当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Assessment of glomerular filtration rate in addition to albuminuria is important in managing type II diabetes.

Assessment of glomerular filtration rate in addition to albuminuria is important in managing type II diabetes.

Abstract：

:Although much emphasis has been placed on screening for albuminuria in type II diabetic patients, less attention has been focused on the role of glomerular filtration rate (GFR) in the assessment of risk. Herein, we examined the association between GFR and vascular complications in a consecutive cohort of 5174 type II diabetic patients between 1995 and 2000. Renal function was assessed by GFR (estimated by Modification of Diet in Renal Disease equation). The frequency of chronic kidney disease (CKD) as defined by GFR <60 ml/min/1.73 m(2), micro- and macrovascular complications, and their associations were analyzed. In this study cohort, 6% had serum creatinine > or =150 micromol/l and 15.8% had CKD. After adjustment for potential confounders, including urinary albumin excretion, odds ratios [95% confidence interval (CI)] across different stages of estimated GFR (> or =90, 60-89, 30-59, 15-29, <15 ml/min/1.73 m(2)) for macrovascular disease were 1.00, 1.42 [1.12-1.80], 1.80 [1.32-2.45], 2.74 [1.64-4.56], and 4.05 [1.77-9.26], respectively (P for trend <0.001); for retinopathy were 1.00, 1.23 [1.04-1.46], 1.80 [1.40-2.30], 2.05 [1.25-3.37], and 4.12 [1.56-10.90], respectively (P for trend <0.001); for sensory neuropathy were 1.00, 1.53[1.27-1.85], 2.09 [1.58-2.76], 4.32 [2.41-7.77], and 3.16 [1.25-8.02], respectively (P for trend <0.001); and for microalbumuria (with GFR <15 ml/min/1.73 m(2) excluded from the analysis) were 1.00, 1.51 [1.30-1.75], 5.80 [4.52-7.44], and 52.5 [16.4-168.2] respectively (P for trend <0.001). Measurement of serum creatinine alone without GFR may underestimate renal impairment in type II diabetic patients. Decreasing GFR was significantly associated with increasing frequency of micro- and macrovascular complications.

journal_name

Kidney Int

journal_title

Kidney international

authors

Kong AP,So WY,Szeto CC,Chan NN,Luk A,Ma RC,Ozaki R,Ng VW,Ho CS,Lam CW,Chow CC,Cockram CS,Chan JC,Tong PC

doi

10.1038/sj.ki.5000061

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

383-7

issue

2

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)51472-5

journal_volume

69

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Induction of VEGF and VEGF receptor gene expression by hypoxia: divergent regulation in vivo and in vitro.

    abstract：:This study examined the expression of EPO, VEGF and VEGF receptor gene under conditions of reduced oxygen supply in primary cultures of rat hepatocytes, and compared it with the expression of these genes in hypoxic rat livers in vivo. To this end we exposed male Sprague-Dawley rats to hypoxia (10% and 8% O2), carbon m...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.60

    authors： Sandner P,Wolf K,Bergmaier U,Gess B,Kurtz A

    更新日期：1997-02-01 00:00:00

  • Production of angiotensinogen and renin-like activity by rabbit proximal tubular cells in culture.

    abstract：:Recent studies suggest the presence of local angiotensin generating system in the kidney. By using in situ hybridization technique, mRNA for angiotensinogen has been shown to be present in the proximal tubule. In the present study, we have attempted to examine the production of angiotensinogen and renin-like activity ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.117

    authors： Yanagawa N,Capparelli AW,Jo OD,Friedal A,Barrett JD,Eggena P

    更新日期：1991-05-01 00:00:00

  • Formaldehyde kinetics and bacteriology in dialyzers.

    abstract：:The kinetics of formaldehyde washout in new and reused dialyzers with 2% (w/v) and 4% formaldehyde solution was studied. Using a standard method of rinsing, the concentration of formaldehyde decreases exponentially, but the rate of decrease and the steady-state level depends on the type of dialyzer. The residual quant...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.221

    authors： Hakim RM,Friedrich RA,Lowrie EG

    更新日期：1985-12-01 00:00:00

  • Glucocorticoid regulation of proteoglycan synthesis in mesangial cells.

    abstract：BACKGROUND:Proteoglycans are integral components of the mesangial matrix and glomerular permeability barrier. Recent studies have shown that changes in glomerular proteoglycan expression may play a major role in the pathogenesis of renal disease. Steroid hormones are used as first-choice therapy for the treatment of gl...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00524.x

    authors： Kuroda M,Sasamura H,Shimizu-Hirota R,Mifune M,Nakaya H,Kobayashi E,Hayashi M,Saruta T

    更新日期：2002-09-01 00:00:00

  • The hallmarks of mitochondrial dysfunction in chronic kidney disease.

    abstract：:Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received increasing attention as a therapeutic target in a variety of diseases because they serve as key regulatory hubs uniquely situated at crossroads be...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1016/j.kint.2017.05.034

    authors： Galvan DL,Green NH,Danesh FR

    更新日期：2017-11-01 00:00:00

  • Parapelvic kidney cysts: a distinguishing feature with high prevalence in Fabry disease.

    abstract：BACKGROUND:Fabry disease is an X-linked generalized progressive debilitating lysosomal storage disorder. The disease usually manifests in childhood, but the diagnosis is often made following the occurrence of late-stage complications such as progressive kidney failure. In order to identify key novel renal diagnostic im...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00846.x

    authors： Ries M,Bettis KE,Choyke P,Kopp JB,Austin HA 3rd,Brady RO,Schiffmann R

    更新日期：2004-09-01 00:00:00

  • Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans.

    abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calc...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.241

    authors： Lorthioir A,Joannidès R,Rémy-Jouet I,Fréguin-Bouilland C,Iacob M,Roche C,Monteil C,Lucas D,Renet S,Audrézet MP,Godin M,Richard V,Thuillez C,Guerrot D,Bellien J

    更新日期：2015-02-01 00:00:00

  • Quartan malarial nephrotic syndrome in children.

    abstract：:Quartan malarial infection causes an immune complex nephritis in some individuals, which, once established, is sustained by mechanisms not yet fully explained, but which probably involve autoimmune processes. The presenting clinical and biochemical findings of the quartan malarial nephrotic syndrome are similar to tho...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1979.103

    authors： Hendrickse RG,Adeniyi A

    更新日期：1979-07-01 00:00:00

  • Significance of the tissue kallikrein promoter and transforming growth factor-beta1 polymorphisms with renal progression in children with vesicoureteral reflux.

    abstract：BACKGROUND:Tissue kallikrein regulates blood circulation. Low urinary kallikrein excretion was associated with hypertension and renal disease in blacks. The polymorphic KLK1 promoter includes -130 GN coupled with multiple single base substitutions. The -130 G12 allele in the KLK1 promoter was associated with lower tran...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00526.x

    authors： Lee-Chen GJ,Liu KP,Lai YC,Juang HS,Huang SY,Lin CY

    更新日期：2004-04-01 00:00:00

  • Effects of recombinant human erythropoietin on HLA sensitization and cell mediated immunity.

    abstract：:Highly presensitized patients wait longer for a renal allograft than unsensitized patients and have a poorer allograft survival rate. Repeated blood transfusions have been implicated in the induction and maintenance of sensitization. To determine the effect of recombinant human erythropoietin (rHuEPO) therapy on five ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.161

    authors： Grimm PC,Sinai-Trieman L,Sekiya NM,Robertson LS,Robinson BJ,Fine RN,Ettenger RB

    更新日期：1990-07-01 00:00:00

  • Changes in bone structure and the muscle-bone unit in children with chronic kidney disease.

    abstract：:The impact of pediatric chronic kidney disease (CKD) on acquisition of volumetric bone mineral density (BMD) and cortical dimensions is lacking. To address this issue, we obtained tibia quantitative computed tomography scans from 103 patients aged 5-21 years with CKD (26 on dialysis) at baseline and 12 months later. G...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.347

    authors： Tsampalieros A,Kalkwarf HJ,Wetzsteon RJ,Shults J,Zemel BS,Foster BJ,Foerster DL,Leonard MB

    更新日期：2013-03-01 00:00:00

  • First responders: understanding monocyte-lineage traffic in the acutely injured kidney.

    abstract：:Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2008.555

    authors： Swaminathan S,Griffin MD

    更新日期：2008-12-01 00:00:00

  • Estimation of podocyte number: a comparison of methods.

    abstract：BACKGROUND:The podocyte is the focus of much research into the mechanisms of renal disease progression, and the number of podocytes per glomerulus has thus become a parameter of much interest. When counting podocytes, the actual particle counted is the cell nucleus. The majority of published studies estimating podocyte...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1523-1755.2004.00787.x

    authors： White KE,Bilous RW

    更新日期：2004-08-01 00:00:00

  • Effect of dietary protein restriction on nutritional status in the Modification of Diet in Renal Disease Study.

    abstract：:The safety of dietary protein and phosphorous restriction was evaluated in the Modification of Diet in Renal Disease (MDRD) Study. In Study A, 585 patients with a glomerular filtration rate (GFR) of 25 to 55 ml/min/1.73 m2 were randomly assigned to a usual-protein diet (1.3 g/kg/day) or a low-protein diet (0.58 g/kg/d...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/ki.1997.395

    authors： Kopple JD,Levey AS,Greene T,Chumlea WC,Gassman JJ,Hollinger DL,Maroni BJ,Merrill D,Scherch LK,Schulman G,Wang SR,Zimmer GS

    更新日期：1997-09-01 00:00:00

  • Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery.

    abstract：:Acute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic instability and sympathetic activity, and adversely influences prognosis. Here, we investigated in a randomized placebo-controlled trial whether dexmedetomidine, an α2 adrenoreceptor agonist, could prevent AKI after valvular h...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ki.2015.306

    authors： Cho JS,Shim JK,Soh S,Kim MK,Kwak YL

    更新日期：2016-03-01 00:00:00

  • Low protein diet in uremia: effects on glucose metabolism and energy production rate.

    abstract：:Low-protein diets (LPD) increase insulin-mediated glucose disposal in chronic renal failure (CRF), but the fate of the better utilized glucose and the effect on energy production rate are unknown. Using a two-step (1 and 5 mU x kg(-1) x min(-1)) euglycemic hyperinsulinemic clamp combined with indirect calorimetry, we ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.167

    authors： Rigalleau V,Combe C,Blanchetier V,Aubertin J,Aparicio M,Gin H

    更新日期：1997-04-01 00:00:00

  • Breaking the ice: urine proteomics of medullary sponge kidney disease.

    abstract：:Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinicall...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.10.032

    authors： Chutipongtanate S

    更新日期：2017-02-01 00:00:00

  • In vivo unaltered muscle protein synthesis in experimental chronic metabolic acidosis.

    abstract：:Chronic metabolic acidosis (CMA) is a major cause of growth defect, implying disturbances of protein metabolism. Previously, in vivo studies performed in the fasting state showed enhanced whole body protein turnover, whereas in vitro studies showed unchanged muscle protein synthesis. The present study is the first to ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1994.472

    authors： Maniar S,Laouari D,Dechaux M,Motel V,Yvert JP,Mathian B,Kleinknecht C

    更新日期：1994-12-01 00:00:00

  • Don't trick me twice!

    abstract：:Chemotherapy-induced nephrotoxicity limits the success of cancer therapy. Landau et al. now describe a mechanism by which a first dose of cisplatin renders the kidney sensitive to necroptosis mediated by a second dose. Unresolved injury and sustained necrosis, therefore, may represent a pathophysiological means of tra...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2018.12.004

    authors： Tonnus W,Belavgeni A,Xu Y,Linkermann A

    更新日期：2019-04-01 00:00:00

  • Renal tubular transport of gentamicin in the rat.

    abstract：:The renal handling of gentamicin in the rat was examined by clearance, microinjection, and renal cortical-slice techniques. The steady-state renal clearance of 14C-gentamicin, when corrected for the 7.5% binding to plasma protein, was not significantly different from that of 3H-inulin. At the end of the renal clearanc...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1979.149

    authors： Pastoriza-Munoz E,Bowman RL,Kaloyanides GJ

    更新日期：1979-10-01 00:00:00

  • Carbonic anhydrase in the human kidney: a histochemical and immunocytochemical study.

    abstract：:The intracellular distribution of carbonic anhydrase was studied in nine human donor kidneys by the histochemical method of Hansson and by an immunofluorescence technique using antisera specific against the cytoplasmic isoenzymes HCA B and HCA C. Only HCA C was found in the renal tubules. Convoluted proximal tubules s...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1984.106

    authors： Lönnerholm G,Wistrand PJ

    更新日期：1984-06-01 00:00:00

  • Nitric oxide increases adrenomedullin receptor function in rat mesangial cells.

    abstract：BACKGROUND:Adrenomedullin (ADM) exerts antiproliferative effects on rat mesangial cells in vitro and, therefore is a possible renoprotective agent. In contrast, nitric oxide (NO) is capable of exerting both cytoprotective and cytotoxic actions. It was the objective of the present study to examine whether NO stimulates ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00330.x

    authors： Dötsch J,Schoof E,Schöcklmann HO,Brüne B,Knerr I,Repp R,Rascher W

    更新日期：2002-05-01 00:00:00

  • Low oxygen stimulates the immune system.

    abstract：:Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.15

    authors： Maltzman JS,Haase VH

    更新日期：2008-04-01 00:00:00

  • Necrosis and apoptosis of polymorphonuclear cells exposed to peritoneal dialysis fluids in vitro.

    abstract：:Conventional peritoneal dialysis (PD) fluids are known to inhibit polymorphonuclear cells (PMN) phagocytosis, oxidative burst and enzyme release. However, the relative contributions of apoptosis and/or necrosis to this dysfunction have not been examined. We investigated the effects of osmolality, glucose concentration...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.495

    authors： Cendoroglo M,Sundaram S,Groves C,Ucci AA,Jaber BL,Pereira BJ

    更新日期：1997-12-01 00:00:00

  • Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus.

    abstract：BACKGROUND:Many studies have reported that blocking the renin-angiotensin-system (RAS) with an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker in the patient with diabetes mellitus leads to an increase in renal plasma flow (RPF), no change in glomerular filtration rate (GFR), and a fall...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.2003.00701.x

    authors： Hollenberg NK,Price DA,Fisher ND,Lansang MC,Perkins B,Gordon MS,Williams GH,Laffel LM

    更新日期：2003-01-01 00:00:00

  • Cellular and molecular pathways of renal repair after acute kidney injury.

    abstract：:The acutely injured mammalian kidney mounts a cellular and molecular response to repair itself. However, in patchy regions such intrinsic processes are impaired and dysregulated leading to chronic kidney disease. Currently, no therapy exists to treat established acute kidney injury per se. Strategies to augment human ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1016/j.kint.2017.07.030

    authors： Kumar S

    更新日期：2018-01-01 00:00:00

  • High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.

    abstract：BACKGROUND:The alteration of renal cell growth is one of the early abnormalities in the diabetic nephropathy. However, the effects of high glucose and its action mechanism in renal proximal tubule cell (PTC) proliferation have not been elucidated. METHODS:The effects of 25 mmol/L glucose on cell proliferation, thymidi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.0590051695.x

    authors： Park SH,Choi HJ,Lee JH,Woo CH,Kim JH,Han HJ

    更新日期：2001-05-01 00:00:00

  • Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.

    abstract：BACKGROUND:Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent scavenger of free radicals and has the antioxidant ability to inhibit lipid peroxidation. Its protective effect on brain ischemia has been shown. This study aimed to elucidate its possible therapeutic effects on renal oxidative stress in a rat ische...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00567.x

    authors： Doi K,Suzuki Y,Nakao A,Fujita T,Noiri E

    更新日期：2004-05-01 00:00:00

  • Albumin interaction with the glomerular capillary wall in vitro.

    abstract：:The binding of albumin to the glomerular capillary wall was studied using albumin-gold in perfused kidneys, the interaction of [3H]albumin with isolated glomeruli at 37 degrees C and 4 degrees C and the interaction at [3H]albumin with purified basement membrane. The albumin-gold was found to bind predominantly to the ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.149

    authors： Adal Y,Smit MF,Osicka TM,Comper WD

    更新日期：1995-04-01 00:00:00

  • Effect of conjugated estrogens on platelet function and prostacyclin generation in CRF.

    abstract：:In a double-blind, randomized, placebo-controlled cross-over study, we investigated in seven patients with chronic renal failure the effect of conjugated estrogens (0.6 mg/kg/day for 5 days) on template bleeding time and on thromboxane A2 (TxA2), beta-thromboglobulin (beta-TG) and prostacyclin (PGI2) concentrations in...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/ki.1990.331

    authors： Heistinger M,Stockenhuber F,Schneider B,Pabinger I,Brenner B,Wagner B,Balcke P,Lechner K,Kyrle PA

    更新日期：1990-12-01 00:00:00