Somatostatin-like immunoreactivity in the glomerulus of rat kidney.

abstract：:Recent linkage analyses of nondiabetic African-American patients with focal segmental glomerulosclerosis (FSGS) have identified MYH9, encoding nonmuscle myosin heavy chain IIA (NMMHC-IIA), as a gene having a critical role in this disease. Abnormalities of the MYH9 locus also underlie rare autosomal dominant diseases s...

journal_title：Kidney international

authors： Sekine T,Konno M,Sasaki S,Moritani S,Miura T,Wong WS,Nishio H,Nishiguchi T,Ohuchi MY,Tsuchiya S,Matsuyama T,Kanegane H,Ida K,Miura K,Harita Y,Hattori M,Horita S,Igarashi T,Saito H,Kunishima S

更新日期：2010-07-01 00:00:00

abstract：:In recent times, therapy for renal anemia has changed dramatically in that iron administration has increased and doses of erythropoiesis-stimulating agents (ESAs) have decreased. Here we used a prospective, observational, multicenter design and measured the serum ferritin and hemoglobin levels every 3 months for 2 yea...

journal_title：Kidney international

authors： Kuragano T,Matsumura O,Matsuda A,Hara T,Kiyomoto H,Murata T,Kitamura K,Fujimoto S,Hase H,Joki N,Fukatsu A,Inoue T,Itakura I,Nakanishi T

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The impact of obesity on survival in end-stage renal disease (ESRD) patients as related to dialysis modality (i.e., a direct comparison of hemodialysis with peritoneal dialysis) has not been assessed adjusting for differences in medication use, follow-up > or =2 years, or accounting for changes in dialysis m...

journal_title：Kidney international

authors： Abbott KC,Glanton CW,Trespalacios FC,Oliver DK,Ortiz MI,Agodoa LY,Cruess DF,Kimmel PL

更新日期：2004-02-01 00:00:00

abstract：:Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure. Histologically, the classic picture of focal segmental glomerulosclerosis (FSGS) was found; males were more severely affected than females. Among the early...

journal_title：Kidney international

authors： Kriz W,Hähnel B,Rösener S,Elger M

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

journal_title：Kidney international

authors： Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

更新日期：2003-07-01 00:00:00

abstract：:Abnormalities of bone mineral metabolism and vascular calcification are prevalent in patients with kidney failure. Clinical management is based on biochemical targets, in particular parathyroid hormone (PTH) concentrations, but this has many limitations including high biological variation. A possible alternative is bo...

journal_title：Kidney international

authors： Sardiwal S,Gardham C,Coleman AE,Stevens PE,Delaney MP,Lamb EJ

更新日期：2012-07-01 00:00:00

abstract：:Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer ...

journal_title：Kidney international

authors： Blosser CD,Haber G,Engels EA

更新日期：2020-11-04 00:00:00

abstract：:Progressive renal vascular sclerosis is a key feature of chronic kidney disease (CKD). Adiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease. In this study, we evaluated the predictive value of adip...

journal_title：Kidney international

authors： Kollerits B,Fliser D,Heid IM,Ritz E,Kronenberg F,MMKD Study Group.

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:In uremic patients with secondary hyperparathyroidism (2HPT), nodular hyperplasia of parathyroid gland shows a monoclonal pattern of cell proliferation, in which a decreased density of vitamin D receptor (VDR) also is demonstrated. The present study aimed at elucidating the mechanism of parathyroid cell prol...

journal_title：Kidney international

authors： Tokumoto M,Tsuruya K,Fukuda K,Kanai H,Kuroki S,Hirakata H

更新日期：2002-10-01 00:00:00

abstract：:Carefully age-matched, purebred male beagle dogs that underwent uninephrectomy one month after they were made diabetic with alloxan were used to establish a model of rapidly developing diabetic nephropathy in a large animal. The diabetic animals, all requiring insulin, were divided into two groups: one group with cont...

journal_title：Kidney international

authors： Steffes MW,Buchwald H,Wigness BD,Groppoli TJ,Rupp WM,Rohde TD,Blackshear PJ,Mauer SM

更新日期：1982-05-01 00:00:00

abstract：:We report the stepwise application of the RIFLE classification in 155,624 admissions in the UK Intensive Care National Audit & Research Centre Case Mix Programme database. The assumptions required to define RIFLE and their relationship with renal replacement therapy (RRT) and ICU mortality were assessed. Previous repo...

journal_title：Kidney international

authors： Harris SK,Lewington AJ,Harrison DA,Rowan KM

更新日期：2015-08-01 00:00:00

abstract：:Chronic kidney disease is characterized as impaired renal function along with the imbalance and dysregulation of mineral metabolism; recognized as chronic kidney disease-mineral and bone disorder. Hyperphosphatemia, characterized by altered phosphate homeostasis along with elevated fibroblast growth factor-23 and inta...

journal_title：Kidney international

authors： Tsuboi Y,Ohtomo S,Ichida Y,Hagita H,Ozawa K,Iida M,Nagao S,Ikegami H,Takahashi T,Horiba N

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:In addition to nitric oxide (NO) and prostacyclin (PGI2), the vascular endothelium can influence local vascular tone by a mechanism involving the hyperpolarization of vascular smooth muscle cells. This response is attributed to the release of an endothelium-derived hyperpolarizing factor (EDHF). The present ...

journal_title：Kidney international

authors： Büssemaker E,Popp R,Binder J,Busse R,Fleming I

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Disorders that manifest hypokalemic metabolic alkalosis, such as Bartter's syndrome and Gitelman's syndrome, are caused by the malfunction of renal tubular electrolyte transporters. Bartter's syndrome may be linked to dysfunction of Na-K-2Cl cotransporter (NKCC2), renal outer medullary K channel (ROMK), or C...

journal_title：Kidney international

authors： Fukuyama S,Okudaira S,Yamazato S,Yamazato M,Ohta T

更新日期：2003-09-01 00:00:00

abstract：:Ultrafiltration failure is a major complication of long-term peritoneal dialysis, resulting in dialysis failure. Peritoneal fibrosis induced by continuous exposure to high glucose dialysate is the major contributor of ultrafiltration failure, for which there is no effective treatment. Overactivation of several signali...

journal_title：Kidney international

authors： Li L,Shen N,Wang N,Wang W,Tang Q,Du X,Carrero JJ,Wang K,Deng Y,Li Z,Lin H,Wu T

更新日期：2018-06-01 00:00:00

abstract：:Bone marrow (BM) cells are reported to contribute to the process of regeneration following myocardial infarction. The present study examined two independent clonal studies to determine the origin of bone marrow (BM)-derived cardiomyocytes. First, we transplanted single CD34(-)c-kit(+)Sca-1(+)lineage(-) side population...

journal_title：Kidney international

authors： Fukuda K,Fujita J

更新日期：2005-11-01 00:00:00

abstract：:The maximum rate of inorganic phosphorus (P1) reabsorption (Tmp1) was measured during phosphate infusion in chronically parathyroidectomized rats. In either initially hydropenic rats or others which underwent moderate preliminary saline loading, Tmp1 tended to rise during early phosphate infusion and then decline, so ...

journal_title：Kidney international

authors： Engle JE,Steele TH

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Mice overexpressing thymic stromal lymphopoietin (TSLP) develop mixed cryoglobulinemia with renal disease closely resembling human cryoglobulin-associated membranoproliferative glomerulonephritis (MPGN), including glomerular deposits of immunoglobulins and complement. We assessed the effect of complement inh...

journal_title：Kidney international

authors： Mühlfeld AS,Segerer S,Hudkins K,Farr AG,Bao L,Kraus D,Holers VM,Quigg RJ,Alpers CE

更新日期：2004-04-01 00:00:00

abstract：:Defects in the primary cilium/basal body complex of renal tubular cells cause polycystic kidney disease (PKD). To uncover pathways associated with disease progression, we determined the kidney transcriptome of 10-day-old severely and mildly affected cpk mice, a model of recessive PKD. In the severe phenotype, the most...

journal_title：Kidney international

authors： Mrug M,Zhou J,Woo Y,Cui X,Szalai AJ,Novak J,Churchill GA,Guay-Woodford LM

更新日期：2008-01-01 00:00:00

abstract：:Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. Kidney biopsy is required to establish the diagnosis. Recent studies have identified abundant glomerular deposition of DNAJB9 as a unique histological marker of FGN. We developed an immunoprecipitation-based multiple reaction monitoring method to measur...

journal_title：Kidney international

authors： Nasr SH,Dasari S,Lieske JC,Benson LM,Vanderboom PM,Holtz-Heppelmann CJ,Giesen CD,Snyder MR,Erickson SB,Fervenza FC,Leung N,Kurtin PJ,Alexander MP

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Inhibition of angiotensin action, pharmacologically or genetically, during the neonatal period leads to renal anomalies involving hypoplastic papilla and dilated calyx. Recently, we documented that angiotensinogen (Agt -/-) or angiotensin type 1 receptor nullizygotes (Agtr1 -/-) do not develop renal pelvis n...

journal_title：Kidney international

authors： Miyazaki Y,Tsuchida S,Fogo A,Ichikawa I

更新日期：1999-05-01 00:00:00

abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

journal_title：Kidney international

authors： Zager RA

更新日期：2005-10-01 00:00:00

abstract：:Ambient glucose concentrations alter type 1 angiotensin II receptor (AT1R) expression in renal tissues. The direction of change in AT1R density may depend on the specific cell type and the capacity for that cell type to use glucose as an energy substrate. Given the effects of angiotensin II (Ang II) in proximal tubule...

journal_title：Kidney international

authors： Becker BN,Kondo S,Cheng HF,Harris RC

更新日期：1997-07-01 00:00:00

abstract：:Previous studies have demonstrated that dietary potassium deprivation in healthy human subjects eating diets otherwise containing normal quantities of NaCl is accompanied by an increase in urinary calcium excretion. This increase in urinary Ca excretion occurs in association with reductions in urinary Na and Cl excret...

journal_title：Kidney international

authors： Lemann J Jr,Pleuss JA,Hornick L,Hoffman RG

更新日期：1995-03-01 00:00:00

abstract：:Anecdotal reports of complement component deficiencies in patients with immune complex disease led to a systematic study of the levels of seven complement components in serum specimens from 178 patients with glomerulonephritis and 163 normal subjects. Deficiencies were found with significantly higher frequency (22.7%)...

journal_title：Kidney international

authors： Coleman TH,Forristal J,Kosaka T,West CD

更新日期：1983-11-01 00:00:00

abstract：:Transepithelial fluid secretion promotes the progressive enlargement of cysts in autosomal dominant polycystic kidney disease (ADPKD). Recent indirect evidence indicated that active chloride transport may drive net fluid secretion in cultures of epithelia derived from ADPKD cysts. We now report that forskolin, which s...

journal_title：Kidney international

authors： Davidow CJ,Maser RL,Rome LA,Calvet JP,Grantham JJ

更新日期：1996-07-01 00:00:00

abstract：:Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinicall...

journal_title：Kidney international

authors： Chutipongtanate S

更新日期：2017-02-01 00:00:00

abstract：:Hypertriglyceridemia in nephrotic (NS) and Nagase analbuminemic rats (Analb) results from reduced triglyceride clearance. NS and Analb have reduced or absent albumin, reduced plasma oncotic pressure (pi), but Analb lack proteinuria. The heparin releasable lipoprotein lipase (LpL) pool in both models is greatly reduced...

journal_title：Kidney international

authors： Shearer GC,Kaysen GA

更新日期：2006-08-01 00:00:00

abstract：:A new study in dialysis patients demonstrates that more than one-third of rehospitalizations within 30 days of discharge occur within the first week, and these rehospitalizations are associated with worse survival. Imposing a penalty on the dialysis provider for these rehospitalizations, as mandated by the Hospital Re...

journal_title：Kidney international

authors： Streja E

更新日期：2017-10-01 00:00:00

abstract：:Data from the national French Renal Epidemiology and Information Network (REIN) registry were used to compare survival between transplant recipients under age 65 who resumed dialysis after graft failure during 2007-2009 and transplant-naïve incident dialysis patients matched for age, gender, diabetes mellitus, and yea...

journal_title：Kidney international

authors： Mourad G,Minguet J,Pernin V,Garrigue V,Peraldi MN,Kessler M,Jacquelinet C,Couchoud C,Duny Y,Daurès JP

更新日期：2014-07-01 00:00:00