Characterization of the endothelium-derived hyperpolarizing factor (EDHF) response in the human interlobar artery.

abstract：BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

journal_title：Kidney international

authors： Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

更新日期：1999-08-01 00:00:00

abstract：:It has been proposed that one of the primary events in the development of essential hypertension is a growth-related process initiated as early as during fetal development. Differences in kidney size have been observed between most rat models of hypertension and their respective controls. In this study, we analyzed re...

journal_title：Kidney international

authors： Hamet P,Pausova Z,Dumas P,Sun YL,Tremblay J,Pravenec M,Kunes J,Krenova D,Kren V

更新日期：1998-06-01 00:00:00

abstract：:Acute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic instability and sympathetic activity, and adversely influences prognosis. Here, we investigated in a randomized placebo-controlled trial whether dexmedetomidine, an α2 adrenoreceptor agonist, could prevent AKI after valvular h...

journal_title：Kidney international

authors： Cho JS,Shim JK,Soh S,Kim MK,Kwak YL

更新日期：2016-03-01 00:00:00

abstract：:beta 2-microglobulin-related amyloidosis (A beta 2M) represents a frequent complication in long-term dialysis patients. Although the pathogenetic mechanism has yet to be fully understood, it is known that amyloid fibrils usually consist of intact molecules of beta 2-microglobulin (beta 2m). Plasma proteinase inhibitor...

journal_title：Kidney international

authors： Campistol JM,Shirahama T,Abraham CR,Rodgers OG,Solé M,Cohen AS,Skinner M

更新日期：1992-10-01 00:00:00

abstract：:Defective recycling of megalin consequent to impaired phosphatidylinositol metabolism has been implicated as a mechanism causing tubular proteinuria in patients with Lowe syndrome. In this issue, Berquez et al. describe an innovative approach using a clinically approved drug to "rebalance" phosphatidylinositols and re...

journal_title：Kidney international

authors： Weisz OA

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Dialysis efficiency has a great influence on the outcome of patients. Few data are available on the removal of solutes with molecular weights higher than urea and creatinine. The aim of our study was to assess the transport and the removal of substances with molecular weights up to 15 kD and to evaluate the ...

journal_title：Kidney international

authors： Montini G,Amici G,Milan S,Mussap M,Naturale M,Rätsch IM,Ammenti A,Sorino P,Verrina E,Andreetta B,Zacchello G,Italian Registry of Pediatric Peritoneal Dialysis.

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Various gene transfer vectors as well as delivery systems have been developed; however, many problems remain to be solved. We already achieved a technique to introduce genes into glomerular mesangial cells by hemagglutinating virus of Japan (HVJ) liposome-mediated gene transfer via renal artery. The main lim...

journal_title：Kidney international

authors： Tsujie M,Isaka Y,Nakamura H,Kaneda Y,Imai E,Hori M

更新日期：2001-04-01 00:00:00

abstract：:The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...

journal_title：Kidney international

authors： Keddis MT,El Ters M,Rodrigo E,Dean P,Wohlfahrtova M,Kudva YC,Lorenz EC,Cosio FG

更新日期：2014-09-01 00:00:00

abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...

journal_title：Kidney international

authors： Luciani A,Freedman BS

更新日期：2020-07-01 00:00:00

abstract：:The defect in urinary acidification induced by amphotericin B (AMB) was further characterized in turtle bladder. Since AMB has been shown to increase the hydrogen ion (H+) permeability of this epithelium in the absence of exogenous bicarbonate ions (HCO3-), we explored the permeability characteristics in the presence ...

journal_title：Kidney international

authors： Finn JT,Cohen LH,Steinmetz PR

更新日期：1977-04-01 00:00:00

abstract：:Iron is critical for cellular, organismal, and possibly universal existence. Use of iron complexes to treat human diseases is ancient and is described in detail in Ayurveda/Siddha systems of medicine. Old aphorisms from Siddha medicine ("Alavukku Minjinal Amirdhamum Nanjagum," an elixir turns poisonous when taken in e...

journal_title：Kidney international

authors： Swaminathan S

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:In renal cells, hyperosmolarity has been shown to induce the accumulation of myo-inositol, via the Na+/myo-inositol cotransporter (SMIT). Previously we showed that SMIT mRNA in the kidney is localized in the medullary thick ascending limb of Henle (TALH). Here we used renal cells derived from the rabbit oute...

journal_title：Kidney international

authors： Yorek MA,Dunlap JA,Lowe WL Jr

更新日期：1999-01-01 00:00:00

abstract：:Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glomerular epithelial cells (podocytes) and is known to be tyrosine phosphorylated by Src family kinases. We studied the role of phosphoinositide 3-kinase (PI3K), activated via the phosphorylation of nephrin, in actin cyto...

journal_title：Kidney international

authors： Zhu J,Sun N,Aoudjit L,Li H,Kawachi H,Lemay S,Takano T

更新日期：2008-03-01 00:00:00

abstract：:Bovine serum albumin (BSA, pI 4.9) was maleylated to yield highly anionic MBSA (pI 3.0). Maleylation of BSA lead to an expansion of molecular size of native BSA from an effective molecular radius (EMR) of 37 A to 57 A for MBSA as assessed by gel filtration chromatography. MBSA, but not BSA, bound to the peripheral cap...

journal_title：Kidney international

authors： Barnes JL,Reznicek MJ,Radnik RA,Venkatachalam MA

更新日期：1988-08-01 00:00:00

abstract：:Glomerular deposition of hepatitis B virus (HBV) antigens are observed in chronic HBsAg carriers with different glomerulonephritides yet the etiologic role of HBV remains uncertain. We examined the paraffin section of kidney biopsies from 40 chronic HBsAg carriers with membranous nephropathy (MGN), mesangiocapillary g...

journal_title：Kidney international

authors： Lai KN,Ho RT,Tam JS,Lai FM

更新日期：1996-12-01 00:00:00

abstract：:Recent studies including the current article by Sawinski et al. demonstrate that hepatitis C virus (HCV) infection is associated with worse outcomes in kidney transplant recipients with and without HIV infection. We comment on the significance of these findings in the context of newer options for the treatment of HCV ...

journal_title：Kidney international

authors： Del Bello D,Ross MJ,Huprikar SS

更新日期：2015-08-01 00:00:00

abstract：:Recent evidence suggesting a strong interplay between components of the renin-angiotensin system and key mediators of fibrosis led us to hypothesize that renin, independent of its enzymatic action to enhance angiotensin (Ang) II synthesis, directly increases production of the fibrogenic cytokine transforming growth fa...

journal_title：Kidney international

authors： Huang Y,Wongamorntham S,Kasting J,McQuillan D,Owens RT,Yu L,Noble NA,Border W

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Vascular access failure is the main cause of morbidity in hemodialysis. Venous stenosis and subsequent thrombosis, as the result of intimal hyperplasia, is the major cause of vascular access failure. Intimal hyperplasia of the arteriovenous fistula (AVF) closely resembles the main histopathologic feature of ...

journal_title：Kidney international

authors： Grandaliano G,Teutonico A,Allegretti A,Losappio R,Mancini A,Gesualdo L,Schena FP,Pertosa G

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Adrenomedullin (ADM) exerts antiproliferative effects on rat mesangial cells in vitro and, therefore is a possible renoprotective agent. In contrast, nitric oxide (NO) is capable of exerting both cytoprotective and cytotoxic actions. It was the objective of the present study to examine whether NO stimulates ...

journal_title：Kidney international

authors： Dötsch J,Schoof E,Schöcklmann HO,Brüne B,Knerr I,Repp R,Rascher W

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Pre-eclampsia is characterized by hypertension, proteinuria and edema. Simultaneous studies of kidney function and structure have not been reported. We wished to explore the degree and nature of glomerular dysfunction in pre-eclampsia. METHODS:Physiologic techniques were used to estimate glomerular filtrati...

journal_title：Kidney international

authors： Lafayette RA,Druzin M,Sibley R,Derby G,Malik T,Huie P,Polhemus C,Deen WM,Myers BD

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Renal tract malformations are, on occasion, associated with uterine malformations. The transcription factor hepatocyte nuclear factor (HNF)-1beta is expressed from the earliest stages of development of the Wolffian duct, the mesonephros and metanephros, and the Müllerian ducts in the mouse. In adult mice HNF...

journal_title：Kidney international

authors： Bingham C,Ellard S,Cole TR,Jones KE,Allen LI,Goodship JA,Goodship TH,Bakalinova-Pugh D,Russell GI,Woolf AS,Nicholls AJ,Hattersley AT

更新日期：2002-04-01 00:00:00

abstract：:We demonstrate that salts of diatrizoate and iothalamate, radiographic contrast agents, depress the active transport of sodium in the urinary bladder of the Columbian toad, Bufo marinus. Isolated toad bladders were incubated in isotonic Ringer's solutions with isosmolar displacement of sodium chloride by contrast medi...

journal_title：Kidney international

authors： Ziegler TW,Ludens JH,Fanestil DD,Talner LB

更新日期：1975-02-01 00:00:00

abstract：:The remnant kidney (RK) exhibits an enhanced fractional excretion of phosphate (FEPi) even in the absence of parathyroid hormone (PTH). Thus, factors other than PTH contribute to this adaptive phosphaturia. Dopamine (DA) infusion is phosphaturic, whereas stimulation of adrenoreceptors is antiphosphaturic. Therefore, t...

journal_title：Kidney international

authors： Isaac J,Berndt TJ,Thothathri V,Tyce GM,Knox FG

更新日期：1993-05-01 00:00:00

abstract：:In experimental membranous nephropathy, antibody binding to glomerular epithelial cell membrane antigens results in complement activation and formation of complement C5b-9 membrane attack complexes in glomeruli. During active disease, the C5b-9 complexes are shed into the urine. To test the hypothesis that a similar m...

journal_title：Kidney international

authors： Schulze M,Donadio JV Jr,Pruchno CJ,Baker PJ,Johnson RJ,Stahl RA,Watkins S,Martin DC,Wurzner R,Gotze O

更新日期：1991-09-01 00:00:00

abstract：:We have studied acid-base balance in 32 patients attending the renal clinic of Mount Sinai Hospital. The parameters of acid-base balance measured included acid production measured as urinary sulfate and organic anions, net acid excretion measured as urinary ammonia plus titratable acid minus bicarbonate, and net GI ab...

journal_title：Kidney international

authors： Uribarri J,Douyon H,Oh MS

更新日期：1995-02-01 00:00:00

abstract：:The hormonal responsiveness profile of the cortical collecting duct varies from one species to another. To identify the hormones and agonists that modulate the functions of this tubule segment in the human species, we generated a cell line (HCD) immortalized by SV40 virus. The tubular origin of this cell line was asse...

journal_title：Kidney international

authors： Prié D,Friedlander G,Coureau C,Vandewalle A,Cassingéna R,Ronco PM

更新日期：1995-05-01 00:00:00

abstract：:We investigated the effects of epidermal growth factor (EGF) and arginine vasopressin (AVP) on Raf-1-MAP kinase cascade, including Raf-1-kinase (Raf-1-K), MAP kinase kinase (MAPKK), MAP kinase (MAPK) and S6 kinase (S6K) in Madin-Darby canine kidney (MDCK) cells. In a dose-dependent manner (10(-10) M to 10(-6) M), EGF ...

journal_title：Kidney international

authors： Yamada T,Terada Y,Homma MK,Nonoguchi H,Sasaki S,Yuasa Y,Tomita K,Marumo F

更新日期：1995-09-01 00:00:00

abstract：:With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major health problem worldwide. Approximately, 80% of kidney stones are composed of calcium and hypercalciuria is found in up to 40% of stone-formers. Although the mechanisms resulting in precipitation and growth of calcium crystals in...

journal_title：Kidney international

authors： Devuyst O,Pirson Y

更新日期：2007-11-01 00:00:00

abstract：:Cystinuria is a common inherited aminoaciduria that leads to recurrent cystine nephrolithiasis. Mutations in a gene encoding a renal amino acid transporter (SLC3A1) have been identified in patients with cystinuria establishing one molecular cause for the disease. To facilitate systematic screening of this gene for mut...

journal_title：Kidney international

authors： Endsley JK,Phillips JA 3rd,Hruska KA,Denneberg T,Carlson J,George AL Jr

更新日期：1997-06-01 00:00:00

abstract：:In normal subjects, beta-adrenergic stimulation lowers the serum potassium, whereas alpha-stimulation raises it. Epinephrine, a mixed alpha and beta agonist, acutely lowers the blood potassium in normal subjects, but not in patients with end-stage renal disease. This study was designed to determine whether the resista...

journal_title：Kidney international

authors： Allon M,Shanklin N

更新日期：1991-12-01 00:00:00