当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective.

Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective.

Abstract：

:We described the characteristics in a referred cohort of type II diabetic patients in the Developing Education on Microalbuminuria for Awareness of renal and cardiovascular risk in Diabetes study evaluating the global prevalence and determinants of microalbuminuria (MA). A cross-sectional study evaluating 32,208 type II diabetic patients without known albuminuria from 33 countries was performed. Overall, 8057 patients were excluded, either because of prior known proteinuria or non-diabetic nephropathy (3670), or because of invalid urine collections (4387). One single random urinary albumin/creatinine ratio was obtained in 24,151 patients (75%). The overall global prevalence of normo-, micro-, and macroalbuminuria was 51, 39, and 10%, respectively. The Asian and Hispanic patients had the highest prevalence of a raised urinary albumin/creatinine ratio (55%) and Caucasians the lowest (40.6), P<0.0001. HbA1c, systolic blood pressure (BP), ethnicity, retinopathy, duration of diabetes, kidney function, body height, and smoking were all independent risk factors of MA, P<0.0001. Estimated glomerular filtration rate was below 60 ml/min/1.73 m(2) in 22% of the 11,573 patients with available data. Systolic BP below 130 mmHg was found in 33 and 43% had an HbA1c below 7%. The frequency of patients receiving aspirin was 32%, statins 29%, and BP-lowering therapy 63%. A high prevalence globally of MA and reduced kidney function, both conditions associated with enhanced renal and cardiovascular risk, was detected in type II diabetic patients without prior known nephropathy. Early detection, monitoring of vascular complications, and more aggressive multifactorial treatment aiming at renal and vascular protection are urgently needed.

journal_name

Kidney Int

journal_title

Kidney international

authors

Parving HH,Lewis JB,Ravid M,Remuzzi G,Hunsicker LG,DEMAND investigators.

doi

10.1038/sj.ki.5000377

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

2057-63

issue

11

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)51405-1

journal_volume

69

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Aberrant IgM on T cells: biomarker or pathogenic factor in childhood nephrotic syndrome?

    abstract：:Although the pathogenesis of steroid-sensitive nephrotic syndrome (SSNS) remains elusive, multiple epidemiologic, clinical, and experimental studies converge on the common theme of immune dysregulation. Initially, T-cell adaptive immunity was solely emphasized; however, the role of humoral immunity in nephrotic syndro...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2019.05.031

    authors： Chambers ET,Gbadegesin RA

    更新日期：2019-10-01 00:00:00

  • Atrial fibrillation in incident dialysis patients.

    abstract：:Despite the importance of cardiovascular disease in dialysis patients, the frequency of atrial fibrillation in incident dialysis patients has not been determined. We analyzed the prevalence of atrial fibrillation in patients starting dialysis over a 4-year period, its occurrence over the course of dialysis, and its in...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.185

    authors： Vazquez E,Sanchez-Perales C,Garcia-Garcia F,Castellano P,Garcia-Cortes MJ,Liebana A,Lozano C

    更新日期：2009-08-01 00:00:00

  • Contribution of dietary oxalate to urinary oxalate excretion.

    abstract：BACKGROUND:The amount of oxalate excreted in urine has a significant impact on calcium oxalate supersaturation and stone formation. Dietary oxalate is believed to make only a minor (10 to 20%) contribution to the amount of oxalate excreted in urine, but the validity of the experimental observations that support this co...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00488.x

    authors： Holmes RP,Goodman HO,Assimos DG

    更新日期：2001-01-01 00:00:00

  • Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.

    abstract：:The relationship between commonly occurring genetic variants (G1 and G2) in the APOL1 gene in African Americans and different disease traits, such as kidney disease, cardiovascular disease, and pre-eclampsia, remains the subject of controversy. Here we took a genotype-first approach, a phenome-wide association study, ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.01.027

    authors： Bajaj A,Ihegword A,Qiu C,Small AM,Wei WQ,Bastarache L,Feng Q,Kember RL,Risman M,Bloom RD,Birtwell DL,Williams H,Shaffer CM,Chen J,Center RG,Denny JC,Rader DJ,Stein CM,Damrauer SM,Susztak K

    更新日期：2020-05-01 00:00:00

  • Modulation of salt transport rate affects DNA synthesis in vivo in rat renal tubules.

    abstract：:In adult male Wistar rats we investigated whether cell proliferation contributes to salt load-induced hypertrophy of distal tubules. In one treatment group salt transport in the thick ascending limb (TAL) was inhibited by furosemide (7.5 mg/100 g body wt/24 hr, via osmotic minipump) and stimulated in the successive di...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.225

    authors： Loffing J,Le Hir M,Kaissling B

    更新日期：1995-06-01 00:00:00

  • How best to improve survival in hemodialysis patients: solute clearance or volume control?

    abstract：:How much dialysis is required for optimal well-being and long-term survival? The Frequent Hemodialysis Network completed two prospective trials examining the effect of more frequent, short hours and, now, of nocturnal hemodialysis compared with standard thrice-weekly treatments. Whereas the short-hours trial reported ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2011.267

    authors： Davenport A

    更新日期：2011-11-01 00:00:00

  • Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells.

    abstract：BACKGROUND:The clinical use of cyclosporine (CsA) is limited by its nephrotoxicity. Apoptosis, perhaps instigated by increased nitric oxide synthase (NOS) activity, may play a role in such toxicity. METHODS:Human mesangial cells, human tubular cells, human umbilical vein endothelial cells, or murine endothelial cells ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00999.x

    authors： Amore A,Emancipator SN,Cirina P,Conti G,Ricotti E,Bagheri N,Coppo R

    更新日期：2000-04-01 00:00:00

  • Biphasic glomerular hypertrophy in rats administered puromycin aminonucleoside.

    abstract：:Recent evidence suggests that glomerular hypertrophy is a key event in the development of focal and segmental glomerulosclerosis and hyalinosis (FSGS) in humans and in many experimental models of FSGS. The initial aim of the present study was to determine if glomerular hypertrophy occurs in a puromycin aminonucleoside...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.375

    authors： Cahill MM,Ryan GB,Bertram JF

    更新日期：1996-09-01 00:00:00

  • The hallmarks of mitochondrial dysfunction in chronic kidney disease.

    abstract：:Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received increasing attention as a therapeutic target in a variety of diseases because they serve as key regulatory hubs uniquely situated at crossroads be...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1016/j.kint.2017.05.034

    authors： Galvan DL,Green NH,Danesh FR

    更新日期：2017-11-01 00:00:00

  • Transcriptome analysis of a rat PKD model: Importance of genes involved in extracellular matrix metabolism.

    abstract：:Transcriptome analysis of a rat polycystic kidney disease (PKD) model: importance of genes involved in extracellular matrix metabolism. PKD is a common genetic cause of chronic renal failure, and is characterized by the accumulation of fluid-filled cysts in the kidneys and other organs. Abnormalities in the expression...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000309

    authors： Riera M,Burtey S,Fontés M

    更新日期：2006-05-01 00:00:00

  • Decreased ATPase activity in adriamycin nephrosis is independent of proteinuria.

    abstract：:In previous studies from this laboratory it has been shown that ATP-ase activity in situ in the glomerular basement membrane (GBM) is clearly reduced in rats rendered nephrotic after treatment with adriamycin (ADR). The question was raised whether this reduction of ATP-ase activity in the GBM is due to toxic activity ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1987.55

    authors： Bakker WW,Kalicharan D,Donga J,Hulstaert CE,Hardonk MJ

    更新日期：1987-03-01 00:00:00

  • Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney.

    abstract：BACKGROUND:We aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene. METHODS:A partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enric...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00143.x

    authors： Hilgers KF,Nagaraj SK,Karginova EA,Kazakova IG,Chevalier RL,Carey RM,Pentz ES,Gomez RA

    更新日期：1998-11-01 00:00:00

  • Critical role for osteopontin in diabetic nephropathy.

    abstract：:The profibrotic adhesion molecule, osteopontin (OPN), is upregulated in kidneys of humans and mice with diabetes. The thiazolidinedione (TZD) insulin sensitizers decrease albuminuria in diabetic nephropathy (DN) and reduce OPN expression in vascular and cardiac tissue. To examine whether OPN is a critical mediator of ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.518

    authors： Nicholas SB,Liu J,Kim J,Ren Y,Collins AR,Nguyen L,Hsueh WA

    更新日期：2010-04-01 00:00:00

  • Expression of heat shock proteins 47 and 70 in the peritoneum of patients on continuous ambulatory peritoneal dialysis.

    abstract：BACKGROUND:Peritoneal sclerosis, characterized by collagen accumulation, is a serious complication in continuous ambulatory peritoneal dialysis (CAPD) therapy. Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperon and is closely associated with collagen synthesis. METHODS:We determined the expression...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00883.x

    authors： Shioshita K,Miyazaki M,Ozono Y,Abe K,Taura K,Harada T,Koji T,Taguchi T,Kohno S

    更新日期：2000-02-01 00:00:00

  • Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

    abstract：:Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.2

    authors： Pepper RJ,Hamour S,Chavele KM,Todd SK,Rasmussen N,Flint S,Lyons PA,Smith KG,Pusey CD,Cook HT,Salama AD

    更新日期：2013-06-01 00:00:00

  • Identification of a monocyte phagocytic defect in a subpopulation of patients with nephritis.

    abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1983.105

    authors： Ooi YM,Ooi BS

    更新日期：1983-06-01 00:00:00

  • Surface areas of brush border and lateral cell walls in the rabbit proximal nephron.

    abstract：:A morphometric technique is used to estimate the absolute and relative surface areas of the brush border microvilli and cell walls bordering lateral intercellular spaces. In isolated, perfused proximal tubule from rabbit, the luminal and lateral surfaces are equal in area. For proximal convoluted tubules (PCT) each su...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1975.125

    authors： Welling LW,Welling DJ

    更新日期：1975-12-01 00:00:00

  • AUC-guided dosing of tacrolimus prevents progressive systemic overexposure in renal transplant recipients.

    abstract：BACKGROUND:Tacrolimus has a narrow therapeutic window, and bioavailability is known to vary considerably between renal transplant recipients. Most centers still rely on measurement of trough levels, but there are conflicting reports on the correlation between tacrolimus trough levels and systemic exposure, as measured ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00352.x

    authors： Scholten EM,Cremers SC,Schoemaker RC,Rowshani AT,van Kan EJ,den Hartigh J,Paul LC,de Fijter JW

    更新日期：2005-06-01 00:00:00

  • The chemokine receptor 5 Delta32 mutation is associated with increased renal survival in patients with IgA nephropathy.

    abstract：BACKGROUND:Chemokine receptor 5 (CCR5) plays an important role in the recruitment of monocytes and T cells in inflammation and experimental studies suggest that CCR5 might be involved in the pathogenesis of IgA nephropathy. A mutation in the CCR5 gene (CCR5 Delta32), leading to a nonfunctional receptor, was recently de...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00057.x

    authors： Panzer U,Schneider A,Steinmetz OM,Wenzel U,Barth P,Reinking R,Becker JU,Harendza S,Zahner G,Fischereder M,Krämer BK,Schlöndorff D,Ostendorf T,Floege J,Helmchen U,Stahl RA

    更新日期：2005-01-01 00:00:00

  • Correlation of histology to clinical rejection reversal: a thymoglobulin multicenter trial report.

    abstract：UNLABELLED:Correlation of histology to rejection reversal: A Thymoglobulin Multicenter Trial report BACKGROUND:Histology may provide a link between clinical response to antirejection therapy and graft function. In a subset of centers, renal biopsy was a secondary end point for the Thymoglobulin Multicenter Trial. MET...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1046/j.1523-1755.1999.00494.x

    authors： Gaber LW,Moore LW,Gaber AO,Tesi RJ,Meyer J,Schroeder TJ

    更新日期：1999-06-01 00:00:00

  • Secretion of insulin-like growth factor I and its binding proteins by collecting duct cells.

    abstract：:Insulin-like growth factor I (IGF-I) has been found in the kidney, particularly in the collecting duct in the rat. Since cultured rabbit collecting duct cells constitute a convenient system for in vitro studies, we have examined whether these cells secrete IGF-I. Culture medium conditioned by collecting duct cells was...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.3

    authors： Aron DC,Saadi HF,Nye CN,Douglas JG

    更新日期：1991-01-01 00:00:00

  • Hemoglobin of 12 g/dl and above is not associated with increased cardiovascular morbidity in children on hemodialysis.

    abstract：:In adults on chronic hemodialysis, achieving a hemoglobin concentration of 12g/dl and above with erythropoiesis stimulating agents leads to increased cardiovascular events and mortality, but this may not be true in children. Therefore, we conducted a retrospective cohort study of pediatric patients (under 18) from the...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.09.013

    authors： Rheault MN,Molony JT,Nevins T,Herzog CA,Chavers BM

    更新日期：2017-01-01 00:00:00

  • Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis.

    abstract：BACKGROUND:Mice overexpressing thymic stromal lymphopoietin (TSLP) develop mixed cryoglobulinemia with renal disease closely resembling human cryoglobulin-associated membranoproliferative glomerulonephritis (MPGN), including glomerular deposits of immunoglobulins and complement. We assessed the effect of complement inh...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00495.x

    authors： Mühlfeld AS,Segerer S,Hudkins K,Farr AG,Bao L,Kraus D,Holers VM,Quigg RJ,Alpers CE

    更新日期：2004-04-01 00:00:00

  • Fibronectin synthesis in tubular epithelial cells: up-regulation of the EDA splice variant by transforming growth factor beta.

    abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.479

    authors： Viedt C,Bürger A,Hänsch GM

    更新日期：1995-12-01 00:00:00

  • B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection.

    abstract：:We explored how B-lymphocytes influence in vitro T-cell alloresponses in patients with antibody-mediated rejection (AMR), testing whether B-cells would be preferentially involved in this group of patients. Peripheral blood mononuclear cells were collected from 65 patients having biopsy: 14 patients with AMR and 5 with...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.100

    authors： Shiu KY,McLaughlin L,Rebollo-Mesa I,Zhao J,Semik V,Cook HT,Roufosse C,Brookes P,Bowers RW,Galliford J,Taube D,Lechler RI,Hernandez-Fuentes MP,Dorling A

    更新日期：2015-09-01 00:00:00

  • Kallistatin protects against diabetic nephropathy in db/db mice by suppressing AGE-RAGE-induced oxidative stress.

    abstract：:Kallistatin is a serine protease inhibitor with anti-inflammatory, anti-angiogenic, and anti-oxidative properties. Since oxidative stress plays a critical role in the pathogenesis of diabetic nephropathy, we studied the effect and mechanisms of action of kallistatin superinduction. Using ultrasound-microbubble-mediate...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.331

    authors： Yiu WH,Wong DW,Wu HJ,Li RX,Yam I,Chan LY,Leung JC,Lan HY,Lai KN,Tang SC

    更新日期：2016-02-01 00:00:00

  • Lanthanum and phosphate: science, policy, and survival.

    abstract：:Mineral metabolism in chronic kidney disease is attracting intense interest and unprecedented levels of research. The pharmaceutical industry has responded by developing various new agents. Bervoets et al. report the use of an unusual combination of basic-science techniques to increase understanding of the kinetics of...

    journal_title：Kidney international

    pub_type： 评论,杂志文章,评审

    doi：10.1038/ki.2008.627

    authors： Hutchison AJ

    更新日期：2009-02-01 00:00:00

  • Transcription factor HNF1beta and novel partners affect nephrogenesis.

    abstract：:Heterozygous mutations of the tissue-specific transcription factor hepatocyte nuclear factor (HNF)1beta, cause maturity onset diabetes of the young (MODY5) and kidney anomalies including agenesis, hypoplasia, dysplasia and cysts. Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.149

    authors： Dudziak K,Mottalebi N,Senkel S,Edghill EL,Rosengarten S,Roose M,Bingham C,Ellard S,Ryffel GU

    更新日期：2008-07-01 00:00:00

  • Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation.

    abstract：:The renal 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme inactivates 11-hydroxy steroids in the kidney, thus protecting the nonselective mineralocorticoid receptor (MR) from occupation by glucocorticoids. The gene is highly expressed in all sodium-transporting epithelia, but also in human placenta, pan...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.2000.00978.x

    authors： Ferrari P,Krozowski Z

    更新日期：2000-04-01 00:00:00

  • Transcription, not synthesis, of interleukin-1 and tumor necrosis factor by complement.

    abstract：:Stimulation of interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF alpha) production was studied during in vitro hemodialysis (HD) of whole blood using cuprammonium (Cup) or polysulfone (PS) dialyzers. In the absence of LPS, circulation of whole blood for two hours through Cup or PS dialyzers was not suffici...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/ki.1990.12

    authors： Schindler R,Lonnemann G,Shaldon S,Koch KM,Dinarello CA

    更新日期：1990-01-01 00:00:00