Reduced renal prepro-epidermal growth factor mRNA and decreased EGF excretion in ARF.

abstract：BACKGROUND:To identify susceptibility genes for diabetic nephropathy, GeneChip Expression Analysis was employed to survey the gene expression profile of diabetic KK/Ta mouse kidneys. METHODS:Kidneys from three KK/Ta and two BALB/c mice at 20 weeks of age were dissected. Total RNA was extracted and labeled for hybridiz...

journal_title：Kidney international

authors： Fan Q,Shike T,Shigihara T,Tanimoto M,Gohda T,Makita Y,Wang LN,Horikoshi S,Tomino Y

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Carriers of autosomal-recessive and X-linked Alport syndrome often have a thinned glomerular basement membrane (GBM) and have mutations in the COL4A3/COL4A4 and COL4A5 genes respectively. Recently, we have shown that many individuals with thin basement membrane disease (TBMD) are also from families where hem...

journal_title：Kidney international

authors： Buzza M,Wang YY,Dagher H,Babon JJ,Cotton RG,Powell H,Dowling J,Savige J

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:In uremic patients with secondary hyperparathyroidism (2HPT), nodular hyperplasia of parathyroid gland shows a monoclonal pattern of cell proliferation, in which a decreased density of vitamin D receptor (VDR) also is demonstrated. The present study aimed at elucidating the mechanism of parathyroid cell prol...

journal_title：Kidney international

authors： Tokumoto M,Tsuruya K,Fukuda K,Kanai H,Kuroki S,Hirakata H

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The long-term prognostic associations of pre- and post-dialysis blood pressures, interdialytic weight gain, and antihypertensive use in hemodialysis patients are unclear. METHODS:The United States Renal Data System (USRDS) Dialysis Morbidity and Mortality Waves 3 and 4 Study, a randomly generated sample of ...

journal_title：Kidney international

authors： Foley RN,Herzog CA,Collins AJ,United States Renal Data System.

更新日期：2002-11-01 00:00:00

abstract：:Congenital nephrotic syndrome is clinically and genetically heterogeneous. The majority of cases can be attributed to mutations in the genes NPHS1, NPHS2, and WT1. By homozygosity mapping in a consanguineous family with isolated congenital nephrotic syndrome, we identified a potential candidate region on chromosome 3p...

journal_title：Kidney international

authors： Hasselbacher K,Wiggins RC,Matejas V,Hinkes BG,Mucha B,Hoskins BE,Ozaltin F,Nürnberg G,Becker C,Hangan D,Pohl M,Kuwertz-Bröking E,Griebel M,Schumacher V,Royer-Pokora B,Bakkaloglu A,Nürnberg P,Zenker M,Hildebrandt F

更新日期：2006-09-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) and MHC class II (Ia) antigens are increased on proximal tubular epithelial cells (TEC) in autoimmune nephritis and transplant rejection. ICAM-1 is a member of the immunoglobulin gene superfamily that increases the avidity of T cell interactions with antigen-presenting cells ...

journal_title：Kidney international

authors： Jevnikar AM,Wuthrich RP,Takei F,Xu HW,Brennan DC,Glimcher LH,Rubin-Kelley VE

更新日期：1990-09-01 00:00:00

abstract：:Tubulointerstitial fibrosis is one of the most important histologic features that predicts progression in kidney disease. Thrombospondin 1 is an extracellular matrix protein that can activate latent TGF-beta, a cytokine implicated in the pathogenesis of tubulointerstitial fibrosis. We examined the expression of thromb...

journal_title：Kidney international

authors： Hugo C,Shankland SJ,Pichler RH,Couser WG,Johnson RJ

更新日期：1998-02-01 00:00:00

abstract：:Cystinuria is a common inherited aminoaciduria that leads to recurrent cystine nephrolithiasis. Mutations in a gene encoding a renal amino acid transporter (SLC3A1) have been identified in patients with cystinuria establishing one molecular cause for the disease. To facilitate systematic screening of this gene for mut...

journal_title：Kidney international

authors： Endsley JK,Phillips JA 3rd,Hruska KA,Denneberg T,Carlson J,George AL Jr

更新日期：1997-06-01 00:00:00

abstract：:Acute kidney injury (AKI), previously termed acute renal failure, is associated with increased mortality, prolonged hospital stay, and accelerated chronic kidney disease (CKD). Over the past 2 decades, dramatic rises in the incidences of AKI have been reported, particularly within the United States. The question arise...

journal_title：Kidney international

authors： Siew ED,Davenport A

更新日期：2015-01-01 00:00:00

abstract：:Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. To better characterize the glomerular disease associated with myeloproliferative neoplasms, we evaluated features of 11 patients with myeloproliferative neoplasm-related glomerulopathy that included ...

journal_title：Kidney international

authors： Said SM,Leung N,Sethi S,Cornell LD,Fidler ME,Grande JP,Herrmann S,Tefferi A,D'Agati VD,Nasr SH

更新日期：2011-10-01 00:00:00

abstract：:The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...

journal_title：Kidney international

authors： Keddis MT,El Ters M,Rodrigo E,Dean P,Wohlfahrtova M,Kudva YC,Lorenz EC,Cosio FG

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:The plasma concentrations of total homocysteine (tHcy) and total cysteine (tCys) are determined by intracellular metabolism and by renal plasma clearance, and we hypothesized that glomerular filtration is a major determinant of plasma tHcy and tCys. We studied the relationships between the glomerular filtrat...

journal_title：Kidney international

authors： Wollesen F,Brattström L,Refsum H,Ueland PM,Berglund L,Berne C

更新日期：1999-03-01 00:00:00

abstract：:There are two fundamentally different growth responses for cells comprising the nephron: hyperplasia or hypertrophy. Cells that progress through the normal cell cycle double their DNA content and eventually divide during mitosis. Those cells that hypertrophy stop the growth process in the G1-phase of the cell cycle; w...

journal_title：Kidney international

authors： Wolf G

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Cyclosporine (CsA) is effective for the treatment of children with steroid-dependent and -resistant nephrotic syndrome (NS), but it can result in chronic CsA nephrotoxicity including CsA-induced tubulointerstitial lesions. The factors responsible for the development of CsA-induced tubulointerstitial lesions ...

journal_title：Kidney international

authors： Iijima K,Hamahira K,Tanaka R,Kobayashi A,Nozu K,Nakamura H,Yoshikawa N

更新日期：2002-05-01 00:00:00

abstract：:The X-linked Hyp and Gy mutations are murine homologues of X-linked hypophosphatemia (XLH), a dominant disorder of phosphate (Pi) homeostasis characterized by growth retardation, rickets, hypophosphatemia and decreased renal tubular maximum for Pi reabsorption relative to glomerular filtration rate (Tmp/GFR). In Hyp a...

journal_title：Kidney international

authors： Tenenhouse HS,Beck L

更新日期：1996-04-01 00:00:00

abstract：:Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit ...

journal_title：Kidney international

authors： Yokoi H,Yanagita M

更新日期：2016-04-01 00:00:00

abstract：:Many transgenic and knockout mice with increased urine flow have structural abnormalities of the renal pelvis and inner medulla. Here, we used high resolution contrast enhanced T1-weighted magnetic resonance imaging of mice whose urea transporters UT-A1 and UT-A3 were deleted (UT-A1/3(-/-) mice) as a model for the in ...

journal_title：Kidney international

authors： Jacob VA,Harbaugh CM,Dietz JR,Fenton RA,Kim SM,Castrop H,Schnermann J,Knepper MA,Chou CL,Anderson SA

更新日期：2008-11-01 00:00:00

abstract：:The family of bone morphogenetic proteins. Bone morphogenetic proteins (BMPs) are secreted signaling molecules belonging to the transforming growth factor-beta (TGF-beta) superfamily of growth factors. The first BMPs were originally identified by their ability to induce ectopic bone formation when implanted under the ...

journal_title：Kidney international

authors： Ducy P,Karsenty G

更新日期：2000-06-01 00:00:00

abstract：:How the dialysis dose is normalized is just one of several assumptions that clinicians need to take into account when prescribing peritoneal dialysis. El-Kateb et al. confirm that estimating the volume of urea distribution is associated with significant error and show that energy expenditure is not linearly related to...

journal_title：Kidney international

authors： Davies SJ

更新日期：2016-12-01 00:00:00

abstract：:The pathologic and clinical features of 16 patients with dense intramembranous deposit disease are described. By light microscopy nine patients had membranoproliferative glomerulonephritis, five had focal segmental necrotizing glomerulonephritis with segmental epithelial crescents, four of whom also had a prominent tu...

journal_title：Kidney international

authors： Sibley RK,Kim Y

更新日期：1984-04-01 00:00:00

abstract：:Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2(*)) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. This parameter was...

journal_title：Kidney international

authors： Michaely HJ,Metzger L,Haneder S,Hansmann J,Schoenberg SO,Attenberger UI

更新日期：2012-04-01 00:00:00

abstract：:Angiotensinase A (aminopeptidase A; ATA) is an angiotensin II splitting exopeptidase, which is localized in endothelial and epithelial cells of the glomerular tuft. In order to investigate the influence of a reduction in renal mass on enzyme activity, ATA activity was measured in isolated rat glomeruli five and 14 wee...

journal_title：Kidney international

authors： Wolf G,Thaiss F,Scherberich JE,Schoeppe W,Stahl RA

更新日期：1990-11-01 00:00:00

abstract：:The OSCAR study was a multicenter, prospective randomized open-label blinded end-point study of 1164 Japanese elderly hypertensive patients comparing the efficacy of angiotensin II receptor blocker (ARB) uptitration to an ARB plus calcium channel blocker (CCB) combination. In this prospective study, we performed presp...

journal_title：Kidney international

authors： Kim-Mitsuyama S,Ogawa H,Matsui K,Jinnouchi T,Jinnouchi H,Arakawa K

更新日期：2013-01-01 00:00:00

abstract：:A study of dialysis costs in five major dialysis centers throughout the United States was conducted in 1973. When available, home, home training, limited care, satellite and in-hospital-full-care dialysis were included. The study's objective was to determine the cost per dialysis for each separate dialysis modality. A...

journal_title：Kidney international

authors： Hoffstein PA,Krueger KK,Wineman RJ

更新日期：1976-03-01 00:00:00

abstract：:A controlled trial of cyclosporine in patients diagnosed with progressive membranous nephropathy (MGN) was carried out to determine whether cyclosporine (D) would be more effective than placebo (P) in reducing the rate of deterioration in renal function. Patients (N = 64) with MGN were placed on a restricted protein d...

journal_title：Kidney international

authors： Cattran DC,Greenwood C,Ritchie S,Bernstein K,Churchill DN,Clark WF,Morrin PA,Lavoie S

更新日期：1995-04-01 00:00:00

abstract：:Antibody-mediated rejection represents the first cause of graft loss in renal transplant recipients, and it is imperative to identify appropriate tools to enable risk stratification of such patients. Lately, the usefulness of measuring complement-binding anti-human leukocyte antigen (HLA) donor-specific antibodies (DS...

journal_title：Kidney international

authors： Cozzi E,Biancone L

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Macrophages have been regarded as "blackguards" in the generation of glomerular injury. However, it is still unclear what kind of cellular machinery is responsible for their pathogenic actions. To explore this issue, this investigation aims at developing a novel strategy using adoptive transfer of "loss-of-f...

journal_title：Kidney international

authors： Kitamura M

更新日期：2000-02-01 00:00:00

abstract：:The increasing use of mice in renal and cardiovascular studies has necessitated adapting physiological methods used for rats to mice, which are far smaller in size. We have adapted measurements of continuous renal blood flow, pressure natriuresis and diuresis, and laser-Doppler cortical and medullary flow to 40 g mice...

journal_title：Kidney international

authors： Gross V,Lippoldt A,Luft FC

更新日期：1997-11-01 00:00:00

abstract：:We have analyzed the protein content of proximal tubular fluid (PTF) by ultramicro disc electrophoresis and measured total protein excretion rates both in control conditions and during angiotensin infusion to the rat. Under control conditions PTF albumin concentration was 1.49 +/- 1.12 (SD) mg/100 ml and did not incre...

journal_title：Kidney international

authors： Eisenbach GM,Liew JB,Boylan JW,Manz N,Muir P

更新日期：1975-08-01 00:00:00

abstract：:Residual renal function is a major survival determinant for peritoneal dialysis patients. Hypovolemia can cause acute kidney injury and loss of residual renal function, and it has been suggested that patients receiving peritoneal dialysis should preferably be maintained hypervolemic to preserve residual renal function...

journal_title：Kidney international

authors： McCafferty K,Fan S,Davenport A

更新日期：2014-01-01 00:00:00