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Aquaporins in the kidney: emerging new aspects.

Abstract：

:Since 1992 and the discovery of an MIP (major intrinsic protein of lens fiber cell) homologue protein that selectively permeates water, aquaporin (AQP), there has been an explosion of research in this field. Early research speculated that aquaporins played indispensible physiological roles in bacteria and plants, as well as in mammalian organs such as red blood cells, kidney, eye, brain and lung, where water transport rapidly takes place. Yet human subjects were identified who lacked AQP1 and yet had no apparent phenotypical changes clinically. To date 10 aquaporins have been discovered and a plethora of MIP members, and their prevalance in almost all organisms is a testament to their indispensible roles in the body, possibly as water and small neutral solute transporting channels. The recent localization of many different aquaporins in the same organ indicates that they may work cooperatively, which may partially explain the mystery of their physiological mechanism. Because the physiological roles of most aquaporins are currently only speculation, more extensive research is necessary to understand the exact function of each aquaporin.

journal_name

Kidney Int

journal_title

Kidney international

authors

Yamamoto T,Sasaki S

doi

10.1046/j.1523-1755.1998.00123.x

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

1041-51

issue

4

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)30726-2

journal_volume

54

pub_type

杂志文章,评审

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