Overexpression of innate immune response genes in a model of recessive polycystic kidney disease.

abstract：BACKGROUND:This multicenter, open-label, dose-titration study assessed the safety and efficacy of RenaGel(R), a nonabsorbed calcium- and aluminum-free phosphate binder, in lowering serum phosphorus. Secondary outcomes were its effects on serum intact parathyroid hormone (iPTH) and serum lipids. METHODS:Phosphate binde...

journal_title：Kidney international

authors： Slatopolsky EA,Burke SK,Dillon MA

更新日期：1999-01-01 00:00:00

abstract：:During the heterologous phase of experimental anti-glomerular basement membrane (anti-GBM) nephritis, leukocyte influx peaks within hours, whereas albuminuria occurs within 1 day. In the subsequent autologous phase, endogenous anti-GBM IgG develops and albuminuria persists. Heparan sulfate (HS) proteoglycans like synd...

journal_title：Kidney international

authors： Rops AL,Götte M,Baselmans MH,van den Hoven MJ,Steenbergen EJ,Lensen JF,Wijnhoven TJ,Cevikbas F,van den Heuvel LP,van Kuppevelt TH,Berden JH,van der Vlag J

更新日期：2007-11-01 00:00:00

abstract：:Measures related to red cell oxygen transport were evaluated in 17 hemodialysis patients receiving androgen therapy, 15 untreated hemodialysis patients and 15 normal subjects. Hemoglobin levels were higher in androgen-treated patients than in the untreated population and were directly related to the reticulocyte index...

journal_title：Kidney international

authors： Hendler ED,Solomon L

更新日期：1987-01-01 00:00:00

abstract：:Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and are an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteod...

journal_title：Kidney international

authors： Moe S,Drüeke T,Cunningham J,Goodman W,Martin K,Olgaard K,Ott S,Sprague S,Lameire N,Eknoyan G,Kidney Disease: Improving Global Outcomes (KDIGO).

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:While metabolically generated oxidants are produced locally in experimental glomerular diseases, little is still known of their significance and the respective scavenger systems in human glomerular diseases. METHODS:Here we studied kidneys from patients with congenital nephrotic syndrome of the Finnish type...

journal_title：Kidney international

authors： Solin ML,Ahola H,Haltia A,Ursini F,Montine T,Roveri A,Kerjaschki D,Holthöfer H

更新日期：2001-02-01 00:00:00

abstract：:Inflammation is the immune system's response to infectious or noninfectious sources of danger. Danger recognition is facilitated by various innate immune receptor families including the Toll-like receptors (TLRs), which detect danger signals in extracellular and intracellular compartments. It is an evolving concept th...

journal_title：Kidney international

authors： Anders HJ,Schlondorff DO

更新日期：2010-07-01 00:00:00

abstract：:Glomerular podocytes are terminally differentiated cells, and podocyte loss is a common feature of progressive renal pathologies. In this issue, Romoli et al. focus on podocyte progenitors that were proposed to reside in the Bowman's capsule. They demonstrate that suppression of CXCL12/CXCR4 signaling activates pariet...

journal_title：Kidney international

authors： Massa F,Schedl A

更新日期：2018-12-01 00:00:00

abstract：:Fourteen subjects with persistent azotemia and normal glomerular filtration rate were studied by renal clearances and hormonal determinations to establish the nephron site of altered urea transport and the mechanism(s) responsible for their azotemia. During constant alimentary protein, urea nitrogen appearance was nor...

journal_title：Kidney international

authors： Conte G,Dal Canton A,Terribile M,Cianciaruso B,Di Minno G,Pannain M,Russo D,Andreucci VE

更新日期：1987-11-01 00:00:00

abstract：:Patients with chronic kidney disease have elevated circulating asymmetric dimethylarginine (ADMA). Recent studies have suggested that ADMA impairs endothelial nitric oxide synthase (eNOS) by effects other than competition with the substrate L-arginine. Here, we sought to identify the molecular mechanism by which incre...

journal_title：Kidney international

authors： Kajimoto H,Kai H,Aoki H,Yasuoka S,Anegawa T,Aoki Y,Ueda S,Okuda S,Imaizumi T

更新日期：2012-04-01 00:00:00

abstract：:For decades, ill-defined autosomal dominant renal diseases have been reported, which originate from tubular cells and lead to tubular atrophy and interstitial fibrosis. These diseases are clinically indistinguishable, but caused by mutations in at least four different genes: UMOD, HNF1B, REN, and, as recently describe...

journal_title：Kidney international

authors： Ekici AB,Hackenbeck T,Morinière V,Pannes A,Buettner M,Uebe S,Janka R,Wiesener A,Hermann I,Grupp S,Hornberger M,Huber TB,Isbel N,Mangos G,McGinn S,Soreth-Rieke D,Beck BB,Uder M,Amann K,Antignac C,Reis A,Eckardt K

更新日期：2014-09-01 00:00:00

abstract：:Excess fatty acids accompanied by triglyceride accumulation in parenchymal cells of multiple tissues including skeletal and cardiac myocytes, hepatocytes, and pancreatic beta cells results in chronic cellular dysfunction and injury. The process, now termed lipotoxicity, can account for many manifestations of the 'meta...

journal_title：Kidney international

authors： Weinberg JM

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Mesangial immunoglobulin A (IgA) deposition is incidentally encountered in asymptomatic individuals, but its precise frequency and significance had not been clarified. The background of the latent IgA deposition is related to the epidemiology and pathogenesis of IgA nephropathy. METHODS:Zero-hour allograft ...

journal_title：Kidney international

authors： Suzuki K,Honda K,Tanabe K,Toma H,Nihei H,Yamaguchi Y

更新日期：2003-06-01 00:00:00

abstract：:A morphometric study was undertaken to quantitate the morphologic changes induced by ADH availability in the rat kidney. Homozygous Brattleboro rats with hereditary diabetes insipidus (DI) (no ADH) were compared to heterozygous Brattleboro control rats (HZ) and to DI rats after 5 to 6 weeks of continuous ADH infusion ...

journal_title：Kidney international

authors： Bouby N,Bankir L,Trinh-Trang-Tan MM,Minuth WW,Kriz W

更新日期：1985-09-01 00:00:00

abstract：:Disturbed pulsatile LH secretion has been suggested to play a role in the etiology of delayed puberty and disturbed reproductive function in chronic renal failure (CRF), but interpretation of gonadotropin secretion from plasma concentration measurements is confounded by alterations in hormone metabolic clearance. To s...

journal_title：Kidney international

authors： Schaefer F,Veldhuis JD,Robertson WR,Dunger D,Schärer K

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Microalbuminuria (MA) is a strong predictor of cardiovascular disease, but its causes are incompletely understood. Hyperhomocysteinemia is a recently recognized risk factor for cardiovascular disease independent of established risk factors. It is not known whether hyperhomocysteinemia is associated with MA, ...

journal_title：Kidney international

authors： Hoogeveen EK,Kostense PJ,Jager A,Heine RJ,Jakobs C,Bouter LM,Donker AJ,Stehouwer CD

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Renal failure and toxic acute tubular necrosis (ATN) may be seen following exposure to a variety of therapeutic agents. Zoledronate (Zometa) is a new, highly potent bisphosphonate used in the treatment of hypercalcemia of malignancy. We report the first clinical-pathologic study of nephrotoxicity associated ...

journal_title：Kidney international

authors： Markowitz GS,Fine PL,Stack JI,Kunis CL,Radhakrishnan J,Palecki W,Park J,Nasr SH,Hoh S,Siegel DS,D'Agati VD

更新日期：2003-07-01 00:00:00

abstract：:The effect of the tricarboxylic acid (TCA) cycle precursor, pyruvate, on glutamine metabolism by isolated renal cortical mitochondria was assessed by quantitating its key nitrogen and carbon metabolites. When mitochondria from normal rats were incubated at pH 7.4, pyruvate (2 mM) inhibited ammonia production by almost...

journal_title：Kidney international

authors： Tannen RL,Kunin AS

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Acute renal failure (ARF) has a high morbidity and mortality. Many therapies have worked in animals but were unsuccessful in clinical trials. The inability to diagnose ARF early may have impaired the success of these trials. METHOD:We screened a subtraction library to search for potential disease markers th...

journal_title：Kidney international

authors： Muramatsu Y,Tsujie M,Kohda Y,Pham B,Perantoni AO,Zhao H,Jo SK,Yuen PS,Craig L,Hu X,Star RA

更新日期：2002-11-01 00:00:00

abstract：:Anti-NDP has been detected in the sera of 38 of 430 patients on regular hemodialysis at the Regional Kidney Disease Program in Minneapolis. It developed in these patients from 7 to 58 months after commencement of dialysis. Bacterial infection appeared temporally related to the development of anti-NDP in 12 patients. H...

journal_title：Kidney international

authors： Crosson JT,Moulds J,Comty CM,Polesky HF

更新日期：1976-12-01 00:00:00

abstract：:The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. We have shown that the interaction of VDRs with VDREs is inhibited by uremic toxins. We hypothesize that uremic toxins form Schiff bases with the lysine re...

journal_title：Kidney international

authors： Patel SR,Koenig RJ,Hsu CH

更新日期：1996-11-01 00:00:00

abstract：:Few studies have examined tubular function after subtotal nephrectomy (Nx) and conservative treatments. The effects of 70% and 80% Nx (associated with dietary phosphate restriction in the latter case) on the apical brush border membrane (BBM) enzymes 5'-nucleotidase, gamma glutamyl-transferase and alkaline-phosphatase...

journal_title：Kidney international

authors： Laouari D,Friedlander G,Burtin M,Silve C,Dechaux M,Garabedian M,Kleinknecht C

更新日期：1997-12-01 00:00:00

abstract：:IgA1 proteins from sera of patients with IgA nephropathy (IgAN) are galactosylated to a lesser degree than those from healthy controls. The increased reactivity of intact or de-sialylated serum IgA1 with N-acetylgalactosamine (GalNAc)-specific lectins, Helix aspersa (HAA) and Caragana arborescens (CAA) and de-sialylat...

journal_title：Kidney international

authors： Tomana M,Matousovic K,Julian BA,Radl J,Konecny K,Mestecky J

更新日期：1997-08-01 00:00:00

abstract：:Glomerular deposition of hepatitis B virus (HBV) antigens are observed in chronic HBsAg carriers with different glomerulonephritides yet the etiologic role of HBV remains uncertain. We examined the paraffin section of kidney biopsies from 40 chronic HBsAg carriers with membranous nephropathy (MGN), mesangiocapillary g...

journal_title：Kidney international

authors： Lai KN,Ho RT,Tam JS,Lai FM

更新日期：1996-12-01 00:00:00

abstract：:Cilnidipine, a dual L-/N-type calcium channel blocker, dilates both efferent and afferent arterioles and is renoprotective. Our multi-center, open-labeled, and randomized trial compared the antiproteinuric effect of cilnidipine with that of amlodipine in hypertensive patients with kidney disease. A group of 339 patien...

journal_title：Kidney international

authors： Fujita T,Ando K,Nishimura H,Ideura T,Yasuda G,Isshiki M,Takahashi K,Cilnidipine versus Amlodipine Randomised Trial for Evaluation in Renal Desease(CARTER) Study Investigators.

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:High-dose folinic acid is used to accelerate methotrexate elimination to avoid renal toxicity of the drug. The present study was carried out to examine the role of the renal organic anion transporters OAT-K1 and OAT-K2 in the urinary excretion of methotrexate, especially in the methotrexate-folinic acid resc...

journal_title：Kidney international

authors： Takeuchi A,Masuda S,Saito H,Doi T,Inui K

更新日期：2001-09-01 00:00:00

abstract：:Intravital multiphoton microscopy is a powerful tool to study kidney physiology in living animals. However, certain technical issues have curbed its usage to date, including limited depth of tissue penetration and high background emission of endogenous signals. Most previous studies have used the excitation range 700–...

journal_title：Kidney international

authors： Schuh CD,Haenni D,Craigie E,Ziegler U,Weber B,Devuyst O,Hall AM

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Prolactin (PRL), originally identified as an anterior pituitary hormone exhibiting lactogenic activity, is now recognized as a versatile hormone expressed in a wide variety of tissues. METHODS:In this study, the expression of PRL in the mouse kidney was investigated by solution-phase and in situ reverse tra...

journal_title：Kidney international

authors： Sakai Y,Hiraoka Y,Ogawa M,Takeuchi Y,Aiso S

更新日期：1999-03-01 00:00:00

abstract：:The role of endogenous atrial natriuretic peptide (ANP) in the immediate response of sodium excretion to unilateral nephrectomy (UNX) was investigated in anesthetized euvolemic rats through measurement of UNX-induced change in plasma ANP concentration and the response of the remaining kidney to UNX following administr...

journal_title：Kidney international

authors： Valentin JP,Ribstein J,Neuser D,Nüssberger J,Mimran A

更新日期：1993-06-01 00:00:00

abstract：:Freeze-fracture and thin-section electron microscopy and morphometry were used to characterize further the response of the rat medullary collecting duct to potassium depletion. In freeze-fracture replicas, principal cells and intercalated cells were identified based on the assumption that intercalated cells possess a ...

journal_title：Kidney international

authors： Stetson DL,Wade JB,Giebisch G

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Peritonitis in peritoneal dialysis patients is accompanied by an enhanced migration of neutrophils (PMNs) and increased protein loss into the peritoneal cavity; however, the role of PMNs in governing increased protein loss during peritonitis associated with peritoneal dialysis is unknown. METHODS:We determi...

journal_title：Kidney international

authors： Luo Q,Cheung AK,Kamerath CD,Reimer LG,Leypoldt JK

更新日期：2000-04-01 00:00:00