Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta2-microglobulin amyloid fibrils in vitro.

abstract：:Administration of antibody, directed against glomerular basement membrane (GBM) heparan sulfate-proteoglycan, into a presensitized rat results in the induction of membranous nephropathy with subepithelial immune-complex deposits. In this investigation, we examined the mechanisms responsible for the formation of subepi...

journal_title：Kidney international

authors： Makino H,Lelongt B,Kanwar YS

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:Cux-1 is a murine homeobox gene that is highly expressed in the nephrogenic zone of the developing kidney. Transgenic mice ectopically expressing Cux-1 develop renal hyperplasia associated with down-regulation of the cyclin kinase inhibitor p27. Because the reduction of p27 has been associated with mesangial...

journal_title：Kidney international

authors： Brantley JG,Sharma M,Alcalay NI,Heuvel GB

更新日期：2003-04-01 00:00:00

abstract：:In seven patients on maintenance hemodialysis, de novo recurrent renal stone formation was observed. In all patients, the underlying disease was glomerulonephritis, with or without the nephrotic syndrome. All patients had considerable persistent proteinuria. The stones consisted predominantly of protein, as revealed b...

journal_title：Kidney international

authors： Bommer J,Ritz E,Tschöpe W,Waldherr R,Gebhardt M

更新日期：1979-12-01 00:00:00

abstract：:The current study was undertaken to examine the effects of dithiothreitol (DDT), a sulfhydryl-reducing agent and heavy metal chelator, on the course of heavy metal-induced acute renal failure in the rat. Groups of rats in metabolic cages received uranyl nitrate (UN) alone, UN plus DTT, mercuric chloride (HgCl2) alone,...

journal_title：Kidney international

authors： Kleinman JG,McNeil JS,Schwartz JH,Hamburger RJ,Flamenbaum W

更新日期：1977-08-01 00:00:00

abstract：:The hypoxia-inducible factor-1 (HIF-1) was first described as a DNA binding activity that specifically recognizes an 8 bp hypoxia response element (HRE) known to be essential for oxygen-regulated erythropoietin gene expression. In electrophoretic mobility shift assays (EMSAs) HIF-1 DNA binding activity is only detecta...

journal_title：Kidney international

authors： Kvietikova I,Wenger RH,Marti HH,Gassmann M

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Strict glycemic control and antihypertensive treatment may decrease but not eliminate the risk of progressive nephropathy in diabetic patients. C-peptide has been shown to exert beneficial effects on complications, including incipient nephropathy, in type 1 diabetes. METHODS:Renal effects of 14 days of intr...

journal_title：Kidney international

authors： Samnegård B,Jacobson SH,Jaremko G,Johansson BL,Sjöquist M

更新日期：2001-10-01 00:00:00

abstract：:We previously demonstrated that urinary endothelin excretion is increased in rats with extensive renal mass reduction, a model of progressive renal disease. Here we explored whether the increased urinary endothelin in this model were due to induction of renal pre-pro-endothelin-1 gene and whether changes in endothelin...

journal_title：Kidney international

authors： Orisio S,Benigni A,Bruzzi I,Corna D,Perico N,Zoja C,Benatti L,Remuzzi G

更新日期：1993-02-01 00:00:00

abstract：:The proportion of deceased donor kidneys procured for transplant but subsequently discarded has been growing steadily in the United States, but factors contributing to the rising discard rate remain unclear. To assess the reasons for and probability of organ discard we assembled a cohort of 212,305 deceased donor kidn...

journal_title：Kidney international

authors： Mohan S,Chiles MC,Patzer RE,Pastan SO,Husain SA,Carpenter DJ,Dube GK,Crew RJ,Ratner LE,Cohen DJ

更新日期：2018-07-01 00:00:00

abstract：:Calcitonin secretion is stimulated by acute hypercalcemia. Furthermore, in the rat, the calcemic response to parathyroid hormone (PTH) is decreased by calcitonin stimulation. However, in renal failure, it is not known if an increase in the serum calcium concentration within the physiologic range of serum calcium stimu...

journal_title：Kidney international

authors： Torres A,Rodriguez M,Felsenfeld A,Martin-Malo A,Llach F

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Studies in animal models have shown that the alternative pathway of complement is activated in the kidney after ischemia/reperfusion. In addition, mice deficient in complement factor B, a necessary component of the alternative pathway, are protected from ischemic acute renal failure. The purpose of this stud...

journal_title：Kidney international

authors： Thurman JM,Lucia MS,Ljubanovic D,Holers VM

更新日期：2005-02-01 00:00:00

abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...

journal_title：Kidney international

authors： Liu D,Lun L,Huang Q,Ning Y,Zhang Y,Wang L,Yin Z,Zhang Y,Xia L,Yin Z,Fu B,Cai G,Sun X,Chen X

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease. METHODS:Stereologic studies were performed 10 weeks afte...

journal_title：Kidney international

authors： Rasch R,Nyengaard JR,Marcussen N,Meyer TW

更新日期：2002-08-01 00:00:00

abstract：:Suzuki et al. analyzed a mouse model of erythropoietin-deficient anemia to show that during iron overload renal interstitial fibroblasts accumulate iron, and this impairs the hypoxia-driven transcription of the erythropoietin gene. The authors show that excess iron decreases levels of hypoxia-inducible transcription f...

journal_title：Kidney international

authors： Ganz T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:A considerable diversity in prognosis is seen with lupus glomerulonephritis (LGN). Hence, the clinical usefulness of a recent International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification to judge the long-term outcome of human LGN has been investigated. METHODS:We studied retros...

journal_title：Kidney international

authors： Yokoyama H,Wada T,Hara A,Yamahana J,Nakaya I,Kobayashi M,Kitagawa K,Kokubo S,Iwata Y,Yoshimoto K,Shimizu K,Sakai N,Furuichi K,Kanazawa Study Group for Renal Diseases and Hypertension.

更新日期：2004-12-01 00:00:00

abstract：:Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs t...

journal_title：Kidney international

authors： Bai M,Chen H,Ding D,Song R,Lin J,Zhang Y,Guo Y,Chen S,Ding G,Zhang Y,Jia Z,Huang S,He JC,Yang L,Zhang A

更新日期：2019-06-01 00:00:00

abstract：:Hemodynamic pressure in glomerular capillaries (GCP) and in first order peritubular capillaries (EAP) in superficial nephrons of mutant Wistar rats with surface glomeruli was measured by micropuncture with a servo-nulling device in the following conditions: 1) control;2) norepinephrine infusion (NE); 3) epinephrine in...

journal_title：Kidney international

authors： Andreucci VE,Dal Canton A,Corradi A,Stanziale R,Migone L

更新日期：1976-06-01 00:00:00

abstract：:The presence of nitric oxide (NO) in the kidney has been implicated in the pathogenesis of human glomerulonephritis. However, the exact type of glomerular cells that express NO synthase (NOS) and the NOS isoform involved in the local production of NO has not been identified in the human diseased kidney. We examined th...

journal_title：Kidney international

authors： Furusu A,Miyazaki M,Abe K,Tsukasaki S,Shioshita K,Sasaki O,Miyazaki K,Ozono Y,Koji T,Harada T,Sakai H,Kohno S

更新日期：1998-06-01 00:00:00

abstract：:The OSCAR study was a multicenter, prospective randomized open-label blinded end-point study of 1164 Japanese elderly hypertensive patients comparing the efficacy of angiotensin II receptor blocker (ARB) uptitration to an ARB plus calcium channel blocker (CCB) combination. In this prospective study, we performed presp...

journal_title：Kidney international

authors： Kim-Mitsuyama S,Ogawa H,Matsui K,Jinnouchi T,Jinnouchi H,Arakawa K

更新日期：2013-01-01 00:00:00

abstract：:We studied the effect of three antihypertensive drugs on the growth of glomeruli in four- to five-week-old Munich-Wistar rats (N = 24), which were undergoing rapid maturation processes. Young rats were given an angiotensin converting enzyme inhibitor (ACEI, enalapril, 50 mg/liter drinking water), verapamil (50 mg/lite...

journal_title：Kidney international

authors： Fogo A,Yoshida Y,Yared A,Ichikawa I

更新日期：1990-12-01 00:00:00

abstract：:Hypertension is a well-known complication in children on renal replacement therapy and an important risk factor for cardiovascular disease in later life. In order to define the prevalence of and risk factors for hypertension among children, we enrolled 3337 pediatric patients from 15 countries in the ESPN/ERA-EDTA Reg...

journal_title：Kidney international

authors： Kramer AM,van Stralen KJ,Jager KJ,Schaefer F,Verrina E,Seeman T,Lewis MA,Boehm M,Simonetti GD,Novljan G,Groothoff JW

更新日期：2011-11-01 00:00:00

abstract：:A major factor contributing to failure of arteriovenous fistulas (AVFs) is migration of smooth muscle cells into the forming neointima. To identify the source of smooth muscle cells in neointima, we created end-to-end AVFs by anastomosing the common carotid artery to the jugular vein and studied neural crest-derived s...

journal_title：Kidney international

authors： Liang M,Wang Y,Liang A,Mitch WE,Roy-Chaudhury P,Han G,Cheng J

更新日期：2015-09-01 00:00:00

abstract：:Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased elimination half-life, allowing an extended dosing interval from two to eight weeks. Here we evaluate the efficacy and safety of ravulizumab in adults with atypical hemolytic uremic syndrome presenting with thrombotic microangiopathy. ...

journal_title：Kidney international

authors： Rondeau E,Scully M,Ariceta G,Barbour T,Cataland S,Heyne N,Miyakawa Y,Ortiz S,Swenson E,Vallee M,Yoon SS,Kavanagh D,Haller H,311 Study Group.

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Increasing proteinuria in kidney disease is associated with an increased risk of renal failure. Urinary proteins such as albumin induce inflammatory signaling and gene expression in tubular epithelial cells (TECs). Fibronectin is an extracellular matrix protein that can exist in soluble form and is excreted ...

journal_title：Kidney international

authors： Ren L,Blanchette JB,White LR,Clark SA,Heffner DJ,Tibbles LA,Muruve DA

更新日期：2005-11-01 00:00:00

abstract：:31P NMR as a descriptive technique is of interest to nephrologists. Particular contributions of 31P NMR to our understanding of renal function may be enumerated.: "Free" metabolite levels are different from those classically accepted; in particular, ADP and Pi are low with implications for the control of renal metabol...

journal_title：Kidney international

authors： Ross B,Freeman D,Chan L

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Cadaveric renal transplantation is associated with a survival advantage compared with dialysis patients remaining on the renal transplantation waiting list, but this advantage has not been confirmed in obese end-stage renal disease (ESRD) patients. METHODS:Using data from the USRDS, we studied 7521 patients...

journal_title：Kidney international

authors： Glanton CW,Kao TC,Cruess D,Agodoa LY,Abbott KC

更新日期：2003-02-01 00:00:00

abstract：:Anticoagulation has been reported to ameliorate antiglomerular basement membrane glomerulonephritis (anti-GBM-GN) while its effect on chronic immune complex glomerulonephritis (IC-GN) as studied in the NZB mouse is unclear. Chronic serum sickness IC-GN was induced in rabbits by injecting bovine serum albumin (BSA) dai...

journal_title：Kidney international

authors： Border WA,Wilson CB,Dixon FJ

更新日期：1975-09-01 00:00:00

abstract：:Antibodies against purified rat-kidney-cortex pyruvate carboxylase were raised in rabbits. These polyspecific antibodies recognize pyruvate carboxylase enzymes alone without cross reactivity with other carboxylases as detected by immunoblotting. The abundance of pyruvate carboxylase in the various renal fractions was ...

journal_title：Kidney international

authors： Salto R,Oliver J,del Mar Sola M,Vargas AM

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Variant forms of lysozyme, a ubiquitous bacteriolytic enzyme, are known to lead to hereditary non-neuropathic renal amyloidosis and, so far, three different mutations of the lysozyme gene have been reported. In this study, we report a novel lysozyme variant, Phe57Ile, associated with renal amyloidosis in thr...

journal_title：Kidney international

authors： Yazaki M,Farrell SA,Benson MD

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Tamm-Horsfall glycoprotein (THP) is a unique protein that is produced exclusively by cells of the thick ascending limb of Henle's loop (TALH). This study examined whether dietary salt altered renal THP production. METHODS:Male Sprague-Dawley rats were examined on days 1, 4, and 15 following placement in met...

journal_title：Kidney international

authors： Ying WZ,Sanders PW

更新日期：1998-10-01 00:00:00

abstract：:The highly amiloride-sensitive epithelial sodium channel (ENaC) is an apical membrane constituent of cells of many salt-absorbing epithelia. In the kidney, the functional relevance of ENaC expression has been well established. ENaC mediates the aldosterone-dependent sodium reabsorption in the distal nephron and is inv...

journal_title：Kidney international

authors： Bonny O,Hummler E

更新日期：2000-04-01 00:00:00