Abstract：
BACKGROUND:The hypothesis that angiotensin-converting enzyme (ACE) inhibitors interfere with the treatment of anemia with recombinant human erythropoietin (rHuEPO) remains controversial. To test this hypothesis, a retrospective analysis was conducted in a large group of hemodialysis patients with renal anemia. METHODS:The effects of ACE inhibitors in these patients were evaluated by measuring the weekly increment in hematocrit (DeltaHct) values within 12 weeks of the initiation of rHuEPO treatment. Results from 2213 rHuEPO naïve patients were compared between patients receiving rHuEPO alone and patients receiving both rHuEPO and ACE inhibitors. Because of the demographic differences between the two groups, a propensity score was used to eliminate the influence of confounding factors and to match the patient population in these two patient groups. Multiple regression analysis also was performed. RESULTS:When the DeltaHct values were compared directly between the two groups or were assessed by multiple regression analysis, no effect of ACE inhibitors was observed (P = 0.941 and P = 0.308, respectively). When the effects of ACE inhibitors on the treatment of anemia with rHuEPO were analyzed in 329 patients extracted from each group by their propensity score, DeltaHct did not differ between the two groups (P = 0.355). CONCLUSIONS:These results suggest that ACE inhibitors have no effect on the rHuEPO treatment for anemia in hemodialysis patients who were treated with a relatively low dose of ACE inhibitors and low-dose rHuEPO.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Hayashi K,Hasegawa K,Kobayashi Sdoi
10.1046/j.1523-1755.2001.00028.xsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
1910-6issue
5eissn
0085-2538issn
1523-1755pii
S0085-2538(15)48073-1journal_volume
60pub_type
杂志文章abstract：:A study of dialysis costs in five major dialysis centers throughout the United States was conducted in 1973. When available, home, home training, limited care, satellite and in-hospital-full-care dialysis were included. The study's objective was to determine the cost per dialysis for each separate dialysis modality. A...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1976.31
更新日期：1976-03-01 00:00:00
abstract：:Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production. Tetrahydrobiopterin (BH4) is an essential cofactor for NO synthase, and in ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1994.398
更新日期：1994-11-01 00:00:00
abstract：:Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world, and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading to CKD after acute injury are limited by current animal models of AKI, which concurrently target v...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.20
更新日期：2012-07-01 00:00:00
abstract：:Early kidney transplant results in children lagged behind corresponding results in adults. Multiple advances over the past three decades have eliminated that gap. Most children now have equal or superior long-term allograft and patient survival compared with adult recipients. However, black children in the United Stat...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2014.366
更新日期：2015-03-01 00:00:00
abstract：:Inflammation is the immune system's response to infectious or noninfectious sources of danger. Danger recognition is facilitated by various innate immune receptor families including the Toll-like receptors (TLRs), which detect danger signals in extracellular and intracellular compartments. It is an evolving concept th...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.2010.111
更新日期：2010-07-01 00:00:00
abstract：:Transport and metabolism of adenosine were studied in the S1, S2, and S3 segments of the rabbit proximal renal tubule. Isolated segments were perfused in vitro with uniformly labelled 14C-adenosine to measure the lumen-to-bath flux of adenosine. This flux rate was measured by the disappearance of 14C from the luminal ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.174
更新日期：1992-05-01 00:00:00
abstract：:Hemodialysis adequacy can be quantified using ultraviolet absorbance of the spent dialysate, or by analysis of dialysate conductivity at the dialyzer inlet and outlet in response to changes in dialysate electrolyte concentration. These measurements can be made at every dialysis, including initial and acute treatments ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2010.218
更新日期：2010-11-01 00:00:00
abstract：:Precise immunofluorescence criteria for C3 glomerulopathy remain to be defined. Here we tested hierarchical immunofluorescence criteria with varying stringency for C3 glomerulopathy in a cohort with dense deposit disease as the gold standard and then applied these criteria to analyze the incidence of C3 glomerulopathy...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2013.340
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:The podocyte is the focus of much research into the mechanisms of renal disease progression, and the number of podocytes per glomerulus has thus become a parameter of much interest. When counting podocytes, the actual particle counted is the cell nucleus. The majority of published studies estimating podocyte...
journal_title：Kidney international
pub_type： 临床试验,杂志文章
doi：10.1111/j.1523-1755.2004.00787.x
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Macrophages have been regarded as "blackguards" in the generation of glomerular injury. However, it is still unclear what kind of cellular machinery is responsible for their pathogenic actions. To explore this issue, this investigation aims at developing a novel strategy using adoptive transfer of "loss-of-f...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00893.x
更新日期：2000-02-01 00:00:00
abstract：:Tissandié and colleagues report in this issue on their studies of IgA1 glycosylation and biological activities of IgA1-containing circulating immune complexes in patients with alcoholic cirrhosis who developed secondary renal disease with IgA deposits, secondary IgA nephropathy. Their seminal findings demonstrate abno...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2011.302
更新日期：2011-12-01 00:00:00
abstract：:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2014.373
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Aldosterone has been known for many years to increase sodium (Na(+)) reabsorption by the distal nephron. The present in vitro experiments investigated the effect of the hormone on calcium (Ca(2+)) transport by the luminal membrane of the rabbit nephron, independent of any systemic influence. METHODS:Proxima...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00725.x
更新日期：2004-07-01 00:00:00
abstract：:In summary, it is evident that malnutrition is highly prevalent in ESRD patients. This is clearly related to multiple factors encountered during the pre-dialysis stage, as well as during maintenance dialysis therapy. A body of evidence highlights the existence of relationship between malnutrition and outcome in this p...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.1996.323
更新日期：1996-08-01 00:00:00
abstract：:Ultrafiltration failure is a major complication of long-term peritoneal dialysis, resulting in dialysis failure. Peritoneal fibrosis induced by continuous exposure to high glucose dialysate is the major contributor of ultrafiltration failure, for which there is no effective treatment. Overactivation of several signali...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2017.12.023
更新日期：2018-06-01 00:00:00
abstract：:To determine whether Cyclosporine A (CsA) alters the intrarenal expression of the renin and type 1 angiotensin II receptor genes, male adult Sprague-Dawley rats were given 25 mg/kg/day CsA s.c. for three weeks (CsA, N = 20) and were compared to pair-fed vehicle treated rats (Con, N = 20). The intrarenal distribution o...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1993.90
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to examine the relationship between glomerular filtration rate (GFR) measured at 5 years' diabetes duration and annual urine albumin excretion in a prospective cohort of children with type 1 diabetes (T1DM). METHODS:Three hundred and eight children were followed from diagnosis ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00590.x
更新日期：2005-10-01 00:00:00
abstract：:Experiments were performed using a variety of methods to assess the functional status of different nephron populations following 45 min of renal ischemia in the rat. Micropuncture techniques revealed that SNGFR and reabsorption in the surface nephrons are only modestly reduced after ischemia, whereas kidney GFR and re...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1983.122
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:Gene expression profiling of nephropathies may facilitate development of diagnostic strategies for complex renal diseases as well as provide insight into the molecular pathogenesis of kidney diseases. To test molecular based renal disease categorization, differential gene expression profiles were compared be...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00499.x
更新日期：2004-03-01 00:00:00
abstract：:Meprins are zinc-dependent metalloproteinases that are highly expressed in the brush-border membranes of both the kidney and the intestines. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. In this ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002189
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:IgA nephropathy is the most common glomerular disease. Mechanisms leading to its occurrence and controlling the evolution of the disease remain largely unknown. Various genetic factors have been found, mostly implicating immunologically relevant genes (IgH, TCR, human lymphocyte antigen, and complement loci)...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00253.x
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Renal failure and toxic acute tubular necrosis (ATN) may be seen following exposure to a variety of therapeutic agents. Zoledronate (Zometa) is a new, highly potent bisphosphonate used in the treatment of hypercalcemia of malignancy. We report the first clinical-pathologic study of nephrotoxicity associated ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2003.00071.x
更新日期：2003-07-01 00:00:00
abstract：:Aboriginal dialysis patients have reduced access to kidney transplantation. The reasons for this disparity are unknown. Tonelli et al. show that in Canada, residence location does not significantly impact on an Aboriginal dialysis patient's likelihood of receiving kidney transplantation. This Commentary explores the i...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5001762
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease. METHODS:Stereologic studies were performed 10 weeks afte...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.00481.x
更新日期：2002-08-01 00:00:00
abstract：:We have previously established that interferon (IFN)-gamma stimulated, antigen-pulsed tubular epithelial cells (TEC) stimulate antigen (Ag) specific activation of T cell hybridomas to express IL-2. In contrast, these Ag pulsed TEC do not stimulate T helper 1 (Th1) clones to proliferate, but rather render them unrespon...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1994.147
更新日期：1994-04-01 00:00:00
abstract：:Dialysis providers in the United States may soon be held accountable for their patients' 30-day hospital readmissions. However, few studies have evaluated the timing of readmissions, which determines the window in which dialysis providers could act to prevent readmission. We therefore examined the timing of readmissio...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2017.03.025
更新日期：2017-10-01 00:00:00
abstract：:Spontaneous polycystic kidney and liver disease in an inbred herd of Springbok (Antidorcas marsupialis) was studied by light microscopy, transmission electron microscopy, and microdissection. Springbok are a small species of gazelle of the family Bovidae native to South Africa. Since 1976, 18% of all live calves born ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1982.146
更新日期：1982-08-01 00:00:00
abstract：:To define the pattern of recovery from postischemic acute renal failure (ARF), we performed clearance and micropuncture studies at intervals of 1, 2, 4, and 8 weeks following 60 min of complete unilateral renal artery occlusion in the rat. At 1 week, the inulin clearance (CIn) of the postischemic kidney was less than ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1979.112
更新日期：1979-08-01 00:00:00
abstract：BACKGROUND:Cux-1 is a murine homeodomain protein that functions as a cell cycle-dependent transcriptional repressor in proliferating cells. Targets of Cux-1 repression include the cyclin kinase inhibitors p21 and p27. In the kidney, Cux-1 is spatially and temporally regulated, and ectopic expression of Cux-1 in transge...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.67099.x
更新日期：2005-02-01 00:00:00
abstract：:Systemic AA type amyloidosis with renal involvement is the major cause of morbidity and mortality in patients with familial Mediterranean fever (FMF). A histopathological examination is essential to achieve a definite diagnosis in systemic amyloidosis. The diagnostic yield of the procedure varies according to the biop...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1993.318
更新日期：1993-10-01 00:00:00
