cell-surface receptor system that consists of two transmembrane subunits: the IL-6 binding glycoprotein gp 80 (IL-6R) and the signal-transducing component (gp 130). Soluble forms of the IL-6R (sIL-6R) are generated by shedding of the membrane-associated prote...

journal_title：Kidney international

authors： Memoli B,Postiglione L,Cianciaruso B,Bisesti V,Cimmaruta C,Marzano L,Minutolo R,Cuomo V,Guida B,Andreucci M,Rossi G

更新日期：2000-07-01 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, lipocalin 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it was identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced in renal failure and possesses kid...

journal_title：Kidney international

authors： Mori K,Nakao K

更新日期：2007-05-01 00:00:00

abstract：:There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chro...

journal_title：Kidney international

authors： Leibler C,Thiolat A,Elsner RA,El Karoui K,Samson C,Grimbert P

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Advanced glycation end products (AGEs) accumulate in patients with diabetes, particularly at sites of vascular damage and within atherosclerotic lesions, but whether they have direct actions on vascular smooth muscle cells (VSMCs) is controversial. METHODS:AGEs were constructed and characterized by protein ...

journal_title：Kidney international

authors： Ballinger ML,Thomas MC,Nigro J,Ivey ME,Dilley RJ,Little PJ

更新日期：2005-12-01 00:00:00

abstract：:Intravital multiphoton microscopy is a powerful tool to study kidney physiology in living animals. However, certain technical issues have curbed its usage to date, including limited depth of tissue penetration and high background emission of endogenous signals. Most previous studies have used the excitation range 700–...

journal_title：Kidney international

authors： Schuh CD,Haenni D,Craigie E,Ziegler U,Weber B,Devuyst O,Hall AM

更新日期：2016-03-01 00:00:00

abstract：:Although much emphasis has been placed on screening for albuminuria in type II diabetic patients, less attention has been focused on the role of glomerular filtration rate (GFR) in the assessment of risk. Herein, we examined the association between GFR and vascular complications in a consecutive cohort of 5174 type II...

journal_title：Kidney international

authors： Kong AP,So WY,Szeto CC,Chan NN,Luk A,Ma RC,Ozaki R,Ng VW,Ho CS,Lam CW,Chow CC,Cockram CS,Chan JC,Tong PC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Immune response to oxidized low-density lipoprotein (oxLDL) may modulate the process of atherogenesis and cardiovascular disease. METHODS:We performed a prospective, observational cohort study in 249 patients with end-stage renal disease (ESRD) to examine whether the serum titer of anti-oxLDL antibody can p...

journal_title：Kidney international

authors： Shoji T,Fukumoto M,Kimoto E,Shinohara K,Emoto M,Tahara H,Koyama H,Ishimura E,Nakatani T,Miki T,Tsujimoto Y,Tabata T,Nishizawa Y

更新日期：2002-12-01 00:00:00

abstract：:Leukocytes play a major role in the development and progression of autoimmune diseases. We measured gene expression differences in leukocytes from patients that were antineutrophil cytoplasmic autoantibody (ANCA) positive, patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA), and healthy donor...

journal_title：Kidney international

authors： Alcorta DA,Barnes DA,Dooley MA,Sullivan P,Jonas B,Liu Y,Lionaki S,Reddy CB,Chin H,Dempsey AA,Jennette JC,Falk RJ

更新日期：2007-10-01 00:00:00

abstract：:We studied the specific binding of radiolabeled bradykinin ([3H]BK) and vasopressin ([3H]AVP) to membrane preparations of bovine and porcine kidney medulla. [3H]BK reversibly labeled a single site (Kd = 1.06 nM) in bovine kidney medulla independently of [Mg2+]. The number of BK receptors in bovine kidney medulla, Bmax...

journal_title：Kidney international

authors： Howl J,Yarwood NJ,Davies AR,Wheatley M

更新日期：1996-08-01 00:00:00

abstract：:Using a combination of intra-operative digital photography and micro-biopsy we measured renal cortical and papillary changes in five patients with primary hyperparathyroidism and abundant calcium phosphate kidney stones. Major tissue changes were variable papillary flattening and retraction, dilation of the ducts of B...

journal_title：Kidney international

authors： Evan AE,Lingeman JE,Coe FL,Miller NL,Bledsoe SB,Sommer AJ,Williams JC,Shao Y,Worcester EM

更新日期：2008-07-01 00:00:00

abstract：:We previously reported that oxidative stress and renal tubular damage occur in chronic hyperoxaluric rats. However, the in vivo responses of renal epithelial cells after vitamin E administration and their correlations with calcium oxalate (CaOx) crystal formation have not been evaluated. Male Wistar rats received 0.75...

journal_title：Kidney international

authors： Huang HS,Chen J,Chen CF,Ma MC

更新日期：2006-08-01 00:00:00

abstract：:Reducing proteinuria and blood pressure in chronic kidney disease (CKD) decreases rate of progression. Inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers is beneficial in reducing proteinuria but incomplete in suppressing aldosterone production a...

journal_title：Kidney international

authors： Weinberger MH,Luft FC

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Home nocturnal hemodialysis is an intensive form of hemodialysis, where patients perform their treatments at home for about 7 hours approximately 6 nights a week. Compared with in-center conventional hemodialysis, home nocturnal hemodialysis has been shown to improve physiologic parameters and reduce health ...

journal_title：Kidney international

authors： McFarlane PA,Bayoumi AM,Pierratos A,Redelmeier DA

更新日期：2003-09-01 00:00:00

abstract：:Membranous nephropathy is a major cause of nephrotic syndrome in adults where podocyte injuries were found to mediate the development of proteinuria. Triptolide, a major active component of Tripterygium wilfordii Hook F, has potent immunosuppressive, anti-inflammatory and antiproteinuric effects. To study its antiprot...

journal_title：Kidney international

authors： Chen ZH,Qin WS,Zeng CH,Zheng CX,Hong YM,Lu YZ,Li LS,Liu ZH

更新日期：2010-06-01 00:00:00

abstract：:The relationship of protein intake to urinary oxalate and glycolate excretion was examined in a large cohort (N = 101) of normal individuals on self-selected diets and in 11 individuals on controlled protein diets. On self-selected diets no correlation was detected between protein intake and urinary oxalate or glycola...

journal_title：Kidney international

authors： Holmes RP,Goodman HO,Hart LJ,Assimos DG

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Decay accelerating factor (DAF), a product of mesangial cells in vitro, is expressed on the surface of cells and is a candidate for the focal suppression of complement activation. It is not clear at present whether the levels of expression of DAF and intrarenal C3 synthesis correlate with the level of tissue...

journal_title：Kidney international

authors： Abe K,Miyazaki M,Koji T,Furusu A,Ozono Y,Harada T,Sakai H,Nakane PK,Kohno S

更新日期：1998-07-01 00:00:00

abstract：:Serum fibroblast growth factor 23 (FGF23) is a novel phosphaturic factor and important for the regulation of inorganic phosphate (Pi) homeostasis. In this study, we examined an acute effect of oral Pi loading on serum FGF23 levels to clarify the role in rapid adjustment of serum Pi level. We performed a randomized, do...

journal_title：Kidney international

authors： Nishida Y,Taketani Y,Yamanaka-Okumura H,Imamura F,Taniguchi A,Sato T,Shuto E,Nashiki K,Arai H,Yamamoto H,Takeda E

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Peritoneal sclerosis, characterized by collagen accumulation, is a serious complication in continuous ambulatory peritoneal dialysis (CAPD) therapy. Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperon and is closely associated with collagen synthesis. METHODS:We determined the expression...

journal_title：Kidney international

authors： Shioshita K,Miyazaki M,Ozono Y,Abe K,Taura K,Harada T,Koji T,Taguchi T,Kohno S

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:The long-term prognostic associations of pre- and post-dialysis blood pressures, interdialytic weight gain, and antihypertensive use in hemodialysis patients are unclear. METHODS:The United States Renal Data System (USRDS) Dialysis Morbidity and Mortality Waves 3 and 4 Study, a randomly generated sample of ...

journal_title：Kidney international

authors： Foley RN,Herzog CA,Collins AJ,United States Renal Data System.

更新日期：2002-11-01 00:00:00

abstract：:Albumin is an acceptor of lysophosphatidylcholine (LPC), product of the lecithin:cholesterol acyl transferase (LCAT) reaction, and it has been suggested that low LCAT activity and reduced cholesterol esterification rate in patients with the nephrotic syndrome may be linked to depletion of albumin. Effects of low plasm...

journal_title：Kidney international

authors： Joles JA,Willekes-Koolschijn N,Scheek LM,Koomans HA,Rabelink TJ,van Tol A

更新日期：1994-07-01 00:00:00

abstract：:This very brief summary of the various possible contributions of PG to normal and abnormal renal function should highlight the problem of assigning a specific role to PG in overall renal physiology and pathophysiology. PG produced in specific segments of the nephron will affect specific functions occurring in this seg...

journal_title：Kidney international

authors： Schlondorff D,Ardaillou R

更新日期：1986-01-01 00:00:00

abstract：:Glomerular deposition of hepatitis B virus (HBV) antigens are observed in chronic HBsAg carriers with different glomerulonephritides yet the etiologic role of HBV remains uncertain. We examined the paraffin section of kidney biopsies from 40 chronic HBsAg carriers with membranous nephropathy (MGN), mesangiocapillary g...

journal_title：Kidney international

authors： Lai KN,Ho RT,Tam JS,Lai FM

更新日期：1996-12-01 00:00:00

abstract：:Levels of prepro epidermal growth factor (EGF) mRNA in renal cortical tissue and urinary EGF excretion have been determined during cisplatin and ischemia-induced acute renal failure in the rat. Northern analysis of polyadenylated RNAs of kidney cortical tissue showed diminished renal preproEGF mRNA in rats injected wi...

journal_title：Kidney international

authors： Safirstein R,Zelent AZ,Price PM

更新日期：1989-11-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive kidney disease with high genetic heterogeneity. Understanding the functions of the individual genes contributing to this disease is critical for delineating the pathomechanisms of this disorder. Here, we investigated kidney function of a novel gene associated with nephronopht...

journal_title：Kidney international

authors： Airik R,Airik M,Schueler M,Bates CM,Hildebrandt F

更新日期：2019-08-01 00:00:00

abstract：:Recent studies including the current article by Sawinski et al. demonstrate that hepatitis C virus (HCV) infection is associated with worse outcomes in kidney transplant recipients with and without HIV infection. We comment on the significance of these findings in the context of newer options for the treatment of HCV ...

journal_title：Kidney international

authors： Del Bello D,Ross MJ,Huprikar SS

更新日期：2015-08-01 00:00:00

abstract：:The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absence of exogenous bicarbonate ions (HCO3-), we explored the permeability characteristics in the presence ...

journal_title：Kidney international

authors： Finn JT,Cohen LH,Steinmetz PR

更新日期：1977-04-01 00:00:00

abstract：:Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Here we provide evidence ...

journal_title：Kidney international

authors： Rashmi P,Colussi G,Ng M,Wu X,Kidwai A,Pearce D

更新日期：2017-05-01 00:00:00

abstract：:Chronic metabolic acidosis (CMA) is a major cause of growth defect, implying disturbances of protein metabolism. Previously, in vivo studies performed in the fasting state showed enhanced whole body protein turnover, whereas in vitro studies showed unchanged muscle protein synthesis. The present study is the first to ...

journal_title：Kidney international

authors： Maniar S,Laouari D,Dechaux M,Motel V,Yvert JP,Mathian B,Kleinknecht C

更新日期：1994-12-01 00:00:00

abstract：:Urinary microvesicles, such as 40-100 nm exosomes and 100-1000 nm microparticles, contain many proteins that may serve as biomarkers of renal disease. Microvesicles have been isolated by ultracentrifugation or nanomembrane ultrafiltration from normal urine; however, little is known about the efficiency of these method...

journal_title：Kidney international

authors： Rood IM,Deegens JK,Merchant ML,Tamboer WP,Wilkey DW,Wetzels JF,Klein JB

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Several examinations have been performed to identify the genes involved in chronic renal failure using 5/6 nephrectomized rats. Recently, many systematic techniques for examining molecular expression have been developed. They might also be effective in elucidating the molecular mechanism of progressive renal...

journal_title：Kidney international

authors： Horiba N,Masuda S,Takeuchi A,Saito H,Okuda M,Inui K

更新日期：2004-07-01 00:00:00