MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease.

abstract：INTRODUCTION:Thiazide diuretics have the unique characteristic of increasing renal Na+ excretion, while decreasing Ca2+ excretion. However, the molecular mechanism responsible for this thiazide-induced hypocalciuria remains unclear. The present study investigates the effect of thiazides on the expression of the protein...

journal_title：Kidney international

authors： Nijenhuis T,Hoenderop JG,Loffing J,van der Kemp AW,van Os CH,Bindels RJ

更新日期：2003-08-01 00:00:00

abstract：:Mutations in the inverted formin 2 gene (INF2) have recently been identified as the most common cause of autosomal dominant focal and segmental glomerulosclerosis (FSGS). To quantify the contribution of various genes contributing to FSGS, we sequenced INF2 where all mutations have previously been described (exons 2 to...

journal_title：Kidney international

authors： Barua M,Brown EJ,Charoonratana VT,Genovese G,Sun H,Pollak MR

更新日期：2013-02-01 00:00:00

abstract：UNLABELLED:Inhibition of pressure natriuresis in mice lacking the AT2 receptor. BACKGROUND:Angiotensin II type 2 (AT2) receptor knockout mice have higher blood pressures than wild-type mice; however, the hypertension is imperfectly defined. We tested the hypothesis that renal mechanisms could be contributory. METHODS...

journal_title：Kidney international

authors： Gross V,Schunck WH,Honeck H,Milia AF,Kärgel E,Walther T,Bader M,Inagami T,Schneider W,Luft FC

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:alpha 2 Macroglobulin (alpha 2M), a protease inhibitor, is often increased in plasma of patients with the nephrotic syndrome. Although it has been speculated that synthesis is increased, no direct measurements have been performed. METHODS:alpha 2M synthesis in both normal subjects (N = 4) and nephrotic pati...

journal_title：Kidney international

authors： de Sain-van der Velden MG,Rabelink TJ,Reijngoud DJ,Gadellaa MM,Voorbij HA,Stellaard F,Kaysen GA

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Population-genetic studies investigating genetic polymorphisms of Mendelian inheritance should always test whether the measured genotype frequencies deviate from the expected one. For this purpose Hardy-Weinberg (HW) criteria are generally used. If genotype distribution of control population misses HW equili...

journal_title：Kidney international

authors： Kocsis I,Györffy B,Németh E,Vásárhelyi B

更新日期：2004-05-01 00:00:00

abstract：:Polyomavirus-associated nephropathy (PVAN) is a significant complication after kidney transplantation, often leading to premature graft loss. In order to identify antiviral responses of the renal tubular epithelium, we studied activation of the viral DNA and the double-stranded RNA (dsRNA) sensors Toll-like receptor 3...

journal_title：Kidney international

authors： Ribeiro A,Wörnle M,Motamedi N,Anders HJ,Gröne EF,Nitschko H,Kurktschiev P,Debiec H,Kretzler M,Cohen CD,Gröne HJ,Schlöndorff D,Schmid H

更新日期：2012-01-01 00:00:00

abstract：:The recent identification of RPGRIP1L as a Joubert syndrome gene brings the total of known genes to five. Three of these are also associated with the lethal Meckel syndrome, and two with Senior-Løken syndrome; both of these disorders share Joubert syndrome phenotypes, illustrating the genetic complexity of this. ...

journal_title：Kidney international

authors： Harris PC

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Macrophage (Mphi) infiltration may contribute to chronic renal injury. We therefore sought to examine the expression of genes associated with Mphi recruitment in the rat remnant kidney model. METHODS:Male Munich Wistar rats underwent 5/6 nephrectomy or sham operation (SHM, N = 18) and received no treatment ...

journal_title：Kidney international

authors： Taal MW,Zandi-Nejad K,Weening B,Shahsafaei A,Kato S,Lee KW,Ziai F,Jiang T,Brenner BM,MacKenzie HS

更新日期：2000-10-01 00:00:00

abstract：:Membranous nephropathy is a major cause of nephrotic syndrome in adults where podocyte injuries were found to mediate the development of proteinuria. Triptolide, a major active component of Tripterygium wilfordii Hook F, has potent immunosuppressive, anti-inflammatory and antiproteinuric effects. To study its antiprot...

journal_title：Kidney international

authors： Chen ZH,Qin WS,Zeng CH,Zheng CX,Hong YM,Lu YZ,Li LS,Liu ZH

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Inhibition of the renin-angiotensin system (RAS) prevents development of chronic allograft dysfunction in experimental animals. Whether this therapeutic approach is effective even if started when signs of allograft nephropathy are already manifested has not been investigated. METHODS:To address this issue, ...

journal_title：Kidney international

authors： Noris M,Mister M,Pezzotta A,Azzollini N,Cassis P,Benigni A,Gagliardini E,Perico N,Remuzzi G

更新日期：2003-12-01 00:00:00

abstract：:The profibrotic adhesion molecule, osteopontin (OPN), is upregulated in kidneys of humans and mice with diabetes. The thiazolidinedione (TZD) insulin sensitizers decrease albuminuria in diabetic nephropathy (DN) and reduce OPN expression in vascular and cardiac tissue. To examine whether OPN is a critical mediator of ...

journal_title：Kidney international

authors： Nicholas SB,Liu J,Kim J,Ren Y,Collins AR,Nguyen L,Hsueh WA

更新日期：2010-04-01 00:00:00

abstract：:It has been shown that somatostatin inhibits the antidiuretic action of vasopressin in toad urinary bladder in vitro and in dogs and rats in vivo. The presence of somatostatin-like immunoreactivity (SLI) in the urinary bladder and kidney of the toad has suggested the possibility that somatostatin may act as a local pa...

journal_title：Kidney international

authors： Kurokawa K,Aponte GW,Fujibayashi S,Yamada T

更新日期：1983-12-01 00:00:00

abstract：:The cannabinoid receptor type 2 (CB2) is a G protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the pathogenesis of kidney injury and fibrosis remains poorly understood. Here we demonstrate that CB2 was induced, predominantly in kidney tubular epithelium, i...

journal_title：Kidney international

authors： Zhou L,Zhou S,Yang P,Tian Y,Feng Z,Xie XQ,Liu Y

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia may affect both endothelial function and arterial distensibility (DC). Renal transplant recipients (NTX) exhibit advanced structural and functional alterations of arterial vessel walls. The aim of this double-blind, randomized trial was to evaluate the effects of fluvastatin (FLU) on bra...

journal_title：Kidney international

authors： Hausberg M,Kosch M,Stam F,Heidenreich S,Kisters K,Rahn KH,Barenbrock M

更新日期：2001-04-01 00:00:00

abstract：:To date direct evidence for the presence of a H-K-ATPase in the medulla comes from proton and potassium transport studies performed on K-restricted animals and K dependent ATP hydrolysis and Rb uptake in both normal and K-depleted animals. The present work examines K-dependent acidification in the medulla of rabbits o...

journal_title：Kidney international

authors： Curran KA,Hebert MJ,Cain BD,Wingo CS

更新日期：1992-11-01 00:00:00

abstract：:Complement factor 5a (C5a) interaction with its receptor (C5aR1) contributes to the pathogenesis of inflammatory diseases, including acute kidney injury. However, its role in chronic inflammation, particularly in pathogen-associated disorders, is largely unknown. Here we tested whether the development of chronic infla...

journal_title：Kidney international

authors： Choudhry N,Li K,Zhang T,Wu KY,Song Y,Farrar CA,Wang N,Liu CF,Peng Q,Wu W,Sacks SH,Zhou W

更新日期：2016-09-01 00:00:00

abstract：:The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in osteoarthritis (OA) an...

journal_title：Kidney international

authors： Whelton A,Lefkowith JL,West CR,Verburg KM

更新日期：2006-10-01 00:00:00

abstract：:X-ray films of the hand skeleton (mammography technique), serum chemistry, and quantitative bone histology (micromorphometry of undecalcified sections, iliac crest spongiosa) were compared in 25 patients on maintenance hemodialysis. The X-ray findings correlated better with serum PTH levels than with bone histology. O...

journal_title：Kidney international

authors： Ritz E,Prager P,Krempien B,Bommer J,Malluche HH,Schmidt-Gayk H

更新日期：1978-04-01 00:00:00

abstract：:We investigated the effects of epidermal growth factor (EGF) and arginine vasopressin (AVP) on Raf-1-MAP kinase cascade, including Raf-1-kinase (Raf-1-K), MAP kinase kinase (MAPKK), MAP kinase (MAPK) and S6 kinase (S6K) in Madin-Darby canine kidney (MDCK) cells. In a dose-dependent manner (10(-10) M to 10(-6) M), EGF ...

journal_title：Kidney international

authors： Yamada T,Terada Y,Homma MK,Nonoguchi H,Sasaki S,Yuasa Y,Tomita K,Marumo F

更新日期：1995-09-01 00:00:00

abstract：:Administration of antibody, directed against glomerular basement membrane (GBM) heparan sulfate-proteoglycan, into a presensitized rat results in the induction of membranous nephropathy with subepithelial immune-complex deposits. In this investigation, we examined the mechanisms responsible for the formation of subepi...

journal_title：Kidney international

authors： Makino H,Lelongt B,Kanwar YS

更新日期：1988-08-01 00:00:00

abstract：:Orskov and colleagues demonstrate the impact of birth weight on the mean age of end-stage renal disease (ESRD) in a large Danish ADPKD cohort. Each kilogram of birth weight extended the mean age of ESRD onset by 1.7 years. Placental insufficiency, activation of the renin-angiotensin-aldosterone system, increased fetal...

journal_title：Kidney international

authors： Chapman AB

更新日期：2012-05-01 00:00:00

abstract：:Hypertension is associated with an accelerated rate of decline in renal function in patients with chronic renal disease. To identify factors that might alter the rate of decline in renal function, we reviewed records of 200 patients from the Nephrology Clinic of the Durham VA Medical Center who had chronic progressive...

journal_title：Kidney international

authors： Brazy PC,Fitzwilliam JF

更新日期：1990-04-01 00:00:00

abstract：:Tissandié and colleagues report in this issue on their studies of IgA1 glycosylation and biological activities of IgA1-containing circulating immune complexes in patients with alcoholic cirrhosis who developed secondary renal disease with IgA deposits, secondary IgA nephropathy. Their seminal findings demonstrate abno...

journal_title：Kidney international

authors： Novak J,Julian BA

更新日期：2011-12-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calc...

journal_title：Kidney international

authors： Lorthioir A,Joannidès R,Rémy-Jouet I,Fréguin-Bouilland C,Iacob M,Roche C,Monteil C,Lucas D,Renet S,Audrézet MP,Godin M,Richard V,Thuillez C,Guerrot D,Bellien J

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Alterations of large artery function and structure are frequently observed in renal allograft recipients. However, endothelial function has not yet been assessed in this population. METHODS:Flow-mediated vasodilation is a useful index of endothelial function. We measured the diameter and distensibility of t...

journal_title：Kidney international

authors： Hausberg M,Kisters K,Kosch M,Rahn KH,Barenbrock M

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:While an understanding of the epidemiology and clinical course of HIV-associated nephropathy (HIVAN) is growing, little is known about the risk factors and clinical course of the other renal diseases that may also occur as a complication of HIV infection. This study was undertaken to compare HIVAN to the spe...

journal_title：Kidney international

authors： Szczech LA,Gupta SK,Habash R,Guasch A,Kalayjian R,Appel R,Fields TA,Svetkey LP,Flanagan KH,Klotman PE,Winston JA

更新日期：2004-09-01 00:00:00

abstract：:The mechanism whereby glucocorticoid deficiency impairs renal water excretion was studied in the conscious mineralocorticoid-replaced, adrenalectomized rat. Control animals received physiologic replacement with prednisolone, and experimental animals were deprived of glucocorticoid hormone for either 1 or 14 days. The ...

journal_title：Kidney international

authors： Linas SL,Berl T,Robertson GL,Aisenbrey GA,Schrier RW,Anderson RJ

更新日期：1980-07-01 00:00:00

abstract：:In the epidemiologic study of end-stage renal disease (ESRD), accurate adjustment for comorbidity is essential to controlling bias in the comparison of outcomes across groups of patients or dialysis facilities. Liu et al. derive and validate a novel comorbidity index using data from the United States Renal Data System...

journal_title：Kidney international

authors： Seliger SL

更新日期：2010-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its activation results in beneficial or detrimental consequences, depending on the particular setting. Earlier studies in the animal model of acute kidney injury showed that EGFR activation promotes renal tubular cell proliferation. Activation of E...

journal_title：Kidney international

authors： Tang J,Liu N,Zhuang S

更新日期：2013-05-01 00:00:00

abstract：:Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms underlying these roles are not well understood. Here, we performed a single-cell RNA-sequence (RNA-seq) analysis of mouse mesangial cells using the Fluidigm C1 platform. We found that gene expression in individual mesangial c...

journal_title：Kidney international

authors： Lu Y,Ye Y,Yang Q,Shi S

更新日期：2017-08-01 00:00:00