Long-term comparison between captopril and nifedipine in the progression of renal insufficiency.

Abstract:

:To verify the hypothesis that angiotensin-converting enzyme (ACE) inhibitors possess a unique renoprotective effect in progressive chronic renal disease, we decided to compare the effects of an ACE inhibitor and a calcium antagonist on both hypertension and the progression of non-diabetic renal insufficiency in a long-term study. A four-year, multicenter, prospective, randomized trial was conducted on 142 hypertensive patients (pts) with established chronic renal failure from six Italian nephrology departments. They were on standard antihypertensive therapy with a low-protein diet and underwent twice-monthly surveillance for a one year pre-randomization period. After that year, 121 pts were randomly allocated to captopril or slow-release nifedipine therapies for a three-year study period. The progression of renal insufficiency was monitored every two months. Blood pressure control was significantly better after randomization than during the year of standard antihypertensive therapy. The progression rate before randomization (BR) was definitely higher before than after randomization (AR): Creatinine clearance (CCr) change BR = -0.46 +/- 0.45 ml/min/month, creatinine clearance change AR = -0.23 +/- 0.43 ml/min/month (P less than 0.01). After randomization, the mean blood pressure values were virtually the same throughout the three year period of the study in the two groups treated by captopril (group I), or nifedipine (group II).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Kidney Int

journal_title

Kidney international

authors

Zucchelli P,Zuccalà A,Borghi M,Fusaroli M,Sasdelli M,Stallone C,Sanna G,Gaggi R

doi

10.1038/ki.1992.309

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

452-8

issue

2

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)57738-7

journal_volume

42

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Chronic metabolic acidosis accelerates whole body proteolysis and oxidation in awake rats.

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    pub_type: 杂志文章

    doi:10.1038/ki.1992.223

    authors: May RC,Masud T,Logue B,Bailey J,England B

    更新日期:1992-06-01 00:00:00

  • Influence of initiation of maintenance hemodialysis on biomarkers of inflammation and oxidative stress.

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    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2004.00656.x

    authors: Pupim LB,Himmelfarb J,McMonagle E,Shyr Y,Ikizler TA

    更新日期:2004-06-01 00:00:00

  • Prolongation of canine allograft survival with donor pretreatment.

    abstract::Donor pretreatment of 100 mg/kg each of cyclophosphamide (CY) and methylprednisolone (P) infused 5 hours before nephrectomy invariably prolongs the survival of DLA mismatched, MLC incompatible nonlittermate Beagle renal allografts as well as the survival of mongrel renal allografts. The effect of donor pretreatment ap...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1982.25

    authors: Brom HL,van Breda Vriesman PJ,Terpstra JL

    更新日期:1982-02-01 00:00:00

  • Mechanisms of fluid secretion by polycystic epithelia.

    abstract::We have sought to determine the mechanisms driving fluid secretion by the cystic epithelium in autosomal dominant polycystic kidney disease (ADPKD). We have performed in vitro experiments on intact cysts dissected from discarded ADPKD kidneys, on monolayers of cells cultured from the cystic epithelium and on microcyst...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/ki.1996.230

    authors: Sullivan LP,Grantham JJ

    更新日期:1996-06-01 00:00:00

  • Thrombin regulates components of the fibrinolytic system in human mesangial cells.

    abstract::Besides its procoagulant activity, thrombin has been shown to stimulate cell proliferation and to regulate the fibrinolytic pathway. We report here the effect of purified human alpha thrombin on the synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) by cultured human me...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1990.297

    authors: Villamediana LM,Rondeau E,He CJ,Medcalf RL,Peraldi MN,Lacave R,Delarue F,Sraer JD

    更新日期:1990-11-01 00:00:00

  • Endotoxin provocation of experimental renal cystic disease.

    abstract::Germ free rats provide a unique model in which to assess biological response to environment. In 48 germ-free male, Sprague-Dawley rats we examined the consequences of oral exposure to nordihydroguaiaretic acid (NDGA), a nephrotoxin; to Staphylococcus epidermidis and bacillus species, non-endotoxin-containing bacteria;...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1987.213

    authors: Gardner KD Jr,Reed WP,Evan AP,Zedalis J,Hylarides MD,Leon AA

    更新日期:1987-09-01 00:00:00

  • Mutations of NPHP2 and NPHP3 in infantile nephronophthisis.

    abstract::Nephronophthisis is an autosomal recessive chronic tubulointerstitial disease that progresses to end-stage renal disease (ESRD) in about 10% of cases during infancy. Mutations in the INVS (NPHP2) gene were found in a few patients with infantile nephronophthisis. Mutations of NPHP3, known to be associated with adolesce...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2008.662

    authors: Tory K,Rousset-Rouvière C,Gubler MC,Morinière V,Pawtowski A,Becker C,Guyot C,Gié S,Frishberg Y,Nivet H,Deschênes G,Cochat P,Gagnadoux MF,Saunier S,Antignac C,Salomon R

    更新日期:2009-04-01 00:00:00

  • Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus.

    abstract:BACKGROUND:The plasma concentrations of total homocysteine (tHcy) and total cysteine (tCys) are determined by intracellular metabolism and by renal plasma clearance, and we hypothesized that glomerular filtration is a major determinant of plasma tHcy and tCys. We studied the relationships between the glomerular filtrat...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1999.0550031028.x

    authors: Wollesen F,Brattström L,Refsum H,Ueland PM,Berglund L,Berne C

    更新日期:1999-03-01 00:00:00

  • Gene expression variance based on random sequencing in rat remnant kidney.

    abstract:BACKGROUND:Several examinations have been performed to identify the genes involved in chronic renal failure using 5/6 nephrectomized rats. Recently, many systematic techniques for examining molecular expression have been developed. They might also be effective in elucidating the molecular mechanism of progressive renal...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2004.00704.x

    authors: Horiba N,Masuda S,Takeuchi A,Saito H,Okuda M,Inui K

    更新日期:2004-07-01 00:00:00

  • Interactions between gender and the angiotensin type 1 receptor gene polymorphism.

    abstract:BACKGROUND:The cardiovascular effects of angiotensin II are mediated by the angiotensin II type 1 receptor (AGT1R); one polymorphism of the AGT1R gene, A1166-->C, has been associated with hypertension. The hemodynamic response to angiotensin II is blunted in women compared to men, but interactions between gender, blood...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1523-1755.2003.00867.x

    authors: Reich H,Duncan JA,Weinstein J,Cattran DC,Scholey JW,Miller JA

    更新日期:2003-04-01 00:00:00

  • The diagnostic value of serum concentrations of 2-(alpha-mannopyranosyl)-L-tryptophan for normal renal function.

    abstract:BACKGROUND:We have previously reported that the serum concentration of 2-(alpha-mannopyranosyl)-L-tryptophan (MPT), tryptophan glycoconjugate, is a more accurate measure of renal function than that of serum creatinine concentration. The aim of the present study was to compare the diagnostic value of serum concentration...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2004.00521.x

    authors: Yonemura K,Takahira R,Yonekawa O,Wada N,Hishida A

    更新日期:2004-04-01 00:00:00

  • Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.

    abstract::Insulin resistance from chronic kidney disease (CKD) stimulates muscle protein wasting but mechanisms causing this resistance are controversial. To help resolve this, we used microarray analyses to identify initiators of insulin resistance in the muscles of mice with CKD, glucose intolerance, and insulin resistance. C...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2013.97

    authors: Thomas SS,Dong Y,Zhang L,Mitch WE

    更新日期:2013-08-01 00:00:00

  • Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients.

    abstract::Co-presentation with both ANCA and anti-GBM antibodies is thought to be relatively rare. Current studies of such 'double-positive' cases report small numbers and variable outcomes. To study this further we retrospectively analyzed clinical features and long-term outcomes of a large cohort of 568 contemporary patients ...

    journal_title:Kidney international

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.kint.2017.03.014

    authors: McAdoo SP,Tanna A,Hrušková Z,Holm L,Weiner M,Arulkumaran N,Kang A,Satrapová V,Levy J,Ohlsson S,Tesar V,Segelmark M,Pusey CD

    更新日期:2017-09-01 00:00:00

  • The hypercalcemia of malignancy.

    abstract::The hypercalcemia of malignancy is mediated by complex and heterogeneous mechanisms. Once thought of as a simple paraneoplastic syndrome mediated by the effects of tumor production of PTH, it is now clear that multiple mechanisms are involved and that these mechanisms involve abnormalities in calcium transport in bone...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1987.21

    authors: Mundy GR

    更新日期:1987-01-01 00:00:00

  • Cardiovascular risk factors in chronic kidney disease: does phosphate qualify?

    abstract::Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/ki.2011.24

    authors: Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

    更新日期:2011-04-01 00:00:00

  • Prevalence of raised sodium-lithium countertransport activity in type 1 diabetic patients.

    abstract::The prevalence of raised Na+/Li+ countertransport (CT) activity (greater than 0.41 mmol/liter RBC/hr) was assessed in 185 consecutive insulin-dependent diabetic patients attending an outpatient diabetic clinic. Normoalbuminuria was defined as an overnight albumin excretion rate (AER) of less than 20 micrograms/min (N ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1992.134

    authors: Lopes de Faria JB,Friedman R,Tariq T,Viberti G

    更新日期:1992-04-01 00:00:00

  • Rapid, enhanced, and persistent protection of patients with renal insufficiency by AS02(V)-adjuvanted hepatitis B vaccine.

    abstract::The adjuvanted hepatitis B vaccine, HB-AS04, elicits more rapid and persistent protective antibody concentrations than double doses of conventional recombinant vaccines in patients with renal insufficiency. We compared the immunogenicity, reactogenicity, and safety of the AS02(V)-adjuvanted hepatitis B vaccine HB-AS02...

    journal_title:Kidney international

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/ki.2009.454

    authors: Surquin M,Tielemans CL,Kulcsár I,Ryba M,Vörös P,Mat O,Treille S,Dhaene M,Stolear JC,Kuriyakose SO,Leyssen MX,Houard SA

    更新日期:2010-02-01 00:00:00

  • The role of PDGF-D in healthy and fibrotic kidneys.

    abstract::Platelet-derived growth factor (PDGF)-D, a specific PDGF receptor β (PDGFR-β) ligand, mediates mesangial proliferation in vitro and in vivo. However, its role in renal development, physiology, and fibrosis is relatively unknown. In healthy murine kidneys, PDGF-D was found to be expressed on renal mesenchymal cells (me...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2015.12.037

    authors: Buhl EM,Djudjaj S,Babickova J,Klinkhammer BM,Folestad E,Borkham-Kamphorst E,Weiskirchen R,Hudkins K,Alpers CE,Eriksson U,Floege J,Boor P

    更新日期:2016-04-01 00:00:00

  • Role of distinct type IV collagen networks in glomerular development and function.

    abstract:BACKGROUND:In X-linked Alport syndrome, mutations in the COL4A5 gene encoding the alpha 5 chain of type IV collagen result in progressive renal failure. This nephropathy appears to relate to the arrest of a switch from an alpha 1/alpha 2 to an alpha 3/alpha 4/alpha 5 network of type IV collagen in the developing glomer...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1998.00188.x

    authors: Harvey SJ,Zheng K,Sado Y,Naito I,Ninomiya Y,Jacobs RM,Hudson BG,Thorner PS

    更新日期:1998-12-01 00:00:00

  • Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury.

    abstract::Innate lymphoid cells are a recently recognized group of immune cells with critical roles in tissue homeostasis and inflammation. Regulatory innate lymphoid cells are a newly identified subset of innate lymphoid cells, which play a suppressive role in the innate immune response, favoring the resolution of intestinal i...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2019.07.019

    authors: Cao Q,Wang R,Wang Y,Niu Z,Chen T,Wang C,Jin L,Huang Q,Li Q,Wang XM,Azmi F,Lee VWS,Wang YM,Zheng G,Alexander SI,Harris DCH

    更新日期:2020-01-01 00:00:00

  • A common-source outbreak of fulminant hepatitis B in hemodialysis patients induced by precore mutant.

    abstract::From September 9 to October 3, 1994, five patients on maintenance hemodialysis in a dialysis unit in Tokyo contracted hepatitis B virus (HBV) infection successively, and four of them died of fulminant hepatitis. The unit treated 181 patients three times a week on eight shifts, and all five afflicted patients were on t...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1995.499

    authors: Tanaka S,Yoshiba M,Iino S,Fukuda M,Nakao H,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

    更新日期:1995-12-01 00:00:00

  • A controlled trial of cyclosporine in patients with progressive membranous nephropathy. Canadian Glomerulonephritis Study Group.

    abstract::A controlled trial of cyclosporine in patients diagnosed with progressive membranous nephropathy (MGN) was carried out to determine whether cyclosporine (D) would be more effective than placebo (P) in reducing the rate of deterioration in renal function. Patients (N = 64) with MGN were placed on a restricted protein d...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1038/ki.1995.161

    authors: Cattran DC,Greenwood C,Ritchie S,Bernstein K,Churchill DN,Clark WF,Morrin PA,Lavoie S

    更新日期:1995-04-01 00:00:00

  • Klotho expression in osteocytes regulates bone metabolism and controls bone formation.

    abstract::Osteocytes within the mineralized bone matrix control bone remodeling by regulating osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the functional role of this protein in skeletal homeostasis is unknown. Here we identify Klotho expression in osteocytes as a potent regulator of b...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2017.02.014

    authors: Komaba H,Kaludjerovic J,Hu DZ,Nagano K,Amano K,Ide N,Sato T,Densmore MJ,Hanai JI,Olauson H,Bellido T,Larsson TE,Baron R,Lanske B

    更新日期:2017-09-01 00:00:00

  • Impaired renal acidification following acute renal ischemia in the dog.

    abstract::Transient renal tubular acidosis may complicate acute renal failure (ARF). To clarify this phenomenon, the present study examined tubular H+ ion secretory capacity in an ischemic model of ARF. Clearance studies were performed in dogs subjected to 60 minutes, unilateral renal artery clamping. The contralateral kidney s...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1986.271

    authors: Winaver J,Agmon D,Harari R,Better OS

    更新日期:1986-12-01 00:00:00

  • AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients.

    abstract:BACKGROUND:Tacrolimus has a narrow therapeutic window, and bioavailability is known to vary considerably between renal transplant recipients. Most centers still rely on measurement of trough levels, but there are conflicting reports on the correlation between tacrolimus trough levels and systemic exposure, as measured ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2005.00352.x

    authors: Scholten EM,Cremers SC,Schoemaker RC,Rowshani AT,van Kan EJ,den Hartigh J,Paul LC,de Fijter JW

    更新日期:2005-06-01 00:00:00

  • Therapy of relapsing minimal-change disease in adults: a new approach?

    abstract::Multiple-relapsing minimal-change disease (MCD) often requires exposure to potentially toxic agents in an attempt to achieve a lasting remission of nephrotic syndrome. Munyentwali and co-workers describe an experience using rituximab in adults with multiple-relapsing MCD that supports both efficacy and safety of this ...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/ki.2012.412

    authors: Glassock RJ

    更新日期:2013-03-01 00:00:00

  • Acute phosphate nephropathy.

    abstract::Acute phosphate nephropathy (APhN) is a clinical pathological entity characterized by acute and subsequent chronic renal failure following exposure to oral sodium phosphate (OSP) bowel purgatives. Renal biopsy findings include acute and chronic tubular injury with prominent tubular and interstitial calcium phosphate d...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/ki.2009.308

    authors: Markowitz GS,Perazella MA

    更新日期:2009-11-01 00:00:00

  • Primary outcomes of the Monitoring in Dialysis Study indicate that clinically significant arrhythmias are common in hemodialysis patients and related to dialytic cycle.

    abstract::Sudden death is one of the more frequent causes of death for hemodialysis patients, but the underlying mechanisms, contribution of arrhythmia, and associations with serum chemistries or the dialysis procedure are incompletely understood. To study this, implantable loop recorders were utilized for continuous cardiac rh...

    journal_title:Kidney international

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.kint.2017.11.019

    authors: Roy-Chaudhury P,Tumlin JA,Koplan BA,Costea AI,Kher V,Williamson D,Pokhariyal S,Charytan DM,MiD investigators and committees.

    更新日期:2018-04-01 00:00:00

  • Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction.

    abstract::Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) and F4/80(-) dendritic cells, monocytes, neutrophils and T-cells 24-72 h following obstruction. D...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2008.394

    authors: Dong X,Bachman LA,Miller MN,Nath KA,Griffin MD

    更新日期:2008-11-01 00:00:00

  • Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus.

    abstract:BACKGROUND:The detailed mechanisms of glucocorticoid action in idiopathic nephrotic syndrome and progressive glomerulonephritides have not been clearly elucidated. The pharmacological actions of glucocorticoids are mediated by their binding to an intracellular protein, the glucocorticoid receptor (GR). The determinatio...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1999.00503.x

    authors: Yan K,Kudo A,Hirano H,Watanabe T,Tasaka T,Kataoka S,Nakajima N,Nishibori Y,Shibata T,Kohsaka T,Higashihara E,Tanaka H,Watanabe H,Nagasawa T,Awa S

    更新日期:1999-07-01 00:00:00