Expression of leucocyte and lymphocyte adhesion molecules in the human kidney.

abstract：:US adults with metabolic syndrome, as defined by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, have been shown to be at increased risk of chronic kidney disease (CKD), but there is limited information in other populations. The relationship between metabolic syndrome and CKD ...

journal_title：Kidney international

authors： Kitiyakara C,Yamwong S,Cheepudomwit S,Domrongkitchaiporn S,Unkurapinun N,Pakpeankitvatana V,Sritara P

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Aldosterone has been known for many years to increase sodium (Na(+)) reabsorption by the distal nephron. The present in vitro experiments investigated the effect of the hormone on calcium (Ca(2+)) transport by the luminal membrane of the rabbit nephron, independent of any systemic influence. METHODS:Proxima...

journal_title：Kidney international

authors： Leclerc M,Brunette MG,Couchourel D

更新日期：2004-07-01 00:00:00

abstract：:The plasmin protease system may have a role in maintaining the patency of renal tubules and in regulating matrix degradation within the glomerulus. Urokinase-plasminogen activator (u-PA) is a serine protease which plays an important part in the regulation of plasmin production from plasminogen. The synthesis of u-PA b...

journal_title：Kidney international

authors： Brown PA,Wilson HM,Reid FJ,Booth NA,Simpson JG,Morrison L,Power DA,Haites NE

更新日期：1994-01-01 00:00:00

abstract：:Modern dietary habits are characterized by high-sodium and low-potassium intakes, each of which was correlated with a higher risk for hypertension. In this study, we examined whether long-term variations in the intake of sodium and potassium induce lasting changes in the plasma concentration of circulating steroids by...

journal_title：Kidney international

authors： Elabida B,Edwards A,Salhi A,Azroyan A,Fodstad H,Meneton P,Doucet A,Bloch-Faure M,Crambert G

更新日期：2011-08-01 00:00:00

abstract：:The monitoring of the levels of alloantibodies following transplantation might facilitate early diagnosis of chronic rejection (CR), the leading cause of renal allograft failure. Here, we used serial alloantibody surveillance to monitor patients with preoperative positive flow cytometric crossmatch (FCXM). Sixty-nine ...

journal_title：Kidney international

authors： Kimball PM,Baker MA,Wagner MB,King A

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Since the cloning of the gene for autosomal dominant polycystic kidney disease type 2 (PKD2), approximately 40 different mutations of that gene have been reported to be associated with the disease. The relationship between the PKD2 genotype and phenotype, however, remains unclear. METHODS:Detailed clinical ...

journal_title：Kidney international

authors： Hateboer N,Veldhuisen B,Peters D,Breuning MH,San-Millán JL,Bogdanova N,Coto E,van Dijk MA,Afzal AR,Jeffery S,Saggar-Malik AK,Torra R,Dimitrakov D,Martinez I,de Castro SS,Krawczak M,Ravine D

更新日期：2000-04-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a key cause of hypertension and a potent independent risk for cardiovascular disease. Epidemiological studies suggest a strong genetic component determining susceptibility for renal disease and, by inference, the associated cardiovascular risk. With a subtotal nephrectomy model of kidne...

journal_title：Kidney international

authors： Salzler HR,Griffiths R,Ruiz P,Chi L,Frey C,Marchuk DA,Rockman HA,Le TH

更新日期：2007-11-01 00:00:00

abstract：:Kidney transplant patients receiving phenytoin or phenobarbital may have decreased graft survival. These drugs have been shown to enhance the metabolism of glucocorticoids. We determined the disposition of total and unbound prednisolone in six stable kidney transplant patients receiving prednisone for immunosuppressio...

journal_title：Kidney international

authors： Gambertoglio JG,Holford NH,Kapusnik JE,Nishikawa R,Saltiel M,Stanik-Lizak P,Birnbaum JL,Hau T,Amend WJ Jr

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The "intact" parathyroid hormone (PTH) assay recognizes PTH-(1-84) as well as amino terminally truncated PTH fragments, that is, large carboxyterminal PTH fragments (C-PTH fragments). The present study investigated whether the use of the plasma PTH-(1-84)/C-PTH fragment ratio enhances the noninvasive assessm...

journal_title：Kidney international

authors： Monier-Faugere MC,Geng Z,Mawad H,Friedler RM,Gao P,Cantor TL,Malluche HH

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Peritonitis in peritoneal dialysis patients is accompanied by an enhanced migration of neutrophils (PMNs) and increased protein loss into the peritoneal cavity; however, the role of PMNs in governing increased protein loss during peritonitis associated with peritoneal dialysis is unknown. METHODS:We determi...

journal_title：Kidney international

authors： Luo Q,Cheung AK,Kamerath CD,Reimer LG,Leypoldt JK

更新日期：2000-04-01 00:00:00

abstract：:In Australia, Canada, New Zealand, and the United States indigenous people have high rates of chronic kidney disease but poor access to effective therapies. To more fully define these issues, we compared the demographics of renal transplantation of indigenous patients in these 4 countries. Data encompassing 312,507 in...

journal_title：Kidney international

authors： Yeates KE,Cass A,Sequist TD,McDonald SP,Jardine MJ,Trpeski L,Ayanian JZ

更新日期：2009-09-01 00:00:00

abstract：:Sudden death is one of the more frequent causes of death for hemodialysis patients, but the underlying mechanisms, contribution of arrhythmia, and associations with serum chemistries or the dialysis procedure are incompletely understood. To study this, implantable loop recorders were utilized for continuous cardiac rh...

journal_title：Kidney international

authors： Roy-Chaudhury P,Tumlin JA,Koplan BA,Costea AI,Kher V,Williamson D,Pokhariyal S,Charytan DM,MiD investigators and committees.

更新日期：2018-04-01 00:00:00

abstract：:ESKD patients have a large burden of disease, with high rates of readmission to hospital compared with the general population. A readmission after an acute index hospital discharge is either planned or unplanned. A proportion of unplanned readmissions are potentially avoidable, and could have been prevented with optim...

journal_title：Kidney international

authors： Mathew AT,Strippoli GF,Ruospo M,Fishbane S

更新日期：2015-12-01 00:00:00

abstract：:Determination of serum oxalate concentration is important for the diagnosis and monitoring of hyperoxalurias, and extends to patients with all types of renal disease. Approximately 5 to 10 ml of blood is required for each test by conventional methods, and the test is not adapted for use in children. We developed a hig...

journal_title：Kidney international

authors： Gaulier JM,Cochat P,Lardet G,Vallon JJ

更新日期：1997-12-01 00:00:00

abstract：:Familial aggregation of non-diabetic end-stage renal disease (ESRD) is found in African Americans and variants in the apolipoprotein L1 gene (APOL1) contribute to this risk. To detect genetic associations with milder forms of nephropathy in the high-risk families, analyses were performed using generalized estimating e...

journal_title：Kidney international

authors： Freedman BI,Langefeld CD,Turner J,Núñez M,High KP,Spainhour M,Hicks PJ,Bowden DW,Reeves-Daniel AM,Murea M,Rocco MV,Divers J

更新日期：2012-10-01 00:00:00

abstract：:A new study by Xu et al. presents compelling evidence for an important role of the glomerular endothelium in acute kidney injury. They show that lipopolysaccharide reduces the endothelial surface layer, resulting in mild albuminuria, reduced glomerular filtration rate, and fewer endothelial fenestrae. Tumor necrosis f...

journal_title：Kidney international

authors： Haraldsson BS

更新日期：2014-01-01 00:00:00

abstract：:In summary, it is evident that malnutrition is highly prevalent in ESRD patients. This is clearly related to multiple factors encountered during the pre-dialysis stage, as well as during maintenance dialysis therapy. A body of evidence highlights the existence of relationship between malnutrition and outcome in this p...

journal_title：Kidney international

authors： Ikizler TA,Hakim RM

更新日期：1996-08-01 00:00:00

abstract：:Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation d...

journal_title：Kidney international

authors： Ferrara N

更新日期：1999-09-01 00:00:00

abstract：:Dysregulated production of adipocytokines may be involved in the development of atherosclerotic cardiovascular disease in metabolic syndrome and chronic kidney disease (CKD) associated with metabolic syndrome. The aim of this study was to determine the effects of treatment with angiotensin II (Ang II) type-1 receptor ...

journal_title：Kidney international

authors： Kurata A,Nishizawa H,Kihara S,Maeda N,Sonoda M,Okada T,Ohashi K,Hibuse T,Fujita K,Yasui A,Hiuge A,Kumada M,Kuriyama H,Shimomura I,Funahashi T

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The glomerular endothelial cell is a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration. During gram-negative sepsis, glomerulonephritis, and acute renal failure, bacterial lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) may cause severe cell dam...

journal_title：Kidney international

authors： Messmer UK,Briner VA,Pfeilschifter J

更新日期：1999-06-01 00:00:00

abstract：:Ischemia-reperfusion injury is an important cause of graft failure. Because carnitine regulates substrate flux and energy balance across membranes which may be deranged in ischemia we determined whether its use was effective in preventing kidney injury in an allogeneic transplant model. Brown Norway rats received a Le...

journal_title：Kidney international

authors： Azzollini N,Cugini D,Cassis P,Pezzotta A,Gagliardini E,Abbate M,Arduini A,Peschechera A,Remuzzi G,Noris M

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:This multicenter, open-label, dose-titration study assessed the safety and efficacy of RenaGel(R), a nonabsorbed calcium- and aluminum-free phosphate binder, in lowering serum phosphorus. Secondary outcomes were its effects on serum intact parathyroid hormone (iPTH) and serum lipids. METHODS:Phosphate binde...

journal_title：Kidney international

authors： Slatopolsky EA,Burke SK,Dillon MA

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The underlying mechanisms of renal transplant dysfunction are poorly understood. There is little information on tubular function in kidney grafts. The cDNAs encoding kidney-specific cell surface proteins required for renal reabsorption of sodium (sodium cotransporter in thick ascending limb of Henle, rBSC1) ...

journal_title：Kidney international

authors： Michimata M,Wang W,Fujita S,Mizutani H,Fujimori K,Satomi S,Ohta M,Ito S,Kimura T,Araki T,Imai Y,Matsubara M

更新日期：2001-08-01 00:00:00

abstract：:The cytokine interleukin-6 (IL-6) is a major cell regulatory factor that may play an important role in the bone remodeling of patients with renal failure. IL-6 exerts its action by binding to its receptor (IL-6R), which leads to transduction of a second messenger cascade within cells. In vitro as well as in vivo data ...

journal_title：Kidney international

authors： Langub MC Jr,Koszewski NJ,Turner HV,Monier-Faugere MC,Geng Z,Malluche HH

更新日期：1996-08-01 00:00:00

abstract：:This study examined the expression of EPO, VEGF and VEGF receptor gene under conditions of reduced oxygen supply in primary cultures of rat hepatocytes, and compared it with the expression of these genes in hypoxic rat livers in vivo. To this end we exposed male Sprague-Dawley rats to hypoxia (10% and 8% O2), carbon m...

journal_title：Kidney international

authors： Sandner P,Wolf K,Bergmaier U,Gess B,Kurtz A

更新日期：1997-02-01 00:00:00

abstract：:These studies were undertaken to examine effects of elevated glucose levels on glycolysis, sorbitol pathway activity, and the cytosolic redox state of NADH/NAD+ in isolated glomeruli. Blood-free glomeruli were isolated from kidneys of male, Sprague-Dawley rats using standard sieving techniques, then incubated for one ...

journal_title：Kidney international

authors： Tilton RG,Baier LD,Harlow JE,Smith SR,Ostrow E,Williamson JR

更新日期：1992-04-01 00:00:00

abstract：:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. ...

journal_title：Kidney international

authors： Alexander JJ,Chaves LD,Chang A,Jacob A,Ritchie M,Quigg RJ

更新日期：2015-05-01 00:00:00

abstract：:To assess in vitro erythropoietic cultures as a tool to discriminate between patients whose anemia improves with and those whose anemia fails to improve with androgens, bone marrows of 24 anemic patients receiving maintenance hemodialysis in hormone-depleted plasma clots were cultured. While erythroid colony prolifera...

journal_title：Kidney international

authors： Kalmanti M,Dainiak N,Martino J,Dewey M,Kulkarni V,Howard D

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D3, is a potent immunomodulatory agent on several cell types such as monocytes and mesangial cells. Recruitment of inflammatory cells, as well as stimulation of resident cells and mesangial matrix accumulation are key features of various expe...

journal_title：Kidney international

authors： Panichi V,Migliori M,Taccola D,Filippi C,De Nisco L,Giovannini L,Palla R,Tetta C,Camussi G

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...

journal_title：Kidney international

authors： Shahin H,Reddy G,Sharafuddin M,Katz D,Franzwa BS,Dixon BS

更新日期：2005-11-01 00:00:00