Albumin interaction with the glomerular capillary wall in vitro.

abstract：:This report describes the occurrence of immune complex glomerulonephritis in a patient with eosinophilic gastroenteritis and food hypersensitivity. A coincident allergen injection may have been a contributing factor in the sudden development of the nephrotic syndrome. Markedly elevated levels of circulating immune com...

journal_title：Kidney international

authors： McCrory WW,Becker CG,Cunningham-Rundles C,Klein RF,Mouradian J,Reisman L

更新日期：1986-10-01 00:00:00

abstract：:Suzuki et al. analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene. The authors show that excess iron decreases levels of hypoxia-inducible transcription f...

journal_title：Kidney international

authors： Ganz T

更新日期：2018-11-01 00:00:00

abstract：:The importance of the relationship between the alteration of podocytic processes (PP) and proteinuria has been controversial for almost 30 years. In spite of several morphometric studies the range of PP alterations in different proteinuric conditions has gone unnoticed. Thus, we studied the distribution of abnormally ...

journal_title：Kidney international

authors： Fries JW,Rumpelt HJ,Thoenes W

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:To identify susceptibility genes for diabetic nephropathy, GeneChip Expression Analysis was employed to survey the gene expression profile of diabetic KK/Ta mouse kidneys. METHODS:Kidneys from three KK/Ta and two BALB/c mice at 20 weeks of age were dissected. Total RNA was extracted and labeled for hybridiz...

journal_title：Kidney international

authors： Fan Q,Shike T,Shigihara T,Tanimoto M,Gohda T,Makita Y,Wang LN,Horikoshi S,Tomino Y

更新日期：2003-12-01 00:00:00

abstract：:Podocyte foot process effacement is characteristic of proteinuric renal diseases. In minimal change nephrotic syndrome (MCNS) foot processes are diffusely effaced whereas the extent of effacement varies in focal segmental glomerulosclerosis (FSGS). Here we measured foot process effacement in FSGS and compared it to th...

journal_title：Kidney international

authors： Deegens JK,Dijkman HB,Borm GF,Steenbergen EJ,van den Berg JG,Weening JJ,Wetzels JF

更新日期：2008-12-01 00:00:00

abstract：:Endostatin (EST), an antiangiogenic factor, is enriched in aging kidneys. EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whether EST and TG2 play a role in the fibrosis of aging. In wild-type mice, aging kidneys exhibited a 2- to...

journal_title：Kidney international

authors： Lin CH,Chen J,Zhang Z,Johnson GV,Cooper AJ,Feola J,Bank A,Shein J,Ruotsalainen HJ,Pihlajaniemi TA,Goligorsky MS

更新日期：2016-06-01 00:00:00

abstract：:Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glo...

journal_title：Kidney international

authors： Working Group of the International IgA Nephropathy Network and the Renal Pathology Society.,Roberts IS,Cook HT,Troyanov S,Alpers CE,Amore A,Barratt J,Berthoux F,Bonsib S,Bruijn JA,Cattran DC,Coppo R,D'Agati V,D'Amico G,Emanci

更新日期：2009-09-01 00:00:00

abstract：:The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated erythropoietin gene expression. In electrophoretic mobility shift assays (EMSAs) HIF-1 DNA binding activity is only detecta...

journal_title：Kidney international

authors： Kvietikova I,Wenger RH,Marti HH,Gassmann M

更新日期：1997-02-01 00:00:00

abstract：:Chemotherapy-induced nephrotoxicity limits the success of cancer therapy. Landau et al. now describe a mechanism by which a first dose of cisplatin renders the kidney sensitive to necroptosis mediated by a second dose. Unresolved injury and sustained necrosis, therefore, may represent a pathophysiological means of tra...

journal_title：Kidney international

authors： Tonnus W,Belavgeni A,Xu Y,Linkermann A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Cyclosporine (CsA) is effective for the treatment of children with steroid-dependent and -resistant nephrotic syndrome (NS), but it can result in chronic CsA nephrotoxicity including CsA-induced tubulointerstitial lesions. The factors responsible for the development of CsA-induced tubulointerstitial lesions ...

journal_title：Kidney international

authors： Iijima K,Hamahira K,Tanaka R,Kobayashi A,Nozu K,Nakamura H,Yoshikawa N

更新日期：2002-05-01 00:00:00

abstract：:Defective recycling of megalin consequent to impaired phosphatidylinositol metabolism has been implicated as a mechanism causing tubular proteinuria in patients with Lowe syndrome. In this issue, Berquez et al. describe an innovative approach using a clinically approved drug to "rebalance" phosphatidylinositols and re...

journal_title：Kidney international

authors： Weisz OA

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Macrophages have been regarded as "blackguards" in the generation of glomerular injury. However, it is still unclear what kind of cellular machinery is responsible for their pathogenic actions. To explore this issue, this investigation aims at developing a novel strategy using adoptive transfer of "loss-of-f...

journal_title：Kidney international

authors： Kitamura M

更新日期：2000-02-01 00:00:00

abstract：:Angiotensinase A (aminopeptidase A; ATA) is an angiotensin II splitting exopeptidase, which is localized in endothelial and epithelial cells of the glomerular tuft. In order to investigate the influence of a reduction in renal mass on enzyme activity, ATA activity was measured in isolated rat glomeruli five and 14 wee...

journal_title：Kidney international

authors： Wolf G,Thaiss F,Scherberich JE,Schoeppe W,Stahl RA

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Transforming growth factor-beta (TGF-beta) is known to play an important role in the pathophysiology of renal tubular disease. Researchers have recently identified a novel mitogen-activated protein kinase kinase kinase (MAPKKK), TAK (TGF-beta activated kinase)1, which stimulates the MKK3/6-p38K pathway. The ...

journal_title：Kidney international

authors： Terada Y,Nakashima O,Inoshita S,Kuwahara M,Sasaki S,Marumo F

更新日期：1999-10-01 00:00:00

abstract：:The cellular redox state is altered in a number of pathological conditions, including various forms of glomerular injury and diabetes. For example, glucose, via the pentose phosphate pathway generates NADPH, which maintains glutathione (GSH) (part of a major intracellular reducing system) in its reduced state. GSH in ...

journal_title：Kidney international

authors： Shan Z,Tan D,Satriano J,Silbiger S,Schlondorff D

更新日期：1994-08-01 00:00:00

abstract：:Cholesterol conversion to and biliary excretion of bile acids represents the principal pathway of cholesterol catabolism in mammals. Cholesterol 7 alpha-hydroxylase (Ch-7 alpha-H) is the first and the rate limiting step in bile acid production. Recently, Ch-7 alpha-H enzymatic activity has been shown to be normal in r...

journal_title：Kidney international

authors： Liang KH,Oveisi F,Vaziri ND

更新日期：1996-03-01 00:00:00

abstract：:Transgenic rats [TGR; strain name TGR(mRen2)27] harboring the mouse Ren-2 renin gene have been recently generated as a model for the study of primary hypertension that offers the advantage of a clearly-defined genetic alteration. Expression of the mouse Ren-2 gene causes severe hypertension (200 to 260 mm Hg) which is...

journal_title：Kidney international

authors： Bachmann S,Peters J,Engler E,Ganten D,Mullins J

更新日期：1992-01-01 00:00:00

abstract：:Antioxidants have been used as therapies to decrease oxidative stress and improve CVD risk in hemodialysis (HD) patients. A systematic search of the Medline database (search date 30 April 2011) found 56 studies investigating the effects of antioxidant therapies on biomarkers of oxidative stress (53 studies) or clinica...

journal_title：Kidney international

authors： Coombes JS,Fassett RG

更新日期：2012-02-01 00:00:00

abstract：:Previous studies have shown that nonsteroidal anti-inflammatory drug (NSAID) use might be associated with a lower risk of developing cancer in the general population. Patients on dialysis have increased risk for cancer, but there are no studies to determine the relationship between NSAID use and cancer risk in these p...

journal_title：Kidney international

authors： Ou SM,Chen YT,Chao PW,Lee YJ,Liu CJ,Yeh CM,Chen TJ,Chen TW,Yang WC,Li SY

更新日期：2013-07-01 00:00:00

abstract：:Vitamin D hydroxylated at carbon 25 (25(OH)D) is generally recognized as a precursor of active vitamin D. Despite its low affinity for the vitamin D receptor (VDR), both deficient and excessive 25(OH)D levels are associated with poor clinical outcomes. Here we studied direct effects of 25(OH)D3 on the kidney using 25(...

journal_title：Kidney international

authors： Kusunoki Y,Matsui I,Hamano T,Shimomura A,Mori D,Yonemoto S,Takabatake Y,Tsubakihara Y,St-Arnaud R,Isaka Y,Rakugi H

更新日期：2015-11-01 00:00:00

abstract：:Erythropoietin (EPO) therapy in hemodialysis patients may be associated with an enhanced risk of vascular access and extracorporeal thrombosis. Assessment of blood coagulation and fibrinolysis was performed monthly on a group of 21 hemodialysis patients treated with EPO, and on four iron-deficient hemodialysis patient...

journal_title：Kidney international

authors： Taylor JE,Belch JJ,McLaren M,Henderson IS,Stewart WK

更新日期：1993-07-01 00:00:00

abstract：:Functional and morphological changes developed rapidly in rats after the intravenous administration of the organic nephrotoxin p-aminophenol. Proximal intratubular pressure remained close to its mean control value of 14.9 +/- 0.9 mm Hg up to 40 min after injection of the nephrotoxin then rose rapidly over the followin...

journal_title：Kidney international

authors： Davis JM,Emslie KR,Sweet RS,Walker LL,Naughton RJ,Skinner SL,Tange JD

更新日期：1983-12-01 00:00:00

abstract：:Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been proposed for these disorders, including 'Medullary Cystic Kidney Disease (MCKD) type 2', 'Familial Ju...

journal_title：Kidney international

authors： Eckardt KU,Alper SL,Antignac C,Bleyer AJ,Chauveau D,Dahan K,Deltas C,Hosking A,Kmoch S,Rampoldi L,Wiesener M,Wolf MT,Devuyst O,Kidney Disease: Improving Global Outcomes.

更新日期：2015-10-01 00:00:00

abstract：:To determine whether the induction of immune-mediated glomerular injury influences the formation of cyclooxygenase products by glomerular cells, we determined prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) (as the stable metabolite of TXA2) formation in isolated glomeruli of rats with passive Heymann nephritis (PHN...

journal_title：Kidney international

authors： Stahl RA,Adler S,Baker PJ,Chen YP,Pritzl PM,Couser WG

更新日期：1987-05-01 00:00:00

abstract：:The distribution of precursor nitrogen between urea and glutamine was studied in control and acidotic rats. Acidosis, either acutely induced with hydrochloric acid or chronically induced with ammonium chloride, resulted in a rise in ammonia and a fall in urinary urea excretion; the percent of urinary nitrogen excreted...

journal_title：Kidney international

authors： Phromphetcharat V,Jackson A,Dass PD,Welbourne TC

更新日期：1981-11-01 00:00:00

abstract：:Hydrogen sulfide has recently been found decreased in chronic kidney disease. Here we determined the effect and underlying mechanisms of hydrogen sulfide on a rat model of unilateral ureteral obstruction. Compared with normal rats, obstructive injury decreased the plasma hydrogen sulfide level. Cystathionine-β-synthas...

journal_title：Kidney international

authors： Song K,Wang F,Li Q,Shi YB,Zheng HF,Peng H,Shen HY,Liu CF,Hu LF

更新日期：2014-06-01 00:00:00

abstract：:Inflammatory responses in the kidney lead to tubulointerstitial fibrosis, a common feature of chronic kidney diseases. Here we examined the role of prostaglandin E(2) (PGE(2)) in the development of tubulointerstitial fibrosis. In the kidneys of wild-type mice, unilateral ureteral obstruction leads to progressive tubul...

journal_title：Kidney international

authors： Nakagawa N,Yuhki K,Kawabe J,Fujino T,Takahata O,Kabara M,Abe K,Kojima F,Kashiwagi H,Hasebe N,Kikuchi K,Sugimoto Y,Narumiya S,Ushikubi F

更新日期：2012-07-01 00:00:00

abstract：:Insulin resistance has been associated with kidney disease even in the absence of diabetes; however, pathways linking insulin resistance to kidney disease are unclear. The purpose of this study was to determine if transforming growth factor (TGF)-beta1, a key cytokine associated with kidney disease, responds to circul...

journal_title：Kidney international

authors： Huan Y,DeLoach S,Daskalakis C,Dunn SR,Sharma K,Falkner B

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Home nocturnal hemodialysis is an intensive form of hemodialysis, where patients perform their treatments at home for about 7 hours approximately 6 nights a week. Compared with in-center conventional hemodialysis, home nocturnal hemodialysis has been shown to improve physiologic parameters and reduce health ...

journal_title：Kidney international

authors： McFarlane PA,Bayoumi AM,Pierratos A,Redelmeier DA

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Tubular transepithelial reabsorption of chloride along the nephron is a major determinant of body salt and water homeostasis and blood pressure regulation. About 40% of the glomerulary filtered sodium chloride are reabsorbed in the distal nephrons. Vectorial transepithelial sodium chloride transport is criti...

journal_title：Kidney international

authors： Jeck N,Waldegger P,Doroszewicz J,Seyberth H,Waldegger S

更新日期：2004-01-01 00:00:00