当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > The IL-4 receptor α has a critical role in bone marrow-derived fibroblast activation and renal fibrosis.

The IL-4 receptor α has a critical role in bone marrow-derived fibroblast activation and renal fibrosis.

Abstract：

:Renal fibrosis is a common pathway leading to the progression of chronic kidney disease, and bone marrow-derived fibroblasts contribute significantly to the development of renal fibrosis. However, the signaling mechanisms underlying the activation of these fibroblasts are not completely understood. Here, we examined the role of IL-4 receptor α (IL-4Rα) in the activation of myeloid fibroblasts in two experimental models of renal fibrosis. Compared with wild-type mice, IL-4Rα knockout mice accumulated fewer bone marrow-derived fibroblasts and myofibroblasts in their kidneys. IL-4Rα deficiency suppressed the expression of α-smooth muscle actin, extracellular matrix proteins and the development of renal fibrosis. Furthermore, IL-4Rα deficiency inhibited the activation of signal transducer and activator of transcription 6 (STAT6) in the kidney. Moreover, wild-type mice engrafted with bone marrow cells from IL-4Rα knockout mice exhibited fewer myeloid fibroblasts in the kidney and displayed less severe renal fibrosis following ureteral obstructive injury compared with wild-type mice engrafted with wild-type bone marrow cells. In vitro, IL-4 activated STAT6 and stimulated expression of α-smooth muscle actin and fibronectin in mouse bone marrow monocytes. This was abolished in the absence of IL-4Rα. Thus, IL-4Rα plays an important role in bone marrow-derived fibroblast activation, resulting in extracellular matrix protein production and fibrosis development. Hence, the IL-4Rα/STAT6 signaling pathway may serve as a novel therapeutic target for chronic kidney disease.

journal_name

Kidney Int

journal_title

Kidney international

authors

Liang H,Zhang Z,Yan J,Wang Y,Hu Z,Mitch WE,Wang Y

doi

10.1016/j.kint.2017.04.021

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

1433-1443

issue

6

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(17)30314-9

journal_volume

92

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • ISCHEMIA in chronic kidney disease: improving the representation of patients with chronic kidney disease in cardiovascular trials.

    abstract：:Despite the high cardiovascular risk associated with chronic kidney disease, a recent systematic review confirmed that patients with kidney disease remain underrepresented in cardiovascular trials. Two ongoing trials are assessing the risk:benefit of aggressive evaluation and intervention for ischemic heart disease in...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.03.012

    authors： Wyatt CM,Shineski M,Chertow GM,Bangalore S

    更新日期：2016-06-01 00:00:00

  • Regulatory interactions of alphabeta and gammadelta T cells in glomerulonephritis.

    abstract：BACKGROUND:Several lines of evidence suggest that cellular immune mechanisms contribute to glomerulonephritis. METHODS:The roles of alphabeta and gammadelta T cells in the pathogenesis of glomerulonephritis were investigated in a model of nephrotoxic nephritis in mice deficient in either T-cell population [T-cell rece...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00263.x

    authors： Rosenkranz AR,Knight S,Sethi S,Alexander SI,Cotran RS,Mayadas TN

    更新日期：2000-09-01 00:00:00

  • Myofibroblastic conversion of mesothelial cells.

    abstract：BACKGROUND:The continuous chemical, physical, and inflammatory insults of prolonged continuous ambulatory peritoneal dialysis (CAPD) incite mesothelial cell responses, which may result in peritoneal fibrosis. The transforming growth factor-beta (TGF-beta), especially the isoform TGF-beta 1, has long been known to play ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00861.x

    authors： Yang AH,Chen JY,Lin JK

    更新日期：2003-04-01 00:00:00

  • Genotype-based changes in serum uric acid affect blood pressure.

    abstract：:Elevated serum levels of uric acid consistently correlate with hypertension, but the directionality of the association remains debated. To help define this relationship, we used a controlled setting within a homogeneous Amish community and the Mendelian randomization of a nonsynonymous coding single-nucleotide polymor...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.414

    authors： Parsa A,Brown E,Weir MR,Fink JC,Shuldiner AR,Mitchell BD,McArdle PF

    更新日期：2012-03-01 00:00:00

  • Risk factors in idiopathic renal vasculitis and glomerulonephritis.

    abstract：:In this retrospective study, we analyzed clinical laboratory, and pathologic variables to determine their value in predicting survival and survival free of renal failure for 170 consecutive patients with idiopathic renal vasculitis and glomerulonephritis evaluated during a 15 year period. Of the 170 patients, 108 had ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.312

    authors： Wilkowski MJ,Velosa JA,Holley KE,Offord KP,Chu CP,Torres VE,McCarthy JT,Donadio JV Jr,Wagoner RD

    更新日期：1989-12-01 00:00:00

  • Glomerular platelet-activating factor levels and origin in experimental glomerulonephritis.

    abstract：:The content of platelet activating factor (PAF) in glomeruli isolated from rats with nephrotoxic serum glomerulonephritis (NSGN) was quantified at various stages of the disease and the role of complement, platelets and neutrophils in mediating changes in glomerular PAF levels was evaluated. PAF content was assessed fo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.40

    authors： Lianos EA,Zanglis A

    更新日期：1990-02-01 00:00:00

  • Expression of endothelial and inducible nitric oxide synthase in human glomerulonephritis.

    abstract：:The presence of nitric oxide (NO) in the kidney has been implicated in the pathogenesis of human glomerulonephritis. However, the exact type of glomerular cells that express NO synthase (NOS) and the NOS isoform involved in the local production of NO has not been identified in the human diseased kidney. We examined th...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00907.x

    authors： Furusu A,Miyazaki M,Abe K,Tsukasaki S,Shioshita K,Sasaki O,Miyazaki K,Ozono Y,Koji T,Harada T,Sakai H,Kohno S

    更新日期：1998-06-01 00:00:00

  • Validation of serum ferritin values by magnetic susceptometry in predicting iron overload in dialysis patients.

    abstract：BACKGROUND:Guidelines for treating anemia in dialysis patients accept, as high-end range of serum ferritin useful to optimize erythropoietin therapy, values high as 500 to 900 microg/L, on the hypothesis that ferritin might be not representative of iron overload. METHODS:A superconducting quantum interference device (...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00480.x

    authors： Canavese C,Bergamo D,Ciccone G,Longo F,Fop F,Thea A,Martina G,Piga A

    更新日期：2004-03-01 00:00:00

  • Effect of angiotensin on the filtration of protein in the rat kidney: a micropuncture study.

    abstract：:We have analyzed the protein content of proximal tubular fluid (PTF) by ultramicro disc electrophoresis and measured total protein excretion rates both in control conditions and during angiotensin infusion to the rat. Under control conditions PTF albumin concentration was 1.49 +/- 1.12 (SD) mg/100 ml and did not incre...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1975.83

    authors： Eisenbach GM,Liew JB,Boylan JW,Manz N,Muir P

    更新日期：1975-08-01 00:00:00

  • Regulation of human renin gene promoter activity: a new negative regulatory region determines the responsiveness to TNF alpha.

    abstract：BACKGROUND:The renin-angiotensin system has been known to regulate blood pressure and body fluid homeostasis. Several lines of evidence have shown that renin gene expression and release are up-regulated by beta-adrenergic stimulation, sodium depletion, and angiotensin converting enzyme inhibition, but down-regulated by...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00209.x

    authors： Chen LS,Cuddy MP,LaVallette LA

    更新日期：1998-12-01 00:00:00

  • Von Willebrand factor regulates complement on endothelial cells.

    abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.03.023

    authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

    更新日期：2016-07-01 00:00:00

  • Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin-angiotensin system inhibitors in the community increases the risk of acute kidney injury.

    abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of acute kidney injury (AKI) when used in triple combination with renin-angiotensin system inhibitors and diuretics, but previous research reported that NSAIDs in dual combinations with either renin-angiotensin system inhibitors or diu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.101

    authors： Dreischulte T,Morales DR,Bell S,Guthrie B

    更新日期：2015-08-01 00:00:00

  • Innate immune receptors and autophagy: implications for autoimmune kidney injury.

    abstract：:Inflammation is the immune system's response to infectious or noninfectious sources of danger. Danger recognition is facilitated by various innate immune receptor families including the Toll-like receptors (TLRs), which detect danger signals in extracellular and intracellular compartments. It is an evolving concept th...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2010.111

    authors： Anders HJ,Schlondorff DO

    更新日期：2010-07-01 00:00:00

  • Fibronectin synthesis in tubular epithelial cells: up-regulation of the EDA splice variant by transforming growth factor beta.

    abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.479

    authors： Viedt C,Bürger A,Hänsch GM

    更新日期：1995-12-01 00:00:00

  • Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy.

    abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00565.x

    authors： Zager RA

    更新日期：2005-10-01 00:00:00

  • The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphorus in secondary hyperparathyroidism.

    abstract：BACKGROUND:A need exists for a therapy that lowers parathyroid hormone (PTH) without increasing calcium x phosphorus in patients with secondary hyperparathyroidism. The calcimimetic AMG 073 increases the sensitivity of the parathyroid calcium-sensing receptor to extracellular calcium, thereby reducing PTH secretion. Co...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1046/j.1523-1755.2003.00720.x

    authors： Lindberg JS,Moe SM,Goodman WG,Coburn JW,Sprague SM,Liu W,Blaisdell PW,Brenner RM,Turner SA,Martin KJ

    更新日期：2003-01-01 00:00:00

  • The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy.

    abstract：BACKGROUND:Inhibition of angiotensin action, pharmacologically or genetically, during the neonatal period leads to renal anomalies involving hypoplastic papilla and dilated calyx. Recently, we documented that angiotensinogen (Agt -/-) or angiotensin type 1 receptor nullizygotes (Agtr1 -/-) do not develop renal pelvis n...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00420.x

    authors： Miyazaki Y,Tsuchida S,Fogo A,Ichikawa I

    更新日期：1999-05-01 00:00:00

  • Location of mutations within the PKD2 gene influences clinical outcome.

    abstract：BACKGROUND:Since the cloning of the gene for autosomal dominant polycystic kidney disease type 2 (PKD2), approximately 40 different mutations of that gene have been reported to be associated with the disease. The relationship between the PKD2 genotype and phenotype, however, remains unclear. METHODS:Detailed clinical ...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1046/j.1523-1755.2000.00989.x

    authors： Hateboer N,Veldhuisen B,Peters D,Breuning MH,San-Millán JL,Bogdanova N,Coto E,van Dijk MA,Afzal AR,Jeffery S,Saggar-Malik AK,Torra R,Dimitrakov D,Martinez I,de Castro SS,Krawczak M,Ravine D

    更新日期：2000-04-01 00:00:00

  • Acute renal failure with preserved renal plasma flow induced by cancer immunotherapy.

    abstract：:Adoptive immunotherapy in patients with advanced cancer produces significant regression of metastatic disease in selected patients, but it is complicated by severe side effects. Prevention of these complications is still limited because their precise mechanisms remain unknown. For this reason we have investigated rena...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.215

    authors： Mercatello A,Hadj-Aïssa A,Négrier S,Allaouchiche B,Coronel B,Tognet E,Bret M,Favrot M,Pozet N,Moskovtchenko JF

    更新日期：1991-08-01 00:00:00

  • Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats.

    abstract：:Kidney disease is associated with increased cardiovascular morbidity, but underlying mechanisms are poorly understood. We tested the hypothesis that chronic renal insufficiency impairs angioadaptation in a rat model of hindlimb ischemia. Twenty male Sprague-Dawley rats (8 weeks old) underwent subtotal nephrectomy (5/6...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000448

    authors： Jacobi J,Porst M,Cordasic N,Namer B,Schmieder RE,Eckardt KU,Hilgers KF

    更新日期：2006-06-01 00:00:00

  • Rapid, enhanced, and persistent protection of patients with renal insufficiency by AS02(V)-adjuvanted hepatitis B vaccine.

    abstract：:The adjuvanted hepatitis B vaccine, HB-AS04, elicits more rapid and persistent protective antibody concentrations than double doses of conventional recombinant vaccines in patients with renal insufficiency. We compared the immunogenicity, reactogenicity, and safety of the AS02(V)-adjuvanted hepatitis B vaccine HB-AS02...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ki.2009.454

    authors： Surquin M,Tielemans CL,Kulcsár I,Ryba M,Vörös P,Mat O,Treille S,Dhaene M,Stolear JC,Kuriyakose SO,Leyssen MX,Houard SA

    更新日期：2010-02-01 00:00:00

  • Circulating immune complexes in membranoproliferative glomerulonephritis.

    abstract：:Circulating immune complexes (CIC), measured by the solid-phase Clq method, were found to be in abnormal concentration in about half of 39 patients with membranoproliferative glomerulonephritis (MPGN). In contrast, they were present, usually in higher concentration, in nearly all patients with active lupus nephritis. ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.203

    authors： Davis CA,Marder H,West CD

    更新日期：1981-12-01 00:00:00

  • The intersecting roles of endoplasmic reticulum stress, ubiquitin- proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease.

    abstract：:Protein misfolding in the endoplasmic reticulum (ER) leads to ER stress. The unfolded protein response and ER-associated degradation (ERAD) interact in a coordinated manner with the ubiquitin-proteasome system and autophagy to alleviate protein misfolding or its consequences. The intersecting actions of these processe...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2012.390

    authors： Cybulsky AV

    更新日期：2013-07-01 00:00:00

  • Effects of C-peptide on glomerular and renal size and renal function in diabetic rats.

    abstract：BACKGROUND:Strict glycemic control and antihypertensive treatment may decrease but not eliminate the risk of progressive nephropathy in diabetic patients. C-peptide has been shown to exert beneficial effects on complications, including incipient nephropathy, in type 1 diabetes. METHODS:Renal effects of 14 days of intr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00964.x

    authors： Samnegård B,Jacobson SH,Jaremko G,Johansson BL,Sjöquist M

    更新日期：2001-10-01 00:00:00

  • Oral zeranol shortens the prolonged bleeding time of uremic rats.

    abstract：:Intravenous conjugated estrogens reduce the prolonged bleeding time in uremic patients and in a rat model of uremia. However, estrogens have major side effects related to their hormonal activity. We investigated whether a beta-resorcylic acid lactone, zeranol (a compound with close spatial similarity to estrogens but ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.172

    authors： Zoja C,Viganò G,Corna D,Salmona M,Remuzzi G,Garattini S

    更新日期：1990-07-01 00:00:00

  • Association between residence location and likelihood of kidney transplantation in Aboriginal patients treated with dialysis in Canada.

    abstract：:For reasons that are not well understood, Aboriginal people with end-stage renal disease (ESRD) have lower rates of kidney transplantation. We hypothesized that distance between residence location and the closest transplant center was greater in Aboriginal dialysis patients and would partially explain the lower rate o...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5001607

    authors： Tonelli M,Hemmelgarn B,Kim AK,Bertazzon S,Klarenbach S,Manns B,Wiebe N,Culleton B,Gill JS,Alberta Kidney Disease Network.

    更新日期：2006-09-01 00:00:00

  • Effects of arteriovenous fistulas on cardiac oxygen supply and demand.

    abstract：BACKGROUND:Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. MET...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00433.x

    authors： Bos WJ,Zietse R,Wesseling KH,Westerhof N

    更新日期：1999-05-01 00:00:00

  • A cross-sectional study of 502 patients found a diffuse hyperechoic kidney medulla pattern in patients with severe gout.

    abstract：:We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria)...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.08.024

    authors： Bardin T,Nguyen QD,Tran KM,Le NH,Do MD,Richette P,Letavernier E,Correas JM,Resche-Rigon M

    更新日期：2021-01-01 00:00:00

  • Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils.

    abstract：BACKGROUND:Recently, the in vivo pathogenic role of anti-neutrophil cytoplasm autoantibodies (ANCA) in ANCA-associated vasculitis has been challenged by Abdel-Salam et al. In their report, they observed that ANCA directed against proteinase 3 (PR3) cannot bind to their target autoantigen PR3 on circulating neutrophils ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00431.x

    authors： Van Rossum AP,van der Geld YM,Limburg PC,Kallenberg CG

    更新日期：2005-08-01 00:00:00

  • Hyperhomocysteinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins.

    abstract：BACKGROUND:High-efficiency hemodialysis may induce a deficiency in hydrosoluble vitamins. Supplementation with B-complex vitamins has been shown to lower serum homocysteine concentrations in several groups, but relatively few studies have concerned hemodialysis patients. Our objectives were to determine the status in B...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1523-1755.2000.00234.x

    authors： Tremblay R,Bonnardeaux A,Geadah D,Busque L,Lebrun M,Ouimet D,Leblanc M

    更新日期：2000-08-01 00:00:00